The Science of Stroke: Mechanisms in Search of Treatments

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673 · see citing works

Tissue Plasminogen Activator for Acute Ischemic Stroke

(1995) · New England Journal of Medicine · doi:10.1056/nejm199512143332401 · Cited by 11,654 · see citing works

Nitric Oxide and Peroxynitrite in Health and Disease

Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390 · see citing works

Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced Hypothermia

Bernard, S. A., Gray, T. W., Buist, M., Jones, B. M., Silvester, W., Gutteridge, G. A., & Smith, K. L. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa003289 · Cited by 5,388 · see citing works

Alzheimer’s disease

Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569 · see citing works

Pathobiology of ischaemic stroke: an integrated view

Dirnagl, U., Iadecola, C., & Moskowitz, M. A. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01401-0 · Cited by 3,943 · see citing works

Heart Disease and Stroke Statistics—2009 Update

WRITING GROUP MEMBERS, Lloyd‐Jones, D. M., Adams, R. J., Carnethon, M. R., SIMONE, G. D., Ferguson, T. B., Flegal, K. M., Ford, E. S., Furie, K. L., Go, A. S., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.191259 · Cited by 3,891 · see citing works

Heart Disease and Stroke Statistics—2009 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee

WRITING GROUP MEMBERS, Lloyd-Jones, D., Adams, R., Carnethon, M., De Simone, G., Ferguson, T. B., Flegal, K., Ford, E., Furie, K., Go, A., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.191261 · Cited by 3,140 · see citing works

Regeneration beyond the glial scar

Silver, J., & Miller, J. H. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1326 · Cited by 3,090 · see citing works

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

Degterev, A., Huang, Z., Boyce, M., Li, Y., Jagtap, P., Mizushima, N., Cuny, G. D., Mitchison, T. J., Moskowitz, M. A., & Yuan, J. (2005) · Nature Chemical Biology · doi:10.1038/nchembio711 · Cited by 3,068 · see citing works

High-Dose Atorvastatin after Stroke or Transient Ischemic Attack

The Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Investigators (2006) · New England Journal of Medicine · doi:10.1056/nejmoa061894 · Cited by 2,887 · see citing works

Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy

Shankaran, S., Laptook, A. R., Ehrenkranz, R. A., Tyson, J. E., McDonald, S. A., Donovan, E. F., Fanaroff, A. A., Poole, W. K., Wright, L. L., Higgins, R. D., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmcps050929 · Cited by 2,862 · see citing works

Thresholds in cerebral ischemia - the ischemic penumbra.

Astrup, J., Siesjö, B. K., & Symon, L. (1981) · Stroke · doi:10.1161/01.str.12.6.723 · Cited by 2,820 · see citing works

Neuronal replacement from endogenous precursors in the adult brain after stroke

Arvidsson, A., Collin, T., Kirik, D., Kokaia, Z., & Lindvall, O. (2002) · Nature Medicine · doi:10.1038/nm747 · Cited by 2,799 · see citing works

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

Cho, Y., Challa, S., Moquin, D., Genga, R., Ray, T. D., Guildford, M., & Chan, F. K.-M. (2009) · Cell · doi:10.1016/j.cell.2009.05.037 · Cited by 2,435 · see citing works

Excitotoxic cell death

Choi, D. W. (1992) · Journal of Neurobiology · doi:10.1002/neu.480230915 · Cited by 2,304 · see citing works

Neurovascular regulation in the normal brain and in Alzheimer's disease

Iadecola, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1387 · Cited by 2,213 · see citing works

The Role Of Glutamate Neurotoxicity In Hypoxic-Ischemic Neuronal Death

Choi, D. W., & Rothman, S. M. (1990) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.13.030190.001131 · Cited by 2,210 · see citing works

Disease-Specific Induced Pluripotent Stem Cells.

Park, I.-H., Arora, N., Huo, H., Maherali, N., Ahfeldt, T., Shimamura, A., Lensch, M. W., Cowan, C., Hochedlinger, K., & Daley, G. Q. (2008) · Cell · doi:10.1016/j.cell.2008.07.041 · Cited by 2,196 · see citing works

Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons

Dimos, J. T., Rodolfa, K. T., Niakan, K. K., Weisenthal, L. M., Mitsumoto, H., Chung, W. K., Croft, G. F., Saphier, G., Leibel, R. L., Goland, R., et al. (2008) · Science · doi:10.1126/science.1158799 · Cited by 1,959 · see citing works

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

Bonfoco, E., Krainc, D., Ankarcrona, M., Nicotera, P., & Lipton, S. A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7162 · Cited by 1,958 · see citing works

Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis

Wald, D. S., Law, M., & Morris, J. K. (2002) · BMJ · doi:10.1136/bmj.325.7374.1202 · Cited by 1,945 · see citing works

Plasticity during stroke recovery: from synapse to behaviour

Murphy, T. H., & Corbett, D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2735 · Cited by 1,938 · see citing works

Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule

Holler, N., Zaru, R., Micheau, O., Thome, M., Attinger, A., Valitutti, S., Bodmer, J.-L., Schneider, P., Seed, B., & Tschopp, J. (2000) · Nature Immunology · doi:10.1038/82732 · Cited by 1,932 · see citing works

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

Zhang, D.-W., Shao, J., Lin, J., Zhang, N., Lu, B.-J., Lin, S.-C., Dong, M.-Q., & Han, J. (2009) · Science · doi:10.1126/science.1172308 · Cited by 1,931 · see citing works

Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function

Ankarcrona, M., Dypbukt, J. M., Bonfoco, E., Zhivotovsky, B., Orrenius, S., Lipton, S. A., & Nicotera, P. (1995) · Neuron · doi:10.1016/0896-6273(95)90186-8 · Cited by 1,884 · see citing works

Mechanisms, challenges and opportunities in stroke

Lo, E. H., Dalkara, T., & Moskowitz, M. A. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1106 · Cited by 1,783 · see citing works

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

Hardingham, G. E., Fukunaga, Y., & Bading, H. (2002) · Nature Neuroscience · doi:10.1038/nn835 · Cited by 1,686 · see citing works

Analysis of pooled data from the randomised controlled trials of endarterectomy for symptomatic carotid stenosis

Rothwell, P. M., Eliasziw, M., Gutnikov, S., Fox, A. J., Taylor, D., Mayberg, M. R., Warlow, C. P., & Barnett, H. J. M. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12228-3 · Cited by 1,669 · see citing works

Antithrombotic Therapy To Prevent Stroke in Patients with Atrial Fibrillation

Hart, R. G., Benavente, O., McBride, R., & Pearce, L. A. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-131-7-199910050-00003 · Cited by 1,638 · see citing works

Reactive Oxygen Radicals in Signaling and Damage in the Ischemic Brain

Chan, P. H. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200101000-00002 · Cited by 1,589 · see citing works

Induced pluripotent stem cells from a spinal muscular atrophy patient

Ebert, A. D., Yu, J., Rose, F. F., Mattis, V. B., Lorson, C. L., Thomson, J. A., & Svendsen, C. N. (2009) · Nature · doi:10.1038/nature07677 · Cited by 1,441 · see citing works

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

Nagai, M., Re, D. B., Nagata, T., Chalazonitis, A., Jessell, T. M., Wichterle, H., & Przedborski, S. (2007) · Nature Neuroscience · doi:10.1038/nn1876 · Cited by 1,220 · see citing works

The inflammatory response in stroke.

Wang, Q., Tang, X.-N., & Yenari, M. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.11.014 · Cited by 1,195 · see citing works

Thresholds of focal cerebral ischemia in awake monkeys

Jones, T. H., Morawetz, R. B., Crowell, R. M., Marcoux, F. W., FitzGibbon, S., Girolami, U. D., & Ojemann, R. G. (1981) · Journal of neurosurgery · doi:10.3171/jns.1981.54.6.0773 · Cited by 1,159 · see citing works

Neonatal Brain Injury

Ferriero, D. M. (2004) · New England Journal of Medicine · doi:10.1056/nejmra041996 · Cited by 1,148 · see citing works

Mechanisms of Spreading Depression and Hypoxic Spreading Depression-Like Depolarization

Somjen, G. G. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1065 · Cited by 1,124 · see citing works

Nitric oxide and superoxide in inflammation and immune regulation.

