Vascular growth factors in neuropsychiatry

Newton, Samuel S.; Fournier, Neil M.; Duman, Ronald S.

doi:10.1007/s00018-013-1281-9

Cited by 48Nerve injury and regenerationAngiogenesis and VEGF in CancerNeurological Disease Mechanisms and Treatments

Vascular growth factors in neuropsychiatry

Open access

Newton, Samuel S., Fournier, Neil M., Duman, Ronald S.·2013·Cellular and Molecular Life Sciences

DOI 10.1007/s00018-013-1281-9PMC PMC3951730

Open this paper in CoChat — free account

Abstract

Recent advances in understanding the cellular and molecular basis of psychiatric illnesses have shed light on the important role played by trophic factors in modulating functional parameters associated with disease causality and drug action. Disease mechanisms are now thought to involve multiple cell types, including neurons and endothelial cells. These functionally distinct but interactively coupled cell types engage in cellular cross talk via shared and common signaling molecules. Dysregulation in their cellular signaling pathways influences brain function and alters behavioral performance. Multifunctional trophic factors such as VEGF and EPO that possess both neurotrophic and angiogenic actions are of particular interest due to their ability to rescue structural and plasticity deficits in neurons and vasculature. Obtaining insight into the behavioral, cellular and molecular actions of multi-functional trophic factors has the potential to open new and transformative therapeutic approaches.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s00018-013-1281-9

