Purification of a new neurotrophic factor from mammalian brain.
Open accessAbstract
We report the purification from pig brain of a factor supporting the survival of, and fibre outgrowth from, cultured embryonic chick sensory neurons. The purified factor migrates as one single band, mol. wt. 12 300, on gel electrophoresis in the presence of sodium dodecylsulphate (SDS) and is a basic molecule (pI greater than or equal to 10.1). Approximately 1 microgram factor was isolated from 1.5 kg brain. The final degree of purification was estimated to be 1.4 X 10(6)-fold, and the specific activity 0.4 ng/ml/unit, which is similar to that of nerve growth factor (NGF) using the same assay system. This factor is the first neurotrophic factor to be purified since NGF, from which it is clearly distinguished because it has different antigenic and functional properties.
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BDNF protein is a highly conserved protein of 247 amino acids, synthesized and folded in the endoplasmic reticulum as preproBDNF (32-35 kDa).
“The BDNF protein, discovered in 1982 [66], is a highly conserved protein of 247 amino acids, synthesized and folded in the endoplasmic reticulum as preproBDNF (32–35 kDa).”
From Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer (2020) · cites this paper as [66]
NGF and BDNF were discovered because they support the survival of neurons and neurites during development.
“The first neurotrophic factors, nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) were discovered through their ability to support the survival of neurons and neurites during development15–17; other members of the neurotrophin family, neurotrophin-3 (NT-3)18–20 and neurotrophin-4 (NT-4)21–23 were then identified through sequence similarity to NGF and BDNF.”
From Neuronal plasticity and neurotrophic factors in drug responses (2017) · cites this paper as [16]
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PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 315,771 · see citing works
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961 · see citing works
Raza, H., John, A., & Nemmar, A. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350087 · Cited by 47,311 · see citing works
A simplified ultrasensitive silver stain for detecting proteins in polyacrylamide gels
Oakley, B. R., Kirsch, D. R., & Morris, N. R. (1980) · Analytical Biochemistry · doi:10.1016/0003-2697(80)90470-4 · Cited by 3,248 · see citing works
Disk Electrophoresis of Basic Proteins and Peptides on Polyacrylamide Gels
Reisfeld, R., Lewis, U., & Williams, D. E. (1962) · Nature · doi:10.1038/195281a0 · Cited by 2,569 · see citing works
Physiology of nerve growth factor.
Thoenen, H., & Barde, Y. (1980) · Physiological Reviews · doi:10.1152/physrev.1980.60.4.1284 · Cited by 1,573 · see citing works
Self-citationTHE NERVE GROWTH FACTOR: PURIFICATION AS A 30,000-MOLECULAR-WEIGHT PROTEIN
Bocchini, V., & Angeletti, P. U. (1969) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.64.2.787 · Cited by 910 · see citing works
Purification of a fibroblast growth factor from bovine pituitary.
Gospodarowicz, D. (1975) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)41631-1 · Cited by 539 · see citing works
Reversible Denaturation of Enzymes by Sodium Dodecyl Sulfate
Weber, K. K., & Kuter, D. J. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62040-x · Cited by 437 · see citing works
Sensory neurons in culture: Changing requirements for survival factors during embryonic development
Barde, Y., Edgar, D., & Thoenen, H. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.2.1199 · Cited by 299 · see citing works
Self-citationSuda, K., Barde, Y., & Thoenen, H. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.8.4042 · Cited by 245 · see citing works
Self-citationPurification and preliminary characterization of a glial growth factor from the bovine pituitary.
