Neurotrophic Factors and Their Potential Applications in Tissue Regeneration

Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy

Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,951

Neurotrophins: Roles in Neuronal Development and Function

Huang, E. J., & Reichardt, L. F. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.677 · Cited by 4,394

Translational Findings on Brain-Derived Neurotrophic Factor and Anxiety: Contributions from Basic Research to Clinical Practice

da Luz, A. C. D. D. S., Dias, G. P., Bevilaqua, M. C. D. N., Cocks, G. D., Gardino, P. F., Thuret, S., & Nardi, A. E. (2013) · Neuropsychobiology · doi:10.1159/000353269 · Cited by 4,015

GDNF: a Glial Cell Line-Derived Neurotrophic Factor for Midbrain Dopaminergic Neurons

Lin, L.-F. H., Doherty, D. H., Lile, J. D., Bektesh, S. L., & Collins, F. (1993) · Science · doi:10.1126/science.8493557 · Cited by 3,206

Neurotrophin-regulated signalling pathways

Reichardt, L. F. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1894 · Cited by 2,195

The GDNF family: Signalling, biological functions and therapeutic value

Airaksinen, M. S., & Saarma, M. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn812 · Cited by 1,832

Purification of a new neurotrophic factor from mammalian brain.

Barde, Y. A., Edgar, D., & Thoenen, H. (1982) · The EMBO Journal · doi:10.1002/j.1460-2075.1982.tb01207.x · Cited by 1,822

Adult Bone Marrow Stromal Cells Differentiate into Neural Cells in Vitro

Sanchez‐Ramos, J., Song, S., Cardozo‐Pelaez, F., Hazzi, C., Stedeford, T. J., Willing, A. E., Freeman, T. B., Saporta, S., Janssen, W. E., Patel, N. A., et al. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7389 · Cited by 1,568

Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.

Korte, M., Carroll, P., Wolf, E., Brem, G., Thoenen, H., & Bonhoeffer, T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8856 · Cited by 1,426

Regulation of Cell Fate Decision of Undifferentiated Spermatogonia by GDNF

Meng, X., Lindahl, M., Hyvönen, M. E., Parvinen, M., de Rooij, D. G., Hess, M. W., Raatikainen-Ahokas, A., Sainio, K., Rauvala, H., Lakso, M., et al. (2000) · Science · doi:10.1126/science.287.5457.1489 · Cited by 1,404

Long-Lasting Neurotrophin-Induced Enhancement of Synaptic Transmission in the Adult Hippocampus

Kang, H., & Schuman, E. M. (1995) · Science · doi:10.1126/science.7886457 · Cited by 1,354

Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF

Maisonpierre, P. C., Belluscio, L., Squinto, S., Ip, N. Y., Furth, M. E., Lindsay, R. M., & Yancopoulos, G. D. (1990) · Science · doi:10.1126/science.2321006 · Cited by 1,322

Direct brain infusion of glial cell line–derived neurotrophic factor in Parkinson disease

Gill, S. S., Patel, N. K., Hotton, G. R., O'Sullivan, K., McCarter, R., Bunnage, M., Brooks, D. J., Svendsen, C. N., & Heywood, P. (2003) · Nature Medicine · doi:10.1038/nm850 · Cited by 1,290

Nerve Growth Factor Signaling, Neuroprotection, and Neural Repair

Sofroniew, M. V., Howe, C. L., & Mobley, W. C. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1217 · Cited by 1,284

Recombinant BDNF Rescues Deficits in Basal Synaptic Transmission and Hippocampal LTP in BDNF Knockout Mice

Patterson, S. L., Abel, T., Deuel, T. A. S., Martin, K. C., Rose, J. C., & Kandel, E. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80140-3 · Cited by 1,233

Renal agenesis and the absence of enteric neurons in mice lacking GDNF

Sánchez, M. P., Silos‐Santiago, I., Frisén, J., He, B., Lira, S. A., & Barbacid, M. (1996) · Nature · doi:10.1038/382070a0 · Cited by 1,196

Defects in enteric innervation and kidney development in mice lacking GDNF

Pichel, J. G., Shen, L., SHENG, H. Z., Granholm, A., Drago, J., Grinberg, A., Lee, E. J., Huang, S. P., Saarma, M., Hoffer, B. J., et al. (1996) · Nature · doi:10.1038/382073a0 · Cited by 1,153

Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family

Hohn, A., Leibrock, J., Bailey, K., & Barde, Y.-A. (1990) · Nature · doi:10.1038/344339a0 · Cited by 1,145

Loss of Huntingtin-Mediated BDNF Gene Transcription in Huntington's Disease

Zuccato, C., Ciammola, A., Rigamonti, D., Leavitt, B. R., Goffredo, D., Conti, L., MacDonald, M. E., Friedlander, R. M., Silani, V., Hayden, M. R., et al. (2001) · Science · doi:10.1126/science.1059581 · Cited by 1,123

Mice lacking brain-derived neurotrophic factor develop with sensory deficits

Ernfors, P., Lee, K.-F., & Jaenisch, R. (1994) · Nature · doi:10.1038/368147a0 · Cited by 1,067

TrkB signalling pathways in LTP and learning

Minichiello, L. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2738 · Cited by 1,055

A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease

Tuszynski, M. H., Thal, L., Pay, M., Salmon, D. P., U, H. S., Bakay, R., Patel, P., Blesch, A., Vahlsing, H. L., Ho, G., et al. (2005) · Nature Medicine · doi:10.1038/nm1239 · Cited by 1,050

Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development

Jones, K. R., Fariñas, I., Backus, C., & Reichardt, L. F. (1994) · Cell · doi:10.1016/0092-8674(94)90377-8 · Cited by 1,041

Randomized controlled trial of intraputamenal glial cell line–derived neurotrophic factor infusion in Parkinson disease

Lang, A. E., Gill, S., Patel, N., Lozano, A., Nutt, J. G., Penn, R., Brooks, D. J., Hotton, G. R., Moro, E., Heywood, P., et al. (2006) · Annals of Neurology · doi:10.1002/ana.20737 · Cited by 987

Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene

Smeyne, R. J., Klein, R., Schnapp, A., Long, L. K., Bryant, S., Lewin, A. C., Lira, S. A., & Barbacid, M. (1994) · Nature · doi:10.1038/368246a0 · Cited by 980

Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes

Zuccato, C., Tartari, M., Crotti, A., Goffredo, D., Valenza, M., Conti, L., Cataudella, T., Leavitt, B. R., Hayden, M. R., Timmusk, T., et al. (2003) · Nature Genetics · doi:10.1038/ng1219 · Cited by 979

Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo

Levi‐Montalcini, R., & Hamburger, V. (1951) · Journal of Experimental Zoology · doi:10.1002/jez.1401160206 · Cited by 958

Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system

Lee, K., Li, E., Huber, L. J., Landis, S. C., Sharpe, A. H., Chao, M. V., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90286-l · Cited by 949

BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease

Phillips, H. S., Hains, J. M., Armanini, M., Laramee, G. R., Johnson, S. A., & Winslow, J. W. (1991) · Neuron · doi:10.1016/0896-6273(91)90273-3 · Cited by 921

Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities

Lyons, W. E., Mamounas, L. A., Ricaurte, G. A., Coppola, V., Reid, S. W., Bora, S. H., Wihler, C., Koliatsos, V. E., & Tessarollo, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.15239 · Cited by 862

