The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Deoxyribozymes: useful DNA catalysts in vitro and in vivo
Open accessAbstract
Abstract.Deoxyribozymes (DNA enzymes; DNAzymes) are catalytic DNA sequences. Using the technique of in vitro selection, individual deoxyribozymes have been identified that catalyze RNA cleavage, RNA ligation, and a growing range of other chemical reactions. DNA enzymes have been used in vitro for applications such as biochemical RNA manipulation and analytical assays for metal ions, small organic compounds, oligonucleotides, and proteins. Deoxyribozymes have also been utilized as in vivo therapeutic agents to destroy specific mRNA targets. Although many conceptual and practical challenges remain to be addressed, deoxyribozymes have substantial promise to contribute meaningfully for applications both in vitro and in vivo.
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Cites
The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme
Guerrier-Takada, C., Gardiner, K., Marsh, T., Pace, N., & Altman, S. (1983) · Cell · doi:10.1016/0092-8674(83)90117-4 · Cited by 2,684
The chemical repertoire of natural ribozymes
Doudna, J. A., & Cech, T. R. (2002) · Nature · doi:10.1038/418222a · Cited by 745
Li, Y., & Breaker, R. R. (1999) · Journal of the American Chemical Society · doi:10.1021/ja990592p · Cited by 587
EMILSSON, G. M., NAKAMURA, S., ROTH, A., & BREAKER, R. R. (2003) · RNA · doi:10.1261/rna.5680603 · Cited by 216
In vitro evolution suggests multiple origins for the hammerhead ribozyme
Salehi-Ashtiani, K., & Szostak, J. W. (2001) · Nature · doi:10.1038/35102081 · Cited by 183
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DNAzyme‐Loaded Metal–Organic Frameworks (MOFs) for Self‐Sufficient Gene Therapy
Wang, H., Chen, Y., Wang, H., Liu, X., Zhou, X., & Wang, F. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201902714 · Cited by 417
Binary Probes for Nucleic Acid Analysis
Kolpashchikov, D. M. (2010) · Chemical Reviews · doi:10.1021/cr900323b · Cited by 298
Ruff, K. M., Snyder, T. M., & Liu, D. R. (2010) · Journal of the American Chemical Society · doi:10.1021/ja103023m · Cited by 86
Metadata
- Authors
- Baum, D. A., & Silverman, S. K.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2008-03-29
- Volume
- 65
- Issue
- 14
- Pages
- 2156-2174
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- OpenAlex
- W1977383342
- Cited by
- 174
- References
- 5
- FWCI
- 6.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Baum, D. A., & Silverman, S. K. (2008). Deoxyribozymes: useful DNA catalysts in vitro and in vivo. Cellular and Molecular Life Sciences. https://doi.org/10.1007/s00018-008-8029-y
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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