Brockes, J. P., Lemke, G., & Balzer, D. R. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43500-4 · Cited by 222 · see citing works
New factor released by cultured glioma cells supporting survival and growth of sensory neurones
Barde, Y., Lindsay, R. M., Monard, D., & Thoenen, H. (1978) · Nature · doi:10.1038/274818a0 · Cited by 171 · see citing works
Self-citationEdgar, D., Barde, Y., & Thoenen, H. (1981) · Nature · doi:10.1038/289294a0 · Cited by 140 · see citing works
Self-citationPURIFICATION OF NERVE GROWTH FACTOR ANTIBODIES BY AFFINITY CHROMATOGRAPHY
Stoeckel, K., Gagnon, C., Guroff, G., et al. (1976) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1976.tb07008.x · Cited by 131 · see citing works
Server, A. C., & Shooter, E. M. (1977) · Advances in protein chemistry · doi:10.1016/s0065-3233(08)60221-1 · Cited by 110 · see citing works
Target Cells, Biological Effects, and Mechanism of Action of Nerve Growth Factor and its Antibodies
Harper, G., & Thoenen, H. (1981) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.21.040181.001225 · Cited by 105 · see citing works
Self-citationChapman, C. A., Banks, B. E. C., Carstairs, J. R., et al. (1979) · FEBS Letters · doi:10.1016/0014-5793(79)80644-4 · Cited by 33 · see citing works
Flagged first, then by citations
Research works printed but not linked: 7
- Barde,Y.-A., Edgar,D., and Thoenen,H. (1980) Proc. Natl. Acad. Sci. USA, 77, 1199-1203.
- Bocchini,V., and Angeletti,P.U. (1969) Proc. Nati. Acad. Sci. USA, 64, 787- 794.
- Harper,G.P., Glanville,R.W., and Thoenen,H. (1982) J. Biol. Chem., in press.
- Jacobson,M. (1978) Developmental Neurobiology, 2nd edn., published by Plenum, NY, pp. 279-302.
- Suda,K., Barde,Y.-A., and Thoenen,H. (1978) Proc. Natl. Acad. Sci. USA, 75, 4042-4046.
- Turner,J.E., Barde,Y.-A., Schwab,M.E., and Thoenen,H. (1982) Dev. Brain Res., in press.
- Varon,S.A., and Adler,R. (1981) in Federoff,S., and Herz,L. (eds.), Advances in Cellular Neurobiology, 2, Academic Press, NY, pp. 115-163.
Cited by
Sorted by citations
Neurotrophin-regulated signalling pathways
Reichardt, L. F. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1894 · Cited by 2,195 · see citing works
Neurotrophin regulation of neural circuit development and function
Park, H., & Poo, M.-M. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3379 · Cited by 2,060 · see citing works
Trophic factors and neuronal survival
Barde, Y.-A. (1989) · Neuron · doi:10.1016/0896-6273(89)90040-8 · Cited by 1,625 · see citing works
Self-citationBrain-Derived Neurotrophic Factor and Neuropsychiatric Disorders
Autry, A. E., & Monteggia, L. M. (2012) · Pharmacological Reviews · doi:10.1124/pr.111.005108 · Cited by 1,390 · see citing works
Brain-derived neurotrophic factor and its clinical Implications
Bathina, S., & Das, U. N. (2015) · Archives of Medical Science · doi:10.5114/aoms.2015.56342 · Cited by 1,381 · see citing works
BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity
Kowiański, P., Lietzau, G., Czuba, E., Waśkow, M., Steliga, A., & Moryś, J. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0510-4 · Cited by 1,359 · see citing works
Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF
Maisonpierre, P. C., Belluscio, L., Squinto, S., Ip, N. Y., Furth, M. E., Lindsay, R. M., & Yancopoulos, G. D. (1990) · Science · doi:10.1126/science.2321006 · Cited by 1,322 · see citing works
Hohn, A., Leibrock, J., Bailey, K., & Barde, Y.-A. (1990) · Nature · doi:10.1038/344339a0 · Cited by 1,145 · see citing works
Self-citationMice lacking brain-derived neurotrophic factor develop with sensory deficits
Ernfors, P., Lee, K.-F., & Jaenisch, R. (1994) · Nature · doi:10.1038/368147a0 · Cited by 1,067 · see citing works
Colucci-D’Amato, L., Speranza, L., & Volpicelli, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207777 · Cited by 991 · see citing works
Klein, R., Nanduri, V., Jing, S., Lamballe, F., Tapley, P., Bryant, S., Cordon-Cardo, C., Jones, K. R., Reichardt, L. F., & Barbacid, M. (1991) · Cell · doi:10.1016/0092-8674(91)90628-c · Cited by 958 · see citing works
Knaepen, K., Goekint, M., Heyman, E. M., & Meeusen, R. (2010) · Sports Medicine · doi:10.2165/11534530-000000000-00000 · Cited by 882 · see citing works
Murer, M. G., Yan, Q., & Raisman-Vozari, R. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00014-9 · Cited by 874 · see citing works
Potential therapeutic uses of BDNF in neurological and psychiatric disorders
Nagahara, A. H., & Tuszynski, M. H. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3366 · Cited by 867 · see citing works