Neurotrophin-5: A novel neurotrophic factor that activates trk and trkB

Berkemeier, L. R., Winslow, J. W., Kaplan, D. R., Nikolics, K., Goeddel, D. V., & Rosenthal, A. (1991) · Neuron · doi:10.1016/0896-6273(91)90287-a · Cited by 836

Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents

Ernfors, P., Lee, K., Kučera, J., & Jaenisch, R. (1994) · Cell · doi:10.1016/0092-8674(94)90213-5 · Cited by 813

BDNF regulates eating behavior and locomotor activity in mice

Kernie, S. G., Liebl, D. J., & Parada, L. F. (2000) · The EMBO Journal · doi:10.1093/emboj/19.6.1290 · Cited by 806

A BDNF autocrine loop in adult sensory neurons prevents cell death

Acheson, A., Conover, J. C., Fandl, J. P., DeChiara, T. M., Russell, M., Thadani, A., Squinto, S. P., Yancopoulos, G. D., & Lindsay, R. M. (1995) · Nature · doi:10.1038/374450a0 · Cited by 765

Rapid and selective induction of BDNF expression in the hippocampus during contextual learning

Hall, J., Thomas, K. L., & Everitt, B. (2000) · Nature Neuroscience · doi:10.1038/75698 · Cited by 669

Novel functions and signalling pathways for GDNF

Sariola, H. V., & Saarma, M. (2003) · Journal of Cell Science · doi:10.1242/jcs.00786 · Cited by 648

The Neural Cell Adhesion Molecule NCAM Is an Alternative Signaling Receptor for GDNF Family Ligands

Paratcha, G., Ledda, F., & Ibáñez, C. F. (2003) · Cell · doi:10.1016/s0092-8674(03)00435-5 · Cited by 627

Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.

Ip, N. Y., Ibáñez, C. F., Nye, S. H., McClain, J., Jones, P. F., Gies, D. R., Belluscio, L., Le Beau, M. M., Espinosa, R., & Squinto, S. P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.7.3060 · Cited by 626

Brain-Derived Neurotrophic Factor/TrkB Signaling in Memory Processes

Yamada, K., & Nabeshima, T. (2003) · Journal of Pharmacological Sciences · doi:10.1254/jphs.91.267 · Cited by 595

BDNF-induced TrkB activation down-regulates the K+–Cl− cotransporter KCC2 and impairs neuronal Cl− extrusion

Rivera, C., Li, H., Thomas-Crusells, J., Lahtinen, H., Viitanen, T., Nanobashvili, A., Kokaia, Z., Airaksinen, M. S., Voipio, J., Kaila, K., et al. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200209011 · Cited by 566

Studies on the expression of the beta nerve growth factor (NGF) gene in the central nervous system: level and regional distribution of NGF mRNA suggest that NGF functions as a trophic factor for several distinct populations of neurons.

Shelton, D. L., & Reichardt, L. F. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.8.2714 · Cited by 532

Reduced BDNF mRNA Expression in the Parkinson's Disease Substantia Nigra

Howells, D. W., Porritt, M. J., Wong, J. Y. F., Batchelor, P. E., Kalnins, R., Hughes, A. J., & Donnan, G. A. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7483 · Cited by 513

Persephin, a Novel Neurotrophic Factor Related to GDNF and Neurturin

Milbrandt, J., de Sauvage, F. J., Fahrner, T. J., Baloh, R. H., Leitner, M. L., Tansey, M. G., Lampe, P. A., Heuckeroth, R. O., Kotzbauer, P. T., Simburger, K. S., et al. (1998) · Neuron · doi:10.1016/s0896-6273(00)80453-5 · Cited by 494

Neurotrophins and Time: Different Roles for TrkB Signaling in Hippocampal Long-Term Potentiation

Kang, H., Welcher, A. A., Shelton, D., & Schuman, E. M. (1997) · Neuron · doi:10.1016/s0896-6273(00)80378-5 · Cited by 481

Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line—derived neurotrophic factor

Slevin, J. T., Gerhardt, G. A., Smith, C. D., Gash, D. M., Kryscio, R. J., & Young, B. A. (2005) · Journal of neurosurgery · doi:10.3171/jns.2005.102.2.0216 · Cited by 474

Learning deficit in BDNF mutant mice.

Linnarsson, S., Björklund, A., & Ernfors, P. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01687.x · Cited by 471

Nerve growth factor: from the early discoveries to the potential clinical use

Aloe, L., Rocco, M. L., Bianchi, P., & Manni, L. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-239 · Cited by 460

Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT4

Conover, J., Erickson, J., Katz, D. M., Bianchi, L., Poueymirou, W., Mcclain, J., Pan, L., Helgren, M. E., Ip, N. Y., Boland, P., et al. (1995) · Nature · doi:10.1038/375235a0 · Cited by 428

BDNF and Full-length and Truncated TrkB Expression in Alzheimer Disease. Implications in Therapeutic Strategies

Ferrer, I., Marı́n, C., Rey, M. J., Ribalta, T., Goutan, E., Blanco, R., Tolosa, E. S., & Martı́, E. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199907000-00007 · Cited by 407

The effect of systemically administered recombinant human nerve growth factor in healthy human subjects

Petty, B. G., Cornblath, D. R., Adornato, B. T., Chaudhry, V., Flexner, C. W., Wachsman, M., Sinicropi, D. V., Burton, L. E., & Peroutka, S. J. (1994) · Annals of Neurology · doi:10.1002/ana.410360221 · Cited by 402

Mesenchymal stem cells that produce neurotrophic factors reduce ischemic damage in the rat middle cerebral artery occlusion model

Kurozumi, K., Nakamura, K., Tamiya, T., Kawano, Y., Ishii, K., Kobune, M., Hirai, S., Uchida, H., Sasaki, K., Ito, Y., et al. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2004.09.020 · Cited by 398

The Neurotrophin Family of Neurotrophic Factors: An Overview

Skaper, S. D. (2012) · Methods in molecular biology · doi:10.1007/978-1-61779-536-7_1 · Cited by 393

Arrest of Motor Neuron Disease in wobbler Mice Cotreated with CNTF and BDNF

Mitsumoto, H., Ikeda, K., Klinkosz, B., Cedarbaum, J. M., Wong, V., & Lindsay, R. M. (1994) · Science · doi:10.1126/science.8066451 · Cited by 386

Sensory but not motor neuron deficits in mice lacking NT4 and BDNF

Liu, X., Ernfors, P., Wu, H.-L., & Jaenisch, R. (1995) · Nature · doi:10.1038/375238a0 · Cited by 379

Virus-mediated gene transfer into hippocampal CA1 region restores long-term potentiation in brain-derived neurotrophic factor mutant mice.