Guzik, T. J., Korbut, R., & Adamek-Guzik, T. (2003) · PubMed · Cited by 1,096 · see citing works

CADASIL

Chabriat, H., Joutel, A., Dichgans, M., Tournier-Lasserve, E., & Bousser, M.-G. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70127-9 · Cited by 1,088 · see citing works

Common mechanisms of nerve and blood vessel wiring

Carmeliet, P., & Tessier-Lavigne, M. (2005) · Nature · doi:10.1038/nature03875 · Cited by 1,085 · see citing works

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke

Liesz, A., Suri-Payer, E., Veltkamp, C., Doerr, H., Sommer, C., Rivest, S., Giese, T., & Veltkamp, R. (2009) · Nature Medicine · doi:10.1038/nm.1927 · Cited by 1,059 · see citing works

Neuroprotection in Ischemia

Xiong, Z., Zhu, X., Chu, X., Minami, M., Hey, J. G., Wei, W., MacDonald, J. F., Wemmie, J. A., Price, M. P., Welsh, M. J., et al. (2004) · Cell · doi:10.1016/j.cell.2004.08.026 · Cited by 1,026 · see citing works

Rat forebrain neurogenesis and striatal neuron replacement after focal stroke

Parent, J. M., Vexler, Z. S., Gong, C., Derugin, N., & Ferriero, D. M. (2002) · Annals of Neurology · doi:10.1002/ana.10393 · Cited by 1,020 · see citing works

S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death

Gu, Z., Kaul, M., Yan, B., Kridel, S. J., Cui, J., Strongin, A., Smith, J. W., Liddington, R. C., & Lipton, S. A. (2002) · Science · doi:10.1126/science.1073634 · Cited by 950 · see citing works

Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-κB signalling cascades

Digicaylioglu, M., & Lipton, S. A. (2001) · Nature · doi:10.1038/35088074 · Cited by 932 · see citing works

Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond

Lipton, S. A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd1958 · Cited by 909 · see citing works

Gabapentin Receptor α2δ-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis

Eroglu, Ç., Allen, N. J., Susman, M. W., O'Rourke, N. A., Park, C. Y., Özkan, E., Chakraborty, C., Mulinyawe, S. B., Annis, D. S., Huberman, A. D., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.025 · Cited by 893 · see citing works

Activation and Cleavage of Caspase-3 in Apoptosis Induced by Experimental Cerebral Ischemia

Namura, S., Zhu, J., Fink, K., Endres, M., Srinivasan, A. N., Tomaselli, K. J., Yuan, J., & Moskowitz, M. A. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-10-03659.1998 · Cited by 892 · see citing works

Blood–brain barrier: Ageing and microvascular disease – systematic review and meta-analysis

Farrall, A. J., & Wardlaw, J. M. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.07.015 · Cited by 882 · see citing works

A Neurovascular Niche for Neurogenesis after Stroke

Ohab, J. J., Fleming, S., Blesch, A., & Carmichael, S. T. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4323-06.2006 · Cited by 878 · see citing works

Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury

Shichita, T., Sugiyama, Y., Ooboshi, H., Sugimori, H., Nakagawa, R., Takada, I., Iwaki, T., Okada, Y., Iida, M., Cua, D. J., et al. (2009) · Nature Medicine · doi:10.1038/nm.1999 · Cited by 842 · see citing works

Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia

Schinzel, A. C., Takeuchi, O., Huang, Z., Fisher, J. K., Zhou, Z., Rubens, J., Hetz, C., Danial, N. N., Moskowitz, M. A., & Korsmeyer, S. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505294102 · Cited by 820 · see citing works

Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications

Simard, J. M., Kent, T. A., Chen, M., Tarasov, K. V., & Gerzanich, V. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70055-8 · Cited by 799 · see citing works

Selective Vulnerability of Late Oligodendrocyte Progenitors to Hypoxia–Ischemia

Back, S. A., Han, B. H., Luo, N. L., Chricton, C. A., Xanthoudakis, S., Tam, J., Arvin, K. L., & Holtzman, D. M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-02-00455.2002 · Cited by 795 · see citing works

Administration of CD34+ cells after stroke enhances neurogenesis via angiogenesisin a mouse model

Taguchi, A., Soma, T., Tanaka, H., Kanda, T., Nishimura, H., Yoshikawa, H., Tsukamoto, Y., Iso, H., Fujimori, Y., Stern, D. M., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci20622 · Cited by 785 · see citing works

A Key Role for TRPM7 Channels in Anoxic Neuronal Death

Aarts, M. M., Iihara, K., Wei, W.-L., Xiong, Z.-G., Arundine, M., Cerwinski, W., MacDonald, J. F., & Tymianski, M. (2003) · Cell · doi:10.1016/s0092-8674(03)01017-1 · Cited by 784 · see citing works

Alarmins: chemotactic activators of immune responses

Oppenheim, J. J., & Yang, D. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.06.002 · Cited by 780 · see citing works

Nitric oxide and oxidative stress in vascular disease

Förstermann, U. (2010) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-010-0808-2 · Cited by 780 · see citing works

Neuroprotection for ischemic stroke: Past, present and future

Ginsberg, M. D. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.12.007 · Cited by 779 · see citing works

Treatment of Stroke With Erythropoietin Enhances Neurogenesis and Angiogenesis and Improves Neurological Function in Rats

Wang, L., Zhang, Z., Wang, Y., Zhang, R., & Chopp, M. (2004) · Stroke · doi:10.1161/01.str.0000132196.49028.a4 · Cited by 760 · see citing works

The arterial lesions underlying lacunes

Fisher, C. M. (1969) · Acta Neuropathologica · doi:10.1007/bf00685305 · Cited by 755 · see citing works

Cerebral preconditioning and ischaemic tolerance

Gidday, J. M. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1927 · Cited by 751 · see citing works

The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling

Nicole, O., Docagne, F., Ali, C., Margaill, I., Carmeliet, P., MacKenzie, E. T., Vivien, D., & Buisson, A. (2001) · Nature Medicine · doi:10.1038/83358 · Cited by 734 · see citing works

NXY-059 for the Treatment of Acute Ischemic Stroke

Shuaib, A. M., Lees, K. R., Lyden, P. D., Grotta, J. C., Dávalos, A., Davis, S. M., Diener, H., Ashwood, T. J., Wasiewski, W. W., & Emeribe, U. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa070240 · Cited by 733 · see citing works

Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective

Young, D., Lawlor, P. A., Leone, P., Dragunow, M., & During, M. J. (1999) · Nature Medicine · doi:10.1038/7449 · Cited by 731 · see citing works

Apoptosis-inducing factor mediates poly(ADP-ribose) (PAR) polymer-induced cell death

Yu, S.-W., Andrabi, S. A., Wang, H., Kim, N. S., Poirier, G. G., Dawson, T. M., & Dawson, V. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606528103 · Cited by 718 · see citing works

Enlarged Infarcts in Endothelial Nitric Oxide Synthase Knockout Mice are Attenuated by Nitro-L-Arginine

Huang, Z., Huang, P. L., Ma, J., Meng, W., Ayata, C., Fishman, M. C., & Moskowitz, M. A. (1996) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199609000-00023 · Cited by 718 · see citing works

Blood Pressure and Stroke

Lawes, C. M. M., Bennett, D., Feigin, V. L., & Rodgers, A. (2004) · Stroke · doi:10.1161/01.str.0000116869.64771.5a · Cited by 706 · see citing works

Role of matrix metalloproteinases in delayed cortical responses after stroke

Zhao, B., Wang, S. Y., Kim, H.-Y., Storrie, H., Rosen, B. R., Mooney, D. J., Wang, X., & Lo, E. H. (2006) · Nature Medicine · doi:10.1038/nm1387 · Cited by 704 · see citing works

Three Distinct Mechanisms Generate Oxygen Free Radicals in Neurons and Contribute to Cell Death during Anoxia and Reoxygenation

Abramov, A. Y., Scorziello, A., & Duchen, M. R. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4468-06.2007 · Cited by 686 · see citing works

Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II

Zou, Y., Akazawa, H., Qin, Y., Sano, M., Takano, H., Minamino, T., Makita, N., Iwanaga, K., Zhu, W., Kudoh, S., et al. (2004) · Nature Cell Biology · doi:10.1038/ncb1137 · Cited by 685 · see citing works

Blood brain barrier: ageing and microvascular disease-systematic review and meta-analysis

Farrall, A., & Wardlaw, J. M. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.02.089 · Cited by 639 · see citing works

The Age-Related Decrease in CNS Remyelination Efficiency Is Attributable to an Impairment of Both Oligodendrocyte Progenitor Recruitment and Differentiation

Sim, F. J., Zhao, C., Penderis, J., & Franklin, R. J. M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02451.2002 · Cited by 625 · see citing works

Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosis

Trapp, B. D., & Stys, P. K. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70043-2 · Cited by 621 · see citing works

A new penumbra: transitioning from injury into repair after stroke

Lo, E. H. (2008) · Nature Medicine · doi:10.1038/nm1735 · Cited by 611 · see citing works

Poststroke dementia

Leys, D., Hénon, H., Mackowiak-Cordoliani, M.-A., & Pasquier, F. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70221-0 · Cited by 609 · see citing works

Recombinant Human Erythropoietin in the Treatment of Acute Ischemic Stroke

Ehrenreich, H., Weissenborn, K., Prange, H., Schneider, D., Weimar, C., Wartenberg, K., Schellinger, P. D., Bohn, M., Becker, H., Wegrzyn, M., et al. (2009) · Stroke · doi:10.1161/strokeaha.109.564872 · Cited by 605 · see citing works

Ventricular Dysfunction and the Risk of Stroke after Myocardial Infarction

Loh, E., Sutton, M. S. J., Wun, C., Rouleau, J. L., Flaker, G. C., Gottlieb, S. S., Lamas, G. A., Moyé, L. A., Goldhaber, S. Z., & Pfeffer, M. A. (1997) · New England Journal of Medicine · doi:10.1056/nejm199701233360403 · Cited by 602 · see citing works

Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic

Zhang, Z. G., & Chopp, M. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70061-4 · Cited by 596 · see citing works

Matrix metalloproteinases and their multiple roles in neurodegenerative diseases

Rosenberg, G. A. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70016-x · Cited by 594 · see citing works

Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use

Dirnagl, U., Becker, K. J., & Meisel, A. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70054-7 · Cited by 588 · see citing works

White Matter Lesions in an Unselected Cohort of the Elderly: Molecular Pathology Suggests Origin From Chronic Hypoperfusion Injury

