Cited by 345T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisCancer Immunotherapy and Biomarkers

The DOI matches its Crossref record; 221 of the 221 references it cites were found in a registry or an index.

The development and function of regulatory T cells

Open access

Workman, Creg J., Szymczak-Workman, Andrea L., Collison, Lauren W., Pillai, Meenu R., Vignali, Dario A. A.·2009·Cellular and Molecular Life Sciences

DOI 10.1007/s00018-009-0026-2PMC PMC2715449

Open this paper in CoChat — free account

Abstract

Regulatory T cells (Tregs) are a critical subset of T cells that mediate peripheral tolerance. There are two types of Tregs: natural Tregs, which develop in the thymus, and induced Tregs, which are derived from naive CD4(+) T cells in the periphery. Tregs utilize a variety of mechanisms to suppress the immune response. While Tregs are critical for the peripheral maintenance of potential autoreactive T cells, they can also be detrimental by preventing effective anti-tumor responses and sterilizing immunity against pathogens. In this review, we will discuss the development of natural and induced Tregs as well as the role of Tregs in a variety of disease settings and the mechanisms they utilize for suppression.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s00018-009-0026-2

Cites

221 of 221 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
Hartkopf, A. D., Taran, F., Wallwiener, M., Walter, C. B., Krämer, B., Grischke, E., & Brucker, S. Y. (2016) · Breast Care · doi:10.1159/000453569 · Cited by 30,989
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992
Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells
Park, J., Adoro, S., Guinter, T. I., Erman, B., Alag, A., Catálfamo, M., Kimura, M. Y., Cui, Y., Lucas, P. J., Gress, R. E., et al. (2010) · Nature Immunology · doi:10.1038/ni.1840 · Cited by 5,835
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M., & Toda, M. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.3.1151 · Cited by 5,608
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
Curiel, T. J., Coukos, G., Zou, L., Alvarez, X., Cheng, P., Mottram, P., Evdemon-Hogan, M., Conejo-Garcia, J. R., Zhang, L., Burow, M., et al. (2004) · Nature Medicine · doi:10.1038/nm1093 · Cited by 5,151
IL-17 and th17 cells
Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873
Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3
Chen, W., Jin, W., Hardegen, N. J., Lei, K.-J., Li, L., Marinos, N. J., McGrady, G., & Wahl, S. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030152 · Cited by 4,678
Interleukin-10-deficient mice develop chronic enterocolitis
Kühn, R., Löhler, J., Rennick, D. M., Rajewsky, K., & Müller, W. (1993) · Cell · doi:10.1016/0092-8674(93)80068-p · Cited by 4,248
The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer
Zhang, L., Xu, J., Zhang, X., Zhang, Y., Wang, L., Huang, X., & Xu, Z. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479442 · Cited by 4,090
A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
Groux, H., O’Garra, A., Bigler, M., Rouleau, M., Antonenko, S. V., de Vries, J. E., & Roncarolo, M. G. (1997) · Nature · doi:10.1038/39614 · Cited by 3,588
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
Bennett, C. L., Christie, J., Ramsdell, F., Brunkow, M., Ferguson, P., Whitesell, L., Kelly, T., Saulsbury, F., Chance, P., & Ochs, H. (2001) · Nature Genetics · doi:10.1038/83713 · Cited by 3,576
How regulatory T cells work
Vignali, D. A. A., Collison, L. W., & Workman, C. J. (2008) · Nature Reviews Immunology · doi:10.1038/nri2343 · Cited by 3,463
Self-citation
N aturally A rising CD4+R egulatory T C ells for I mmunologic S elf -T olerance and N egative C ontrol of I mmune R esponses
Sakaguchi, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141122 · Cited by 3,315
CTLA-4 Control over Foxp3 + Regulatory T Cell Function
Wing, K., Onishi, Y., Prieto-Martin, P., Yamaguchi, T., Miyara, M., Fehervari, Z., Nomura, T., & Sakaguchi, S. (2008) · Science · doi:10.1126/science.1160062 · Cited by 2,956
An essential role for Scurfin in CD4+CD25+ T regulatory cells
Khattri, R., Cox, T., Yasayko, S.-A., & Ramsdell, F. (2003) · Nature Immunology · doi:10.1038/ni909 · Cited by 2,860
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism
Coombes, J. L., Siddiqui, K. R. R., Arancibia-Cárcamo, C. V., Hall, J. A., Sun, C., Belkaid, Y., & Powrie, F. M. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070590 · Cited by 2,708
Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self
Sakaguchi, S. (2005) · Nature Immunology · doi:10.1038/ni1178 · Cited by 2,669
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
Liu, W., Putnam, A. L., Xu-yu, Z., Szot, G. L., Lee, M. R., Zhu, S., Gottlieb, P. A., Kapranov, P., Gingeras, T. R., de St. Groth, B. F., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060772 · Cited by 2,606
Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein
Anderson, M. S., Venanzi, E. S., Klein, L., Chen, Z.-B., Berzins, S., Turley, S., von Boehmer, H., Bronson, R., Dierich, A., Benoist, C., et al. (2002) · Science · doi:10.1126/science.1075958 · Cited by 2,582
Intraepithelial CD8 + tumor-infiltrating lymphocytes and a high CD8 + /regulatory T cell ratio are associated with favorable prognosis in ovarian cancer
Sato, E., Olson, S. H., Ahn, J., Bundy, B. N., Nishikawa, H., Qian, F., Jungbluth, A. A., Frosina, D., Gnjatic, S., Ambrosone, C. B., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509182102 · Cited by 2,445
Ido expression by dendritic cells: tolerance and tryptophan catabolism
Mellor, A. L., & Munn, D. H. (2004) · Nature Reviews Immunology · doi:10.1038/nri1457 · Cited by 2,341
The inhibitory cytokine IL-35 contributes to regulatory T-cell function
Collison, L., Workman, C., Kuo, T. T., Boyd, K., Wang, Y., Vignali, K. M., Cross, R., Sehy, D., Blumberg, R., & Vignali, D. (2007) · Nature · doi:10.1038/nature06306 · Cited by 2,152
Self-citation
B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes
Salomon, B. L., Lenschow, D. J., Rhee, L., Ashourian, N., Singh, B., Sharpe, A. H., & Bluestone, J. A. (2000) · Immunity · doi:10.1016/s1074-7613(00)80195-8 · Cited by 2,058
Reciprocal T H 17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid
Mucida, D., Park, Y., Kim, G., Turovskaya, O., Scott, I., Kronenberg, M., & Cheroutre, H. (2007) · Science · doi:10.1126/science.1145697 · Cited by 1,982
Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.
Kulkarni, A. B., Huh, C. G., Becker, D., Geiser, A., Lyght, M., Flanders, K. C., Roberts, A. B., Sporn, M. B., Ward, J. M., & Karlsson, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.2.770 · Cited by 1,967
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
Sun, C., Hall, J. A., Blank, R. B., Bouladoux, N. J., Oukka, M., Mora, J. R., & Belkaid, Y. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070602 · Cited by 1,880
Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis
Viglietta, V., Baecher‐Allan, C., Weiner, H. L., & Hafler, D. A. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031579 · Cited by 1,858
