The chemical repertoire of natural ribozymes

The Complete Atomic Structure of the Large Ribosomal Subunit at 2.4 Å Resolution

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The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme

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Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena

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The Structural Basis of Ribosome Activity in Peptide Bond Synthesis

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Crystal Structure of a Group I Ribozyme Domain: Principles of RNA Packing

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Modelling of the three-dimensional architecture of group I catalytic introns based on comparative sequence analysis

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In Vitro Selection of Functional Nucleic Acids

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Three-dimensional structure of a hammerhead ribozyme

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Reversible Unfolding of Single RNA Molecules by Mechanical Force

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Crystal structure of a hepatitis delta virus ribozyme

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A Single-Molecule Study of RNA Catalysis and Folding

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Unusual Resistance of Peptidyl Transferase to Protein Extraction Procedures

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The crystal structure of an AII-RNAhammerhead ribozyme: A proposed mechanism for RNA catalytic cleavage

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The Three-Dimensional Structure of Ribonuclease-S

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RIBONUCLEASE P: Unity and Diversity in a tRNA Processing Ribozyme

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Crystal structure of a hairpin ribozyme–inhibitor complex with implications for catalysis

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Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin

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Capturing the Structure of a Catalytic RNA Intermediate: The Hammerhead Ribozyme

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General Acid-Base Catalysis in the Mechanism of a Hepatitis Delta Virus Ribozyme

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Rational design of allosteric ribozymes

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The hammerhead, hairpin and VS ribozymes are catalytically proficient in monovalent cations alone

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RNA Cleavage by a DNA Enzyme with Extended Chemical Functionality

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A Preorganized Active Site in the Crystal Structure of the Tetrahymena Ribozyme

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RNA-catalysed nucleotide synthesis

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Two-Metal-Ion Catalysis in Adenylyl Cyclase

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Imidazole Rescue of a Cytosine Mutation in a Self-Cleaving Ribozyme

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Metal-ion coordination by U6 small nuclear RNA contributes to catalysis in the spliceosome

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Ribozyme-catalysed amino-acid transfer reactions

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Triple-strand formation in the homopurine:homopyrimidine DNA oligonucleotides d(G-A)4 and d(T-C)4

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Exploring the folding landscape of a structured RNA

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Exposing the kinetic traps in RNA folding

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MECHANISTIC ASPECTS OF ENZYMATIC CATALYSIS: Lessons from Comparison of RNA and Protein Enzymes

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Splicing-related catalysis by protein-free snRNAs

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The Structural Basis of Hammerhead Ribozyme Self-Cleavage

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Ribosomal peptidyl transferase can withstand mutations at the putative catalytic nucleotide

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E ARLY E VENTS IN RNA F OLDING

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A unique mechanism for RNA catalysis: the role of metal cofactors in hairpin ribozyme cleavage

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An unusual pH-independent and metal-ion-independent mechanism for hairpin ribozyme catalysis

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Analysis of mutations at residues A2451 and G2447 of 23S rRNA in the peptidyltransferase active site of the 50S ribosomal subunit

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Beyond kinetic traps in RNA folding

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Identification of the Hammerhead Ribozyme Metal Ion Binding Site Responsible for Rescue of the Deleterious Effect of a Cleavage Site Phosphorothioate

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In vitro evolution suggests multiple origins for the hammerhead ribozyme

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Efficient integration of an intron RNA into double-stranded DNA by reverse splicing

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The question remains: is the spliceosome a ribozyme?

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Formation of a stable triplex from a single DNA strand

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Structural Basis of the Enhanced Stability of a Mutant Ribozyme Domain and a Detailed View of RNA–Solvent Interactions

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Comparison of the hammerhead cleavage reactions stimulated by monovalent and divalent cations

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Selection of RNA amide synthases

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Defining the Catalytic Metal Ion Interactions in the Tetrahymena Ribozyme Reaction

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The hammerhead cleavage reaction in monovalent cations

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Folding of the Hairpin Ribozyme in Its Natural Conformation Achieves Close Physical Proximity of the Loops

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Assembly of a Ribonucleoprotein Catalyst by Tertiary Structure Capture

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Metal ion binding sites in a group II intron core.