Fernando, M. S., Simpson, J. E., Matthews, F., Brayne, C., Lewis, C. E., Barber, R., Kalaria, R. N., Forster, G., Esteves, F., Wharton, S. B., et al. (2006) · Stroke · doi:10.1161/01.str.0000221308.94473.14 · Cited by 587 · see citing works

Hypertension and Cerebrovascular Dysfunction

Iadecola, C., & Davisson, R. L. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.03.010 · Cited by 557 · see citing works

Efficacy and Safety of Memantine in Patients With Mild to Moderate Vascular Dementia: A Randomized, Placebo-Controlled Trial (MMM 300)

Orgogozo, J.-M., Rigaud, A.-S., Stöffler, A., Möbius, H.-J., & Forette, F. (2002) · Stroke · doi:10.1161/01.str.0000020094.08790.49 · Cited by 539 · see citing works

NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation

Brennan, A. M., Suh, S. W., Won, S. J., Narasimhan, P., Kauppinen, T. M., Lee, H., Edling, Y., Chan, P. H., & Swanson, R. A. (2009) · Nature Neuroscience · doi:10.1038/nn.2334 · Cited by 538 · see citing works

The Significance of Cerebral White Matter Abnormalities 100 Years After Binswanger’s Report

Pantoni, L., & García, J. H. (1995) · Stroke · doi:10.1161/01.str.26.7.1293 · Cited by 536 · see citing works

BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex

Kleim, J. A., Chan, S., Pringle, E., Schallert, K., Procaccio, V., Jimenez, R., & Cramer, S. C. (2006) · Nature Neuroscience · doi:10.1038/nn1699 · Cited by 529 · see citing works

Efficacy and adverse effects of cholinesterase inhibitors and memantine in vascular dementia: a meta-analysis of randomised controlled trials

Kavirajan, H., & Schneider, L. S. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70195-3 · Cited by 497 · see citing works

DAPK1 Interaction with NMDA Receptor NR2B Subunits Mediates Brain Damage in Stroke

Tu, W., Xu, X., Peng, L., Zhong, X., Zhang, W., Soundarapandian, M. M., Belal, C., Wang, M., Jia, N., Zhang, W., et al. (2010) · Cell · doi:10.1016/j.cell.2009.12.055 · Cited by 493 · see citing works

<i>S</i> -Nitrosylation in Cardiovascular Signaling

Lima, B., Forrester, M. T., Hess, D. T., & Stamler, J. S. (2010) · Circulation Research · doi:10.1161/circresaha.109.207381 · Cited by 490 · see citing works

Lipid Oxidation and Peroxidation in CNS Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities

Adibhatla, R. M., & Hatcher, J. F. (2010) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2009.2668 · Cited by 480 · see citing works

Lipoprotein receptor–mediated induction of matrix metalloproteinase by tissue plasminogen activator

Wang, X., Lee, S.-R., Arai, K., Lee, S., Tsuji, K., Rebeck, G. W., & Lo, E. H. (2003) · Nature Medicine · doi:10.1038/nm926 · Cited by 462 · see citing works

Erythropoietin Is a Paracrine Mediator of Ischemic Tolerance in the Brain: Evidence from anIn VitroModel

Ruscher, K., Freyer, D., Karsch, M., Исаев, Н. К., Megow, D., Sawitzki, B., Priller, J., Dirnagl, U., & Meisel, A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-23-10291.2002 · Cited by 462 · see citing works

Ageing and diabetes: implications for brain function

Biessels, G. J., van der Heide, L. P., Kamal, A., Bleys, R. L. A. W., & Gispen, W. H. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01486-3 · Cited by 458 · see citing works

Spreading depolarizations occur in human ischemic stroke with high incidence

Dohmen, C., Sakowitz, O. W., Fabricius, M. E., Bosche, B., Reithmeier, T., Ernestus, R.-I., Brinker, G., Dreier, J. P., Woitzik, J., Strong, A. J., et al. (2008) · Annals of Neurology · doi:10.1002/ana.21390 · Cited by 436 · see citing works

Mechanisms of anti-inflammatory and neuroprotective actions of PPAR-gamma agonists

Kapadia, R. (2008) · Frontiers in Bioscience · doi:10.2741/2802 · Cited by 433 · see citing works

Role of the renin–angiotensin system in vascular inflammation

Marchesi, C., Paradis, P., & Schiffrin, E. L. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.05.003 · Cited by 432 · see citing works

Nitric oxide, tetrahydrobiopterin, oxidative stress, and endothelial dysfunction in hypertension

Schulz, E., Jansen, T., Wenzel, P., Daiber, A., & Münzel, T. (2008) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2007.1989 · Cited by 430 · see citing works

Long-term neuroblast migration along blood vessels in an area with transient angiogenesis and increased vascularization after stroke

Thored, P., Wood, J., Arvidsson, A., Cammenga, J., Kokaia, Z., & Lindvall, O. (2007) · Stroke · doi:10.1161/strokeaha.107.488445 · Cited by 421 · see citing works

Correlation between periinfarct DC shifts and ischaemic neuronal damage in rat

Mies, G., lijima, T., & Hossmann, K.-A. (1993) · Neuroreport · doi:10.1097/00001756-199306000-00027 · Cited by 406 · see citing works

Early Release of HMGB-1 from Neurons after the Onset of Brain Ischemia

Qiu, J., Nishimura, M., Wang, Y., Sims, J. R., Qiu, S., Savitz, S. I., Salomone, S., & Moskowitz, M. A. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600582 · Cited by 405 · see citing works

Two-Photon Imaging of Cortical Surface Microvessels Reveals a Robust Redistribution in Blood Flow after Vascular Occlusion

Schaffer, C. B., Friedman, B., Nishimura, N., Schroeder, L. F., Tsai, P. S., Ebner, F. F., Lyden, P. D., & Kleinfeld, D. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040022 · Cited by 400 · see citing works

Reactive oxygen species and the modulation of stroke

Crack, P. J., & Taylor, J. M. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.01.019 · Cited by 378 · see citing works

Prostaglandin E2 EP1 receptors: downstream effectors of COX-2 neurotoxicity

Kawano, T., Anrather, J., Zhou, P., Park, L., Wang, G., Frys, K. A., Kunz, A. B., Cho, S., Orio, M., & Iadecola, C. (2006) · Nature Medicine · doi:10.1038/nm1362 · Cited by 376 · see citing works

Microglial activation precedes and predominates over macrophage infiltration in transient focal cerebral ischemia: a study in green fluorescent protein transgenic bone marrow chimeric mice

Schilling, M., Besselmann, M., Leonhard, C., Mueller, M., Ringelstein, E. B., & Kiefer, R. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00082-7 · Cited by 375 · see citing works

Patterns of cerebral blood flow reduction in patients with ischemic leukoaraiosis

O’Sullivan, M., Lythgoe, D. J., Pereira, A. C., Summers, P. E., Jarosz, J. M., Williams, S. C. R., & Markus, H. S. (2002) · Neurology · doi:10.1212/wnl.59.3.321 · Cited by 360 · see citing works

Vasculature Guides Migrating Neuronal Precursors in the Adult Mammalian Forebrain via Brain-Derived Neurotrophic Factor Signaling

Snapyan, M., Lemasson, M., Brill, M. S., Blais, M., Massouh, M., Ninkovic, J., Gravel, C., Berthod, F., Götz, M., Barker, P. A., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4956-08.2009 · Cited by 346 · see citing works

Neurovascular signalling defects in neurodegeneration

Zacchigna, S., Lambrechts, D., & Carmeliet, P. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2336 · Cited by 345 · see citing works

Plasma β-amyloid and white matter lesions in AD, MCI, and cerebral amyloid angiopathy

Gurol, M. E., Irizarry, M. C., Smith, E. E., Raju, S., Diaz-Arrastia, R., Bottiglieri, T., Rosand, J., Growdon, J. H., & Greenberg, S. M. (2006) · Neurology · doi:10.1212/01.wnl.0000191403.95453.6a · Cited by 339 · see citing works

Fruit and vegetable consumption and risk of stroke: A meta-analysis of cohort studies

Dauchet, L., Amouyel, P., & Dallongeville, J. (2005) · Neurology · doi:10.1212/01.wnl.0000180600.09719.53 · Cited by 339 · see citing works

Depletion of GGA3 Stabilizes BACE and Enhances β-Secretase Activity

Tesco, G., Koh, Y. H., Kang, E. L., Cameron, A. N., Das, S., Sena-Esteves, M., Hiltunen, M., Yang, S.-H., Zhong, Z., Shen, Y., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.012 · Cited by 337 · see citing works

Passive smoking as well as active smoking increases the risk of acute stroke

Bonita, R., Duncan, J. R., Truelsen, T. C., Jackson, R., & Beaglehole, R. (1999) · Tobacco Control · doi:10.1136/tc.8.2.156 · Cited by 331 · see citing works

Vasoconstrictive Neurovascular Coupling during Focal Ischemic Depolarizations

Shin, H. K., Dunn, A. K., Jones, P., Boas, D. A., Moskowitz, M. A., & Ayata, C. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600252 · Cited by 320 · see citing works

Blood glucose and risk of cardiovascular disease in the Asia Pacific region.

Asia Pacific Cohort Studies Collaboration (2004) · Diabetes Care · doi:10.2337/diacare.27.12.2836 · Cited by 302 · see citing works

Microvasculature changes and cerebral amyloid angiopathy in Alzheimer’s disease and their potential impact on therapy

Weller, R. O., Boche, D., & Nicoll, J. A. R. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0498-z · Cited by 297 · see citing works

Changing perspectives regarding late-life dementia

Fotuhi, M., Hachinski, V., & Whitehouse, P. J. (2009) · Nature Reviews Neurology · doi:10.1038/nrneurol.2009.175 · Cited by 291 · see citing works

Evaluation of C-Reactive Protein Measurement for Assessing the Risk and Prognosis in Ischemic Stroke

Napoli, M. D., Schwaninger, M., Cappelli, R., Ceccarelli, E., Gianfilippo, G. D., Donati, C., Emsley, H. C. A., Forconi, S., Hopkins, S. J., Masotti, L., et al. (2005) · Stroke · doi:10.1161/01.str.0000165929.78756.ed · Cited by 288 · see citing works

Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke

Arai, K., Jin, G., Navaratna, D., & Lo, E. H. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07176.x · Cited by 286 · see citing works

Hypoxia-Induced Stroke Tolerance in the Mouse Is Mediated by Erythropoietin

Prass, K., Scharff, A., Ruscher, K., Löwl, D., Muselmann, C., Victorov, I. V., Kapinya, K. J., Dirnagl, U., & Meisel, A. (2003) · Stroke · doi:10.1161/01.str.0000080381.76409.b2 · Cited by 285 · see citing works

Involvement of Matrix Metalloproteinase in Neuroblast Cell Migration from the Subventricular Zone after Stroke

Lee, S., Kim, H.-Y., Rogowska, J., Zhao, B., Bhide, P. G., Parent, J. M., & Lo, E. H. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4085-05.2006 · Cited by 284 · see citing works

Increased Expression of TGF-β1 in Brain Tissue After Ischemic Stroke in Humans

Krupiński, J., Kumar, P., Kumar, S., & Kałuza, J. (1996) · Stroke · doi:10.1161/01.str.27.5.852 · Cited by 282 · see citing works

Correlation between Brain Reorganization, Ischemic Damage, and Neurologic Status after Transient Focal Cerebral Ischemia in Rats: A Functional Magnetic Resonance Imaging Study

Dijkhuizen, R. M., Singhal, A. B., Mandeville, J. B., Wu, O., Halpern, E. F., Finklestein, S. P., Rosen, B. R., & Lo, E. H. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-02-00510.2003 · Cited by 281 · see citing works

Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease

Wu, Z., Guo, H., Chow, N., Sallstrom, J., Bell, R. D., Deane, R., Brooks, A. I., Kanagala, S., Rubio, A., Sagare, A., et al. (2005) · Nature Medicine · doi:10.1038/nm1287 · Cited by 280 · see citing works

Peroxynitrite and Vascular Endothelial Dysfunction in Diabetes Mellitus

Zou, M., Cohen, R. A., & Ullrich, V. (2004) · Endothelium · doi:10.1080/10623320490482619 · Cited by 270 · see citing works

SRF and myocardin regulate LRP-mediated amyloid-β clearance in brain vascular cells

Bell, R. D., Deane, R., Chow, N., Long, X., Sagare, A., Singh, I., Streb, J. W., Guo, H., Rubio, A., Van Nostrand, W., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1819 · Cited by 261 · see citing works

Postischemic treatment of neonatal cerebral ischemia should target autophagy

Puyal, J., Vaslin, A., Mottier, V., & Clarke, P. G. H. (2009) · Annals of Neurology · doi:10.1002/ana.21714 · Cited by 261 · see citing works

Pathologically activated therapeutics for neuroprotection

Lipton, S. A. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2229 · Cited by 259 · see citing works

Leisure time, occupational, and commuting physical activity and the risk of stroke

Hu, G., Sarti, C., Jousilahti, P., Silventoinen, K., Barengo, N. C., & Tuomilehto, J. (2005) · Stroke · doi:10.1161/01.str.0000177868.89946.0c · Cited by 258 · see citing works

Risk Factors for Ischemic Stroke

Simons, L. A., McCallum, J. C., Friedlander, Y., & Simons, J. (1998) · Stroke · doi:10.1161/01.str.29.7.1341 · Cited by 256 · see citing works

NMDA Receptor Activation Increases Free Radical Production through Nitric Oxide and NOX2

Girouard, H., Wang, G., Gallo, E. F., Anrather, J., Zhou, P., Pickel, V. M., & Iadecola, C. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0133-09.2009 · Cited by 254 · see citing works

Neuroprotection via matrix-trophic coupling between cerebral endothelial cells and neurons

Guo, S., Kim, W. J., Lok, J., Lee, S.-R., Besancon, E., Luo, B.-H., Stins, M. F., Wang, X., Dedhar, S., & Lo, E. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801105105 · Cited by 253 · see citing works

Body Mass Index, Waist Circumference, and Waist-Hip Ratio on the Risk of Total and Type-Specific Stroke

Hu, G., Tuomilehto, J. O., Silventoinen, K., Sarti, C., Männistö, S., & Jousilahti, P. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.13.1420 · Cited by 252 · see citing works

Molecular Physiology of Preconditioning-Induced Brain Tolerance to Ischemia

Obrenovitch, T. P. (2008) · Physiological Reviews · doi:10.1152/physrev.00039.2006 · Cited by 250 · see citing works

Induction of Spreading Depression in the Ischemic Hemisphere following Experimental Middle Cerebral Artery Occlusion: Effect on Infarct Morphology

Back, T., Ginsberg, M. D., Dietrich, W. D., & Watson, B. D. (1996) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199603000-00004 · Cited by 248 · see citing works

Activated protein C inhibits tissue plasminogen activator–induced brain hemorrhage

Cheng, T., Petraglia, A. L., Li, Z., Thiyagarajan, M., Zhong, Z., Wu, Z., Liu, D., Maggirwar, S. B., Deane, R., Fernández, J. A., et al. (2006) · Nature Medicine · doi:10.1038/nm1498 · Cited by 247 · see citing works

An Oligovascular Niche: Cerebral Endothelial Cells Promote the Survival and Proliferation of Oligodendrocyte Precursor Cells

Arai, K., & Lo, E. H. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0035-09.2009 · Cited by 246 · see citing works

Role of connexin-based gap junction channels and hemichannels in ischemia-induced cell death in nervous tissue

Contreras, J. E., Sánchez, H. A., Véliz, L. P., Bukauskas, F. F., Bennett, M. V. L., & Sáez, J. C. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.08.002 · Cited by 244 · see citing works

Impaired Cerebral Autoregulation in Patients With Malignant Hypertension

Immink, R. V., van den Born, B. H., van Montfrans, G. A., Koopmans, R. P., Karemaker, J. M., & LIESHOUT, J. J. V. (2004) · Circulation · doi:10.1161/01.cir.0000144472.08647.40 · Cited by 244 · see citing works

Inflammation and the neurovascular unit in the setting of focal cerebral ischemia

del Zoppo, G. J. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2008.08.028 · Cited by 243 · see citing works

The Neurotoxicity of Tissue Plasminogen Activator?

Kaur, J., Zhao, Z., Klein, G., Lo, E. H., & Buchan, A. M. (2004) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000137868.50767.e8 · Cited by 242 · see citing works

Brain-Specific Knock-Out of Hypoxia-Inducible Factor-1α Reduces Rather Than Increases Hypoxic-Ischemic Damage

Helton, R., Cui, J., Scheel, J. R., Ellison, J. A., Ames, C. P., Gibson, C. L., Blouw, B., Ouyang, L., Dragatsis, I., Zeitlin, S. O., et al. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4555-04.2005 · Cited by 240 · see citing works

Antioxidants in Central Nervous System Diseases: Preclinical Promise and Translational Challenges

Kamat, C. D., Gadal, S., Mhatre, M., Williamson, K. S., Pye, Q. N., & Hensley, K. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-15314 · Cited by 237 · see citing works

Role of erythropoietin in the brain

Noguchi, C. T., Asavaritikrai, P., Teng, R., & Jia, Y. (2007) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2007.03.001 · Cited by 237 · see citing works

Current Status of Neuroprotection for Cerebral Ischemia

Ginsberg, M. D. (2008) · Stroke · doi:10.1161/strokeaha.108.528877 · Cited by 236 · see citing works

Differential regional vulnerability in transient focal cerebral ischemia.

Marcoux, F. W., Morawetz, R. B., Crowell, R. M., DeGirolami, U., & Halsey, J. H. (1982) · Stroke · doi:10.1161/01.str.13.3.339 · Cited by 234 · see citing works

Beyond NMDA and AMPA glutamate receptors: emerging mechanisms for ionic imbalance and cell death in stroke

Besancon, E., Guo, S., Lok, J. M., Tymianski, M., & Lo, E. H. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.02.003 · Cited by 231 · see citing works

Extension of the Thrombolytic Time Window With Minocycline in Experimental Stroke

Murata, Y., Rosell, A., Scannevin, R. H., Rhodes, K. J., Wang, X., & Lo, E. H. (2008) · Stroke · doi:10.1161/strokeaha.108.514026 · Cited by 225 · see citing works

PDZ Protein Interactions Underlying NMDA Receptor-Mediated Excitotoxicity and Neuroprotection by PSD-95 Inhibitors

Cui, H., Hayashi, A., Sun, H.-S., Belmares, M., Cobey, C., Phan, T., Schweizer, J., Salter, M., Wang, Y.-T., Tasker, R., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1464-07.2007 · Cited by 222 · see citing works

Neuroprotective strategies targeting apoptotic and necrotic cell death for stroke

Yuan, J. (2009) · APOPTOSIS · doi:10.1007/s10495-008-0304-8 · Cited by 221 · see citing works

Poly(ADP‐ribose) polymerase‐1 activity promotes NF‐κB‐driven transcription and microglial activation: implication for neurodegenerative disorders

Chiarugi, A., & Moskowitz, M. A. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01684.x · Cited by 216 · see citing works

Risk Factors for Ischaemic Stroke

Allen, C., & Bayraktutan, U. (2008) · International Journal of Stroke · doi:10.1111/j.1747-4949.2008.00187.x · Cited by 212 · see citing works

Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype

Chow, N., Bell, R. D., Deane, R., Streb, J. W., Chen, J., Brooks, A., Van Nostrand, W., Miano, J. M., & Zlokovic, B. V. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608251104 · Cited by 209 · see citing works

Threats to the Mind: Aging, Amyloid, and Hypertension

Iadecola, C., Park, L., & Capone, C. (2009) · Stroke · doi:10.1161/strokeaha.108.533638 · Cited by 207 · see citing works

Increased susceptibility to ischemic brain damage in transgenic mice overexpressing the amyloid precursor protein

Zhang, F., Eckman, C., Younkin, S., Hsiao, K. K., & Iadecola, C. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-20-07655.1997 · Cited by 205 · see citing works

Neurogenesis, angiogenesis, and MRI indices of functional recovery from stroke

Chopp, M., Zhang, Z. G., & Jiang, Q. (2007) · Stroke · doi:10.1161/01.str.0000250235.80253.e9 · Cited by 203 · see citing works

Potential New Risk Factors for Ischemic Stroke

Hankey, G. J. (2006) · Stroke · doi:10.1161/01.str.0000229883.72010.e4 · Cited by 203 · see citing works

Oxidative Stress and Energy Crises in Neuronal Dysfunction

Nicholls, D. G. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.002 · Cited by 199 · see citing works

Pathologically-Activated Therapeutics for Neuroprotection: Mechanism of NMDA Receptor Block by Memantine and S-Nitrosylation

Lipton, S. A. (2007) · Current Drug Targets · doi:10.2174/138945007780618472 · Cited by 192 · see citing works

Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity

Stanika, R. I., Pivovarova, N. B., Brantner, C. A., Watts, C. A., Winters, C. A., & Andrews, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903546106 · Cited by 191 · see citing works

Reactive oxygen species: influence on cerebral vascular tone

Faraci, F. M. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01044.2005 · Cited by 189 · see citing works

Bioenergetics of cerebral ischemia: A cellular perspective

Hertz, L. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.05.023 · Cited by 187 · see citing works

Autophagy in aging, disease and death: the true identity of a cell death impostor

Levine, B., & Kroemer, G. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.139 · Cited by 180 · see citing works

Mitral Annular Calcification, Aortic Valve Sclerosis, and Incident Stroke in Adults Free of Clinical Cardiovascular Disease

Kizer, J. R., Wiebers, D. O., Whisnant, J. P., Galloway, J. M., Welty, T. K., Lee, E. T., Best, L. G., Resnick, H. E., Roman, M. J., & Devereux, R. B. (2005) · Stroke · doi:10.1161/01.str.0000190005.09442.ad · Cited by 171 · see citing works

A Central Role of Connexin 43 in Hypoxic Preconditioning

Lin, J. H.-C., Lou, N., Kang, N., Takano, T., Hu, F., Han, X., Xu, Q., Lovatt, D., Torres, A., Willecke, K., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3827-07.2008 · Cited by 168 · see citing works

Lipopolysaccharide-activated microglia induce death of oligodendrocyte progenitor cells and impede their development

Pang, Y., Campbell, L., Zheng, B., Fan, L.-W., Cai, Z., & Rhodes, P. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.12.040 · Cited by 167 · see citing works

The expression of P- and E-selectins in three models of middle cerebral artery occlusion

Zhang, R., Chopp, M., Zhang, Z., Jiang, N., & Powers, C. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01343-7 · Cited by 166 · see citing works

Vascular dementia in leukoaraiosis may be a consequence of capillary loss not only in the lesions, but in normal-appearing white matter and cortex as well

Brown, W. R., Moody, D. M., Thore, C. R., Challa, V. R., & Anstrom, J. A. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.01.015 · Cited by 162 · see citing works

Differential Roles of NR2A- and NR2B-Containing NMDA Receptors in Activity-Dependent Brain-Derived Neurotrophic Factor Gene Regulation and Limbic Epileptogenesis

Chen, Q., He, S., Hu, X.-L., Yu, J. X., Zhou, Y., Zheng, J. J., Zhang, S., Zhang, C., Duan, W., & Xiong, Z. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3607-06.2007 · Cited by 161 · see citing works

TRPMs and neuronal cell death

Aarts, M. M., & Tymianski, M. (2005) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-005-1439-x · Cited by 156 · see citing works

Inhibition of Reactive Astrocytes with Fluorocitrate Retards Neurovascular Remodeling and Recovery after Focal Cerebral Ischemia in Mice

Hayakawa, K., Nakano, T., Irie, K., Higuchi, S., Fujioka, M., Orito, K., Iwasaki, K., Jin, G., Lo, E. H., Mishima, K., et al. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.257 · Cited by 154 · see citing works

Angiotensin II Attenuates Endothelium-Dependent Responses in the Cerebral Microcirculation Through Nox-2–Derived Radicals

Girouard, H., Park, L., Anrather, J., Zhou, P., & Iadecola, C. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000205849.22807.6e · Cited by 151 · see citing works

Endogenous neuroprotection: Mitochondria as gateways to cerebral preconditioning?

Dirnagl, U., & Meisel, A. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.02.017 · Cited by 149 · see citing works

Vascular cognitive impairment

Selnes, O. A., & Vinters, H. V. (2006) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0294 · Cited by 146 · see citing works

Neurovascular Protection by Ischemic Tolerance: Role of Nitric Oxide and Reactive Oxygen Species

Kunz, A. B., Park, L., Abe, T., Gallo, E. F., Anrather, J., Zhou, P., & Iadecola, C. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1645-07.2007 · Cited by 146 · see citing works

Fibrinogen Concentration and Risk of Ischemic Stroke and Acute Coronary Events in 5113 Patients With Transient Ischemic Attack and Minor Ischemic Stroke

Rothwell, P. M., Howard, S. C., Power, D. A., Gutnikov, S. A., Algra, A., van Gijn, J., Clark, T. G., Murphy, M. F., & Warlow, C. P. (2004) · Stroke · doi:10.1161/01.str.0000141701.36371.d1 · Cited by 146 · see citing works

Cervical artery dissection: Pathology, epidemiology and management

Kim, Y., & Schulman, S. (2009) · Thrombosis Research · doi:10.1016/j.thromres.2009.01.013 · Cited by 144 · see citing works

Mechanisms of Inducible Nitric Oxide Synthase–Mediated Vascular Dysfunction

Gunnett, C. A., Lund, D. D., McDowell, A. K., Faraci, F. M., & Heistad, D. D. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000172626.00296.ba · Cited by 141 · see citing works

Associations of Inflammatory and Haemostatic Biomarkers with Poor Outcome in Acute Ischaemic Stroke

Welsh, P. I., Barber, M., Langhorne, P., Rumley, A., Lowe, G. D. O., & Stott, D. J. (2009) · Cerebrovascular Diseases · doi:10.1159/000196823 · Cited by 141 · see citing works

Delayed treatment with sildenafil enhances neurogenesis and improves functional recovery in aged rats after focal cerebral ischemia

Zhang, R. L., Zhang, Z., Zhang, L., Wang, Y., Zhang, C., & Chopp, M. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20813 · Cited by 138 · see citing works

White Matter Vulnerability to Ischemic Injury Increases with Age Because of Enhanced Excitotoxicity

Baltan, S., Besancon, E., Mbow, B., Ye, Z., Hamner, M. A., & Ransom, B. R. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5137-07.2008 · Cited by 132 · see citing works

Preliminary Evidence That Ketamine Inhibits Spreading Depolarizations in Acute Human Brain Injury

Sakowitz, O. W., Kiening, K. L., Krajewski, K. L., Sarrafzadeh, A. S., Fabricius, M. E., Strong, A. J., Unterberg, A. W., & Dreier, J. P. (2009) · Stroke · doi:10.1161/strokeaha.109.549303 · Cited by 131 · see citing works

Suppression of inflammation in ischemic and hemorrhagic stroke: therapeutic options

Kleinig, T. J., & Vink, R. (2009) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32832b4db3 · Cited by 130 · see citing works

Neuroprotection mediated via neurotrophic factors and induction of neurotrophic factors

Semkova, I., & Krieglstein, J. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00013-2 · Cited by 128 · see citing works

Anion channels in astrocytes: Biophysics, pharmacology, and function

Kimelberg, H. K., MacVicar, B. A., & Sontheimer, H. W. (2006) · Glia · doi:10.1002/glia.20423 · Cited by 125 · see citing works

Two-Photon Imaging during Prolonged Middle Cerebral Artery Occlusion in Mice Reveals Recovery of Dendritic Structure after Reperfusion

Li, P., & Murphy, T. H. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3724-08.2008 · Cited by 120 · see citing works