A function for interleukin 2 in Foxp3-expressing regulatory T cells
Fontenot, J. D., Rasmussen, J. P., Gavin, M. A., & Rudensky, A. Y. (2005) · Nature Immunology · doi:10.1038/ni1263 · Cited by 1,819
Regulatory T Cells
Sakaguchi, S. (2000) · Cell · doi:10.1016/s0092-8674(00)80856-9 · Cited by 1,812
CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity
Belkaid, Y., Piccirillo, C. A., Méndez, S., Shevach, E. M., & Sacks, D. L. (2002) · Nature · doi:10.1038/nature01152 · Cited by 1,726
Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide
Jordan, M. S., Boesteanu, A. C., Reed, A. J., Petrone, A. L., Holenbeck, A. E., Lerman, M. A., Naji, A., & Caton, A. J. (2001) · Nature Immunology · doi:10.1038/86302 · Cited by 1,661
An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation
Asseman, C., Mauze, S., Leach, M. W., Coffman, R. L., & Powrie, F. M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.7.995 · Cited by 1,617
Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces
Rubtsov, Y. P., Rasmussen, J. P., Chi, E. Y., Fontenot, J., Castelli, L., Ye, X., Treuting, P., Siewe, L., Roers, A., Henderson, W. R., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.02.017 · Cited by 1,586
Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.
Takahashi, T., Kuniyasu, Y., Toda, M., Sakaguchi, N., Itoh, M., Iwata, M., Shimizu, J., & Sakaguchi, S. (1998) · International Immunology · doi:10.1093/intimm/10.12.1969 · Cited by 1,566
Retinoic acid imprints gut-homing specificity on T cells
Iwata, M., Hirakiyama, A., Eshima, Y., Kagechika, H., Kato, C., & Song, S.-Y. (2004) · Immunity · doi:10.1016/j.immuni.2004.08.011 · Cited by 1,541
Induction of Tumor Immunity by Removing CD25+CD4+ T Cells: A Common Basis Between Tumor Immunity and Autoimmunity
Shimizu, J., Yamazaki, S., & Sakaguchi, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.10.5211 · Cited by 1,491
Prevalence of Regulatory T Cells Is Increased in Peripheral Blood and Tumor Microenvironment of Patients with Pancreas or Breast Adenocarcinoma
Liyanage, U. K., Moore, T. T., Joo, H., Tanaka, Y., Herrmann, V. M., Doherty, G. M., Drebin, J. A., Strasberg, S. M., Eberlein, T. J., Goedegebuure, P. S., et al. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.5.2756 · Cited by 1,466
Modulation of tryptophan catabolism by regulatory T cells
Fallarino, F., Grohmann, U., Hwang, K. W., Orabona, C., Vacca, C., Bianchi, R., Belladonna, M. L., Fioretti, M. C., Alegre, M., & Puccetti, P. (2003) · Nature Immunology · doi:10.1038/ni1003 · Cited by 1,375
Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation.
Asano, M., Toda, M., Sakaguchi, N., & Sakaguchi, S. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.2.387 · Cited by 1,328
Natural versus adaptive regulatory T cells
Bluestone, J. A., & Abbas, A. K. (2003) · Nature reviews. Immunology · doi:10.1038/nri1032 · Cited by 1,319
Epigenetic Control of the foxp3 Locus in Regulatory T Cells
Floess, S., Freyer, J., Siewert, C., Baron, U., Olek, S., Polansky, J. K., Schlawe, K., Chang, H., Bopp, T., Schmitt, E., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050038 · Cited by 1,296
Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25– T cells
Walker, M., Kasprowicz, D. J., Gersuk, V. H., Bénard, A., Landeghen, M. V., Buckner, J. H., & Ziegler, S. F. (2003) · Journal of Clinical Investigation · doi:10.1172/jci19441 · Cited by 1,242
Inducing and expanding regulatory T cell populations by foreign antigen
Kretschmer, K., Apostolou, I., Hawiger, D., Khazaie, K., Nussenzweig, M. C., & von Boehmer, H. (2005) · Nature Immunology · doi:10.1038/ni1265 · Cited by 1,240
In Vitro–expanded Antigen-specific Regulatory T Cells Suppress Autoimmune Diabetes
Tang, Q., Henriksen, K., Bi, M., Finger, E. B., Szot, G. L., Ye, J., Masteller, E. L., McDevitt, H. O., Bonyhadi, M. L., & Bluestone, J. A. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040139 · Cited by 1,232
Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific
Thornton, A. M., & Shevach, E. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.1.183 · Cited by 1,229
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus
Herold, K. C., Hagopian, W., Auger, J. A., Poumian-Ruiz, E., Taylor, L., Donaldson, D., Gitelman, S. E., Harlan, D. M., Xu, D., Zivin, R. A., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012864 · Cited by 1,222
Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans
Roncarolo, M. G., Gregori, S., Battaglia, M., Bacchetta, R., Fleischhauer, K., & Levings, M. K. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00420.x · Cited by 1,206
In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines
Barrat, F. J., Cua, D. J., Boonstra, A., Richards, D. F., Crain, C., Savelkoul, H. F. J., Malefyt, R. D. W., Coffman, R. L., Hawrylowicz, C. M., & O’Garra, A. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011629 · Cited by 1,161
Foxp3-dependent programme of regulatory T-cell differentiation
Gavin, M. A., Rasmussen, J. P., Fontenot, J. D., Vasta, V., Manganiello, V. C., Beavo, J. A., & Rudensky, A. Y. (2007) · Nature · doi:10.1038/nature05543 · Cited by 1,127
Pillars Article: Control of Regulatory T Cell Development by the Transcription Factor Foxp3 . Science 2003. 299: 1057–1061
Hori, S., Nomura, T., & Sakaguchi, S. (2017) · The Journal of Immunology · doi:10.1093/jimmunol/198.3.981 · Cited by 1,124
Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance
Cao, X., Cai, S. F., Fehniger, T. A., Song, J., Collins, L. I., Piwnica-Worms, D. R., & Ley, T. J. (2007) · Immunity · doi:10.1016/j.immuni.2007.08.014 · Cited by 1,117
Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer.
Woo, E. Y., Chu, C., Goletz, T. J., Schlienger, K., Yeh, H., Coukos, G., Rubin, S. C., Kaiser, L. R., & June, C. H. (2001) · PubMed · Cited by 1,113
Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody.
Onizuka, S., Tawara, I., Shimizu, J., Sakaguchi, S., Fujita, T., & Nakayama, E. (1999) · PubMed · Cited by 1,062
The Foxp3+ regulatory T cell: a jack of all trades, master of regulation
Tang, Q., & Bluestone, J. A. (2008) · Nature Immunology · doi:10.1038/ni1572 · Cited by 1,047
Natural regulatory T cells in infectious disease
Belkaid, Y., & Rouse, B. T. (2005) · Nature Immunology · doi:10.1038/ni1181 · Cited by 1,044
The infusion of ex vivo activated and expanded CD4+CD25+ immune regulatory cells inhibits graft-versus-host disease lethality
Taylor, P. A., Lees, C. J., & Blazar, B. R. (2002) · Blood · doi:10.1182/blood.v99.10.3493 · Cited by 1,039
Tumor-Infiltrating FOXP3 + T Regulatory Cells Show Strong Prognostic Significance in Colorectal Cancer
Salama, P. R., Phillips, M. R., Grieu, F., Morris, M. J., Zeps, N., Joseph, D. J., Platell, C. F. E., & Iacopetta, B. J. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2008.18.7229 · Cited by 1,025
CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor–β–dependent manner
Ghiringhelli, F., Menard, C., Terme, M., Flament, C., Taı̈eb, J., Chaput, N., Puig, P. E., Novault, S., Escudier, B. J., Vivier, É., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051511 · Cited by 1,004
Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17–producing T cell responses
Denning, T. L., Wang, Y., Patel, S. R., Williams, I. R., & Pulendran, B. (2007) · Nature Immunology · doi:10.1038/ni1511 · Cited by 995
TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells
Marie, J. C., Letterio, J. J., Gavin, M. A., & Rudensky, A. Y. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042276 · Cited by 986
Multiple sclerosis: a complicated picture of autoimmunity
McFarland, H. F., & Martin, R. (2007) · Nature Immunology · doi:10.1038/ni1507 · Cited by 985
Role of interleukin 10 in specific immunotherapy.
Akdiş, C. A., Blesken, T., Akdiş, M., Wüthrich, B., & Blaser, K. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2250 · Cited by 966
Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease
Gorelik, L., & Flavell, R. A. (2000) · Immunity · doi:10.1016/s1074-7613(00)80170-3 · Cited by 959
Cutting Edge: Contact-Mediated Suppression by CD4+CD25+ Regulatory Cells Involves a Granzyme B-Dependent, Perforin-Independent Mechanism
Gondek, D. C., Lu, L., Quezada, S. A., Sakaguchi, S., & Noelle, R. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.4.1783 · Cited by 943
Cutting Edge: Cure of Colitis by CD4+CD25+ Regulatory T Cells
Mottet, C., Uhlig, H. H., & Powrie, F. M. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.8.3939 · Cited by 928
FOXP3: Of Mice and Men
Ziegler, S. F. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090547 · Cited by 921
A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.
Powrie, F. M., Carlino, J. A., Leach, M. W., Mauze, S., & Coffman, R. L. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.6.2669 · Cited by 894
Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production
Allan, S. E., Crome, S. Q., Crellin, N. K., Passerini, L., Steiner, T. S., Bacchetta, R., Roncarolo, M. G., & Levings, M. K. (2007) · International Immunology · doi:10.1093/intimm/dxm014 · Cited by 872
"Infectious" Transplantation Tolerance
Qin, S., Cobbold, S. P., Pope, H., Elliott, J. I., Kioussis, D., Davies, J. D., & Waldmann, H. (1993) · Science · doi:10.1126/science.8094901 · Cited by 872
Induction and mechanism of action of transforming growth factor‐β‐secreting Th3 regulatory cells
Weiner, H. L. (2001) · Immunological Reviews · doi:10.1034/j.1600-065x.2001.1820117.x · Cited by 850
Origin of regulatory T cells with known specificity for antigen
Apostolou, I., Sarukhan, A., Klein, L., & von Boehmer, H. (2002) · Nature Immunology · doi:10.1038/ni816 · Cited by 847
All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation
Benson, M. J., Pino-Lagos, K., Rosemblatt, M., & Noelle, R. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070719 · Cited by 847
Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation
Korn, T., Reddy, J., Gao, W., Bettelli, E., Awasthi, A., Petersen, T. R., Bäckström, B. T., Sobel, R. A., Wucherpfennig, K. W., Strom, T. B., et al. (2007) · Nature Medicine · doi:10.1038/nm1564 · Cited by 824
Tumor cells convert immature myeloid dendritic cells into TGF-β–secreting cells inducing CD4 + CD25 + regulatory T cell proliferation
Ghiringhelli, F., Puig, P. E., Roux, S., Parcellier, A., Schmitt, E., Solary, É., Kroemer, G., Martin, F., Chauffert, B., & Zitvogel, L. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050463 · Cited by 817
Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signals in vivo
Chen, M.-L., Pittet, M. J., Gorelik, L., Flavell, R. A., Weissleder, R., von Boehmer, H., & Khazaie, K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408197102 · Cited by 806
Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase
Sharma, M. D., Baban, B., Chandler, P., Hou, D., Singh, N., Yagita∥, H., Azuma, M., Blazar, B. R., Mellor, A. L., & Munn, D. H. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31911 · Cited by 791
Antigen-specific regulatory T cells develop via the ICOS–ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity
Akbari, O., Freeman, G. J., Meyer, E. H., Greenfield, E. A., Chang, T. T., Sharpe, A. H., Berry, G. J., DeKruyff, R. H., & Umetsu, D. T. (2002) · Nature Medicine · doi:10.1038/nm745 · Cited by 791
Cutting Edge: CD4+CD25+ Regulatory T Cells Suppress Antigen-Specific Autoreactive Immune Responses and Central Nervous System Inflammation During Active Experimental Autoimmune Encephalomyelitis
Kohm, A. P., Carpentier, P. A., Anger, H. A., & Miller, S. D. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.9.4712 · Cited by 782
CD4 Regulatory T Cells Prevent Lethal Autoimmunity in IL-2Rβ-Deficient Mice
Malek, T. R., Yu, A., Vincek, V., Scibelli, P., & Kong, L. (2002) · Immunity · doi:10.1016/s1074-7613(02)00367-9 · Cited by 781
Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus
Watanabe, N., Wang, Y.-H., Lee, H. K., Ito, T., Wang, Y., Cao, W., & Liu, Y. (2005) · Nature · doi:10.1038/nature03886 · Cited by 772
T Cell-Produced Transforming Growth Factor-β1 Controls T Cell Tolerance and Regulates Th1- and Th17-Cell Differentiation
Li, M. O., Wan, Y. Y., & Flavell, R. A. (2007) · Immunity · doi:10.1016/j.immuni.2007.03.014 · Cited by 769
A CENTRAL ROLE FOR CENTRAL TOLERANCE
Kyewski, B., & Klein, L. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115601 · Cited by 768
Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease
Ling, E. M., Smith, T. R. F., Nguyen, X. D., Pridgeon, C., Dallman, M. J., Arbery, J., Carr, V. A., & Robinson, D. S. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15592-x · Cited by 759
B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma
Kryczek, I., Zou, L., Rodriguez, P., Zhu, G., Wei, S., Mottram, P., Brumlik, M., Cheng, P., Curiel, T., Myers, L., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20050930 · Cited by 748
Cutting Edge: Regulatory T Cells Induce CD4+CD25−Foxp3− T Cells or Are Self-Induced to Become Th17 Cells in the Absence of Exogenous TGF-β
Xu, L., Kitani, A., Fuss, I. J., & Strober, W. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.6725 · Cited by 741
CD4+CD25+ TR Cells Suppress Innate Immune Pathology Through Cytokine-dependent Mechanisms
Maloy, K. J., Salaün, L., Cahill, R., Dougan, G., Saunders, N. J. S. G., & Powrie, F. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021345 · Cited by 740
CD25+ CD4+ T Cells, Expanded with Dendritic Cells Presenting a Single Autoantigenic Peptide, Suppress Autoimmune Diabetes
Tarbell, K. V., Yamazaki, S., Olson, K., Toy, P., & Steinman, R. M. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040180 · Cited by 738
Induction of FOXP3 expression in naive human CD4+FOXP3− T cells by T-cell receptor stimulation is transforming growth factor-β–dependent but does not confer a regulatory phenotype
Tran, D. Q., Ramsey, H. E., & Shevach, E. M. (2007) · Blood · doi:10.1182/blood-2007-06-094656 · Cited by 738
In Vivo Instruction of Suppressor Commitment in Naive T Cells
Apostolou, I., & von Boehmer, H. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040249 · Cited by 728
Recognition of the Peripheral Self by Naturally Arising CD25+ CD4+ T Cell Receptors
