The DOI matches its Crossref record; 221 of the 221 references it cites were found in a registry or an index.
The development and function of regulatory T cells
Open accessAbstract
Regulatory T cells (Tregs) are a critical subset of T cells that mediate peripheral tolerance. There are two types of Tregs: natural Tregs, which develop in the thymus, and induced Tregs, which are derived from naive CD4(+) T cells in the periphery. Tregs utilize a variety of mechanisms to suppress the immune response. While Tregs are critical for the peripheral maintenance of potential autoreactive T cells, they can also be detrimental by preventing effective anti-tumor responses and sterilizing immunity against pathogens. In this review, we will discuss the development of natural and induced Tregs as well as the role of Tregs in a variety of disease settings and the mechanisms they utilize for suppression.
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Cited by
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T cell subsets and their signature cytokines in autoimmune and inflammatory diseases
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Self-citationMechanisms of impaired regulation by CD4+CD25+FOXP3+ regulatory T cells in human autoimmune diseases
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Metadata
- Authors
- Workman, C. J., Szymczak-Workman, A. L., Collison, L. W., Pillai, M. R., & Vignali, D. A. A.
- Affiliations
- St. Jude Children's Research Hospital (US)
- Corresponding author
- Vignali, Dario A. A.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2009-04-24
- Volume
- 66
- Issue
- 16
- Pages
- 2603-2622
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC2715449
- OpenAlex
- W2038689503
- Cited by
- 344
- References
- 221
- Citations by year
- 2026: 16 · 2025: 19 · 2024: 25 · 2023: 14 · 2022: 28 · 2021: 17 · 2020: 25 · 2019: 23 · 2018: 16 · 2017: 17 · 2016: 15 · 2015: 12 · 2014: 20 · 2013: 21 · 2012: 24
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (F32AI072816, R01AI091977, R01AI039480, R01AI052199, R01AI058156)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- regulatory T cells, natural regulatory T cells, induced regulatory T cells, thymus development, CD4+ T cells, immunosuppression, peripheral tolerance, autoreactive T cells, antitumor immunity, sterilizing immunity
- MeSH terms
- Animals, Cell Differentiation, Humans, Immune Tolerance, Immunity, Cellular, Receptors, Antigen, T-Cell, Cytokines, Models, Immunological, T-Lymphocytes, Regulatory, Mice, Forkhead Transcription Factors
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