Neurotrophin-5: A novel neurotrophic factor that activates trk and trkB
Berkemeier, L. R., Winslow, J. W., Kaplan, D. R., Nikolics, K., Goeddel, D. V., & Rosenthal, A. (1991) · Neuron · doi:10.1016/0896-6273(91)90287-a · Cited by 836 · see citing works
Hallböök, F., Ibáñez, C. F., & Persson, H. (1991) · Neuron · doi:10.1016/0896-6273(91)90180-8 · Cited by 834 · see citing works
GDNF, NGF and BDNF as Therapeutic Options for Neurodegeneration
Allen, S. J., Watson, J. J., Shoemark, D. K., Barua, N. U., & Patel, N. K. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.01.004 · Cited by 820 · see citing works
Soppet, D., Escandon, E., Maragos, J., Middlemas, D. S., Raid, S. W., Blair, J., Burton, L. E., Stanton, B. R., Kaplan, D. R., Hunter, T., et al. (1991) · Cell · doi:10.1016/0092-8674(91)90396-g · Cited by 820 · see citing works
The changing scene of neurotrophic factors
Thoenen, H. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90097-e · Cited by 820 · see citing works
Self-citationErnfors, P., Wetmore, C., Olson, L., & Persson, H. (1990) · Neuron · doi:10.1016/0896-6273(90)90090-3 · Cited by 819 · see citing works
Postsynaptic BDNF‐TrkB signaling in synapse maturation, plasticity, and disease
Yoshii, A., & Constantine‐Paton, M. (2010) · Developmental Neurobiology · doi:10.1002/dneu.20765 · Cited by 744 · see citing works
Multiple extracellular signals are required for long-term oligodendrocyte survival
Barres, B. A., Schmid, R., Sendnter, M., & Raff, M. C. (1993) · Development · doi:10.1242/dev.118.1.283 · Cited by 712 · see citing works
Isackson, P. J., Huntsman, M. M., Murray, K. D., & Gall, C. M. (1991) · Neuron · doi:10.1016/0896-6273(91)90234-q · Cited by 711 · see citing works
Ernfors, P., Ibáñez, C. F., Ebendal, T., Olson, L., & Persson, H. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.14.5454 · Cited by 700 · see citing works
Identification of a Signaling Pathway Involved in Calcium Regulation of BDNF Expression
Shieh, P. B., Hu, S.-C., Bobb, K., Timmusk, T., & Ghosh, A. (1998) · Neuron · doi:10.1016/s0896-6273(00)81011-9 · Cited by 693 · see citing works
Inhibition of Ocular Dominance Column Formation by Infusion of NT-4/5 or BDNF
Cabelli, R. J., Hohn, A., & Shatz, C. J. (1995) · Science · doi:10.1126/science.7886458 · Cited by 566 · see citing works
The selfish brain: Competition for energy resources
Peters, A., Schweiger, U., Pellerin, L., Hubold, C., Oltmanns, K. M., Conrad, M., Schultes, B., Born, J., & Fehm, H. L. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.03.002 · Cited by 489 · see citing works
Hefti, F., Hartikka, J., & Knusel, B. (1989) · Neurobiology of Aging · doi:10.1016/0197-4580(89)90118-8 · Cited by 466 · see citing works
The Role of BDNF on Neural Plasticity in Depression
Yang, T., Nie, Z., Shu, H., Kuang, Y., Chen, X., Cheng, J., Yu, S., & Liu, H. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00082 · Cited by 435 · see citing works
BDNF and Hippocampal Synaptic Plasticity
Leal, G., Bramham, C. R., & Duarte, C. B. (2017) · Vitamins and Hormones · doi:10.1016/bs.vh.2016.10.004 · Cited by 425 · see citing works
Role of Myokines in Regulating Skeletal Muscle Mass and Function
Lee, J. H., & Jun, H.-S. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00042 · Cited by 432 · see citing works
Neurobiology of local and intercellular BDNF signaling
Sasi, M., Vignoli, B., Canossa, M., & Blum, R. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-1964-4 · Cited by 324 · see citing works
Neuronal plasticity and neurotrophic factors in drug responses
Castrén, E., & Antila, H. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.61 · Cited by 284 · see citing works
Fernandes, B. S., Molendijk, M. L., Köhler, C. A., Soares, J. C., Leite, C. M. G. S., Machado-Vieira, R., Ribeiro, T. L., Silva, J. C., Sales, P. M. G., Quevedo, J., et al. (2015) · BMC Medicine · doi:10.1186/s12916-015-0529-7 · Cited by 291 · see citing works
Frim, D. M., Uhler, T. A., Galpern, W. R., Beal, M. F., Breakefield, X. O., & Isacson, O. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.5104 · Cited by 269 · see citing works
Walsh, J. J., & Tschakovsky, M. E. (2018) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2018-0192 · Cited by 256 · see citing works
Maffei, L., Berardi, N., Domenici, L., Parisi, V, & Pizzorusso, T. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-12-04651.1992 · Cited by 252 · see citing works
Lactate and BDNF: Key Mediators of Exercise Induced Neuroplasticity?
