Cited by 345T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisCancer Immunotherapy and Biomarkers

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The development and function of regulatory T cells

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Workman, Creg J., Szymczak-Workman, Andrea L., Collison, Lauren W., Pillai, Meenu R., Vignali, Dario A. A.·2009·Cellular and Molecular Life Sciences

DOI 10.1007/s00018-009-0026-2PMC PMC2715449

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Abstract

Regulatory T cells (Tregs) are a critical subset of T cells that mediate peripheral tolerance. There are two types of Tregs: natural Tregs, which develop in the thymus, and induced Tregs, which are derived from naive CD4(+) T cells in the periphery. Tregs utilize a variety of mechanisms to suppress the immune response. While Tregs are critical for the peripheral maintenance of potential autoreactive T cells, they can also be detrimental by preventing effective anti-tumor responses and sterilizing immunity against pathogens. In this review, we will discuss the development of natural and induced Tregs as well as the role of Tregs in a variety of disease settings and the mechanisms they utilize for suppression.

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Authors: Workman, C. J., Szymczak-Workman, A. L., Collison, L. W., Pillai, M. R., & Vignali, D. A. A.
Affiliations: St. Jude Children's Research Hospital (US)
Corresponding author: Vignali, Dario A. A.
ORCID: Workman, Creg J.
Szymczak-Workman, Andrea L.
Vignali, Dario A. A.
Venue: Cellular and Molecular Life Sciences
Publisher: Springer Science and Business Media LLC
Published: 2009-04-24
Volume: 66
Issue: 16
Pages: 2603-2622
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s00018-009-0026-2
PMC: PMC2715449
OpenAlex: W2038689503
Cited by: 344
References: 221
Citations by year: 2026: 16 · 2025: 19 · 2024: 25 · 2023: 14 · 2022: 28 · 2021: 17 · 2020: 25 · 2019: 23 · 2018: 16 · 2017: 17 · 2016: 15 · 2015: 12 · 2014: 20 · 2013: 21 · 2012: 24
FWCI: 1.98
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (F32AI072816, R01AI091977, R01AI039480, R01AI052199, R01AI058156)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords: regulatory T cells, natural regulatory T cells, induced regulatory T cells, thymus development, CD4+ T cells, immunosuppression, peripheral tolerance, autoreactive T cells, antitumor immunity, sterilizing immunity
MeSH terms: Animals, Cell Differentiation, Humans, Immune Tolerance, Immunity, Cellular, Receptors, Antigen, T-Cell, Cytokines, Models, Immunological, T-Lymphocytes, Regulatory, Mice, Forkhead Transcription Factors

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