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Mechanistic Characterization of the HDV Genomic Ribozyme: Assessing the Catalytic and Structural Contributions of Divalent Metal Ions within a Multichannel Reaction Mechanism

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Involvement of a Specific Metal Ion in the Transition of the Hammerhead Ribozyme to Its Catalytic Conformation

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A three‐dimensional perspective on exon binding by a group II self‐splicing intron

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RNA-Catalyzed Amino Acid Activation

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The hairpin ribozyme: structure, assembly and catalysis

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RNAs with Dual Specificity and Dual RNAs with Similar Specificity

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The final cut

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An RNA conformational change between the two chemical steps of group II self‐splicing.

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Metal ion coordination by the AGC triad in domain 5 contributes to group II intron catalysis.

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Novel RNA catalysts for the Michael reaction

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A Tyrosyl-tRNA Synthetase Protein Induces Tertiary Folding of the Group I Intron Catalytic Core

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Direct pKa Measurement of the Active-Site Cytosine in a Genomic Hepatitis Delta Virus Ribozyme

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A tiny RNA that catalyzes both aminoacyl-RNA and peptidyl-RNA synthesis

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Phylogenetic-comparative analysis of the eukaryal ribonuclease P RNA

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Structural Insights into Group II Intron Catalysis and Branch-Site Selection

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In situ Probing of Adenine Protonation in RNA by 13C NMR

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Involvement of a cytosine side chain in proton transfer in the rate-determining step of ribozyme self-cleavage

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A tertiary interaction that links active-site domains to the 5′ splice site of a group II intron

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Role of metal ions in the hydrolysis reaction catalyzed by RNase P RNA from Bacillus subtilis

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Three-dimensional working model of M1 RNA, the catalytic RNA subunit of ribonuclease P from Escherichia coli.

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A re-investigation of the thio effect at the hammerhead cleavage site

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Rearrangement of a Stable RNA Secondary Structure during VS Ribozyme Catalysis

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An Inhibitor of Ribosomal Peptidyl Transferase Using the Transition-State Analogy

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Analysis of the tertiary structure of the ribonuclease P ribozyme-substrate complex by site-specific photoaffinity crosslinking.

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Capture and Visualization of a Catalytic RNA Enzyme-Product Complex Using Crystal Lattice Trapping and X-Ray Holographic Reconstruction

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Specific, rapid synthesis of Phe-RNA by RNA

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Visualizing the solvent‐inaccessible core of a group II intron ribozyme

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Dynamics of Thermal Motions within a Large Catalytic RNA Investigated by Cross-linking with Thiol−Disulfide Interchange

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Adenine Protonation in Domain B of the Hairpin Ribozyme

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Kinetic Characterization of the Second Step of Group II Intron Splicing: Role of Metal Ions and the Cleavage Site 2‘-OH in Catalysis

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A pH-dependent conformational change, rather than the chemical step, appears to be rate-limiting in the hammerhead ribozyme cleavage reaction

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Group I Ribozymes: Substrate Recognition, Catalytic Strategies, and Comparative Mechanistic Analysis

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Does a single metal ion bridge the A-9 and scissile phosphate groups in the catalytically active hammerhead ribozyme structure? 1 1Edited by J. Karn

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Maximizing RNA folding rates: A balancing act

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Acyl-CoAs from Coenzyme Ribozymes

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Investigation of adenosine base ionization in the hairpin ribozyme by nucleotide analog interference mapping.

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Proton Inventory of the Genomic HDV Ribozyme in Mg2+-Containing Solutions

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Control of branch‐site choice by a group II intron

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A subunit of human nuclear RNase P has ATPase activity

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Active site constraints in the hydrolysis reaction catalyzed by bacterial RNase P: analysis of precursor tRNAs with a single 3'-S-phosphorothiolate internucleotide linkage

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An important base triple anchors the substrate helix recognition surface within the Tetrahymena ribozyme active site

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Cell cycle-related changes in regulatory volume decrease and volume-sensitive chloride conductance in mouse fibroblasts

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The hairpin ribozyme: structure, assembly and catalysis

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Guanosine Binds to the Tetrahymena Ribozyme in More than One Step, and Its 2‘-OH and the Nonbridging pro-Sp Phosphoryl Oxygen at the Cleavage Site Are Required for Productive Docking

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Creative catalysis: pieces of the RNA world jigsaw

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Functional Nucleic Acid Sensors

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RNAstructure: software for RNA secondary structure prediction and analysis

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Synthetic biology: applications come of age

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Osteogenesis imperfecta

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Biologically Active Molecules with a “Light Switch”

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Antisense technologies

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Analysis of aptamer discovery and technology

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siRNAs: applications in functional genomics and potential as therapeutics

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