Cites

150 of 150 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

VEGF is responsible for multiple important physiological functions, particularly BBB permeability.
“As a pleiotropic growth factor, VEGF is responsible for multiple important physiological functions, particularly BBB permeability [44, 50, 51].”
From Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain (2022) · cites this paper as [51]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,501 · see citing works
Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients
Locatelli, F., Fishbane, S. N., Block, G. A., & Macdougall, I. C. (2017) · American Journal of Nephrology · doi:10.1159/000455166 · Cited by 4,834 · see citing works
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
Forsythe, J. A., Jiang, B.-H., Iyer, N. V., Agani, F., Leung, S. W., Koos, R. D., & Semenza, G. L. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4604 · Cited by 3,981 · see citing works
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
Semenza, G. L., & Wang, G. L. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5447 · Cited by 2,617 · see citing works
A molecular and cellular theory of depression
Duman, R. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830190015002 · Cited by 2,129 · see citing works
Self-citation
The Science of Stroke: Mechanisms in Search of Treatments
Moskowitz, M. A., Lo, E. H., & Iadecola, C. (2010) · Neuron · doi:10.1016/j.neuron.2010.07.002 · Cited by 1,930 · see citing works
'Vascular Depression' Hypothesis
Alexopoulos, G. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830220033006 · Cited by 1,843 · see citing works
The Relationship of Depression to Cardiovascular Disease: Epidemiology, Biology, and Treatment
Musselman, D. L., Evans, D. L., & Nemeroff, C. B. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.7.580 · Cited by 1,532 · see citing works
Vascular endothelial growth factor (VEGF) stimulates neurogenesis <i>in vitro</i> and <i>in vivo</i>
Jin, K., Zhu, Y., Sun, Y., Mao, X. O., Xie, L., & Greenberg, D. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182296499 · Cited by 1,507 · see citing works
Erythropoietin crosses the blood–brain barrier to protect against experimental brain injury
Brines, M. L., Ghezzi, P., Keenan, S., Agnello, D., de Lanerolle, N. C., Cerami, C., Itri, L. M., & Cerami, A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.19.10526 · Cited by 1,402 · see citing works
VEGF enhances angiogenesis and promotes blood–brain barrier leakage in the ischemic brain
Zhang, Z. G., Zhang, L., Jiang, Q., Zhang, R., Davies, K., Powers, C., Bruggen, N. V., & Chopp, M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9369 · Cited by 1,296 · cited 1× · see citing works
“The timing of VEGF administration significantly influences its efficacy in ischemia models, as early post-ischemic (within 1 h) delivery increases BBB leakage because of its inherent vascular permeabilization property, whereas later (48 h) administration reduces neuronal deficits and improves functional recovery [38].”
Background
VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia
Sun, Y., Jin, K., Xie, L., Childs, J., Mao, X. O., Logvinova, A., & Greenberg, D. A. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317977 · Cited by 1,189 · see citing works
VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia
Sun, Y., Jin, K., Xie, L., Childs, J., Mao, X. O., Logvinova, A. V., & Greenberg, D. A. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17977 · Cited by 1,181 · see citing works
Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation
Breier, G., Albrecht, U., Sterrer, S., & Risau, W. (1992) · Development · doi:10.1242/dev.114.2.521 · Cited by 1,087 · see citing works
Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress
Sirén, A., Fratelli, M., Brines, M. L., Goemans, C. G., Casagrande, S., Lewczuk, P., Keenan, S., Gleiter, C. H., Pasquali, C., Capobianco, A., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051606598 · Cited by 1,019 · see citing works
Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration
Oosthuyse, B., Moons, L., Storkebaum, E., Beck, H., Nuyens, D., Brusselmans, K., Dorpe, J. V., Hellings, P., Gorselink, M., Heymans, S., et al. (2001) · Nature Genetics · doi:10.1038/88842 · Cited by 1,007 · see citing works
A Nuclear Factor Induced by Hypoxia via De Novo Protein Synthesis Binds to the Human Erythropoietin Gene Enhancer at a Site Required for Transcriptional Activation
Semenza, G. L., & Wang, G. L. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5447-5454.1992 · Cited by 951 · see citing works
Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-κB signalling cascades
Digicaylioglu, M., & Lipton, S. A. (2001) · Nature · doi:10.1038/35088074 · Cited by 932 · see citing works
VEGF-receptor signal transduction
Cross, M. J., Dixelius, J., Matsumoto, T., & Claesson, L. (2003) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(03)00193-2 · Cited by 864 · see citing works
Increased Amygdala and Decreased Dorsolateral Prefrontal BOLD Responses in Unipolar Depression: Related and Independent Features
Siegle, G. J., Thompson, W., Carter, C. S., Steinhauer, S. R., & Thase, M. E. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.048 · Cited by 857 · see citing works
Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer’s disease
Bell, R. D., & Zloković, B. V. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0522-3 · Cited by 855 · see citing works
VEGF links hippocampal activity with neurogenesis, learning and memory
Cao, L., Jiao, X., Zuzga, D. S., Liu, Y., Fong, D. M., Young, D., & During, M. J. (2004) · Nature Genetics · doi:10.1038/ng1395 · Cited by 850 · see citing works
The forced swimming test as a model for core and component behavioral effects of antidepressant drugs
Lucki, I. (1997) · Behavioural Pharmacology · doi:10.1097/00008877-199711000-00010 · Cited by 803 · see citing works
Derivatives of Erythropoietin That Are Tissue Protective But Not Erythropoietic
Leist, M., Ghezzi, P., Grasso, G., Bianchi, R., Villa, P., Fratelli, M., Savino, C., Bianchi, M., Nielsen, J., Gerwien, J. G., et al. (2004) · Science · doi:10.1126/science.1098313 · Cited by 803 · see citing works
Vascular Endothelial Growth Factor Has Neurotrophic Activity and Stimulates Axonal Outgrowth, Enhancing Cell Survival and Schwann Cell Proliferation in the Peripheral Nervous System
Sondell, M., Lundborg, G., & Kanje, M. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-14-05731.1999 · Cited by 750 · see citing works
Coordinated Interaction of Neurogenesis and Angiogenesis in the Adult Songbird Brain
Louissaint, A., Rao, S., Leventhal, C., & Goldman, S. A. (2002) · Neuron · doi:10.1016/s0896-6273(02)00722-5 · Cited by 735 · see citing works