Korte, M., Griesbeck, O., Gravel, C., Carroll, P., Staiger, V, Thoenen, H., & Bonhoeffer, T. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.22.12547 · Cited by 351 · cited 2×

The trk B tyrosine protein kinase is a receptor for neurotrophin-4

Klein, R., Lamballe, F., Bryant, S., & Barbacid, M. (1992) · Neuron · doi:10.1016/0896-6273(92)90209-v · Cited by 334

Glial Cell Line-derived Neurotrophic Factor Regulation of Genes Essential for Self-renewal of Mouse Spermatogonial Stem Cells Is Dependent on Src Family Kinase Signaling

Oatley, J. M., Avarbock, M. R., & Brinster, R. L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703474200 · Cited by 320

ERM is required for transcriptional control of the spermatogonial stem cell niche

Chen, C., Ouyang, W., Grigura, V., Zhou, Q., Carnes, K. I., Lim, H. J., Zhao, G.-Q., Arber, S., Kurpios, N. A., Murphy, T. L., et al. (2005) · Nature · doi:10.1038/nature03894 · Cited by 320

Mice Lacking Brain-Derived Neurotrophic Factor Exhibit Visceral Sensory Neuron Losses Distinct from Mice Lacking NT4 and Display a Severe Developmental Deficit in Control of Breathing

Erickson, J. T., Conover, J. C., Borday‐Birraux, V., Champagnat, J., Barbacid, M., Yancopoulos, G. D., & Katz, D. M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-17-05361.1996 · Cited by 295

Glial cell line–derived neurotrophic factor induces neuronal sprouting in human brain

Love, S., Plaha, P., Patel, N. K., Hotton, G. R., Brooks, D. J., & Gill, S. S. (2005) · Nature Medicine · doi:10.1038/nm0705-703 · Cited by 285

Neurotrophic cross‐talk between the nervous and immune systems: Implications for neurological diseases

Kerschensteiner, M., Stadelmann, C., Dechant, G., Wekerle, H., & Hohlfeld, R. (2003) · Annals of Neurology · doi:10.1002/ana.10446 · Cited by 275

Brain-Derived Neurotrophic Factor Modulates Fast Synaptic Inhibition by Regulating GABAAReceptor Phosphorylation, Activity, and Cell-Surface Stability

Jovanovic, J. N., Thomas, P., Kittler, J. T., Smart, T. G., & Moss, S. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3606-03.2004 · Cited by 273

Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration

Mahmoud, A. I., O'Meara, C. C., Gemberling, M. P., Zhao, L., Bryant, D. M., Zheng, R., Gannon, J., Cai, L., Choi, W.-Y., Egnaczyk, G. F., et al. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.06.017 · Cited by 273

Neurotrophin-3 regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma

Wan, G., Gómez‐Casati, M. E., Gigliello, A. R., Liberman, M. C., & Corfas, G. (2014) · eLife · doi:10.7554/elife.03564 · Cited by 267

GABAergic Stimulation Regulates the Phenotype of Hippocampal Interneurons through the Regulation of Brain-Derived Neurotrophic Factor

Marty, S., Berninger, B., Carroll, P., & Thoenen, H. (1996) · Neuron · doi:10.1016/s0896-6273(00)80075-6 · Cited by 263

Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis

Lu, B. C., Cebrián, C., Chi, X., Kuure, S., Kuo, R., Bates, C. M., Arber, S., Hassell, J. A., MacNeil, L. T., Hoshi, M., et al. (2009) · Nature Genetics · doi:10.1038/ng.476 · Cited by 238

Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase

Borrell-Pagés, M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27607 · Cited by 236

Neurturin and GDNF Promote Proliferation and Survival of Enteric Neuron and Glial Progenitorsin Vitro

Heuckeroth, R. O., Lampe, P. A., Johnson, E. M., & Milbrandt, J. (1998) · Developmental Biology · doi:10.1006/dbio.1998.8955 · Cited by 233

RESEARCH ARTICLE: Systematic Assessment of BDNF and Its Receptor Levels in Human Cortices Affected by Huntington's Disease

Zuccato, C., Marullo, M., Conforti, P., MacDonald, M. E., Tartari, M., & Cattaneo, E. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2007.00111.x · Cited by 231

Ultrastructural Localization of Full-Length trkB Immunoreactivity in Rat Hippocampus Suggests Multiple Roles in Modulating Activity-Dependent Synaptic Plasticity

Drake, C. T., Milner, T. A., & Patterson, S. L. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-18-08009.1999 · Cited by 230

Nerve growth factor promotes human hemopoietic colony growth and differentiation.

Matsuda, H., Coughlin, M. D., Bienenstock, J., & Denburg, J. A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.17.6508 · Cited by 228

Targeted mutation in the neurotrophin-3 gene results in loss of muscle sensory neurons.

Tessarollo, L., Vogel, K. S., Palko, M. E., Reid, S. W., & Parada, L. F. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.25.11844 · Cited by 224

Intraputaminal Infusion of Nerve Growth Factor to Support Adrenal Medullary Autografts in Parkinson's Disease

Olson, L. (1991) · Archives of Neurology · doi:10.1001/archneur.1991.00530160037011 · Cited by 214

Phenotypic Knockout of Nerve Growth Factor in Adult Transgenic Mice Reveals Severe Deficits in Basal Forebrain Cholinergic Neurons, Cell Death in the Spleen, and Skeletal Muscle Dystrophy

Ruberti, F., Capsoni, S., Comparini, A., Daniel, E. D., Franzot, J., Gonfloni, S., Rossi, G., Berardi, N., & Cattaneo, A. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-07-02589.2000 · Cited by 212

Brain-Derived Neurotrophic Factor Modulation of GABAergic Synapses by Postsynaptic Regulation of Chloride Transport

Wardle, R. A., & Poo, M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-25-08722.2003 · Cited by 201

Brain-Derived Neurotrophic Factor (BDNF) Modulates Inhibitory, But Not Excitatory, Transmission in the CA1 Region of the Hippocampus

Frerking, M. E., Malenka, R. C., & Nicoll, R. A. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.6.3383 · Cited by 201

Nerve Growth Factor Promotes Cardiac Repair following Myocardial Infarction

Meloni, M., Caporali, A., Graiani, G., Lagrasta, C. A. M., Katare, R., Linthout, S. V., Spillmann, F., Campesi, I., Madeddu, P. R., Quaini, F., et al. (2010) · Circulation Research · doi:10.1161/circresaha.109.210088 · Cited by 193

Parasympathetic stimulation improves epithelial organ regeneration

Knox, S. M., Lombaert, I. M. A., Haddox, C. L., Abrams, S. R., Cotrim, A. P., Wilson, A. J., & Hoffman, M. P. (2013) · Nature Communications · doi:10.1038/ncomms2493 · Cited by 192

Cholinergic denervation of the rat hippocampus by fimbrial transection leads to a transient accumulation of nerve growth factor (NGF) without change in mRNANGF content

Korsching, S. I., Heumann, R., Thoenen, H., & Hefti, F. F. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90186-2 · Cited by 189

Endothelial NT-3 Delivered by Vasculature and CSF Promotes Quiescence of Subependymal Neural Stem Cells through Nitric Oxide Induction

Delgado, A. C., Ferrón, S. R., Vicente, D., Porlan, E., Pérez‐Villalba, A., Trujillo, C. M., D’Ocón, P., & Fariñas, I. (2014) · Neuron · doi:10.1016/j.neuron.2014.06.015 · Cited by 182

AAV-Mediated gene delivery of BDNF or GDNF is neuroprotective in a model of huntington disease

Kells, A. P., Fong, D. M., Dragunow, M., During, M. J., Young, D., & Connor, B. J. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2004.02.016 · Cited by 179

Targeting the RET Pathway in Thyroid Cancer

Wells, S. A., & Santoro, M. M. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2742 · Cited by 168

Critical and distinct roles for key RET tyrosine docking sites in renal developmentPreprint

Jain, S. R., Encinas, M., Johnson, E. M., & Milbrandt, J. (2006) · Genes & Development · doi:10.1101/gad.1387206 · Cited by 165

Glial Cell Line-Derived Neurotrophic Factor Is Essential for Postnatal Survival of Midbrain Dopamine Neurons

Granholm, A., Reyland, M. E., Albeck, D. S., Sanders, L., Gerhardt, G. A., Hoernig, G. R., Shen, L., Westphal, H., & Hoffer, B. J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-09-03182.2000 · Cited by 160

Encapsulated Cell Biodelivery of Nerve Growth Factor to the Basal Forebrain in Patients with Alzheimer’s Disease

Eriksdotter, M., Linderoth, B., Lind, G., Aladellie, L., Almkvist, O., Andreasen, N., Blennow, K., Bogdanović, N., Jelić, V., Kadir, A., et al. (2012) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000336051 · Cited by 158

Neural Cell Differentiation In Vitro from Adult Human Bone Marrow Mesenchymal Stem Cells

Long, X., Olszewski, M., Huang, W., & Kletzel, M. (2005) · Stem Cells and Development · doi:10.1089/scd.2005.14.65 · Cited by 155

Striatal Delivery of Neurturin by CERE-120, an AAV2 Vector for the Treatment of Dopaminergic Neuron Degeneration in Parkinson's Disease

Gasmi, M., Herzog, C. D., Brandon, E. P., Cunningham, J. J., Ramirez, G. A., Ketchum, E. T., & Bartus, R. T. (2006) · Molecular Therapy · doi:10.1038/sj.mt.6300010 · Cited by 153

Embryonic stromal clones reveal developmental regulators of definitive hematopoietic stem cells

Durand, C., Robin, C., Bollérot, K., Baron, M. H., Ottersbach, K., & Dzierzak, E. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706923105 · Cited by 153

Neurotrophin Signaling via TrkB and TrkC Receptors Promotes the Growth of Brain Tumor-initiating Cells

Lawn, S. O., Krishna, N., Pisklakova, A., Qu, X., Fenstermacher, D. A., Fournier, M., Vrionis, F. D., Tran, N., Chan, J. A.-W., Kenchappa, R. S., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.599373 · Cited by 151

Interventional MRI-guided Putaminal Delivery of AAV2-GDNF for a Planned Clinical Trial in Parkinson's Disease

Richardson, R. M., Kells, A. P., Rosenbluth, K. H., Salegio, E. A., Fiandaca, M. S., Larson, P., Starr, P. A., Martin, A. J., Lonser, R. R., Federoff, H. J., et al. (2011) · Molecular Therapy · doi:10.1038/mt.2011.11 · Cited by 150

Ureteric Bud Outgrowth in Response to RET Activation Is Mediated by Phosphatidylinositol 3-Kinase

Tang, M., Cai, Y., Tsai, S.-J., Wang, Y.-K., & Dressler, G. R. (2002) · Developmental Biology · doi:10.1006/dbio.2001.0557 · Cited by 149

GDNF – a stranger in the TGF‐β superfamily?

Saarma, M. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01826.x · Cited by 144

GFRα1 released by nerves enhances cancer cell perineural invasion through GDNF-RET signaling

He, S., Chen, C., Chernichenko, N., He, S., Bakst, R. L., Barajas, F., Deborde, S., Allen, P. J., Vakiani, E., Yu, Z., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402944111 · Cited by 138

Synergistic Effects of GDNF and VEGF on Lifespan and Disease Progression in a Familial ALS Rat Model

Krakora, D., Mulcrone, P. L., Meyer, M., Lewis, C. M., Bernau, K., Gowing, G., Zimprich, C., Aebischer, P., Svendsen, C. N., & Suzuki, M. (2013) · Molecular Therapy · doi:10.1038/mt.2013.108 · Cited by 133

Neuroprotection by NGF and BDNF Against Neurotoxin-Exerted Apoptotic Death in Neural Stem Cells Are Mediated Through Trk Receptors, Activating PI3-Kinase and MAPK Pathways

Nguyen, N., Lee, S. B., Lee, Y. S., Lee, K.-H., & Ahn, J.-Y. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9848-9 · Cited by 132

Four Cation-Selective Transporters Contribute to Apical Uptake and Accumulation of Metformin in Caco-2 Cell Monolayers

Han, T. K., Proctor, W. R., Costales, C., Cai, H., Everett, R., & Thakker, D. R. (2015) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.220350 · Cited by 123

CERE-110, an adeno-associated virus-based gene delivery vector expressing human nerve growth factor for the treatment of Alzheimer's disease.

Mandel, R. J. (2010) · PubMed · Cited by 123

GDNF–RET Signaling in ER-Positive Breast Cancers Is a Key Determinant of Response and Resistance to Aromatase Inhibitors

Morandi, A., Martin, L., Gao, Q., Pancholi, S., Mackay, A. G., Robertson, D. M., Zvelebil, M., Dowsett, M., Plaza-Menacho, I., & Isacke, C. M. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4265 · Cited by 120

GDNF/Ret signaling and renal branching morphogenesis

Costantini, F. D. (2010) · Organogenesis · doi:10.4161/org.6.4.12680 · Cited by 119

Perineural growth in head and neck squamous cell carcinoma: A review

Roh, J., Muelleman, T. J., Tawfik, O. W., & Thomas, S. M. (2014) · Oral Oncology · doi:10.1016/j.oraloncology.2014.10.004 · Cited by 116

Long-term functional recovery from age-induced spatial memory impairments by nerve growth factor gene transfer to the rat basal forebrain.

Martı́nez-Serrano, A., Fischer, W., Söderström, S., Ebendal, T., & Björklund, A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6355 · Cited by 116

Neurotrophic factor GDNF promotes survival of salivary stem cells

Xiao, N., Lin, Y., Cao, H., Sirjani, D. B., Giaccia, A. J., Koong, A. C., Kong, C. S., Diehn, M., & Le, Q. (2014) · Journal of Clinical Investigation · doi:10.1172/jci74096 · Cited by 112

Glial-derived neurotrophic factor (GDNF) prevents ethanol-induced apoptosis and JUN kinase phosphorylation

McAlhany, R. E., West, J. R., & Miranda, R. C. (2000) · Developmental Brain Research · doi:10.1016/s0165-3806(99)00171-6 · Cited by 112

Identification of the prosurvival activity of nerve growth factor on cardiac myocytes

Caporali, A., Sala-Newby, G., Meloni, M., Graiani, G., Pani, E., Cristofaro, B., Newby, A., Madeddu, P., & Emanueli, C. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402263 · Cited by 105

Isolation, Tissue Localization, and Cellular Characterization of Progenitors Derived from Adult Human Salivary Glands

Sato, A., Okumura, K., Matsumoto, S., Hattori, K., Hattori, S., Shinohara, M., & Endo, F. (2007) · Cloning and Stem Cells · doi:10.1089/clo.2006.0054 · Cited by 102

gdnf Activates Midline Repulsion by Semaphorin3B via NCAM during Commissural Axon Guidance

Charoy, C., Nawabi, H., Reynaud, F., Derrington, E. A., Bozon, M., Wright, K. M., Falk, J., Helmbacher, F., Kindbeiter, K., & Castellani, V. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.021 · Cited by 98

Nerve Growth Factor, Neural Stem Cells and Alzheimer’s Disease

Heese, K., Low, J. W., & Inoue, N. (2006) · Neurosignals · doi:10.1159/000094383 · Cited by 97

Proliferation, Differentiation, and Survival of Rat Sensory Neuron Precursors in Vitro Require Specific Trophic Factors

Memberg, S. P., & Hall, A. K. (1995) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1995.1025 · Cited by 97

GDNF‐mediated signaling via RET tyrosine 1062 is essential for maintenance of spermatogonial stem cells

Jijiwa, M., Kawai, K., Fukihara, J., Nakamura, A., Hasegawa, M., Suzuki, C., Sato, T., Enomoto, A., Asai, N., Murakumo, Y., et al. (2008) · Genes to Cells · doi:10.1111/j.1365-2443.2008.01171.x · Cited by 91