Müller, P., Duderstadt, Y., Lessmann, V., & Müller, N. G. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9041136 · Cited by 241 · see citing works
Brain-derived Neurotrophic Factor in Megakaryocytes
Chacón-Fernández, P., Säuberli, K., Colzani, M., Moreau, T., Ghevaert, C., & Barde, Y.-A. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.720029 · Cited by 186 · see citing works
Self-citationTrkB/BDNF signaling pathway and its small molecular agonists in CNS injury
Wang, Y., Liang, J., Xu, B., Yang, J., Wu, Z., & Cheng, L. (2024) · Life Sciences · doi:10.1016/j.lfs.2023.122282 · Cited by 152 · see citing works
Kanato, Y., Kitajima, K., & Sato, C. (2008) · Glycobiology · doi:10.1093/glycob/cwn084 · Cited by 134 · see citing works
Tsukahara, T., Takeda, M., Shimohama, S., Ohara, O., & Hashimoto, N. (1995) · Neurosurgery · doi:10.1227/00006123-199510000-00018 · Cited by 134 · see citing works
Burbach, G. J., Hellweg, R., Haas, C. A., Del Turco, D., Deicke, U., Abramowski, D., Jucker, M., Staufenbiel, M., & Deller, T. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5599-03.2004 · Cited by 132 · see citing works
Kwon, M., Fernandez, J. R., Zegarek, G. F., Lo, S. B., & Firestein, B. L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6785-10.2011 · Cited by 115 · see citing works
Neurotrophins and Proneurotrophins: Focus on Synaptic Activity and Plasticity in the Brain
Gibon, J., & Barker, P. A. (2017) · The Neuroscientist · doi:10.1177/1073858417697037 · Cited by 115 · see citing works
High abundance of BDNF within glutamatergic presynapses of cultured hippocampal neurons
Andreska, T., Aufmkolk, S., Sauer, M., & Blum, R. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00107 · Cited by 100 · see citing works
Edelbrock, A. N., Àlvarez, Z., Simkin, D., Fyrner, T., Chin, S. M., Sato, K., Kiskinis, E., & Stupp, S. I. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b02317 · Cited by 103 · see citing works
Neurotrophic Factors and Their Potential Applications in Tissue Regeneration
Xiao, N., & Le, Q.-T. (2016) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-015-0376-4 · Cited by 93 · see citing works
Zimbone, S., Monaco, I., Gianì, F., Pandini, G., Copani, A. G., Giuffrida, M. L., & Rizzarelli, E. (2018) · Aging Cell · doi:10.1111/acel.12684 · Cited by 79 · see citing works
Physical Exercise-Induced Myokines in Neurodegenerative Diseases
Lee, B., Shin, M., Park, Y., Won, S.-Y., & Cho, K. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115795 · Cited by 79 · see citing works
Yang, J.-W., Ru, J., Ma, W., Gao, Y., Liang, Z., Liu, J., Guo, J.-H., & Li, L.-Y. (2015) · Neuropeptides · doi:10.1016/j.npep.2015.08.005 · Cited by 70 · see citing works
Miyanishi, H., & Nitta, A. (2021) · Pharmaceuticals · doi:10.3390/ph14090889 · Cited by 57 · see citing works
Gupta, A. K., Gupta, S., Mehan, S., Khan, Z., Das Gupta, G., & Narula, A. S. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05001-5 · Cited by 59 · see citing works
Murphy, G. M., Sarginson, J. E., Ryan, H. S., O’Hara, R., Schatzberg, A. F., & Lazzeroni, L. C. (2013) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e328360b175 · Cited by 50 · see citing works
Vitaliano, G. D., Kim, J. K., Kaufman, M. J., Adam, C. W., Zeballos, G., Shanmugavadivu, A., Subburaju, S., McLaughlin, J. P., Lukas, S. E., & Vitaliano, F. (2022) · Communications Biology · doi:10.1038/s42003-022-03177-3 · Cited by 48 · see citing works
TrkB neurotrophin receptor at the core of antidepressant effects, but how?
Rantamäki, T. (2019) · Cell and Tissue Research · doi:10.1007/s00441-018-02985-6 · Cited by 45 · see citing works
Osborne, A., Wang, A. X. Z., Tassoni, A., Widdowson, P. S., & Martin, K. R. (2018) · Human Gene Therapy · doi:10.1089/hum.2017.069 · Cited by 43 · see citing works
Zhang, H.-Y., Jin, X.-B., & Lue, T. F. (2011) · Asian Journal of Andrology · doi:10.1038/aja.2010.162 · Cited by 39 · see citing works
Dahlström, M., Madjid, N., Nordvall, G., Halldin, M. M., Vazquez-Juarez, E., Lindskog, M., Sandin, J., Winblad, B., Eriksdotter, M., & Forsell, P. (2021) · Cells · doi:10.3390/cells10081871 · Cited by 33 · see citing works
The genetics of retinopathy of prematurity: A model for neovascular retinal disease
Swan, R., Kim, S. J., Campbell, J. P., Chan, R. V. P., Sonmez, K., Taylor, K. D., Li, X., Chen, Y.-D. I., Rotter, J. I., Simmons, C., et al. (2018) · Ophthalmology Retina · doi:10.1016/j.oret.2018.01.016 · Cited by 30 · see citing works
Anderzhanova, E., Hafner, K., Genewsky, A. J., Soliman, A., Pöhlmann, M. L., Schmidt, M. V., Blum, R., Wotjak, C. T., & Gassen, N. C. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2020.100239 · Cited by 29 · see citing works
Positive Allosteric Modulators of Trk Receptors for the Treatment of Alzheimer’s Disease
Forsell, P., Parrado Fernández, C., Nilsson, B., Sandin, J., Nordvall, G., & Segerdahl, M. (2024) · Pharmaceuticals · doi:10.3390/ph17080997 · Cited by 14 · see citing works
Wang, N., Zhu, S., Chen, S., Zou, J., Zeng, P., & Tan, S. (2025) · Reviews in the Neurosciences · doi:10.1515/revneuro-2024-0147 · Cited by 12 · see citing works
- Authors
- Barde, Y. A., Edgar, D., & Thoenen, H.
- Affiliations
- Max Planck Institute of Psychiatry (DE)
- ORCID
- Barde, Y.A.
- Venue
- The EMBO Journal
- Published
- 1982-05-01
- Volume
- 1
- Issue
- 5
- Pages
- 549-553
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC553086
- OpenAlex
- W1527035699
- Cited by
- 1,822
- References
- 18
- Citations by year
- 2026: 20 · 2025: 43 · 2024: 47 · 2023: 44 · 2022: 57 · 2021: 47 · 2020: 58 · 2019: 44 · 2018: 57 · 2017: 49 · 2016: 57 · 2015: 48 · 2014: 63 · 2013: 62 · 2012: 39
- FWCI
- 7.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The EMBO Journal (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Hereditary Neurological Disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- neurotrophic factors, pig brain, sensory neuron survival, axon growth, nerve growth factor, protein purification, basic proteins, antigenicity
- MeSH terms
- Animals, Antigen-Antibody Complex, Brain Chemistry, Cell Survival, Cells, Cultured, Chick Embryo, Immune Sera, Molecular Weight, Nerve Growth Factors, Nerve Tissue Proteins, Neurons, Spinal Cord
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