Small Peptides as Potent Mimetics of the Protein Hormone Erythropoietin
Wrighton, N. C., Farrell, F. X., Chang, R., Kashyap, A. K., Barbone, F. P., Mulcahy, L. S., Johnson, D. L., Barrett, R. W., Jolliffe, L. K., & Dower, W. J. (1996) · Science · doi:10.1126/science.273.5274.458 · Cited by 672 · see citing works
Effects of Chronic Fluoxetine in Animal Models of Anxiety and Depression
Dulawa, S. C., Holick, K. A., Gundersen, B., & Hen, R. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300433 · Cited by 671 · see citing works
Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death
Morishita, E., Masuda, S., Nagao, M., Yasuda, Y., & Sasaki, R. (1996) · Neuroscience · doi:10.1016/s0306-4522(96)00306-5 · Cited by 661 · see citing works
Erythropoietin Regulates theIn VitroandIn VivoProduction of Neuronal Progenitors by Mammalian Forebrain Neural Stem Cells
Shingo, T., Sorokan, S. T., Shimazaki, T., & Weiss, S. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-24-09733.2001 · Cited by 653 · see citing works
Functional Mimicry of a Protein Hormone by a Peptide Agonist: The EPO Receptor Complex at 2.8 Å
Livnah, O., Stura, E. A., Johnson, D. L., Middleton, S. A., Mulcahy, L. S., Wrighton, N. C., Dower, W. J., Jolliffe, L. K., & Wilson, I. A. (1996) · Science · doi:10.1126/science.273.5274.464 · Cited by 588 · see citing works
Erythropoietin Gene Expression in Human, Monkey and Murine Brain
Marti, H. H., Wenger, R. H., Rivas, L. A., Straumann, U., Oigicaylioglu, M., Henn, V. S., Yonekawa, Y., Bauer, C., & Gassmann, M. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01252.x · Cited by 553 · see citing works
Efficiency of signalling through cytokine receptors depends critically on receptor orientation
Syed, R. S., Reid, S. W., Li, C., Cheetham, J. C., Aoki, K. H., Liu, B., Zhan, H., Osslund, T. D., Chirino, A. J., Zhang, J., et al. (1998) · Nature · doi:10.1038/26773 · Cited by 551 · see citing works
VEGF Receptor Signal Transduction
Matsumoto, T., & Claesson, L. (2001) · Science s STKE · doi:10.1126/stke.2001.112.re21 · Cited by 506 · see citing works
Localization of specific erythropoietin binding sites in defined areas of the mouse brain.
Digicaylioglu, M. H., Bichet, S., Marti, H. H., et al. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.9.3717 · Cited by 480 · see citing works
A novel site of erythropoietin production. Oxygen-dependent production in cultured rat astrocytes.
Masuda, S., Okano, M., Yamagishi, K., Nagao, M., Ueda, M., & Sasaki, R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32195-6 · Cited by 464 · see citing works
Erythropoietin Is a Paracrine Mediator of Ischemic Tolerance in the Brain: Evidence from anIn VitroModel
Ruscher, K., Freyer, D., Karsch, M., Исаев, Н. К., Megow, D., Sawitzki, B., Priller, J., Dirnagl, U., & Meisel, A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-23-10291.2002 · Cited by 462 · see citing works
Antidepressant Drug Treatment Modifies the Neural Processing of Nonconscious Threat Cues
Harmer, C. J., Mackay, C. E., Reid, C. B., Cowen, P. J., & Goodwin, G. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.015 · Cited by 450 · see citing works
Midlife vs Late-Life Depressive Symptoms and Risk of Dementia
Yaffe, K. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.1481 · Cited by 449 · see citing works
Role and Therapeutic Potential of VEGF in the Nervous System
de Almodóvar, C. R., Lambrechts, D., Mazzone, M., & Carmeliet, P. (2009) · Physiological Reviews · doi:10.1152/physrev.00031.2008 · Cited by 443 · see citing works
VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants
Warner-Schmidt, J. L., & Duman, R. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610282104 · Cited by 438 · see citing works
Self-citation
Hypoxia-induced vascular endothelial growth factor expression causes vascular leakage in the brain
Schoch, H. (2002) · Brain · doi:10.1093/brain/awf257 · Cited by 433 · see citing works
Acute SSRI Administration Affects the Processing of Social Cues in Healthy Volunteers
Harmer, C. J., Bhagwagar, Z., Perrett, D. I., Völlm, B. A., Cowen, P. J., & Goodwin, G. M. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300004 · Cited by 420 · cited 1× · see citing works
“Interestingly, the acute effects of ePO included heightened recognition of happiness and fear in a manner comparable to that of serotonin-reuptake inhibitors and similarly reversed after 1 week [101–103].”
Result
Systemic hypoxia changes the organ-specific distribution of vascular endothelial growth factor and its receptors
Marti, H. H., & Risau, W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15809 · Cited by 410 · see citing works
A Critical Role of Erythropoietin Receptor in Neurogenesis and Post-Stroke Recovery
Tsai, P. T., Ohab, J. J., Kertesz, N. L., Groszer, M., Matter, C., Gao, J., Liu, X., Wu, H., & Carmichael, S. T. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4480-05.2006 · Cited by 406 · see citing works
Depression, mortality, and medical morbidity in patients with coronary heart disease
Carney, R. M., & Freedland, K. E. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00111-2 · Cited by 378 · see citing works
Expression of vascular permeability factor/vascular endothelial growth factor in normal rat tissues
Monacci, W. T., Merrill, M. J., & Oldfield, E. H. (1993) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1993.264.4.c995 · Cited by 373 · see citing works
Vascular endothelial growth factor is a neurotrophic factor which stimulates axonal outgrowth through the flk‐1 receptor
Sondell, M., Sundler, F., & Kanje, M. (2000) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2000.01326.x · Cited by 369 · see citing works
Erythropoietin receptor signalling is required for normal brain development
Yu, X., Shacka, J. J., Eells, J. B., Suarez‐Quian, C. A., Przygodzki, R. M., Beleslin‐Čokić, B. B., Lin, C., Nikodem, V. M., Hempstead, B. L., Flanders, K. C., et al. (2002) · Development · doi:10.1242/dev.129.2.505 · Cited by 366 · see citing works
Gene Profile of Electroconvulsive Seizures: Induction of Neurotrophic and Angiogenic Factors
Newton, S. S., Collier, E. F., Hunsberger, J. G., Adams, D., Terwilliger, R. Z., Selvanayagam, E., & Duman, R. S. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-34-10841.2003 · Cited by 355 · see citing works
Self-citation
Neurovascular signalling defects in neurodegeneration
Zacchigna, S., Lambrechts, D., & Carmeliet, P. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2336 · Cited by 345 · see citing works
Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin
Brines, M. L., Patel, N. S. A., Villa, P., Brines, C. M., Mennini, T., Paola, M. D., Erbayraktar, Z., Erbayraktar, S., Sepodes, B. M. N., Thiemermann, C., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805594105 · Cited by 320 · see citing works