Histone deacetylase inhibitors are neuroprotective and preserve NGF-mediated cell survival following traumatic brain injury

Lu, J., Frerich, J. M., Turtzo, L. C., Li, S., Chiang, J. Y., Yang, C., Wang, X., Zhang, C., Wu, C., Sun, Z., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308950110 · Cited by 89

Brain Changes in Alzheimer's Disease Patients with Implanted Encapsulated Cells Releasing Nerve Growth Factor

Ferreira, D., Initiative, A. D. N., Westman, E., Eyjolfsdottir, H., Almqvist, P. M., Lind, G., Linderoth, B., Seiger, Å., Blennow, K., Karami, A., et al. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141068 · Cited by 88

Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis

Sinkevicius, K. W., Kriegel, C., Bellaria, K. J., Lee, J. J., Lau, A. N., Leeman, K. T., Zhou, P., Beede, A. M., Brainson, C. F., Caswell, D. R., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1404399111 · Cited by 88

The neurotrophic factor neurturin contributes toward an aggressive cancer cell phenotype, neuropathic pain and neuronal plasticity in pancreatic cancer

Wang, K., Demir, İ. E., D’Haese, J. G., Tieftrunk, E., Kujundzic, K., Schorn, S., Xing, B., Kehl, T., Frieß, H., & Ceyhan, G. O. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt312 · Cited by 88

Human umbilical cord blood cells express neurotrophic factors

Fan, C., Zhang, Q.-J., Tang, F., Han, Z., Wang, G.-S., & Han, Z. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.01.070 · Cited by 86

Neurotrophin-3 in the development of the enteric nervous system

Chalazonitis, A. (2004) · Progress in brain research · doi:10.1016/s0079-6123(03)46016-0 · Cited by 85

Neuroprotection by GDNF-secreting stem cells in a Huntington's disease model: optical neuroimage tracking of brain-grafted cells

Pineda, J. R., Rubio, N., Åkerud, P., Urbán, N., Badimón, L., Arenas, E., Alberch, J., Blanco, J., & Canals, J. M. (2006) · Gene Therapy · doi:10.1038/sj.gt.3302847 · Cited by 84

RET proto-oncogene point mutations in sporadic neuroendocrine tumors

Komminoth, P., Roth, J., Muletta-Feurer, S., Saremaslani, P., Seelentag, W. K. F., & Heitz, P. U. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.6.2041 · Cited by 83

Persephin-Overexpressing Neural Stem Cells Regulate the Function of Nigral Dopaminergic Neurons and Prevent Their Degeneration in a Model of Parkinson's Disease

PKERUD, P., Holm, P. C., Castelo‐Branco, G., Sousa, K. M., Rodríguez, F. J., & Arenas, E. (2002) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2002.1171 · Cited by 75

Localized Delivery of Brain-Derived Neurotrophic Factor-Expressing Mesenchymal Stem Cells Enhances Functional Recovery following Cervical Spinal Cord Injury

Gransee, H. M., Zhan, W., Sieck, G. C., & Mantilla, C. B. (2014) · Journal of Neurotrauma · doi:10.1089/neu.2014.3464 · Cited by 75

Sustained delivery of bioactive neurotrophin-3 to the injured spinal cord

Donaghue, I. E., Tator, C. H., & Shoichet, M. S. (2014) · Biomaterials Science · doi:10.1039/c4bm00311j · Cited by 74

Sonic hedgehog and neurotrophin-3 increase oligodendrocyte numbers and myelination after spinal cord injury

Thomas, A. M., Seidlits, S. K., Goodman, A. G., Kukushliev, T. V., Hassani, D. M., Cummings, B. J., Anderson, A. J., & Shea, L. D. (2014) · Integrative Biology · doi:10.1039/c4ib00009a · Cited by 71

Nerve Growth Factor Improves the Muscle Regeneration Capacity of Muscle Stem Cells in Dystrophic Muscle

Lavasani, M., Lu, A., Peng, H., Cummins, J., & Huard, J. (2006) · Human Gene Therapy · doi:10.1089/hum.2006.17.180 · Cited by 71

Neuropoietic cytokines in normal brain development and neurodevelopmental disorders

Stolp, H. B. (2013) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.08.009 · Cited by 70 · cited 1×

Ampakines cause sustained increases in brain-derived neurotrophic factor signaling at excitatory synapses without changes in AMPA receptor subunit expression

Lauterborn, J. C., Pineda, E., Chen, L. Y., Ramirez, E. A., LYNCH, G. S., & Gall, C. M. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.12.018 · Cited by 70

Additional ECT increases BDNF-levels in patients suffering from major depressive disorders compared to patients treated with citalopram only

Haghighi, M., Salehi, I., Erfani, P., Jahangard, L., Bajoghli, H., Holsboer‐Trachsler, E., & Brand, S. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.03.006 · Cited by 70

Non-chromaffin tissue plus nerve growth factor reduces experimental parkinsonism in aged rats

Pezzoli, G., Fahn, S., Dwork, A. J., Truong, D. D., de Yébenes, J. G., Jackson-Lewis, V. R., Herbert, J., & Cadet, J. L. (1988) · Brain Research · doi:10.1016/0006-8993(88)90659-2 · Cited by 68

Deficient long-term memory and long-lasting long-term potentiation in mice with a targeted deletion of neurotrophin-4 gene

Xie, C.-W., Sayah, D. M., Chen, Q.-S., Wei, W., Smith, D., & Liu, X. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.140204597 · Cited by 68

BDNF prevents amyloid-dependent impairment of LTP in the entorhinal cortex by attenuating p38 MAPK phosphorylation

Criscuolo, C., Fabiani, C., Bonadonna, C., Origlia, N., & Domenici, L. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.11.016 · Cited by 67

Nerve Growth Factor Increases Insulin Secretion and Barium Current in Pancreatic β-Cells

Rosenbaum, T., Sánchez-Soto, M. C., & Hiriart, M. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1755 · Cited by 67

Human adipose-Derived Mesenchymal Stem Cells Improve Motor Functions and are Neuroprotective in the 6-Hydroxydopamine-Rat Model for Parkinson’s Disease when Cultured in Monolayer Cultures but Suppress Hippocampal Neurogenesis and Hippocampal Memory Function when Cultured in Spheroids

Berg, J., Roch, M., Altschüler, J., Winter, C., Schwerk, A. M. K., Kurtz, A., & Steiner, B. (2014) · Stem Cell Reviews and Reports · doi:10.1007/s12015-014-9551-y · Cited by 66

Transplantation of neurotrophin-3-expressing bone mesenchymal stem cells improves recovery in a rat model of spinal cord injury

Wang, L., Zhang, R., & Li, J. (2014) · Acta Neurochirurgica · doi:10.1007/s00701-014-2089-6 · Cited by 65

TAM Receptors Support Neural Stem Cell Survival, Proliferation and Neuronal Differentiation

Ji, R., Meng, L., Jiang, X. M., Naresh Kumar, C. V. M., Ding, J., Li, Q., & Lu, Q. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115140 · Cited by 64

Properly scaled and targeted AAV2-NRTN (neurturin) to the substantia nigra is safe, effective and causes no weight loss: Support for nigral targeting in Parkinson's disease

Bartus, R. T., Brown, L., Wilson, A., Kruegel, B. R., Siffert, J. O., Johnson, E. M., Kordower, J. H., & Herzog, C. D. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.05.026 · Cited by 63

