The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
Oxidative damage to RNA: mechanisms, consequences, and diseases
Open accessAbstract
Overproduction of free radicals can damage cellular components resulting in progressive physiological dysfunction, which has been implicated in many human diseases. Oxidative damage to RNA received little attention until the past decade. Recent studies indicate that RNA, such as messenger RNA and ribosomal RNA, is very vulnerable to oxidative damage. RNA oxidation is not a consequence of dying cells but an early event involved in pathogenesis. Oxidative modification to RNA results in disturbance of the translational process and impairment of protein synthesis, which can cause cell deterioration or even cell death. In this review, we discuss the mechanisms of oxidative damage to RNA and the possible biological consequences of damaged RNA. Furthermore, we review recent evidence suggesting that oxidative damage to RNA may contribute to progression of many human diseases.
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Cited by
Consequences of oxidative stress in age-related macular degeneration
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Base excision repair: A critical player in many games
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Metadata
- Authors
- Kong, Q., & Lin, C.-L. G.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2010-02-11
- Volume
- 67
- Issue
- 11
- Pages
- 1817-1829
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- OpenAlex
- W1998171008
- Cited by
- 349
- References
- 118
- FWCI
- 6.73
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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