Erythropoietin and VEGF Exhibit Equal Angiogenic Potential
Jaquet, K., Krause, K., Tawakol-Khodai, M., Geidel, S., & Kück, K. (2002) · Microvascular Research · doi:10.1006/mvre.2002.2426 · Cited by 317 · see citing works
Rapid Induction of Vascular Endothelial Growth Factor Gene Expression After Transient Middle Cerebral Artery Occlusion in Rats
Hayashi, T., Abe, K., Suzuki, H., & Itoyama, Y. (1997) · Stroke · doi:10.1161/01.str.28.10.2039 · Cited by 310 · see citing works
Neuroprotection by Hypoxic Preconditioning Requires Sequential Activation of Vascular Endothelial Growth Factor Receptor and Akt
Wick, A., Wick, W., Waltenberger, J. L., Weller, M., DICHGANS, J., & Schulz, J. B. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06401.2002 · Cited by 283 · see citing works
Paracrine and Autocrine Functions of Neuronal Vascular Endothelial Growth Factor (VEGF) in the Central Nervous System
Ogunshola, O. O., Antic, A., Donoghue, M. J., Fan, S.-Y., Kim, H., Stewart, W. B., Jr., Madri, J. A., & Ment, L. R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111085200 · Cited by 268 · see citing works
Neuronal VEGF expression correlates with angiogenesis in postnatal developing rat brain.
Ogunshola, O., Stewart, W., Mihalcik, V., Solli, T., Madri, J., & Ment, L. (2000) · Brain research. Developmental brain research · doi:10.1016/s0165-3806(99)00125-x · Cited by 257 · see citing works
Reversible modulations of neuronal plasticity by VEGF
Licht, T., Goshen, I., Avital, A., Kreisel, T., Zubedat, S., Eavri, R., Segal, M., Yirmiya, R., & Keshet, E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1007640108 · Cited by 252 · see citing works
The Erythropoietin Receptor: Structure, Activation and Intracellular Signal Transduction
Constantinescu, S. N., Ghaffari, S., & Lodish, H. F. (1999) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(98)00101-5 · Cited by 242 · see citing works
The Transcriptional Activator Hypoxia Inducible Factor 2 (HIF-2/EPAS-1) Regulates the Oxygen-Dependent Expression of Erythropoietin in Cortical Astrocytes
Chavez, J. C., Baranova, O. V., Lin, J. C.-H., & Pichiule, P. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2838-06.2006 · Cited by 240 · see citing works
Brain Capillary Endothelial Cells Express two forms of Erythropoietin Receptor mRNA
Yamaji, R., Okada, T., Moriya, M., Naito, M., Tsuruo, T., Miyatake, K., & Nakano, Y. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.0494u.x · Cited by 238 · see citing works
Depressive Symptoms and Risk of Stroke
Salaycik, K. J., Kelly‐Hayes, M., Beiser, A., Nguyen, A.-H., Brady, S. M., Kase, C. S., & Wolf, P. A. (2006) · Stroke · doi:10.1161/01.str.0000251695.39877.ca · Cited by 231 · see citing works
Intermittent Hypoxia Promotes Hippocampal Neurogenesis and Produces Antidepressant-Like Effects in Adult Rats
Zhu, X.-H., Yan, H., Zhang, J., Qu, H.-D., Qiu, X., Chen, L., Li, S.-J., Cao, X., Bean, J. C., Chen, L. H., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.6414-09.2010 · Cited by 227 · see citing works
Chronic stress in the adult dentate gyrus reduces cell proliferation near the vasculature and VEGF and Flk‐1 protein expression
Heine, V. M., Zareno, J., Maslam, S., Joëls, M., & Lucassen, P. J. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03951.x · Cited by 225 · see citing works
Electroconvulsive seizure and VEGF increase the proliferation of neural stem-like cells in rat hippocampus
Segi‐Nishida, E., Warner‐Schmidt, J. L., & Duman, R. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710858105 · Cited by 223 · see citing works
Self-citation
Imaging phenotypes of major depressive disorder: genetic correlates
Savitz, J. B., & Drevets, W. C. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.03.082 · Cited by 216 · see citing works
Cerebral metabolism in major depression and obsessive-compulsive disorder occurring separately and concurrently
Saxena, S., Brody, A. L., Ho, M. L., Alborzian, S., Ho, M. K., Maidment, K. M., Huang, S.-C., Wu, H.-M., Au, S. C., & Baxter, L. R. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01123-4 · Cited by 209 · see citing works
Impaired brain angiogenesis and neuronal apoptosis induced by conditional homozygous inactivation of vascular endothelial growth factor
Raab, S., Beck, H., Gaumann, A. K. A., Yüce, A., Gerber, H., Plate, K. H., Hammes, H., Ferrara, N., & Breier, G. (2004) · Thrombosis and Haemostasis · doi:10.1160/th03-09-0582 · Cited by 198 · see citing works
Effects of erythropoietin on glial cell development; oligodendrocyte maturation and astrocyte proliferation
Sugawa, M., Sakurai, Y., Ishikawa-Ieda, Y., Suzuki, H., & Asou, H. (2002) · Neuroscience Research · doi:10.1016/s0168-0102(02)00161-x · Cited by 197 · see citing works
Dimerization of the Extracellular Domain of the Erythropoietin (EPO) Receptor by EPO: One High-Affinity and One Low-Affinity Interaction
Philo, J. S., Aoki, K. H., Arakawa, T., et al. (1996) · Biochemistry · doi:10.1021/bi9524272 · Cited by 197 · see citing works
Hematopoietic Factor Erythropoietin Fosters Neuroprotection through Novel Signal Transduction Cascades
Chong, Z. Z., Kang, J., & Maiese, K. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200205000-00001 · Cited by 196 · see citing works
Stress sensitivity and resilience in the chronic mild stress rat model of depression; an in situ hybridization study
Bergström, A., Jayatissa, M. N., Mørk, A., & Wiborg, O. (2007) · Brain Research · doi:10.1016/j.brainres.2007.12.025 · Cited by 195 · see citing works
Microarray analysis of hippocampal gene expression in global cerebral ischemia
Jin, K., Mao, X. O., Eshoo, M. W., Nagayama, T., Minami, M., Simon, R. P., & Greenberg, D. A. (2001) · Annals of Neurology · doi:10.1002/ana.1073 · Cited by 188 · see citing works
Endogenous Erythropoietin Signaling Is Required for Normal Neural Progenitor Cell Proliferation
Chen, Z.-Y., Asavaritikrai, P., Prchal, J. T., & Noguchi, C. T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701988200 · Cited by 185 · see citing works
Vascular endothelial growth factor-B (VEGFB) stimulates neurogenesis: Evidence from knockout mice and growth factor administration
Sun, Y., Jin, K., Childs, J. T., Xie, L., Mao, X. O., & Greenberg, D. A. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2005.10.016 · Cited by 178 · see citing works
Arterial endothelial function is impaired in treated depression
Broadley, A., Korszun, A., Jones, C. J. H., & Frenneaux, M. P. (2002) · Heart · doi:10.1136/heart.88.5.521 · Cited by 176 · see citing works
Spatial and temporal expression of short, long/medium, or both opsins in human fetal cones
Xiao, M., & Hendrickson, A. E. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20001002)425:4 · Cited by 165 · see citing works