Decreased brain damage and curtailed inflammation in transcription factor CCAAT/enhancer binding protein β knockout mice following transient focal cerebral ischemia

Kapadia, R., Türeyen, K., Bowen, K. K., Kalluri, H. S. G., Johnson, P. F., & Vemuganti, R. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04056.x · Cited by 118 · see citing works

Selective reduction of blood flow to white matter during hypercapnia corresponds with leukoaraiosis

Mandell, D. M., Han, J. S., Poublanc, J., Crawley, A. P., Kassner, A., Fisher, J. A., & Mikulis, D. J. (2008) · Stroke · doi:10.1161/strokeaha.107.501692 · Cited by 114 · see citing works

The Transcription Factor Interferon Regulatory Factor 1 Is Expressed after Cerebral Ischemia and Contributes to Ischemic Brain Injury

Iadecola, C., Salkowski, C. A., Zhang, F., Aber, T., Nagayama, M., Vogel, S. N., & Ross, M. E. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.4.719 · Cited by 111 · see citing works

Variability and reversibility of focal cerebral ischemia in unanesthetized monkeys

Crowell, R. M., Marcoux, F. W., & DeGirolami, U. (1981) · Neurology · doi:10.1212/wnl.31.10.1295 · Cited by 111 · see citing works

Experimental models, neurovascular mechanisms and translational issues in stroke research

Lo, E. H. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707626 · Cited by 110 · see citing works

Why now? Moving from stroke risk factors to stroke triggers

Elkind, M. S. (2007) · Current Opinion in Neurology · doi:10.1097/wco.0b013e328012da75 · Cited by 108 · see citing works

NMDA‐receptor blockers but not NBQX, an AMPA‐receptor antagonist, inhibit spreading depression in the rat brain

Nellgård, B., & Wieloch, T. W. (1992) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1992.tb09451.x · Cited by 106 · see citing works

Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease–activated receptor 1

Thiyagarajan, M., Fernández, J. A., Lane, S. M., Griffin, J. H., & Zlokovic, B. V. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3485-08.2008 · Cited by 105 · see citing works

Cerebral Vascular Dysfunction During Hypercholesterolemia

Kitayama, J., Faraci, F. M., Lentz, S. R., & Heistad, D. D. (2007) · Stroke · doi:10.1161/strokeaha.107.481879 · Cited by 102 · see citing works

Astrocytes protect oligodendrocyte precursor cells via MEK/ERK and PI3K/Akt signaling

Arai, K., & Lo, E. H. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22256 · Cited by 101 · see citing works

Relationships between lipoprotein components and risk of ischaemic and haemorrhagic stroke in the Apolipoprotein MOrtality RISk study (AMORIS)

Holme, I., AASTVEIT, A. H., Hammar, N., Jungner, I., & Walldius, G. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2008.02016.x · Cited by 100 · see citing works

Emerging concepts in neural stem cell research: autologous repair and cell-based disease modelling

Koch, P., Kokaia, Z., Lindvall, O., & Brüstle, O. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70202-9 · Cited by 100 · see citing works

A Novel Purification Method for CNS Projection Neurons Leads to the Identification of Brain Vascular Cells as a Source of Trophic Support for Corticospinal Motor Neurons

Dugas, J. C., Mandemakers, W. J., Rogers, M., Ibrahim, A., Daneman, R., & Barres, B. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2010-08.2008 · Cited by 99 · see citing works

Modeling the neurovascular niche: implications for recovery from CNS injury.

Madri, J. A. (2009) · PubMed · Cited by 99 · see citing works

Vascular Contributions to Cognitive Impairment and Dementia: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association

Gorelick, P. B., Scuteri, A., Black, S. E., DeCarli, C., Greenberg, S. M., Iadecola, C., Launer, L. J., Laurent, S., Lopez, O. L., Nyenhuis, D., et al. (2011) · Stroke · doi:10.1161/str.0b013e3182299496 · Cited by 3,811 · see citing works

Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders

Zlokovic, B. V. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3114 · Cited by 2,969 · see citing works

The immunology of stroke: from mechanisms to translation

Iadecola, C., & Anrather, J. (2011) · Nature Medicine · doi:10.1038/nm.2399 · Cited by 2,596 · see citing works

The Pathobiology of Vascular Dementia

Iadecola, C. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.008 · Cited by 1,857 · see citing works

Hallmarks of neurodegenerative diseases

Wilson, D. M., Cookson, M. R., Van Den Bosch, L., Zetterberg, H., Holtzman, D. M., & Dewachter, I. (2023) · Cell · doi:10.1016/j.cell.2022.12.032 · Cited by 1,789 · see citing works

Neuroinflammation and M2 Microglia: The Good, the Bad, and the Inflamed

Cherry, J. D., Olschowka, J. A., & O’Banion, M. K. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-98 · Cited by 1,748 · see citing works

The Vascular Endothelium and Human Diseases

Rajendran, P., Rengarajan, T., Thangavel, J., Nishigaki, Y., Sakthisekaran, D., Sethi, G., & Nishigaki, I. (2013) · International Journal of Biological Sciences · doi:10.7150/ijbs.7502 · Cited by 1,473 · see citing works

Neuroinflammation: friend and foe for ischemic stroke

Jayaraj, R. L., Azimullah, S., Beiram, R., Jalal, F. Y., & Rosenberg, G. A. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1516-2 · Cited by 1,438 · see citing works

Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

Kisler, K., Nelson, A. R., Montagne, A., & Zlokovic, B. V. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.48 · Cited by 1,243 · see citing works

Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States

Mattson, M. P., & Arumugam, T. V. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.05.011 · Cited by 1,242 · see citing works

Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation

Chamorro, Á., Dirnagl, U., Urra, X., & Planas, A. M. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)00114-9 · Cited by 1,198 · see citing works

Inflammation and Stroke: An Overview

Anrather, J., & Iadecola, C. (2016) · Neurotherapeutics · doi:10.1007/s13311-016-0483-x · Cited by 966 · see citing works

Central nervous system pericytes in health and disease

Winkler, E. A., Bell, R. D., & Zlokovic, B. V. (2011) · Nature Neuroscience · doi:10.1038/nn.2946 · Cited by 962 · see citing works

Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions

Qin, C., Yang, S., Chu, Y., Zhang, H., Pang, X., Chen, L., Zhou, L., Chen, M., Tian, D., & Wang, W. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01064-1 · Cited by 971 · see citing works

Immune responses to stroke: mechanisms, modulation, and therapeutic potential.

Iadecola, C., Buckwalter, M. S., & Anrather, J. (2020) · Journal of Clinical Investigation · doi:10.1172/jci135530 · Cited by 853 · see citing works

The biphasic function of microglia in ischemic stroke

Ma, Y., Wang, J., Wang, Y., & Yang, G. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.01.005 · Cited by 724 · see citing works

Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications

Tuo, Q., Zhang, S., & Lei, P. (2021) · Medicinal Research Reviews · doi:10.1002/med.21817 · Cited by 747 · see citing works

History and progress of hypotheses and clinical trials for Alzheimer’s disease

Liu, P.-P., Xie, Y., Meng, X.-Y., & Kang, J.-S. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0063-8 · Cited by 723 · see citing works

Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions

Dyall, S. C., Balas, L., Bazan, N. G., Brenna, J. T., Chiang, N., Souza, F. D. C., Dalli, J., Durand, T., Galano, J., Lein, P. J., et al. (2022) · Progress in Lipid Research · doi:10.1016/j.plipres.2022.101165 · Cited by 681 · see citing works

Animal models of ischemic stroke and their application in clinical research

Kleinschnitz, C., Fluri, F., & Schuhmann, M. K. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s56071 · Cited by 664 · see citing works

The blood-brain barrier: an engineering perspective

Wong, A. D., Ye, M., Levy, A. F., Rothstein, J. D., Bergles, D. E., & Searson, P. C. (2013) · Frontiers in Neuroengineering · doi:10.3389/fneng.2013.00007 · Cited by 662 · see citing works

Pathogenic mechanisms following ischemic stroke

Khoshnam, S. E., Winlow, W., Farzaneh, M., Farbood, Y., & Moghaddam, H. F. (2017) · Neurological Sciences · doi:10.1007/s10072-017-2938-1 · Cited by 618 · see citing works

Ischemic stroke: experimental models and reality

Sommer, C. J. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1667-0 · Cited by 599 · see citing works

ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation

Cui, Y., Zhang, Y., Zhao, X., Shao, L., Liu, G., Sun, C., Xu, R., & Zhang, Z. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.01.003 · Cited by 601 · see citing works

Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke

Liu, Z., & Chopp, M. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.09.008 · Cited by 596 · see citing works

Neuroinflammatory Mechanisms in Ischemic Stroke: Focus on Cardioembolic Stroke, Background, and Therapeutic Approaches

Maida, C. D., Norrito, R. L., Daidone, M., Tuttolomondo, A., & Pinto, A. V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186454 · Cited by 594 · see citing works

Removing brakes on adult brain plasticity: From molecular to behavioral interventions

Bavelier, D., Levi, D. M., Li, R. W., Dan, Y., & Hensch, T. K. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4812-10.2010 · Cited by 589 · see citing works

Engaging neuroscience to advance translational research in brain barrier biology

Neuwelt, E. A., Bauer, B., Fahlke, C. M., Fricker, G., Iadecola, C., Janigro, D., Leybaert, L., Molnár, Z., O’Donnell, M. E., Povlishock, J. T., et al. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn2995 · Cited by 577 · see citing works

Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease

Nelson, A. R., Sweeney, M. D., Sagare, A. P., & Zlokovic, B. V. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.12.016 · Cited by 559 · see citing works

The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia

Iadecola, C. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0718-6 · Cited by 557 · see citing works

Exosomes — beyond stem cells for restorative therapy in stroke and neurological injury

Zhang, Z. G., Buller, B., & Chopp, M. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-018-0126-4 · Cited by 549 · see citing works

Neuroinflammation in Acute Ischemic and Hemorrhagic Stroke

Alsbrook, D. L., Napoli, M. D., Bhatia, K., Biller, J., Andalib, S., Hinduja, A., Rodrigues, R., Rodriguez, M., Sabbagh, S. Y., Selim, M. H., et al. (2023) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-023-01282-2 · Cited by 539 · see citing works

Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis

Leuschner, F., Rauch, P. J., Ueno, T., Gorbatov, R., Marinelli, B. S., Lee, W. W., Dutta, P., Wei, Y., Robbins, C. S., Iwamoto, Y., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20111009 · Cited by 519 · see citing works

A quantitative spatiotemporal analysis of microglia morphology during ischemic stroke and reperfusion

Morrison, H. W., & Filosa, J. A. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-4 · Cited by 506 · see citing works

Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain

Shichita, T., Hasegawa, E., Kimura, A., Morita, R., Sakaguchi, R., Takada, I., Sekiya, T., Ooboshi, H., Kitazono, T., Yanagawa, T., et al. (2012) · Nature Medicine · doi:10.1038/nm.2749 · Cited by 455 · see citing works

Diverse roles of mitochondria in ischemic stroke

Yang, J., Mukda, S., & Chen, S. (2018) · Redox Biology · doi:10.1016/j.redox.2018.03.002 · Cited by 452 · see citing works

Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia

Yang, C., Zhang, X., Fan, H., & Liu, Y. (2009) · Brain Research · doi:10.1016/j.brainres.2009.05.009 · Cited by 444 · see citing works

Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury

Shi, Y., Zhang, L., Pu, H., Mao, L., Hu, X., Jiang, X., Xu, N., Stetler, R. A., Zhang, F., Liu, X., et al. (2016) · Nature Communications · doi:10.1038/ncomms10523 · Cited by 431 · see citing works

Chaos and commotion in the wake of cortical spreading depression and spreading depolarizations

Pietrobon, D., & Moskowitz, M. A. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3770 · Cited by 424 · see citing works

Pathophysiologic Cascades in Ischemic Stroke

Xing, C., Arai, K., Lo, E. H., & Hommel, M. (2012) · International Journal of Stroke · doi:10.1111/j.1747-4949.2012.00839.x · Cited by 421 · see citing works

Bruton’s tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury

Ito, M., Shichita, T., Okada, M., Komine, R., Noguchi, Y., Yoshimura, A., & Morita, R. (2015) · Nature Communications · doi:10.1038/ncomms8360 · Cited by 417 · see citing works

Microglia and Monocytes/Macrophages Polarization Reveal Novel Therapeutic Mechanism against Stroke

Kanazawa, M., Ninomiya, I., Hatakeyama, M., Takahashi, T., & Shimohata, T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102135 · Cited by 396 · see citing works

Autophagy in ischemic stroke

Wang, P., Shao, B., Deng, Z., Chen, S., Yue, Z., & Miao, C. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.01.001 · Cited by 396 · see citing works

Novel Stroke Therapeutics: Unraveling Stroke Pathophysiology and Its Impact on Clinical Treatments

George, P. M., & Steinberg, G. K. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.041 · Cited by 394 · see citing works

Stroke research at a crossroad: asking the brain for directions

Iadecola, C., & Anrather, J. (2011) · Nature Neuroscience · doi:10.1038/nn.2953 · Cited by 390 · see citing works

SOD2 in mitochondrial dysfunction and neurodegeneration

Flynn, J. M., & Melov, S. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.05.027 · Cited by 390 · see citing works

Global Burden, Risk Factor Analysis, and Prediction Study of Ischemic Stroke, 1990–2030

Fan, J., Li, X., Yu, X., Liu, Z., Jiang, Y., Fang, Y., Zong, M., Suo, C., Man, Q., & Xiong, L. (2023) · Neurology · doi:10.1212/wnl.0000000000207387 · Cited by 380 · see citing works

Nrf2 Regulates Oxidative Stress and Its Role in Cerebral Ischemic Stroke

Wang, L., Zhang, X., Xiong, X., Zhu, H., Chen, R., Zhang, S., Chen, G., & Jian, Z. (2022) · Antioxidants · doi:10.3390/antiox11122377 · Cited by 361 · see citing works

Phagocytosis executes delayed neuronal death after focal brain ischemia

Neher, J. J., Emmrich, J., Fricker, M., Mander, P. K., Théry, C., & Brown, G. C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308679110 · Cited by 350 · see citing works

The emerging field of epigenetics in neurodegeneration and neuroprotection

Hwang, J.-Y., Aromolaran, K. A., & Zukin, R. S. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.46 · Cited by 343 · see citing works

Acute ischemic stroke therapy overview

Catanese, L., Tarsia, J., & Fisher, M. (2017) · Circulation Research · doi:10.1161/circresaha.116.309278 · Cited by 341 · see citing works

Targeting autophagy in ischemic stroke: From molecular mechanisms to clinical therapeutics

Ajoolabady, A., Wang, S., Kroemer, G., Penninger, J. M., Uversky, V. N., Praticò, D., Henninger, N., Reiter, R. J., Bruno, A., JOSHIPURA, K. J., et al. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107848 · Cited by 334 · see citing works

Vascular remodeling after ischemic stroke: mechanisms and therapeutic potentials.

Liu, J., Wang, Y., Akamatsu, Y., Lee, C. C., Stetler, R. A., Lawton, M. T., & Yang, G.-Y. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.11.004 · Cited by 335 · see citing works

Pathogenesis of acute stroke and the role of inflammasomes

Fann, D. Y., Lee, S.-Y., Manzanero, S., Chunduri, P., Sobey, C. G., & Arumugam, T. V. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.09.004 · Cited by 334 · see citing works

Roles of Oxidative Stress, Apoptosis, PGC-1α and Mitochondrial Biogenesis in Cerebral Ischemia

Chen, S., Yang, D., Lin, T., Shaw, F.-Z., Liou, C., & Chuang, Y. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12107199 · Cited by 334 · see citing works

Neuronal oxidative stress in acute ischemic stroke: Sources and contribution to cell injury

Manzanero, S., Santro, T., & Arumugam, T. V. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.11.009 · Cited by 333 · see citing works

Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects

Paul, S., Chakraborty, S., Anand, U., Dey, S., Nandy, S., Ghorai, M., Saha, S. C., Patil, M. T., Kandimalla, R., Proćków, J., et al. (2021) · Biomedicine &amp; Pharmacotherapy · doi:10.1016/j.biopha.2021.112175 · Cited by 306 · see citing works

Microglia–blood vessel interactions: a double-edged sword in brain pathologies

Dudvarski Stankovic, N., Teodorczyk, M., Ploen, R., Zipp, F., & Schmidt, M. H. H. (2016) · Acta Neuropathologica · doi:10.1007/s00401-015-1524-y · Cited by 301 · see citing works

Functional differences between microglia and monocytes after ischemic stroke

Ritzel, R. M., Patel, A. R., Grenier, J. M., Crapser, J., Verma, R., Jellison, E. R., & McCullough, L. D. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0329-1 · Cited by 295 · see citing works

Bax regulates primary necrosis through mitochondrial dynamics

Whelan, R. S., Konstantinidis, K., Wei, A.-C., Chen, Y., Reyna, D. E., Jha, S., Yang, Y., Calvert, J. W., Lindsten, T., Thompson, C. B., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201608109 · Cited by 290 · see citing works

Alternative cell death mechanisms in development and beyondPreprint

Yuan, J., & Kroemer, G. (2010) · Genes & Development · doi:10.1101/gad.1984410 · Cited by 290 · see citing works

Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy

Binet, F., Cagnone, G., Crespo-Garcia, S., Hata, M., Neault, M., Dejda, A., Wilson, A. M., Buscarlet, M., Mawambo, G. T., Howard, J. P., et al. (2020) · Science · doi:10.1126/science.aay5356 · Cited by 283 · see citing works

Machine Learning for Brain Stroke: A Review

Sirsat, M. S., Fermé, E., & Câmara, J. (2020) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2020.105162 · Cited by 281 · see citing works

The Pericyte: A Forgotten Cell Type with Important Implications for A lzheimer's Disease?

Winkler, E. A., Sagare, A. P., & Zloković, B. V. (2014) · Brain Pathology · doi:10.1111/bpa.12152 · Cited by 275 · see citing works

RIGOR Guidelines: Escalating STAIR and STEPS for Effective Translational Research

Lapchak, P. A., Zhang, J. H., & Noble‐Haeusslein, L. J. (2012) · Translational Stroke Research · doi:10.1007/s12975-012-0209-2 · Cited by 272 · see citing works

Manganese Superoxide Dismutase and Oxidative Stress Modulation

Bresciani, G., da Cruz, I. B. M., & González‐Gallego, J. (2015) · Advances in clinical chemistry · doi:10.1016/bs.acc.2014.11.001 · Cited by 285 · see citing works

Preclinical stroke research – advantages and disadvantages of the most common rodent models of focal ischaemia

Macrae, I. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01398.x · Cited by 274 · see citing works

Inflammatory Disequilibrium in Stroke

Petrovic‐Djergovic, D., Goonewardena, S. N., & Pinsky, D. J. (2016) · Circulation Research · doi:10.1161/circresaha.116.308022 · Cited by 265 · see citing works

Perivascular microglia promote blood vessel disintegration in the ischemic penumbra

Jolivel, V., Bicker, F., Binamé, F., Ploen, R., Keller, S., Gollan, R., Jurek, B., Birkenstock, J., Poisa-Beiro, L., Bruttger, J., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1372-1 · Cited by 267 · see citing works

The neurovascular link in health and disease: molecular mechanisms and therapeutic implications

Quaegebeur, A., Lange, C., & Carmeliet, P. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.013 · Cited by 247 · see citing works

Mechanisms of Neuronal Protection against Excitotoxicity, Endoplasmic Reticulum Stress, and Mitochondrial Dysfunction in Stroke and Neurodegenerative Diseases

Prentice, H. M., Modi, J. P., & Wu, J. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/964518 · Cited by 256 · see citing works

Intestinal microbial dysbiosis aggravates the progression of Alzheimer’s disease in Drosophila

Wu, S.-C., Cao, Z.-S., Chang, K.-M., & Juang, J. (2017) · Nature Communications · doi:10.1038/s41467-017-00040-6 · Cited by 253 · see citing works

Temporal Expression of Apelin/Apelin Receptor in Ischemic Stroke and its Therapeutic Potential

Wu, Y., Wang, X., Zhou, X., Cheng, B., Li, G., & Bai, B. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00001 · Cited by 254 · see citing works

The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke

Wu, L.-J., Wu, G., Sharif, M. R. A., Baker, A., Jia, Y., Fahey, F. H., Luo, H. R., Feener, E. P., & Clapham, D. E. (2012) · Nature Neuroscience · doi:10.1038/nn.3059 · Cited by 252 · see citing works

Neurovascular Dysfunction and Faulty Amyloid  -Peptide Clearance in Alzheimer Disease

Sagare, A. P., Bell, R. D., & Zlokovic, B. V. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a011452 · Cited by 251 · see citing works

The role of microglia and myeloid immune cells in acute cerebral ischemia

Benakis, C., García‐Bonilla, L., Iadecola, C., & Anrather, J. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00461 · Cited by 249 · see citing works

MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1

Shichita, T., Ito, M., Morita, R., Komai, K., Noguchi, Y., Ooboshi, H., Koshida, R., Takahashi, S., Kodama, T., & Yoshimura, A. (2017) · Nature Medicine · doi:10.1038/nm.4312 · Cited by 249 · see citing works

Noninvasive Molecular Imaging of Neuroinflammation

Jacobs, A. H., Tavitian, B., & the INMiND consortium (2012) · Journal of Cerebral Blood Flow &amp; Metabolism · doi:10.1038/jcbfm.2012.53 · Cited by 245 · see citing works

The Ischemic Environment Drives Microglia and Macrophage Function

Fumagalli, S., Perego, C., Pischiutta, F., Zanier, E. R., & Simoni, M. G. D. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00081 · Cited by 245 · see citing works

Apoptosis-Inducing Factor (AIF) in Physiology and Disease: The Tale of a Repented Natural Born Killer

Bano, D., & Prehn, J. H. M. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.03.016 · Cited by 241 · see citing works

Discovery and Development of Calcium Channel Blockers

Godfraind, T. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00286 · Cited by 237 · see citing works

Silent Information Regulator 1 Protects the Brain Against Cerebral Ischemic Damage

Hernández‐Jiménez, M., Hurtado, O., Cuartero, M. I., Ballesteros, I., Moraga, A., Pradillo, J. M., McBurney, M. W., Lizasoaín, I., & Moro, M. Á. (2013) · Stroke · doi:10.1161/strokeaha.113.001715 · Cited by 234 · see citing works

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a

Chassagnon, I. R., McCarthy, C. A., Chin, Y. K. ‐., Pineda, S. S., Keramidas, A., Mobli, M., Pham, V., Silva, T. M. D., Lynch, J. W., Widdop, R. E., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1614728114 · Cited by 230 · see citing works

Redox signaling in cardiovascular health and disease

Madamanchi, N. R., & Runge, M. S. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.04.001 · Cited by 223 · see citing works

Exosomes in stroke pathogenesis and therapy

Zhang, Z. G., & Chopp, M. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81133 · Cited by 226 · see citing works

Safety and efficacy of natalizumab in patients with acute ischaemic stroke (ACTION): a randomised, placebo-controlled, double-blind phase 2 trial

Elkins, J., Veltkamp, R., Montaner, J., Johnston, S. C., Singhal, A. B., Becker, K., Lansberg, M. G., Tang, W., Chang, I., Muralidharan, K., et al. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(16)30357-x · Cited by 224 · see citing works

Advances in Acute Ischemic Stroke Therapy

Xiong, Y., Wakhloo, A. K., & Fisher, M. (2022) · Circulation Research · doi:10.1161/circresaha.121.319948 · Cited by 221 · see citing works

Post-Ischemic Inflammation in the Brain

Shichita, T., Sakaguchi, R., Suzuki, M., & Yoshimura, A. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00132 · Cited by 221 · see citing works

Clonal Hematopoiesis Is Associated With Higher Risk of Stroke

Bhattacharya, R., Zekavat, S. M., Haessler, J., Fornage, M., Raffield, L. M., Uddin, M. M., Bick, A. G., Niroula, A., Yu, B., Gibson, C. J., et al. (2021) · Stroke · doi:10.1161/strokeaha.121.037388 · Cited by 214 · see citing works

The Role of Selected Pro-Inflammatory Cytokines in Pathogenesis of Ischemic Stroke

Pawluk, H., Woźniak, A., Grześk, G., Kołodziejska, R., Kozakiewicz, M., Kopkowska, E., Grzechowiak, E., & Kozera, G. (2020) · Clinical Interventions in Aging · doi:10.2147/cia.s233909 · Cited by 218 · see citing works

Pathobiology of injury after stroke: the neurovascular unit and beyond

Dirnagl, U. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06691.x · Cited by 208 · see citing works

FGF21 alleviates neuroinflammation following ischemic stroke by modulating the temporal and spatial dynamics of microglia/macrophages

Wang, D., Liu, F., Zhu, L., Lin, P., Han, F., Wang, X., Tan, X., Lin, L., & Xiong, Y. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01921-2 · Cited by 211 · see citing works

Alpha-Linolenic Acid: An Omega-3 Fatty Acid with Neuroprotective Properties—Ready for Use in the Stroke Clinic?

Blondeau, N., Lipsky, R. H., Bourourou, M., Duncan, M. W., Gorelick, P. B., & Marini, A. M. (2015) · BioMed Research International · doi:10.1155/2015/519830 · Cited by 206 · see citing works

The impact of cerebrovascular aging on vascular cognitive impairment and dementia

Yang, T., Sun, Y., Lu, Z., Leak, R. K., & Zhang, F. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.007 · Cited by 206 · see citing works

Mitochondrial Biogenesis as a Pharmacological Target: A New Approach to Acute and Chronic Diseases

Whitaker, R. M., Corum, D. G., Beeson, C., & Schnellmann, R. G. (2015) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010715-103155 · Cited by 200 · see citing works

Pharmacological brain cytoprotection in acute ischaemic stroke — renewed hope in the reperfusion era

Fisher, M., & Savitz, S. I. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-021-00605-6 · Cited by 200 · see citing works

Rapamycin attenuates mitochondrial dysfunction via activation of mitophagy in experimental ischemic stroke

Li, Q., Zhang, T., Wang, J., Zhang, Z., Zhai, Y., Yang, G.-Y., & Sun, X. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.01.032 · Cited by 209 · see citing works

Targeting the Nrf2–Keap1 antioxidant defence pathway for neurovascular protection in stroke

Alfieri, A., Srivastava, S., Siow, R. C. M., Modo, M., Fraser, P. A., & Mann, G. E. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.210294 · Cited by 198 · see citing works

Protecting the ischaemic penumbra as an adjunct to thrombectomy for acute stroke

Baron, J. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0002-2 · Cited by 197 · see citing works

Protecting against vascular disease in brain

Faraci, F. M. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01310.2010 · Cited by 196 · see citing works

Mechanisms and Challenges in Translational Stroke Research

Lo, E. H., & Ning, M. (2016) · Journal of Investigative Medicine · doi:10.1136/jim-2016-000104 · Cited by 25 · see citing works

The Science of Ischemic Stroke: Pathophysiology & Pharmacological Treatment

Kanyal, N. (2015) · International journal of pharma research and review · Cited by 26 · see citing works

Special Issue Article Cellular Mechanisms of Neurovascular Damage and Repair After Stroke

Arai, K., Lok, J., Guo, S., Hayakawa, K., Xing, C., & Lo, E. H. (2011)

Novel therapeutic strategies and targets for the treatment of stroke

Murphy, S. P. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07937.x

Ischemic Stroke: Basic Pathophysiology and Neuroprotective Strategies

Singhal, A. B., Lo, E. H., Dalkara, T., & Moskowitz, M. A. (2010) · Springer eBooks · doi:10.1007/978-3-642-12751-9_1 · Cited by 11 · see citing works