Hsieh, C., Liang, Y., Tyznik, A. J., Self, S. G., Liggitt, D., & Rudensky, A. Y. (2004) · Immunity · doi:10.1016/j.immuni.2004.07.009 · Cited by 719
Foxp3 Expressing CD4+CD25high Regulatory T Cells Are Overrepresented in Human Metastatic Melanoma Lymph Nodes and Inhibit the Function of Infiltrating T Cells
Viguier, M. A., Lemaı̂tre, F., VEROLA, O., Cho, M.-S., Gorochov, G., Dubertret, L., Bachelez, H., Kourilsky, P., & Ferradini, L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.2.1444 · Cited by 707
The cellular mechanism of Aire control of T cell tolerance.
Anderson, M. S., Venanzi, E. S., Chen, Z.-B., Berzins, S., Benoist, C., & Mathis, D. (2005) · Immunity · doi:10.1016/j.immuni.2005.07.005 · Cited by 691
Central tolerance: learning self-control in the thymus
Hogquist, K. A., Baldwin, T. A., & Jameson, S. C. (2005) · Nature reviews. Immunology · doi:10.1038/nri1707 · Cited by 680
Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells
Tang, Q., Henriksen, K., Boden, E. K., Tooley, A. J., Ye, J., Subudhi, S. K., Zheng, X. X., Strom, T. B., & Bluestone, J. A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.7.3348 · Cited by 669
A Two-Step Process for Thymic Regulatory T Cell Development
Lio, C. J., & Hsieh, C. (2008) · Immunity · doi:10.1016/j.immuni.2007.11.021 · Cited by 660
Increased Populations of Regulatory T Cells in Peripheral Blood of Patients with Hepatocellular Carcinoma
Ormandy, L. A., Hillemann, T., Wedemeyer, H. H., Manns, M. P., Greten, T. F., & Korangy, F. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3232 · Cited by 656
IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4+CD25+ Regulatory T Cells
Vieira, P. L., Christensen, J. R., Minaee, S., O’Neill, E. J., Barrat, F. J., Boonstra, A., Barthlott, T., Stockinger, B., Wraith, D. C., & O’Garra, A. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.10.5986 · Cited by 652
A Single Course of Anti-CD3 Monoclonal Antibody hOKT3γ1(Ala-Ala) Results in Improvement in C-Peptide Responses and Clinical Parameters for at Least 2 Years after Onset of Type 1 Diabetes
Herold, K. C., Gitelman, S. E., Masharani, U. B., Hagopian, W., Bisikirska, B. C., DONALDSON, D. L., Rother, K. I., Diamond, B. E., Harlan, D. M., & Bluestone, J. A. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1763 · Cited by 641
Human Plasmacytoid Dendritic Cells Activated by CpG Oligodeoxynucleotides Induce the Generation of CD4+CD25+ Regulatory T Cells
Moseman, E. A., Liang, X., Dawson, A. J., Panoskaltsis‐Mortari, A., Krieg, A. Μ., Liu, Y., Blazar, B. R., & Chen, W. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.7.4433 · Cited by 636
Role of alpha 4-integrins in lymphocyte homing to mucosal tissues in vivo.
Hamann, A., Andrew, D. P., Jablonski‐Westrich, D., Holzmann, B., & Butcher, E. C. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.7.3282 · Cited by 627
Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells
Aschenbrenner, K., D'Cruz, L. M., Vollmann, E. H., Hinterberger, M., Emmerich, J., Swee, L. K., Rolink, A., & Klein, L. (2007) · Nature Immunology · doi:10.1038/ni1444 · Cited by 615
Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.
Powrie, F., Correa-Oliveira, R., Mauze, S., & Coffman, R. L. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.2.589 · Cited by 613
Toll-Like Receptor 2 Suppresses Immunity against Candida albicans through Induction of IL-10 and Regulatory T Cells
Netea, M. G., Sutmuller, R. P. M., Hermann, C., van der Graaf, C. A. A., van der Meer, J. W. M., van Krieken, J. H., Härtung, T., Adema, G. J., & Kullberg, B. J. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.6.3712 · Cited by 611
Infectious Tolerance
Jonuleit, H., Schmitt, E., Kakirman, H., Stassen, M., Knop, J., & Enk, A. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020394 · Cited by 605
Natural Recovery and Protection from Autoimmune Encephalomyelitis: Contribution of CD4+CD25+ Regulatory Cells within the Central Nervous System1
McGeachy, M., Stephens, L. A., & Anderton, S. (2005) · Journal of Immunology · doi:10.4049/jimmunol.175.5.3025 · Cited by 602
IFN-α and IL-10 Induce the Differentiation of Human Type 1 T Regulatory Cells
Levings, M. K., Sangregorio, R., Galbiati, F., Squadrone, S., Malefyt, R. D. W., & Roncarolo, M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.9.5530 · Cited by 595
Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype
Kemper, C., Chan, A. C., Green, J. M., Brett, K. A., MURPHY, K. M. M., & Atkinson, J. P. (2003) · Nature · doi:10.1038/nature01315 · Cited by 589
Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis
Gambineri, E., Torgerson, T. R., & Ochs, H. D. (2003) · Current Opinion in Rheumatology · doi:10.1097/00002281-200307000-00010 · Cited by 575
CD4+CD25−Foxp3− Th1 cells are the source of IL-10–mediated immune suppression in chronic cutaneous leishmaniasis
Anderson, C. F., Oukka, M., Kuchroo, V. K., & Sacks, D. L. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061886 · Cited by 571
An immunomodulatory role for CD4+CD25+ regulatory T lymphocytes in hepatitis C virus infection
Cabrera, R., Tu, Z., Xu, Y., Firpi, R. J., Rosen, H. R., Liu, C., & Nelson, D. R. (2004) · Hepatology · doi:10.1002/hep.20454 · Cited by 561
CD4+CD25+ T Cells Regulate Virus-specific Primary and Memory CD8+ T Cell Responses
Suvas, S., Kumaraguru, U., Pack, C. D., Lee, S., & Rouse, B. T. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030171 · Cited by 527
High numbers of tumor-infiltrating FOXP3-positive regulatory T cells are associated with improved overall survival in follicular lymphoma
Carreras, J., López‐Guillermo, A., Fox, B. C., Colomo, L., Martı́nez, A., Roncador, G., Montserrat, E., Campo, E., & Banham, A. H. (2006) · Blood · doi:10.1182/blood-2006-04-018218 · Cited by 521
Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4 + CD25 + regulatory T cells is interleukin 10 dependent
Kearley, J., Barker, J. E., Robinson, D. S., & Lloyd, C. M. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051166 · Cited by 517
T cells that cannot respond to TGF-β escape control by CD4+CD25+ regulatory T cells
Fahlén, L., Read, S., Gorelik, L., Hurst, S. D., Coffman, R. L., Flavell, R. A., & Powrie, F. M. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20040685 · Cited by 516
Coordination of Early Protective Immunity to Viral Infection by Regulatory T Cells
Lund, J. M., Hsing, L., Pham, T., & Rudensky, A. Y. (2008) · Science · doi:10.1126/science.1155209 · Cited by 514
Regulatory T cells contribute to the impaired immune response in patients with chronic hepatitis B virus infection†‡
Stoop, J. N., Molen, R. G. V. D., Baan, C. C., van der Laan, L. J. W., Kuipers, E. J., Kusters, J. G., & Janssen, H. L. A. (2005) · Hepatology · doi:10.1002/hep.20649 · Cited by 504
Oral tolerance in the absence of naturally occurring Tregs
Mucida, D. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24487 · Cited by 498
CD4 + CD25 + regulatory T cells in patients with gastrointestinal malignancies
Sasada, T., Kimura, M., Yoshida, Y., Kanai, M., & Takabayashi, A. (2003) · Cancer · doi:10.1002/cncr.11618 · Cited by 485
Regulatory T cell development in the absence of functional Foxp3
Lin, W. X., Haribhai, D., Relland, L. M., Truong, N., Carlson, M. R. J., Williams, C. B., & Chatila, T. A. (2007) · Nature Immunology · doi:10.1038/ni1445 · Cited by 485
Cellular Mechanisms of Fatal Early-Onset Autoimmunity in Mice with the T Cell-Specific Targeting of Transforming Growth Factor-β Receptor
Marie, J. C., Liggitt, D., & Rudensky, A. Y. (2006) · Immunity · doi:10.1016/j.immuni.2006.07.012 · Cited by 480
A Unique Subset of CD4+CD25highFoxp3+ T Cells Secreting Interleukin-10 and Transforming Growth Factor-β1 Mediates Suppression in the Tumor Microenvironment
Strauss, L., Bergmann, C., Szczepański, M. J., Gooding, W. E., Johnson, J. T., & Whiteside, T. L. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0472 · Cited by 475
Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients.
Fukaura, H., Kent, S. C., PIETRUSEWICZ, M. J., Khoury, S. J., Weiner, H. L., & Hafler, D. A. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118779 · Cited by 473
In vivo switch to IL-10–secreting T regulatory cells in high dose allergen exposure
Meiler, F., Zumkehr, J., Klunker, S., Rückert, B., Akdiş, C. A., & Akdis, M. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080193 · Cited by 468
Outcome in Hodgkin's Lymphoma Can Be Predicted from the Presence of Accompanying Cytotoxic and Regulatory T Cells
Álvaro, T., Lejeune, M., Salvadó, M. T., Bosch, R., García, J. F., Jaén, J., Banham, A. H., Roncador, G., Montalbán, C., & Piris, M. A. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1869 · Cited by 466
Human CD4+CD25+ Regulatory, Contact-dependent T Cells Induce Interleukin 10–producing, Contact-independent Type 1-like Regulatory T Cells
Dieckmann, D., Bruett, C. H., Ploettner, H., Lutz, M. B., & Schuler, G. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020642 · Cited by 466
Characterization of Foxp3+CD4+CD25+ and IL-10-Secreting CD4+CD25+ T Cells during Cure of Colitis
Uhlig, H. H., Coombes, J. L., Mottet, C., Ízcue, A., Thompson, C., Fanger, A., Tannapfel, A., Fontenot, J. D., Ramsdell, F., & Powrie, F. M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.9.5852 · Cited by 463
Suppressor T Cells
Gershon, R. K., Cohen, P., Hencin, R. S., & Liebhaber, S. A. (1972) · The Journal of Immunology · doi:10.4049/jimmunol.108.3.586 · Cited by 463
Reduced suppressive effect of CD4+CD25high regulatory T cells on the T cell immune response against myelin oligodendrocyte glycoprotein in patients with multiple sclerosis
Haas, J., Hug, A., Viehöver, A., Fritzsching, B., Falk, C. S., Filser, A., Vetter, T., Milkova, L., Korporal, M., Fritz, B., et al. (2005) · European Journal of Immunology · doi:10.1002/eji.200526065 · Cited by 450
CD4+ and CD8+ anergic T cells induced by interleukin-10–treated human dendritic cells display antigen-specific suppressor activity
Steinbrink, K., Graulich, E., Kubsch, S., Knop, J., & Enk, A. (2002) · Blood · doi:10.1182/blood.v99.7.2468 · Cited by 448
Regulatory T Cells are Expanded in Blood and Disease Sites in Patients with Tuberculosis
Revol, V., Innes, J. A., Hackforth, S., Hinks, T., & Lalvani, A. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200508-1294oc · Cited by 444
CD25+CD4+ Regulatory T Cells from the Peripheral Blood of Asymptomatic HIV-infected Individuals Regulate CD4+ and CD8+ HIV-specific T Cell Immune Responses In Vitro and Are Associated with Favorable Clinical Markers of Disease Status
Kinter, A. L., Scull, M. A., Bell, A., Kern, S., Lin, Y., Daucher, M., Planta, M., McGlaughlin, M., Jackson, R. W., Ziegler, S. F., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20032069 · Cited by 436
Intratumoral CD4+CD25+ regulatory T-cell-mediated suppression of infiltrating CD4+ T cells in B-cell non-Hodgkin lymphoma
Yang, Z., Novak, A. J., Stenson, M. J., Witzig, T. E., & Ansell, S. M. (2006) · Blood · doi:10.1182/blood-2005-08-3376 · Cited by 434
Human CD4+CD25+Regulatory T Cells Control T-Cell Responses to Human Immunodeficiency Virus and Cytomegalovirus Antigens
Aandahl, E. M., Michaëlsson, J., Moretto, W. J., Hecht, F. M., & Nixon, D. F. (2004) · Journal of Virology · doi:10.1128/jvi.78.5.2454-2459.2004 · Cited by 428
Adaptive Foxp3+ Regulatory T Cell-Dependent and -Independent Control of Allergic Inflammation
de Lafaille, M. A. C., Kutchukhidze, N., Shen, S., Ding, Y., Yee, H. T., & Lafaille, J. J. (2008) · Immunity · doi:10.1016/j.immuni.2008.05.010 · Cited by 424
Quantitative and functional impairment of pulmonary CD4+CD25hi regulatory T cells in pediatric asthma
Hartl, D., Koller, B., Mehlhorn, A. T., Reinhardt, D., Nicolaï, T., Schendel, D. J., Griese, M., & Krauss‐Etschmann, S. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.02.023 · Cited by 420
Expression of FOXP3 mRNA is not confined to CD4+CD25+ T regulatory cells in humans
Morgan, M. E., van Bilsen, J. H. M., Bakker, A. M., Heemskerk, B., Schilham, M. W., Hartgers, F. C., Elferink, B. G., van der Zanden, L., de Vries, R. R. P., Huizinga, T. W. J., et al. (2004) · Human Immunology · doi:10.1016/j.humimm.2004.05.016 · Cited by 417
CD4 + CD25 + T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and function
Lewkowich, I. P., Herman, N. S., Schleifer, K. W., Dance, M. P., Chen, B. L., Dienger, K. M., Sproles, A. A., Shah, J. S., Köhl, J., Belkaid, Y., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051506 · Cited by 411
Induction of foxP3 + Regulatory T Cells in the Periphery of T Cell Receptor Transgenic Mice Tolerized to Transplants
Cobbold, S. P., Castejón, R., Adams, E., Zélénika, D., Graça, L., Humm, S., & Waldmann, H. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.10.6003 · Cited by 410
Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis
Scott-Browne, J. P., Shafiani, S., Tucker-Heard, G., Ishida-Tsubota, K., Fontenot, J. D., Rudensky, A. Y., Bevan, M. J., & Urdahl, K. B. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062105 · Cited by 408
Mechanisms of regulatory T-cell suppression - a diverse arsenal for a moving target
Sojka, D. K., Huang, Y., & Fowell, D. J. (2008) · Immunology · doi:10.1111/j.1365-2567.2008.02813.x · Cited by 393 · cited 16×
“This is primarily mediated through the interaction of cell surface molecules on Tregs such as CTLA-4 and the lymphocyte activation gene 3 (LAG-3) and their interaction with CD80/CD86 and MHC class II, respectively, on APCs [14, 109, 110].”
Influential
Human immunodeficiency virus–driven expansion of CD4+CD25+ regulatory T cells, which suppress HIV-specific CD4 T-cell responses in HIV-infected patients
Weiss, L., Donkova-Petrini, V., Caccavelli, L., Balbo, M., Carbonneil, C., & Lévy, Y. (2004) · Blood · doi:10.1182/blood-2004-01-0365 · Cited by 384
The Subpopulation of CD4+CD25+ Splenocytes That Delays Adoptive Transfer of Diabetes Expresses L-Selectin and High Levels of CCR7
Szanya, V., Ermann, J., Taylor-Edwards, C., Holness, C. L. L., & Fathman, C. G. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.5.2461 · Cited by 373
Decreased FOXP3 levels in multiple sclerosis patients