Vascular endothelial growth factor regulates adult hippocampal cell proliferation through MEK/ERK- and PI3K/Akt-dependent signaling
Fournier, N. M., Lee, B., Banasr, M., Elsayed, M., & Duman, R. S. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.04.033 · Cited by 164 · see citing works
Self-citation
Erythropoietin enhances hippocampal long-term potentiation and memory
Adamcio, B., Sargin, D., Stradomska, A., Medrihan, L., Gertler, C., Theis, F. J., Zhang, M., Müller, M., Hassouna, I. A., Hannke, K., et al. (2008) · BMC Biology · doi:10.1186/1741-7007-6-37 · Cited by 164 · see citing works
Role of vascular endothelial growth factor in adult hippocampal neurogenesis: Implications for the pathophysiology and treatment of depression
Fournier, N. M., & Duman, R. S. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.04.022 · Cited by 155 · see citing works
Self-citation
Neuroprotection and Angiogenesis: Dual Role of Erythropoietin in Brain Ischemia
Marti, H. H., Bernaudin, M., Petit, E., et al. (2000) · Physiology · doi:10.1152/physiologyonline.2000.15.5.225 · Cited by 152 · see citing works
Vascular endothelial growth factor stimulates neurite outgrowth from cerebral cortical neurons via Rho kinase signaling
Jin, K., Mao, X. O., & Greenberg, D. A. (2005) · Journal of Neurobiology · doi:10.1002/neu.20215 · Cited by 148 · see citing works
Vascular Endothelial Growth Factor Signaling is Required for the Behavioral Actions of Antidepressant Treatment: Pharmacological and Cellular Characterization
Greene, J., Banasr, M., Lee, B., Warner-Schmidt, J., & Duman, R. S. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.68 · Cited by 143 · see citing works
Self-citation
Erythropoietin protects the developing brain against N-methyl-d-aspartate receptor antagonist neurotoxicity
Dzietko, M., Felderhoff‐Mueser, U., Sifringer, M., Krutz, B., Bittigau, P., Thor, F., Heumann, R., Bührer, C., Ikonomidou, C., & Hansen, H. H. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.10.006 · Cited by 137 · see citing works
Treatment of traumatic brain injury in rats with erythropoietin and carbamylated erythropoietin
Mahmood, A., Lu, D., Qu, C., Goussev, A. V., Zhang, Z. G., Lu, C., & Chopp, M. (2007) · Journal of neurosurgery · doi:10.3171/jns-07/08/0392 · Cited by 136 · see citing works
Vascular endothelial growth factor is up-regulated after status epilepticus and protects against seizure-induced neuronal loss in hippocampus
Nicoletti, J. N., Shah, S. K., McCloskey, D. P., Goodman, J. H., Elkady, A., Atassi, H., Hylton, D., Rudge, J. S., Scharfman, H. E., & Croll, S. D. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.09.083 · Cited by 131 · see citing works
Regular exercise cures depression-like behavior via VEGF-Flk-1 signaling in chronically stressed mice
Kiuchi, T., Lee, H., & Mikami, T. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.01.023 · Cited by 116 · see citing works
Vascular endothelial growth factor promotes neurite maturation in primary CNS neuronal cultures
Khaibullina, A. A., Rosenstein, J. M., & Krum, J. M. (2004) · Developmental Brain Research · doi:10.1016/j.devbrainres.2003.09.022 · Cited by 114 · see citing works
Angiogenic factors in patients with current major depressive disorder comorbid with borderline personality disorder
Kahl, K. G., Bens, S., Ziegler, K. J., Rudolf, S., Kordon, A., DIBBELT, L., & Schweiger, U. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.09.016 · Cited by 112 · see citing works
Neurovascular development uses VEGF-A signaling to regulate blood vessel ingression into the neural tube
James, J. M., Gewolb, C., & Bautch, V. L. (2009) · Development · doi:10.1242/dev.028845 · Cited by 106 · see citing works
Gene expression and association analysis of vascular endothelial growth factor in major depressive disorder
Iga, J., Ueno, S., Yamauchi, K., Numata, S., Shibuya‐Tayoshi, S., Kinouchi, S., Nakataki, M., Song, H., Hokoishi, K., Tanabe, H., et al. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.12.011 · Cited by 105 · see citing works
Vascular endothelial growth factor (VEGF) signaling regulates hippocampal neurons by elevation of intracellular calcium and activation of calcium/calmodulin protein kinase II and mammalian target of rapamycin
Kim, B. W., Choi, M. L., Kim, Y.-S., Park, H., Lee, H., Yun, C., Kim, E. J., Choi, J.-S., Kim, S., Rhim, H., et al. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.12.009 · Cited by 104 · see citing works
TNF receptor I sensitizes neurons to erythropoietin- and VEGF-mediated neuroprotection after ischemic and excitotoxic injury
Taoufik, E., Petit, E., Divoux, D., Tseveleki, V., Mengozzi, M., Roberts, M. L., Valable, S., Ghezzi, P., Quackenbush, J. F., Brines, M. L., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801447105 · Cited by 101 · see citing works
The Danish PET/depression project: PET findings in patients with major depression
Videbech, P., Ravnkilde, B., PEDERSEN, A. R., Egander, A., LANDBO, B., Rasmussen, N. A., Andersen, F. L., Stødkilde‐Jørgensen, H., GJEDDE, A. H., & ROSENBERG, R. (2001) · Psychological Medicine · doi:10.1017/s0033291701004469 · Cited by 100 · see citing works
Circulating endothelial progenitor cells and depression: a possible novel link between heart and soul
Döme, P., Teleki, Z., Ríhmer, Z., Peter, L., Dobos, J., Kenessey, I., Tóvári, J., Tı́már, J., Paku, S., Kovács, G. L., et al. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002138 · Cited by 99 · see citing works
Modeling the neurovascular niche: implications for recovery from CNS injury.
Madri, J. A. (2009) · PubMed · Cited by 99 · see citing works
Low plasma vascular endothelial growth factor (VEGF) associated with completed suicide
Isung, J., Mobarrez, F., Nordström, P., Åsberg, M., & Jokinen, J. (2012) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.624549 · Cited by 94 · see citing works
Increased plasma VEGF levels in major depressive or manic episodes in patients with mood disorders
Lee, B.-H., & Kim, Y. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.07.021 · Cited by 92 · see citing works
Erythropoietin modulation of astrocyte water permeability as a component of neuroprotection
Gunnarson, E., Song, Y., Kowalewski, J. M., Brismar, H., Brines, M. L., Cerami, A., Andersson, U., Zelenina, M., & Aperia, A. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812708106 · Cited by 91 · see citing works
Plasma levels of vascular endothelial growth factor and fibroblast growth factor 2 in patients with major depressive disorders
Takebayashi, M., Hashimoto, R., Hisaoka, K., Okada‐Tsuchioka, M., & Kunugi, H. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0452-1 · Cited by 85 · see citing works
Depression and cardiovascular disease: a reciprocal relationship
Plante, G. E. (2005) · Metabolism · doi:10.1016/j.metabol.2005.01.013 · Cited by 84 · see citing works
Enhanced Adult Neurogenesis and Angiogenesis and Altered Affective Behaviors in Mice Overexpressing Vascular Endothelial Growth Factor 120
Udo, H., Yoshida, Y., Kino, T., Ohnuki, K., Mizunoya, W., Mukuda, T., & Sugiyama, H. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3673-08.2008 · Cited by 83 · see citing works
Evidence of a possible role of altered angiotensin function in the treatment, but not etiology, of depression
Gard, P. R., Mandy, A., & Sutcliffe, M. A. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00101-2 · Cited by 80 · see citing works
Erythropoietin Improves Mood and Modulates the Cognitive and Neural Processing of Emotion 3 Days Post Administration
Miskowiak, K. W., Inkster, B., Selvaraj, S., Wise, R. G., Goodwin, G. M., & Harmer, C. J. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301439 · Cited by 79 · see citing works
Erythropoietin Induction by Electroconvulsive Seizure, Gene Regulation, and Antidepressant-Like Behavioral Effects
Girgenti, M. J., Hunsberger, J. G., Duman, C. H., Sathyanesan, M., Terwilliger, R. Z., & Newton, S. S. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.12.005 · Cited by 79 · see citing works
Self-citation
Comparison of the effects of erythropoietin and its carbamylated derivative on behaviour and hippocampal neurogenesis in mice
Leconte, C., Bihel, E., Lepelletier, F.-X., Bouët, V., Saulnier, R., Petit, E., Boulouard, M., Bernaudin, M., & Schumann‐Bard, P. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.09.025 · Cited by 78 · see citing works
Systemically delivered Erythropoietin transiently enhances adult hippocampal neurogenesis
Ransome, M. I., & Turnley, A. M. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04684.x · Cited by 77 · see citing works
Depressive behavior and vascular dysfunction: a link between clinical depression and vascular disease?
d’Audiffret, A. C., Frisbee, S. J., Stapleton, P. A., Goodwill, A. G., Isingrini, E., & Frisbee, J. C. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01440.2009 · Cited by 76 · see citing works
Vascular endothelial growth factor (VEGF) polymorphism is associated with treatment resistant depression
Viikki, M., Anttila, S. A. K., Kampman, O., Illi, A., Huuhka, M., Setälä-Soikkeli, E., Mononen, N., Lehtimäki, T. J., & Leinonen, E. V. J. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.04.039 · Cited by 75 · see citing works
Long-Term Continuous Corticosterone Treatment Decreases VEGF Receptor-2 Expression in Frontal Cortex
Howell, K. R., Kutiyanawalla, A., & Pillai, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020198 · Cited by 75 · see citing works
Induction of nitric oxide by erythropoietin is mediated by the β common receptor and requires interaction with VEGF receptor 2
Sautina, L., Sautin, Y. Y., Beem, E., Zhou, Z., Schuler, A., Brennan, J., Zharikov, S. I., Diao, Y., Bungert, J., & Segal, M. S. (2009) · Blood · doi:10.1182/blood-2009-04-216432 · Cited by 74 · see citing works
Regulation of Neurogenesis and Angiogenesis in Depression
Newton, S. S., & Duman, R. S. (2004) · Current Neurovascular Research · doi:10.2174/1567202043362388 · Cited by 71 · see citing works
Self-citation
AAV9-mediated erythropoietin gene delivery into the brain protects nigral dopaminergic neurons in a rat model of Parkinson's disease
Xue, Y.-Q., Ma, B.-F., Zhao, L.-R., Tatom, J. B., Li, B., Jiang, L.-X., Klein, R. L., & Duan, W.-M. (2009) · Gene Therapy · doi:10.1038/gt.2009.113 · Cited by 70 · see citing works
Positive effects of captopril in the behavioral despair swim test
Giardina, W. J., & Ebert, D. M. (1989) · Biological Psychiatry · doi:10.1016/0006-3223(89)90240-0 · Cited by 67 · see citing works
Induction of Neuronal Vascular Endothelial Growth Factor Expression by cAMP in the Dentate Gyrus of the Hippocampus Is Required for Antidepressant-Like Behaviors
Lee, J.-S., Jang, D. J., Lee, N., Ko, H., Kim, H. Y., Kim, Y. S., Kim, B., Son, J., Kim, S., Chung, H., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1321-09.2009 · Cited by 66 · see citing works
Neuroprotective properties of a novel, non-haematopoietic agonist of the erythropoietin receptor
Pankratova, S., Kiryushko, D. V., Sonn, K., et al. (2010) · Brain · doi:10.1093/brain/awq101 · Cited by 65 · see citing works
99mTc-HMPAO SPECT Study of Cerebral Perfusion After Treatment with Medication and Electroconvulsive Therapy in Major Depression
Kohn, Y., Freedman, N., Lester, H., Krausz, Y., Chisin, R., Lerer, B., & Bonne, O. B. (2007) · Journal of Nuclear Medicine · doi:10.2967/jnumed.106.039354 · Cited by 63 · see citing works
Differential brain, but not serum VEGF levels in a genetic rat model of depression
Elfving, B., Plougmann, P. H., & Wegener, G. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.02.063 · Cited by 61 · see citing works
Astroglial cytoprotection by erythropoietin pre‐conditioning: implications for ischemic and degenerative CNS disorders
Diaz, Z., Assaraf, M. I., Miller, W. H., & Schipper, H. M. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03038.x · Cited by 59 · see citing works
Distribution of Flk‐1 and Flt‐1 receptors in neonatal and adult rat brains
Yang, S., Zhang, L., Huang, Y., & Sun, F. (2003) · The Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary Biology · doi:10.1002/ar.a.10103 · Cited by 57 · see citing works
Vascular factors and depression
Teper, E., & O'Brien, J. T. (2008) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2020 · Cited by 55 · see citing works
VEGF overexpression improves mice cognitive abilities after unilateral common carotid artery occlusion
Plaschke, K., Staub, J., Ernst, E., & Marti, H. H. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.08.014 · Cited by 54 · see citing works
Cerebrovascular Risk Factors, Vascular Disease, and Neuropsychological Outcomes in Adults With Major Depression
Smith, P. J., Blumenthal, J. A., Babyak, M. A., Hoffman, B. M., Doraiswamy, P. M., WAUGH, R. A., Hinderliter, A. L., & Sherwood, A. (2007) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31812f7b8e · Cited by 53 · see citing works
History of Major Depressive Disorder and Endothelial Function in Postmenopausal Women
Wagner, J. A., Tennen, H. A., Mansoor, G. A., & Abbott, G. (2006) · Psychosomatic Medicine · doi:10.1097/01.psy.0000195868.68122.9e · Cited by 53 · see citing works
Quantitative changes in hippocampal microvasculature of chronically stressed rats: No effect of fluoxetine treatment
Czéh, B., Abumaria, N., Ryguła, R., & Fuchs, E. (2009) · Hippocampus · doi:10.1002/hipo.20599 · Cited by 52 · see citing works
Erythropoietin Reduces Neural and Cognitive Processing of Fear in Human Models of Antidepressant Drug Action
Miskowiak, K. W., O’Sullivan, U., & Harmer, C. J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.01.011 · Cited by 51 · see citing works
Plant recombinant erythropoietin attenuates inflammatory kidney cell injury
Conley, A. J., Mohib, K., Jevnikar, A. M., & Brandle, J. E. (2008) · Plant Biotechnology Journal · doi:10.1111/j.1467-7652.2008.00389.x · Cited by 50 · see citing works
Erythropoietin receptor is expressed on adult rat dopaminergic neurons and erythropoietin is neurotrophic in cultured dopaminergic neuroblasts
CSETE, M. E., Rodriguez, L., Wilcox, M., & Chadalavada, S. C. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.01.068 · Cited by 50 · see citing works
Induction of VEGF and its Flt-1 receptor after sciatic nerve crush injury
Islamov, R. R., Chintalgattu, V., Pak, E. S., Katwa, L. C., & Murashov, A. K. (2004) · Neuroreport · doi:10.1097/00001756-200409150-00024 · Cited by 49 · see citing works
Rapid antidepressant changes with sleep deprivation in major depressive disorder are associated with changes in vascular endothelial growth factor (VEGF): A pilot study
Ibrahim, L. A., Duncan, W. R., Luckenbaugh, D. A., Yuan, P., Machado‐Vieira, R., & Zarate, C. A. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.06.003 · Cited by 45 · see citing works
Cerebral Perfusion Response to Successful Treatment of Depression With Different Serotoninergic Agents
Vlassenko, A. G., Sheline, Y. I., FISCHER, K. C., & Mintun, M. A. (2004) · Journal of Neuropsychiatry · doi:10.1176/jnp.16.3.360 · Cited by 44 · see citing works
In vivo stimulatory effect of erythropoietin on endothelial nitric oxide synthase in cerebral arteries
Santhanam, A. V. R., Smith, L. A., Nath, K. A., et al. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00045.2006 · Cited by 42 · see citing works
Erythropoietin modulates neural and cognitive processing of emotional information in biomarker models of antidepressant drug action in depressed patients
Miskowiak, K. W., Favaron, E., Hafizi, S., Inkster, B., Goodwin, G. M., Cowen, P. J., & Harmer, C. J. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1842-7 · Cited by 40 · see citing works
Lovastatin potentiates the antidepressant efficacy of fluoxetine in rats
Renshaw, P. F., Parsegian, A., Yang, C. K., Novero, A., Yoon, S. J., Lyoo, I. K., Cohen, B. M., & Carlezon, W. A. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.10.017 · Cited by 38 · see citing works
Refolding, Purification, and Characterization of Human Erythropoietin Binding Protein Produced inEscherichia coli
Johnson, D. L., Middleton, S. A., McMahon, F. J., et al. (1996) · Protein Expression and Purification · doi:10.1006/prep.1996.0014 · Cited by 35 · see citing works
Circulating vascular endothelial growth factor is independently and negatively associated with trait anxiety and depressive mood in healthy Japanese university students
Katsuura, S., Kamezaki, Y., Yamagishi, N., Kuwano, Y., Nishida, K., Masuda, K., Tanahashi, T., Kawai, T., Arisawa, K., & Rokutan, K. (2011) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2011.04.004 · Cited by 35 · see citing works
A new agonist of the erythropoietin receptor, Epobis, induces neurite outgrowth and promotes neuronal survival
Pankratova, S., Gu, B., Kiryushko, D. V., et al. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07751.x · Cited by 31 · see citing works
HSV-Mediated Delivery of Erythropoietin Restores Dopaminergic Function in MPTP-Treated Mice
Puskovic, V., Wolfe, D. P., Wechuck, J., et al. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2006.07.004 · Cited by 29 · see citing works
Region Specific Hypothalamic Neuronal Activation and Endothelial Cell Proliferation in Response to Electroconvulsive Seizures
Jansson, L., Hellsten, J., & Tingström, A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.019 · Cited by 28 · see citing works
Intra-hippocampal administration of the VEGF receptor blocker PTK787/ZK222584 impairs long-term memory
Pati, S., Orsi, S. A., Moore, A. N., & Dash, P. K. (2008) · Brain Research · doi:10.1016/j.brainres.2008.11.086 · Cited by 27 · see citing works
Investigation of circulating endothelial progenitor cells and angiogenic and inflammatory cytokines during recovery from an episode of major depression
Döme, P., Halmai, Z., Dobos, J., Lazáry, J., Gonda, X., Kenessey, I., Sallai, T., Makkos, Z., & Faludi, G. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.09.027 · Cited by 26 · see citing works
Cerebrovascular diseases and depression
Ghoge, H., Sharma, S., Sonawalla, S., & Parikh, R. M. (2003) · Current Psychiatry Reports · doi:10.1007/s11920-003-0048-7 · Cited by 25 · see citing works
Efficient preparation and PEGylation of recombinant human non-glycosylated erythropoietin expressed as inclusion body in E. coli
Wang, Y., Liu, Y., Chen, J., Hao, S.-J., Hu, T., Ma, G., & Su, Z. G. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.11.016 · Cited by 24 · see citing works
Changes in the Vascular Area Fraction of the Hippocampus and Amygdala are Induced by Prenatal Dexamethasone and/or Adult Stress
Neigh, G. N., Owens, M. J., Taylor, W. R., & Nemeroff, C. B. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.46 · Cited by 22 · see citing works
Upregulation of Vascular Endothelial Growth Factor Receptors Flt-1 And Flk-1 in Rat Hippocampus after Transient Forebrain Ischemia
Choi, J., Kim, H.-Y., Cha, J., Choi, J.-Y., Chun, M., & Lee, M. (2007) · Journal of Neurotrauma · doi:10.1089/neu.2006.0139 · Cited by 22 · see citing works
Exploring Relationships Among Psychosocial Status, Dietary Quality, and Measures of Placental Development During the First Trimester in Low-Income Women
Fowles, E. R., Murphey, C. L., & Ruiz, R. J. (2010) · Biological Research For Nursing · doi:10.1177/1099800410378733 · Cited by 21 · see citing works
Ca2+ antagonists effect an antidepressant-like adaptation of the NMDA receptor complex
Nowak, G., Paul, I. A., Popik, P., et al. (1993) · European Journal of Pharmacology Molecular Pharmacology · doi:10.1016/0922-4106(93)90144-x · Cited by 19 · see citing works
The differential effects of calcium channel blockers in the behavioural despair test in mice
Srivastava, S. K., & Nath, C. (2000) · Pharmacological Research · doi:10.1006/phrs.2000.0696 · Cited by 19 · see citing works
Imaging vulnerability for depression
Norbury, R., Mannie, Z. N., & Cowen, P. J. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.44 · Cited by 15 · see citing works
Changes in Vascular Endothelial Growth Factor (VEGF) Induced by the Morris Water Maze Task
Oh, D. H., Kim, B., Choi, M., Lee, G., Choi, J.-S., & Son, H. (2012) · Molecules and Cells · doi:10.1007/s10059-012-2254-9 · Cited by 10 · see citing works

Flagged first, then by citations

Sorted by citations

Pathogenesis of depression: Insights from human and rodent studies
Ménard, C., Hodes, G. E., & Russo, S. J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.053 · Cited by 593 · see citing works
An astroglial basis of major depressive disorder? An overview
Wang, Q., Jie, W., Liu, J., Yang, J., & Gao, T. (2017) · Glia · doi:10.1002/glia.23143 · Cited by 222 · see citing works
Role of trophic factors GDNF, IGF-1 and VEGF in major depressive disorder: A comprehensive review of human studies
Sharma, A. N., da Costa e Silva, B. F. B., Soares, J. C., Carvalho, A. F., & Quevedo, J. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.02.067 · Cited by 142 · see citing works
Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain
Peng, Z., Peng, S., Lin, K., Zhao, B., Wei, L., Tuo, Q., Liao, D., Yuan, T., & Shi, Z. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02543-6 · Cited by 95 · see citing works

Authors: Newton, S. S., Fournier, N. M., & Duman, R. S.
Affiliations: Yale University (US)
Corresponding author: Newton, Samuel S.
ORCID: Newton, Samuel S.
Fournier, Neil M.
Duman, Ronald S.
Venue: Cellular and Molecular Life Sciences
Publisher: Springer Science and Business Media LLC
Published: 2013-03-12
Volume: 70
Issue: 10
Pages: 1739-1752
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s00018-013-1281-9
PMC: PMC3951730
OpenAlex: W2083227916
Cited by: 48
References: 150
Citations by year: 2026: 1 · 2025: 4 · 2024: 1 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 3 · 2019: 6 · 2018: 2 · 2017: 6 · 2016: 6 · 2015: 8 · 2014: 3 · 2013: 1
FWCI: 0.61
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
Funders: Canadian Institutes of Health Research
National Institute of Mental Health (2P01 MH25642, MH-45481, R37MH045481, P01MH025642, R01MH045481)
National Institute on Drug Abuse (P30DA018343)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: vascular growth factors, neuropsychiatry, vascular endothelial growth factor, erythropoietin, neurotrophic factors, angiogenesis, endothelial cells, neuroplasticity, signaling pathways, behavioral deficits
MeSH terms: Animals, Antidepressive Agents, Astrocytes, Behavior, Animal, Cognition Disorders, Depression, Disease Models, Animal, Erythropoietin, Humans, Neurons, Biomimetics, Vascular Endothelial Growth Factors, Endothelial Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Vascular growth factors in neuropsychiatry

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks