Cited by 183Barrier Structure and Function StudiesAcute Ischemic Stroke ManagementSmoking Behavior and Cessation

Pathophysiological Impact of Cigarette Smoke Exposure on the Cerebrovascular System with a Focus on the Blood-Brain Barrier: Expanding the Awareness of Smoking Toxicity in an Underappreciated Area

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Mazzone, Peter, Tierney, William, Hossain, Mohammed, Puvenna, Vikram, Janigro, Damir, Cucullo, Luca·2010·International Journal of Environmental Research and Public Health

Abstract

Recent evidence has indicated that active and passive cigarette smoking are associated, in a dose-dependent manner, with dysfunction of normal endothelial physiology. Tobacco smoke (TS) may predispose individuals to atherogenic and thrombotic problems, significantly increasing the risk for ischemic manifestations such as acute coronary syndrome and stroke. Despite the strong evidence for an association between smoking and vascular impairment, the impact of TS exposure on the blood-brain barrier (BBB) has only been marginally addressed. This is a major problem given that the BBB is crucial in the maintenance of brain homeostasis. Recent data have also shown that chronic smokers have a higher incidence of small vessel ischemic disease (SVID), a pathological condition characterized by leaky brain microvessels and loss of BBB integrity. In the brain TS increases the risk of silent cerebral infarction (SCI) and stroke owing to the pro-coagulant and atherogenic effects of smoking. In this article we provide a detailed review and analysis of current knowledge of the pathophysiology of tobacco smoke toxicity at the cerebrovascular levels. We also discuss the potential toxicity of recently marketed "potential-reduced exposure products".

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Crossref · 10.3390/ijerph7124111

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  • Blood-brain barrier integrity can be compromised by exposures to certain toxicants and by health conditions through molecular alterations in barrier function.

    “Integrity of the BBB can be compromised because of exposures to certain toxicants, such as pesticides, mixed vehicle emissions, and tobacco smoke, as well as certain health conditions including diabetes and neurological disorders reviewed in Neurotoxicity of PFAS in Sensitive Populations, through molecular alterations in barrier function (Gupta et al., 1999; Weiss et al., 2009; Mazzone et al., 201”

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  1. [74]Kanner AA Marchi N Fazio V Mayberg MR Koltz MT Siomin V Stevens GH Masaryk T Aumayr B Vogelbaum MA Barnett GH Janigro D Serum S100beta: A noninvasive marker of blood-brain barrier function and brain lesions Cancer 2003 97 2806 2813 12767094 PMC4135471

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Authors
Mazzone, P., Tierney, W., Hossain, M., Puvenna, V., Janigro, D., & Cucullo, L.
Affiliations
  • Cleveland Clinic (US)
  • Case Western Reserve University (US)
Corresponding author
Cucullo, Luca
Venue
International Journal of Environmental Research and Public Health
Publisher
MDPI AG
Published
2010-11-26
Volume
7
Issue
12
Pages
4111-4126
ISSN
1660-4601 (ISSN-L)
OpenAlex
W1970824175
Cited by
183
References
97
Citations by year
2026: 9 · 2025: 8 · 2024: 18 · 2023: 11 · 2022: 14 · 2021: 17 · 2020: 22 · 2019: 9 · 2018: 14 · 2017: 14 · 2016: 7 · 2015: 17 · 2014: 4 · 2013: 10 · 2012: 5
FWCI
0.51
Type
journal article
Language
en
Open access
Locations
  • International Journal of Environmental Research and Public Health (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Alternatives Research and Development Foundation
Topics
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
Keywords
cigarette smoke, blood-brain barrier, cerebrovascular system, endothelial dysfunction, small vessel ischemic disease, silent cerebral infarction, stroke, passive smoking, tobacco smoke toxicity, atherosclerosis, thrombosis
MeSH terms
Blood-Brain Barrier, Cerebrovascular Disorders, Endothelium, Vascular, Humans, Smoking, Tobacco Smoke Pollution

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