Development of Survival Responsiveness to Brain-Derived Neurotrophic Factor, Neurotrophin 3 and Neurotrophin 4/5, But Not to Nerve Growth Factor, in Cultured Motoneurons from Chick Embryo Spinal Cord

Becker, E., Soler, R. M., Yuste, V. J., Giné, E., Sanz-Rodrı́guez, C., Egea, J., Martı́n-Zanca, D., & Comella, J. X. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-19-07903.1998 · Cited by 61

Exploratory investigation of eight circulating plasma markers in brain tumor patients

Ilhan‐Mutlu, A., Wagner, L., Widhalm, G., Wöehrer, A., Bartsch, S., Czech, T., Heinzl, H., Leutmezer, F., Prayer, D., Marosi, C., et al. (2012) · Neurosurgical Review · doi:10.1007/s10143-012-0401-6 · Cited by 61

Paracrine regulation of glioma cells invasion by astrocytes is mediated by glial‐derived neurotrophic factor

Shabtay‐Orbach, A., Amit, M., Binenbaum, Y., Na’ara, S., & Gil, Z. (2014) · International Journal of Cancer · doi:10.1002/ijc.29380 · Cited by 61

Modification of the brain-derived neurotrophic factor gene: a portal to transform mesenchymal stem cells into advantageous engineering cells for neuroregeneration and neuroprotection

Zhao, L.-X., Zhang, J., Cao, F., Meng, L., Wang, D., Li, Y., Nan, X., Jiao, W.-C., Zheng, M., Xu, X.-H., et al. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.06.025 · Cited by 61

Citalopram enhances neurovascular regeneration and sensorimotor functional recovery after ischemic stroke in mice

Espinera, A. R., Ogle, M. E., Gu, X., & Li, W. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.011 · Cited by 60

BDNF protects retinal neurons from hyperglycemia through the TrkB/ERK/MAPK pathway

Liu, Y., Tao, L., Xiao, F., Zhao, Y., & Xu, X. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1433 · Cited by 60

Islet injury induces neurotrophin expression in pancreatic cells and reactive gliosis of peri-islet Schwann cells

Teitelman, G., Guz, Y., Ivković, S., & Ehrlich, M. E. (1998) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(199803)34:4 · Cited by 60

Intraventricular nerve growth factor infusion improves cerebral blood flow and stimulates doublecortin expression in two infants with hypoxic–ischemic brain injury

Chiaretti, A., Antonelli, A., Genovese, O., Fernández, E., Giuda, D. D., Mariotti, P., & Riccardi, R. (2008) · Neurological Research · doi:10.1179/016164107x247948 · Cited by 58

DNA damage induces GDNF secretion in the tumor microenvironment with paracrine effects promoting prostate cancer treatment resistance

Huber, R. M., Lucas, J. M., Gomez-Sarosi, L., Coleman, I. M., Zhao, S. Q., COLEMAN, R. T., & Nelson, P. S. (2014) · Oncotarget · doi:10.18632/oncotarget.3040 · Cited by 57

Neuroprotective Effects of Oligodendrocyte Progenitor Cell Transplantation in Premature Rat Brain following Hypoxic-Ischemic Injury

Chen, L.-X., Ma, S., Zhang, P., Fan, Z.-C., Xiong, M., Cheng, G., Yang, Y., Qiu, Z., Zhou, W., & Li, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0115997 · Cited by 57

Influence of citalopram and environmental temperature on exercise-induced changes in BDNF

Goekint, M., Roelands, B., Heyman, E., Njemini, R., & MEEUSEN, R. R. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.03.001 · Cited by 56

The TrkB+ cancer stem cells contribute to post-chemotherapy recurrence of triple-negative breast cancers in an orthotopic mouse model

Yin, B., Y, Z., Zhou, Z., Gao, W., Du, Z., Zhao, Z., & Li, Q.-Q. (2014) · Oncogene · doi:10.1038/onc.2014.8 · Cited by 55

Cytokine Preconditioning Promotes Codifferentiation of Human Fetal Liver CD133 + Stem Cells Into Angiomyogenic Tissue

Shmelkov, S. V., Meeus, S., Moss, N. S., Kermani, P., Rashbaum, W. K., Rabbany, S. Y., Hanson, M. A., Lane, W. J., Clair, R. S., Walsh, K. A., et al. (2005) · Circulation · doi:10.1161/01.cir.0000157155.44008.0f · Cited by 55

Human adipose-derived mesenchymal stromal cells increase endogenous neurogenesis in the rat subventricular zone acutely after 6-hydroxydopamine lesioning

Schwerk, A. M. K., Altschüler, J., Roch, M., Gossen, M., Winter, C., Berg, J., Kurtz, A., & Steiner, B. (2014) · Cytotherapy · doi:10.1016/j.jcyt.2014.09.005 · Cited by 53

p75 neurotrophin receptor is involved in proliferation of undifferentiated mouse embryonic stem cells

Moscatelli, I., Pierantozzi, E., Camaioni, A., Siracusa, G., & Campagnolo, L. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.08.014 · Cited by 52

Medullary thyroid cancer: targeting the RET kinase pathway with sorafenib/tipifarnib

Hong, D. S., Ye, L., Gagel, R. F., Chintala, L., El‐Naggar, A. K., Wright, J., & Kurzrock, R. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-2422 · Cited by 52

Neurotrophin NT3 promotes ovarian primordial to primary follicle transition

Nilsson, E. E., Dole, G., & Skinner, M. K. (2009) · Reproduction · doi:10.1530/rep-09-0179 · Cited by 49

Artemin Stimulates Radio- and Chemo-resistance by Promoting TWIST1-BCL-2-dependent Cancer Stem Cell-like Behavior in Mammary Carcinoma Cells

Banerjee, A., Qian, P., Wu, Z., Ren, X., Steiner, M., Bougen-Zhukov, N. M., Liu, S., Liu, D., Zhu, T., & Lobie, P. E. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.365163 · Cited by 49

Glial cell line-derived neurotrophic factor (GDNF) induces neuritogenesis in the cochlear spiral ganglion via neural cell adhesion molecule (NCAM)

Euteneuer, S., Yang, K. H., Chávez, E., Leichtle, A., Loers, G., Olshansky, A., Pak, K. K., Schachner, M., & Ryan, A. F. (2012) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2012.12.004 · Cited by 47

Expression of nerve growth factor and its high-affinity receptor Trk-A in the rat pancreas during embryonic and fetal life

Miralles, F., Philippe‐Chomette, P., Czernichow, P., & Scharfmann, R. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1560431 · Cited by 46

Nerve Growth Factor Increases in Pancreatic β Cells After Streptozotocin-Induced Damage in Rats

Larrieta, M. E., Vital, P., Mendoza-Rodríguez, C. A., Cerbón, M. A., & Hiriart, M. (2006) · Experimental Biology and Medicine · doi:10.1177/153537020623100405 · Cited by 46

Transient Activation of Hedgehog Pathway Rescued Irradiation-Induced Hyposalivation by Preserving Salivary Stem/Progenitor Cells and Parasympathetic Innervation

Hai, B., Qin, L., Yang, Z., Zhao, Q., Shangguan, L., Ti, X., Zhao, Y., Kim, S., Rangaraj, D., & Liu, F. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1434 · Cited by 46

GDNF increases cell motility in human colon cancer through VEGF–VEGFR1 interaction

Huang, S.-M., Chen, T.-S., Chiu, C.-M., Chang, L.-K., Liao, K., Tan, H.-M., Yeh, W., Chang, G. R., Wang, M.-Y., & Lu, D. (2013) · Endocrine Related Cancer · doi:10.1530/erc-13-0351 · Cited by 46

The Effects of Controlled Release of Neurotrophin-3 from PCLA Scaffolds on the Survival and Neuronal Differentiation of Transplanted Neural Stem Cells in a Rat Spinal Cord Injury Model

Tang, S., Liao, X., Shi, B., Qu, Y., Huang, Z., Lin, Q., Guo, X., & Pei, F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107517 · Cited by 45

Glial-derived neurotrophic factor (GDNF) prevents ethanol (EtOH) induced B92 glial cell death by both PI3K/AKT and MEK/ERK signaling pathways

Villegas, S. N., Njaine, B., Linden, R., & Carri, N. G. (2006) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2006.08.014 · Cited by 44

In vitro and in vivo improvement of islet survival following treatment with nerve growth factor

Miao, G., Mace, J., Kirby, M., Hopper, A., Peverini, R., Chinnock, R., Shapiro, J., & Hathout, E. (2006) · Transplantation · doi:10.1097/01.tp.0000200320.16723.b3 · Cited by 44

Chronic Neurotrophin-3 Strengthens Synaptic Connections to Motoneurons in the Neonatal Rat

Arvanian, V. L., Horner, P. J., Gage, F. H., & Mendell, L. M. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-25-08706.2003 · Cited by 42

Effects of Certain Growth Factors on In Vitro Maturation of Rat Fetal Islet-like Structures

Öberg-Welsh, C., & Welsh, M. (1996) · Pancreas · doi:10.1097/00006676-199605000-00002 · Cited by 40

Role of motoneuron-derived neurotrophin 3 in survival and axonal projection of sensory neurons during neural circuit formation

Usui, N., Watanabe, K., Ono, K., Tomita, K., Tamamaki, N., Ikenaka, K., & Takebayashi, H. (2012) · Development · doi:10.1242/dev.069997 · Cited by 40

Additive effect of glial cell line-derived neurotrophic factor and neurotrophin-4/5 on rat fetal nigral explant cultures

Meyer, M., Matarredona, E. R., Seiler, R., Zimmer, J., & Widmer, H. R. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00418-3 · Cited by 39

Human adipose-derived mesenchymal stem cells: a better cell source for nervous system regeneration

Han, C., Zhang, L., Song, L., Liu, Y., Zou, W., Piao, H. Z., & Liu, J. (2014) · Chinese Medical Journal · doi:10.3760/cma.j.issn.0366-6999.20120064 · Cited by 39

Neurotrophin-4 (Ntf4) Mediates Neurogenesis in Mouse Embryonic Neural Stem Cells Through the Inhibition of the Signal Transducer and Activator of Transcription-3 (Stat3) and the Modulation of the Activity of Protein Kinase B

Shen, Y., Inoue, N., & Heese, K. (2010) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-010-9520-1 · Cited by 36

Nerve growth factor is a neurotrophic factor for forebrain cholinergic neurons; implications for Alzheimer's disease.

Hefti, F. F., & Will, B. E. (1987) · PubMed · Cited by 35

In Vivo AAV1 Transduction With hRheb(S16H) Protects Hippocampal Neurons by BDNF Production

Jeon, M., Nam, J. H., Shin, W.-H., Leem, E., Jeong, K. H., Jung, U. J., Bae, Y., Jin, Y., Kholodilov, N. G., Burke, R. E., et al. (2014) · Molecular Therapy · doi:10.1038/mt.2014.241 · Cited by 34

Neurotrophin-3 gene transduction of mouse neural stem cells promotes proliferation and neuronal differentiation in organotypic hippocampal slice cultures

Lü, H., Hao, Z., Jiao, Q., Xie, W.-L., Zhang, J., Lu, Y.-F., Cai, M., Parker, T. L., & Liu, Y. (2011) · Medical Science Monitor · doi:10.12659/msm.882039 · Cited by 34

Transforming Growth Factor β Cooperates with Persephin for Dopaminergic Phenotype Induction

Roussa, E., Oehlke, O., Rahhal, B., Heermann, S., Heidrich, S., Wiehle, M., & KRIEGLSTEIN, K. G. (2008) · Stem Cells · doi:10.1634/stemcells.2007-0805 · Cited by 33

Neurotrophin-3 Gene-Modified Schwann Cells Promote TrkC Gene-Modified Mesenchymal Stem Cells to Differentiate into Neuron-Like Cells in Poly(Lactic-Acid-Co-Glycolic Acid) Multiple-Channel Conduit

Zhang, Y., He, L., Xing, B., Zeng, X., Zeng, C., Zhang, W., Quan, D., & Zeng, Y. (2011) · Cells Tissues Organs · doi:10.1159/000327724 · Cited by 33

Artemin, a Member of the Glial Cell Line-derived Neurotrophic Factor Family of Ligands, Is HER2-regulated and Mediates Acquired Trastuzumab Resistance by Promoting Cancer Stem Cell-like Behavior in Mammary Carcinoma Cells

Ding, K., Banerjee, A., Tan, S. H., Zhao, J., Qian, Z., Li, R. Q., Qian, P., Liu, S., Wu, Z., Lobie, P. E., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.529552 · Cited by 32

Overexpression of β-NGF promotes differentiation of bone marrow mesenchymal stem cells into neurons through regulation of AKT and MAPK pathway

Yuan, J. J., Huang, G., Xiao, Z., Lin, L., & Han, T.-W. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1768-6 · Cited by 31

Survival, Differentiation, and Neuroprotective Mechanisms of Human Stem Cells Complexed With Neurotrophin-3-Releasing Pharmacologically Active Microcarriers in an Ex Vivo Model of Parkinson's Disease

Daviaud, N., Garbayo, E., Sindji, L., Martı́nez-Serrano, A., Schiller, P. C., & Montero‐Menei, C. N. (2015) · Stem Cells Translational Medicine · doi:10.5966/sctm.2014-0139 · Cited by 28

Neurotrophin‐3 null mutant mice display a postnatal motor neuropathy

Woolley, A. G., Sheard, P. W., & Duxson, M. J. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04052.x · Cited by 26

Neurotrophin-4 is required for tolerance to morphine in the mouse

Smith, D., Leil, T. A., & Liu, X. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00084-3 · Cited by 26

Brain derived neurotrophic factor (BDNF) levels in depressed women treated with open-label escitalopram.

Ladea, M., & Bran, M. (2013) · PubMed · Cited by 25

BDNF expression in olfactory bulb and epithelium during regeneration of olfactory epithelium

Uranagase, A., Katsunuma, S., Doi, K., & Nibu, K. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.03.051 · Cited by 24

Synergistic Effect of Mesenchymal Stem Cells Infected with Recombinant Adenovirus Expressing Human BDNF on Erectile Function in a Rat Model of Cavernous Nerve Injury

Kim, S. J., Choi, S. W., Hur, K. J., Park, S. H., Sung, Y. C., Ha, Y.-S., Cho, H. J., Hong, S., Lee, J. Y., Hwang, T.-K., et al. (2012) · Korean journal of urology · doi:10.4111/kju.2012.53.10.726 · Cited by 24

Stem cells for cell replacement therapy: A therapeutic strategy for HD?