Huan, J., Culbertson, N. E., Spencer, L., Bartholomew, R. M., Burrows, G. G., Chou, Y. K., BOURDETTE, D. N., Ziegler, S. F., Offner, H., & Vandenbark, A. A. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20522 · Cited by 369
CD25− T Cells Generate CD25+Foxp3+ Regulatory T Cells by Peripheral Expansion
de Lafaille, M. A. C., Lino, A. C., Kutchukhidze, N., & Lafaille, J. J. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.12.7259 · Cited by 368
IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cells
Zhang, X. (2004) · International Immunology · doi:10.1093/intimm/dxh029 · Cited by 365
Localization of a Type 1 Diabetes Locus in the IL2RA/CD25 Region by Use of Tag Single-Nucleotide Polymorphisms
Vella, A. V., Cooper, J. D., Lowe, C. E., Walker, N. M., Nutland, S. L., Widmer, B., Jones, R. W., Ring, S. M., McArdle, W. L., Pembrey, M. E., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/429843 · Cited by 363
Escape of malaria parasites from host immunity requires CD4+CD25+ regulatory T cells
Hisaeda, H., Maekawa, Y., 岩川大路, Okada, H., Himeno, K., Kishihara, K., Tsukumo, S., & Yasutomo, K. (2003) · Nature Medicine · doi:10.1038/nm975 · Cited by 360
CD4+CD25+ Regulatory T Cells Control the Severity of Viral Immunoinflammatory Lesions
Suvas, S., Azkur, A. K., Kim, B. S., Kumaraguru, U., & Rouse, B. T. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.7.4123 · Cited by 358
Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease
Paust, S., Lu, L., McCarty, N., & Cantor, H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403342101 · Cited by 328
CCR7-Dependent Cortex-to-Medulla Migration of Positively Selected Thymocytes Is Essential for Establishing Central Tolerance
Kurobe, H., Liu, C., Ueno, T., Saito, F., Ohigashi, I., Seach, N., Arakaki, R., Hayashi, Y., Kitagawa, T., Lipp, M., et al. (2006) · Immunity · doi:10.1016/j.immuni.2005.12.011 · Cited by 321
T regulatory cells in atopic dermatitis and subversion of their activity by superantigens
Ou, L.-S., Goleva, E., Hall, C. F., & Leung, D. Y. M. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.01.772 · Cited by 319
Regulation of immunity by self-reactive T cells
Kronenberg, M., & Rudensky, A. Y. (2005) · Nature · doi:10.1038/nature03725 · Cited by 318
Origin and T Cell Receptor Diversity of Foxp3+CD4+CD25+ T Cells
Pacholczyk, R., Ignatowicz, H., Kraj, P. J., & Ignatowicz, L. (2006) · Immunity · doi:10.1016/j.immuni.2006.05.016 · Cited by 317
Vitamin A Metabolites Induce Gut-Homing FoxP3+ Regulatory T Cells
Kang, S. G., Lim, H. W., ANDRISANI, O. M., Broxmeyer, H. E., & Kim, C. H. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.3724 · Cited by 313
Development of Autoimmunity against Transcriptionally Unrepressed Target Antigen in the Thymus of Aire-Deficient Mice
Kuroda, N., Mitani, T., Takeda, N., Ishimaru, N., Arakaki, R., Hayashi, Y., Bando, Y., Izumi, K., Takahashi, T., Nomura, T., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.4.1862 · Cited by 299
Distinct regulation of IgE, IgG4 and IgA by T regulatory cells and toll‐like receptors
Meiler, F., Klunker, S., Zimmermann, M., Akdiş, C. A., & Akdiş, M. (2008) · Allergy · doi:10.1111/j.1398-9995.2008.01774.x · Cited by 299
Cutting Edge: Regulatory T Cells Prevent Efficient Clearance of Mycobacterium tuberculosis
Kursar, M., Koch, M., Mittrücker, H., Nouailles, G., Bonhagen, K., Kamradt, T., & Kaufmann, S. H. E. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.5.2661 · Cited by 290
Cutting Edge: Induction of B7-H4 on APCs through IL-10: Novel Suppressive Mode for Regulatory T Cells
Kryczek, I., Wei, S., Zou, L., Zhu, G., Mottram, P. J., Xu, H., Chen, L., & Zou, W. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.1.40 · Cited by 288
Tolerance induced by inhaled antigen involves CD4+ T cells expressing membrane-bound TGF-β and FOXP3
Ostroukhova, M., Seguin‐Devaux, C., Oriss, T. B., Dixon‐McCarthy, B., Yang, L., Ameredes, B. T., Corcoran, T. E., & Ray, A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20509 · Cited by 285
CD4+ T helper cells engineered to produce latent TGF-β1 reverse allergen-induced airway hyperreactivity and inflammation
Hansen, G., McIntire, J. J., Yeung, V. P., Berry, G. J., Thorbecke, G. J., Chen, L., DeKruyff, R. H., & Umetsu, D. T. (2000) · Journal of Clinical Investigation · doi:10.1172/jci7589 · Cited by 269
Regulatory T Cell Suppression Is Potentiated by Target T Cells in a Cell Contact, IL-35- and IL-10-Dependent Manner
Collison, L. W., Pillai, M. R., Chaturvedi, V., & Vignali, D. A. A. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803646 · Cited by 259
Self-citation
Tolerance to islet autoantigens in type 1 diabetes.
Bach, J., & Chatenoud, L. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.131 · Cited by 259
Tumor necrosis factor-α regulation of CD4 + C25 + T cell levels in NOD mice
Wu, A. J., Hua, H., Munson, S. H., & McDevitt, H. O. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172382999 · Cited by 250
A Disquisition on Suppressor T Cells
Gershon, R. K. (1975) · Immunological Reviews · doi:10.1111/j.1600-065x.1975.tb00179.x · Cited by 249
Number of T Reg Cells That Differentiate Does Not Increase upon Encounter of Agonist Ligand on Thymic Epithelial Cells
van Santen, H. M., Benoist, C. O., & Mathis, D. J. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041022 · Cited by 244
Inhibitory Feedback Loop Between Tolerogenic Dendritic Cells and Regulatory T Cells in Transplant Tolerance
Min, W., Zhou, D., Ichim, T. E., Strejan, G. H., Xia, X., Yang, J., Huang, X., Garcia, B. M., White, D. J., Dutartre, P., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.3.1304 · Cited by 240
Differentiation of regulatory Foxp3 + T cells in the thymic cortex
Liston, A., Nutsch, K., Farr, A. G., Lund, J. M., Rasmussen, J. P., Koni, P. A., & Rudensky, A. Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801506105 · Cited by 238
Essential role for interleukin-2 for CD4+CD25+ T regulatory cell development during the neonatal period
Bayer, A. L., Yu, A., Adeegbe, D. O., & Malek, T. R. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041179 · Cited by 238
CD4+ and CD8+ Regulatory T Cells Generated Ex Vivo with IL-2 and TGF-β Suppress a Stimulatory Graft-versus-Host Disease with a Lupus-Like Syndrome
Zheng, S. G., Wang, J. H., Koss, M. N., Quismorio, F. P., Gray, J. D., & Horwitz, D. A. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.3.1531 · Cited by 231
CD4+CD25− T Cells That Express Latency-Associated Peptide on the Surface Suppress CD4+CD45RBhigh-Induced Colitis by a TGF-β-Dependent Mechanism
Oida, T., Zhang, X., Goto, M., Hachimura, S., Totsuka, M., Kaminogawa, S., & Weiner, H. L. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.5.2516 · Cited by 227
CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation
Oh, J., Seroogy, C. M., Meyer, E. H., Akbari, O., Berry, G. J., Fathman, C. G., DeKruyff, R. H., & Umetsu, D. T. (2002) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2002.127512 · Cited by 219
Nonself-Antigens Are the Cognate Specificities of Foxp3+ Regulatory T Cells
