Lipid bodies: structural markers of inflammatory macrophages in innate immunity
Abstract
Objective and design The correlation between innate immune responses and formation of cytoplasmic lipid bodies (LBs) was investigated in vivo in inflammatory macrophages from rats infected with Trypanosoma cruzi, the intracellular parasite which causes Chagas' disease. Material and methods We used an experimental model of high-dose irradiation prior to infection, which depletes the humoral and cellular immune responses except for the phagocytic activity of macrophages. Rats, irradiated or not, were infected with T. cruzi and macrophages from different origins (peritoneum, heart, uterus) were studied by transmission electron microscopy (TEM). Results As documented by quantitative TEM, innate immune responses induced prominent formation, structural changes and intracellular interactions of LBs. LBs significantly increased their size and changed their osmiophilia in response to both infection alone and when macrophages were challenged with irradiation-induced increased parasite load. Remarkably, a consistent LB-phagolysosome association was identified. LBs were surrounding, attached to or internalized by phagolysosomes. Conclusions We demonstrated that LBs are dynamic organelles notably involved in the host response to acute T. cruzi infection, an event that may be important for pathogen control during innate immunity. Our findings highlight LBs as structural markers of the innate immune responses in phagocytic cells.
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LDs are present in immune cells, in particular macrophages, where they supply energy for the formation and maturation of phagosomes.
“LDs are also present in immune cells, in particular macrophages, where they supply energy for the formation and maturation of phagosomes (3).”
From Reducing microglial lipid load enhances β amyloid phagocytosis in an Alzheimer’s disease mouse model (2025) · cites this paper as [3]
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Dolganova, O. M., Rudina, M. I., Chrapova, M. V., & Dushkin, M. I. (2014) · Cell and Tissue Biology · doi:10.1134/s1990519x14030055 · Cited by 1 · see citing works
POSSÍVEL ENVOLVIMENTO DA FOSFATIDILSERINA NA INDUÇÃO DE CORPOS LIPÍDICOS EM MACRÓFAGOS
Roberto, J., Mota, L. M. A., Arnholdt, A. C. V., & DaMatta, R. A. (2010) · Confict
Visualising blood flagellates infections in transparent zebrafish
Jacobs, S. H. (2020) · doi:10.18174/519090
(2022) · Elsevier eBooks · doi:10.1016/b978-0-12-813755-0.09990-1
Melo, R. C. N., Dvořàk, A. M., & Weller, P. F. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-813755-0.00004-6
Self-citationLipid Droplets, ApoE, and Inflammatory Disease States
Melo, R. C. N., & Weller, P. F. (2025) · Springer eBooks · doi:10.1007/978-3-031-52641-1_36-1
Self-citationLipid Droplets, ApoE, and Inflammatory Disease States
Melo, R. C. N., & Weller, P. F. (2026) · Springer eBooks · doi:10.1007/978-3-031-96089-5_36
Self-citationAridj, T., Zoudji, S., Dahou, S., Ali, K., Kadi, A., Boumendjel, A., Boudjelal, F., Messali, R., Benarradj, H., Bendjeffel, N. E., et al. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.117239
- Authors
- Melo, R. C. N., Fabrino, D. L., Dias, F. F., & Parreira, G. G.
- Affiliations
- Universidade Federal de Juiz de Fora (BR)
- Universidade Federal de Minas Gerais (BR)
- Corresponding author
- Melo, R. C. N.
- Venue
- Inflammation Research
- Published
- 2006-08
- Volume
- 55
- Issue
- 8
- Pages
- 342-348
- ISSN
- 1023-3830 (ISSN-L)
- 1420-908X
- OpenAlex
- W2075575974
- Cited by
- 73
- References
- 31
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 5 · 2017: 2 · 2016: 5 · 2015: 3 · 2014: 9 · 2013: 2 · 2012: 5
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Inflammation Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Epidemiology › Trypanosoma species research and implications
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- lipid droplets, inflammatory macrophages, innate immunity, Trypanosoma cruzi, Chagas disease, phagolysosomes, macrophage phagocytosis, infection intensity, host-pathogen interaction
- MeSH terms
- Animals, Cytoplasm, Disease Models, Animal, Female, Immunity, Innate, Inflammation, Lipids, Lysosomes, Macrophages, Phagocytosis, Trypanosoma cruzi, Chagas Disease, Biomarkers, Microscopy, Electron, Transmission, Rats
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