Rosser, A., & Svendsen, C. N. (2014) · Movement Disorders · doi:10.1002/mds.26026 · Cited by 24

Electroacupuncture Promotes the Differentiation of Transplanted Bone Marrow Mesenchymal Stem Cells Preinduced with Neurotrophin-3 and Retinoic Acid into Oligodendrocyte-Like Cells in Demyelinated Spinal Cord of Rats

Liu, Z., He, B., Zhang, R.-Y., Zhang, K. K., Ding, Y., Ruan, J., Ling, E., Wu, J., & Zeng, Y. (2014) · Cell Transplantation · doi:10.3727/096368914x682099 · Cited by 24

Stem cell grafting in parkinsonism – Why, how and when

de Munter, J., Melamed, E., & Wolters, E. C. (2013) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(13)70036-1 · Cited by 23

The Effect of Lentivirus-Mediated PSPN Genetic Engineering Bone Marrow Mesenchymal Stem Cells on Parkinson’s Disease Rat Model

Yin, X., Xu, H., Jiang, Y., Deng, W., Wu, Z., Xiang, H., Sun, P., & Xie, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105118 · Cited by 23

CXCR2 and RET Single Nucleotide Polymorphisms in Pancreatic Cancer

Donahue, T. R., & Hines, O. J. (2008) · World Journal of Surgery · doi:10.1007/s00268-008-9826-z · Cited by 23

Extracellular Crosstalk

Zhou, F., Zhong, J., & Snider, W. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00467-7 · Cited by 23

NGF and TERT Co-Transfected BMSCs Improve the Restoration of Cognitive Impairment in Vascular Dementia Rats

Wang, F., Chang, G., & Geng, X. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098774 · Cited by 22

Human umbilical cord blood stem cells and brain-derived neurotrophic factor for optic nerve injury: a biomechanical evaluation

Zhang, Z., Li, Y., Liu, X., Huang, F.-X., Liu, T., Jiang, D., Lv, X., & Luo, M. (2015) · Neural Regeneration Research · doi:10.4103/1673-5374.160110 · Cited by 22

Brain-derived neurotrophic factor (BDNF) expression in normal and regenerating olfactory epithelium of Xenopus laevis

Frontera, J. L., Cervino, A. S., Jungblut, L. D., & Paz, D. A. (2014) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2014.10.010 · Cited by 21

Nerve Growth Factor Improves Survival and Function of Transplanted Islets Via TrkA-mediated β Cell Proliferation and Revascularization

Hata, T., Sakata, N., Yoshimatsu, G., Tsuchiya, H., Fukase, M., Ishida, M., Aoki, T., Katayose, Y., Egawa, S., & Unno, M. (2015) · Transplantation · doi:10.1097/tp.0000000000000655 · Cited by 21

Neurotrophin 3, Not Brain‐Derived Neurotrophic Factor or Neurotrophin 4, Knockout Mice Have Delay in Vestibular Compensation After Unilateral Labyrinthectomy

Gacek, R. R., & Khetarpal, U. (1998) · The Laryngoscope · doi:10.1097/00005537-199805000-00009 · Cited by 20

GDNF‐induced seminomatous tumours in mouse – an experimental model for human seminomas?

Sariola, H. V., & Meng, X. (2003) · Apmis · doi:10.1034/j.1600-0463.2003.11101231.x · Cited by 19

Pancreatic Islet Transplantation Using Vascularised Chambers Containing Nerve Growth Factor Ameliorates Hyperglycaemia in Diabetic Mice

Hussey, A. J., Winardi, M., Wilson, J., Forster, N. A., Morrison, W. A., Penington, A., Knight, K. R., & Feeney, S. J. (2010) · Cells Tissues Organs · doi:10.1159/000276595 · Cited by 18

Neurotrophin-4/5 promotes proliferation of oligodendrocyte-type-2 astrocytes (O-2A)

Scarisbrick, I. A., Asakura, K., & Rodriguez, M. (2000) · Developmental Brain Research · doi:10.1016/s0165-3806(00)00077-8 · Cited by 18

Intrathecal injection of lentivirus‐mediated glial cell line‐derived neurotrophic factor RNA interference relieves bone cancer‐induced pain in rats

Meng, F., Xu, Y. X. Z., Dan, Q., Wei, L., Deng, Y., Liu, J., He, M., Liu, W., Xia, Q., Zhou, F. H., et al. (2015) · Cancer Science · doi:10.1111/cas.12609 · Cited by 17

RET Mutations in Neuroendocrine Tumors: Including Small-Cell Lung Cancer

Rudin, C. M., Drilon, A. E. D. C., & Poirier, J. T. (2014) · Journal of Thoracic Oncology · doi:10.1097/jto.0000000000000301 · Cited by 16

Therapeutic Effect of Myogenic Cells Modified to Express Neurotrophic Factors in a Rat Model of Sciatic Nerve Injury

(2012) · Journal of Stem Cells and Regenerative Medicine · doi:10.46582/jsrm.0801004 · Cited by 16

BDNF and NT4 play interchangeable roles in gustatory development

Huang, T., & Krimm, R. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.12.031 · Cited by 15

Effects of neurotrophin-3 on the differentiation of neural stem cells into neurons and oligodendrocytes.

Guowei, Z., Sun, C., & Liu, W. (2012) · Europe PMC (PubMed Central) · doi:10.3969/j.issn.1673-5374.2012.19.006 · Cited by 14

Autophagy: A Key Regulator of Homeostasis and Disease: An Overview of Molecular Mechanisms and Modulators

Gómez-Virgilio, L., Silva-Lucero, M.-D.-C., Flores-Morelos, D.-S., Gallardo-Nieto, J., Lopez-Toledo, G., Abarca-Fernandez, A.-M., Zacapala-Gómez, A.-E., Luna-Muñoz, J., Montiel-Sosa, F., Soto-Rojas, L. O., et al. (2022) · Cells · doi:10.3390/cells11152262 · Cited by 431

Heparin-Poloxamer Thermosensitive Hydrogel Loaded with bFGF and NGF Enhances Peripheral Nerve Regeneration in Diabetic Rats

Li, R., Li, Y., Wu, Y., Zhao, Y., Chen, H. A., Yuan, Y., Xu, K., Zhang, H., Lu, Y., Wang, J., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.03.044 · Cited by 236

Recent advances on the molecular mechanisms of exercise-induced improvements of cognitive dysfunction

Lü, Y., Bu, F., Wang, F., Liu, L., Zhang, S., Wang, G., & Hu, X. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00341-5 · Cited by 126

Micro- and nanotechnology approaches to improve Parkinson's disease therapy

Torres-Ortega, P. V., Saludas, L., Hanafy, A. S., Garbayo, E., & Blanco‐Prieto, M. J. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.12.036 · Cited by 87

Engineering Silk Fibroin‐Based Nerve Conduit with Neurotrophic Factors for Proximal Protection after Peripheral Nerve Injury

Carvalho, C. R., Chang, W., Silva‐Correia, J., Reis, R. L., Oliveira, J. M., & Kohn, J. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202000753 · Cited by 70

Neurotrophic factors: promising candidates in tissue regeneration

Xiao, N. (2016) · Neural Regeneration Research · doi:10.4103/1673-5374.182696 · Cited by 13

Therapeutic Potential of Neurotrophic Factors

McMahon, S. B., & Murinson, B. B. (2005) · Elsevier eBooks · doi:10.1016/b978-012738903-5/50026-6 · Cited by 2

Roles of Neurotrophic Factors in Neuronal Survival and Nerve Regeneration

김윤희, Kim, M., Cheon, K.-A. A., Jin, S., & Kwon, Y. H. K. (1997)

Neurotrophic Factor in the Nerve Tissue Repair of the Applied Research

Meng, T. (2008) · Jilin Normal University Journal

Neurotrophic Factors

(2008) · Springer eBooks · doi:10.1007/978-3-540-29678-2_3959