Pacholczyk, R., Kern, J., Singh, N., Iwashima, M., Kraj, P. J., & Ignatowicz, L. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.019 · Cited by 216
Autoimmune Diabetes Onset Results From Qualitative Rather Than Quantitative Age-Dependent Changes in Pathogenic T-Cells
You, S., Belghith, M., Cobbold, S. P., Alyanakian, M., Gouarin, C., Barriot, S., Cordier, C., Waldmann, H., Bach, J., & Chatenoud, L. (2005) · Diabetes · doi:10.2337/diabetes.54.5.1415 · Cited by 214
Murine Plasmacytoid Dendritic Cells Initiate the Immunosuppressive Pathway of Tryptophan Catabolism in Response to CD200 Receptor Engagement
Fallarino, F., Asselin‐Paturel, C., Vacca, C., Bianchi, R., Gizzi, S., Fioretti, M. C., Trinchieri, G., Grohmann, U., & Puccetti, P. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.6.3748 · Cited by 214
IL-10 Signaling Is Essential for 1,25-Dihydroxyvitamin D3-Mediated Inhibition of Experimental Autoimmune Encephalomyelitis
Spach, K. M., Nashold, F. E., Dittel, B. N., & Hayes, C. E. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.9.6030 · Cited by 207
Human CD4+CD25+Foxp3+ Regulatory T Cells Do Not Constitutively Express IL-35
Bardel, É., Larousserie, F., Rabiéga, P., L’Herminé, A. C., & Devergne, O. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.10.6898 · Cited by 204
Regulatory CD4+CD25+ T Cells Restrict Memory CD8+ T Cell Responses
Kursar, M., Bonhagen, K., Fensterle, J., Köhler, A. C., HURWITZ, R. M., Kamradt, T., Kaufmann, S. H. E., & Mittrücker, H. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011347 · Cited by 204
Secondary progressive in contrast to relapsing‐remitting multiple sclerosis patients show a normal CD4+CD25+ regulatory T‐cell function and FOXP3 expression
Venken, K., Hellings, N., Hensen, K., Rummens, J., Medaer, R., D'hooghe, M. B., Dubois, B., Raus, J., & Stinissen, P. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20852 · Cited by 185
Adaptive TGF-β-dependent regulatory T cells control autoimmune diabetes and are a privileged target of anti-CD3 antibody treatment
You, S., Leforban, B., Cordier, C., Bach, J., Bluestone, J. A., & Chatenoud, L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701171104 · Cited by 181
Peptide-induced T cell regulation of experimental autoimmune encephalomyelitis: a role for IL-10
Burkhart, C., Liu, G. Y., Anderton, S. M., Metzler, B., & Wraith, D. C. (1999) · International Immunology · doi:10.1093/intimm/11.10.1625 · Cited by 179
Tolerogenic Semimature Dendritic Cells Suppress Experimental Autoimmune Thyroiditis by Activation of Thyroglobulin-Specific CD4+CD25+ T Cells
Verginis, P., Li, H. S., & Carayanniotis, G. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.7433 · Cited by 176
Increased resistance to CD4+CD25hi regulatory T cell-mediated suppression in patients with type 1 diabetes
Lawson, J. M., Tremble, J. M., Dayan, C. M., Beyan, H., Leslie, R. D., Peakman, M., & Tree, T. I. M. (2008) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2008.03810.x · Cited by 175
Colitogenic Th1 Cells Are Present in the Antigen-Experienced T Cell Pool in Normal Mice: Control by CD4+ Regulatory T Cells and IL-10
Asseman, C., Read, S., & Powrie, F. M. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.2.971 · Cited by 172
IL-10 Controls Ultraviolet-Induced Carcinogenesis in Mice
Loser, K., Apelt, J., Voskort, M., Mohaupt, M., Balkow, S., Schwarz, T., Grabbe, S., & Beissert, S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.1.365 · Cited by 160
The IL-4 Receptor α-Chain-Binding Cytokines, IL-4 and IL-13, Induce Forkhead Box P3-Expressing CD25+CD4+ Regulatory T Cells from CD25−CD4+ Precursors
Skapenko, A., Kalden, J. R., Lipsky, P. E., & Schulze‐Koops, H. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.9.6107 · Cited by 157
Induction of Tolerance in Type 1 Diabetes via Both CD4+CD25+ T Regulatory Cells and T Regulatory Type 1 Cells
Battaglia, M., Stabilini, A., Draghici, E., Migliavacca, B., Gregori, S., Bonifacio, E. E., & Roncarolo, M. (2006) · Diabetes · doi:10.2337/db05-1576 · Cited by 153
Latency-Associated Peptide Identifies a Novel CD4+CD25+ Regulatory T Cell Subset with TGFβ-Mediated Function and Enhanced Suppression of Experimental Autoimmune Encephalomyelitis
Chen, M., Yan, B., Bandô, Y., Kuchroo, V. K., & Weiner, H. L. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.11.7327 · Cited by 146
Potential use of IL-2/anti-IL-2 antibody immune complexes for the treatment of cancer and autoimmune disease
Boyman, O., Surh, C. D., & Sprent, J. (2006) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.6.12.1323 · Cited by 145
Cooperation of Invariant NKT Cells and CD4+CD25+ T Regulatory Cells in the Prevention of Autoimmune Myasthenia
Liu, R., Cava, A. L., Bai, X., Jee, Y., Price, M. A., Campagnolo, D. I., Christadoss, P., Vollmer, T. L., Kaer, L. V., & Shi, F. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.12.7898 · Cited by 141
The B7/CD28 costimulatory family in autoimmunity
Keir, M. E., & Sharpe, A. H. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00242.x · Cited by 140
Induction of FOXP3‐expressing regulatory CD4pos T cells by human mature autologous dendritic cells
Verhasselt, V., Vosters, O., Beuneu, C., Nicaise, C., Stordeur, P., & Goldman, M. (2004) · European Journal of Immunology · doi:10.1002/eji.200324552 · Cited by 128
TGF‐β1 production by CD4+CD25+ regulatory T cells is not essential for suppression of intestinal inflammation
Kullberg, M. C., Hay, V., Cheever, A. W., Mamura, M., Sher, A., Letterio, J. J., Shevach, E. M., & Piccirillo, C. A. (2005) · European Journal of Immunology · doi:10.1002/eji.200526106 · Cited by 118
Role of Foxp3‐positive regulatory T cells during infection
Belkaid, Y. (2008) · European Journal of Immunology · doi:10.1002/eji.200738120 · Cited by 115
Suppression of Murine Allergic Airway Disease by IL-2:Anti-IL-2 Monoclonal Antibody-Induced Regulatory T Cells
Wilson, M. S., Pesce, J. T., Ramalingam, T. R., Thompson, R. W., Cheever, A. W., & Wynn, T. A. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.10.6942 · Cited by 111
How many mechanisms do regulatory T cells need?
Vignali, D. A. A. (2008) · European Journal of Immunology · doi:10.1002/eji.200738114 · Cited by 107
Self-citation
Early events in the thymus affect the balance of effector and regulatory T cells
Pennington, D. J., Silva‐Santos, B., Silberzahn, T., Escórcio-Correia, M., Woodward, M. J., Roberts, S. J., Smith, A. L., Dyson, P. J., & Hayday, A. (2006) · Nature · doi:10.1038/nature06051 · Cited by 105
An Inverse Correlation of Human Peripheral Blood Regulatory T Cell Frequency with the Disease Activity of Ulcerative Colitis
Takahashi, M., Nakamura, K., Honda, K., Kitamura, Y., Mizutani, T., Araki, Y., Kabemura, T., Chijiíwa, Y., Harada, N., & Nawata, H. (2006) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-3191-2 · Cited by 102
Peptide Specificity of Thymic Selection of CD4+CD25+ T Cells
Pacholczyk, R., Kraj, P. J., & Ignatowicz, L. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.2.613 · Cited by 102

Sorted by citations

T cell subsets and their signature cytokines in autoimmune and inflammatory diseases
Raphael, I., Nalawade, S. A., Eagar, T. N., & Forsthuber, T. G. (2014) · Cytokine · doi:10.1016/j.cyto.2014.09.011 · Cited by 1,240
IL-35-mediated induction of a potent regulatory T cell population
Collison, L. W., Chaturvedi, V., Henderson, A. L., Giacomin, P., Guy, C. S., Bankoti, J., Finkelstein, D., Forbes, K., Workman, C. J., Brown, S. A., et al. (2010) · Nature Immunology · doi:10.1038/ni.1952 · Cited by 870
Self-citation
Mechanisms of impaired regulation by CD4+CD25+FOXP3+ regulatory T cells in human autoimmune diseases
Buckner, J. H. (2010) · Nature reviews. Immunology · doi:10.1038/nri2889 · Cited by 790
The plasticity and stability of regulatory T cells
Sakaguchi, S., Vignali, D. A. A., Rudensky, A. Y., Niec, R. E., & Waldmann, H. (2013) · Nature reviews. Immunology · doi:10.1038/nri3464 · Cited by 537
Self-citation
Depression and immunity: A role for T cells?
Miller, A. H. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.09.009 · Cited by 345

See all 345

Authors: Workman, C. J., Szymczak-Workman, A. L., Collison, L. W., Pillai, M. R., & Vignali, D. A. A.
Affiliations: St. Jude Children's Research Hospital (US)
Corresponding author: Vignali, Dario A. A.
ORCID: Workman, Creg J.
Szymczak-Workman, Andrea L.
Vignali, Dario A. A.
Venue: Cellular and Molecular Life Sciences
Publisher: Springer Science and Business Media LLC
Published: 2009-04-24
Volume: 66
Issue: 16
Pages: 2603-2622
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s00018-009-0026-2
PMC: PMC2715449
OpenAlex: W2038689503
Cited by: 344
References: 221
Citations by year: 2026: 16 · 2025: 19 · 2024: 25 · 2023: 14 · 2022: 28 · 2021: 17 · 2020: 25 · 2019: 23 · 2018: 16 · 2017: 17 · 2016: 15 · 2015: 12 · 2014: 20 · 2013: 21 · 2012: 24
FWCI: 1.98
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (F32AI072816, R01AI091977, R01AI039480, R01AI052199, R01AI058156)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords: regulatory T cells, natural regulatory T cells, induced regulatory T cells, thymus development, CD4+ T cells, immunosuppression, peripheral tolerance, autoreactive T cells, antitumor immunity, sterilizing immunity
MeSH terms: Animals, Cell Differentiation, Humans, Immune Tolerance, Immunity, Cellular, Receptors, Antigen, T-Cell, Cytokines, Models, Immunological, T-Lymphocytes, Regulatory, Mice, Forkhead Transcription Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The development and function of regulatory T cells

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks