Cited by 295Neurogenesis and neuroplasticity mechanismsRetinoids in leukemia and cellular processesDevelopmental Biology and Gene Regulation

The DOI matches its Crossref record; 269 of the 269 references it cites were found in a registry or an index.

Retinoic acid signaling and neuronal differentiation

Open access

Janesick, Amanda, Wu, Stephanie Cherie, Blumberg, Bruce·2015·Cellular and Molecular Life Sciences

DOI 10.1007/s00018-014-1815-9PMC PMC11113123

Open this paper in CoChat — free account

Abstract

The identification of neurological symptoms caused by vitamin A deficiency pointed to a critical, early developmental role of vitamin A and its metabolite, retinoic acid (RA). The ability of RA to induce post-mitotic, neural phenotypes in various stem cells, in vitro, served as early evidence that RA is involved in the switch between proliferation and differentiation. In vivo studies have expanded this "opposing signal" model, and the number of primary neurons an embryo develops is now known to depend critically on the levels and spatial distribution of RA. The proneural and neurogenic transcription factors that control the exit of neural progenitors from the cell cycle and allow primary neurons to develop are partly elucidated, but the downstream effectors of RA receptor (RAR) signaling (many of which are putative cell cycle regulators) remain largely unidentified. The molecular mechanisms underlying RA-induced primary neurogenesis in anamniote embryos are starting to be revealed; however, these data have been not been extended to amniote embryos. There is growing evidence that bona fide RARs are found in some mollusks and other invertebrates, but little is known about their necessity or functions in neurogenesis. One normal function of RA is to regulate the cell cycle to halt proliferation, and loss of RA signaling is associated with dedifferentiation and the development of cancer. Identifying the genes and pathways that mediate cell cycle exit downstream of RA will be critical for our understanding of how to target tumor differentiation. Overall, elucidating the molecular details of RAR-regulated neurogenesis will be decisive for developing and understanding neural proliferation-differentiation switches throughout development.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s00018-014-1815-9

Cites

269 of 269 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Calcium's Role in Mechanotransduction during Muscle Development
Damm, T. B., & Egli, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356667 · Cited by 14,552
Functional analysis
Rudin, W. (1973) · Cited by 13,740
CDK inhibitors: positive and negative regulators of G1-phase progression
Sherr, C. J., & Roberts, J. M. (1999) · Genes & Development · doi:10.1101/gad.13.12.1501 · Cited by 6,115
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
Wade Harper, J. (1993) · Cell · doi:10.1016/0092-8674(93)90499-g · Cited by 5,651
Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells
Boyer, L. A., Lee, T. I., Cole, M. F., Johnstone, S. E., Levine, S. S., Zucker, J. P., Guenther, M. G., Kumar, R. M., Murray, H. L., Jenner, R. G., et al. (2005) · Cell · doi:10.1016/j.cell.2005.08.020 · Cited by 4,505
Generation of Neurons and Astrocytes from Isolated Cells of the Adult Mammalian Central Nervous System
Reynolds, B. A., & Weiss, S. (1992) · Science · doi:10.1126/science.1553558 · Cited by 4,482
Isolation and Characterization of Tumorigenic, Stem-like Neural Precursors from Human Glioblastoma
Galli, R., Binda, E., Orfanelli, U., Cipelletti, B., Gritti, A., Vitis, S. D., Fiocco, R., Foroni, C., DiMeco, F., & Vescovi, A. L. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1364 · Cited by 2,570
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells
Loh, Y., Wu, Q., Chew, J.-L., Vega, V. B., Zhang, W., Chen, X., Bourque, G., George, J., Leong, B., Liu, J., et al. (2006) · Nature Genetics · doi:10.1038/ng1760 · Cited by 2,438
Prediction of central nervous system embryonal tumour outcome based on gene expression
Pomeroy, S. L., Tamayo, P., Gaasenbeek, M., Sturla, L. M., Angelo, M., McLaughlin, M. E., Kim, J. Y. H., Goumnerova, L. C., Black, P. M., Lau, C. C., et al. (2002) · Nature · doi:10.1038/415436a · Cited by 2,369
Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma
Noushmehr, H., Weisenberger, D. J., Diefes, K., Phillips, H. S., Pujara, K., Berman, B. P., Pan, F., Pelloski, C. E., Sulman, E. P., Bhat, K. P., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.03.017 · Cited by 2,337

Show all 268 references

Research works printed but not linked: 1

Ulrich T (2013) Curing neuroblastoma by making it grow up, vol 2014. Boston Children’s Hospital, Boston

Sorted by citations

SARS‐CoV‐2 targets neurons of 3D human brain organoids
Ramani, A., Müller, L., Ostermann, P. N., Gabriel, E., Abida‐Islam, P., Müller‐Schiffmann, A., Mariappan, A., Goureau, O., Gruell, H., Walker, A., et al. (2020) · The EMBO Journal · doi:10.15252/embj.2020106230 · Cited by 518
Human brain organoids assemble functionally integrated bilateral optic vesicles
Gabriel, E., Albanna, W., Pasquini, G., Ramani, A., Josipović, N., Mariappan, A., Schinzel, F., Karch, C. M. M., Bao, G., Gottardo, M., et al. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.07.010 · Cited by 183
Fatty Acid Signaling Mechanisms in Neural Cells: Fatty Acid Receptors
Falomir‐Lockhart, L. J., Cavazzutti, G. F., Giménez, E., & Toscani, A. M. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00162 · Cited by 164
Mechanistic aspects of carotenoid health benefits – where are we now?
Bohn, T., Bonet, M. L., Borel, P., Keijer, J., Landrier, J., Milisav, I., Ribot, J., Riso, P., Winklhofer‐Roob, B. M., Sharoni, Y., et al. (2021) · Nutrition Research Reviews · doi:10.1017/s0954422421000147 · Cited by 155
Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine
Ferreira, R., Napoli, J., Enver, T., Bernardino, L., & Ferreira, L. (2020) · Nature Communications · doi:10.1038/s41467-020-18042-2 · Cited by 138
Urine Excretion, Organ Distribution, and Placental Transfer of 6PPD and 6PPD-Quinone in Mice and Potential Developmental Toxicity through Nuclear Receptor Pathways
Zhao, H. N., Thomas, S. P., Zylka, M. J., Dorrestein, P. C., & Hu, W. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.3c05026 · Cited by 132
The Role of Vitamins in Neurodegenerative Disease: An Update
Nand, S., Singh, P., Steinbusch, H. W. M., Vamanu, E., Ashraf, G. M., & Singh, M. P. (2021) · Biomedicines · doi:10.3390/biomedicines9101284 · Cited by 126
Discovery of Neuritogenic Securinega Alkaloids from Flueggea suffruticosa by a Building Blocks‐Based Molecular Network Strategy
He, Q., Wu, Z., Li, L., Sun, W., Wang, G., Jiang, R., Hu, L., Shi, L., He, R., Wang, Y., et al. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202103878 · Cited by 116
Human iPSC-Derived Neural Models for Studying Alzheimer’s Disease: from Neural Stem Cells to Cerebral Organoids
Barák, M., Fedorová, V., Pospíšilová, V., Raška, J., Vochyánová, S., Sedmík, J., Hříbková, H., Klímová, H., Váňová, T., & Bohačiaková, D. (2022) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10254-3 · Cited by 102
Differentiation of Mesenchymal Stem Cells to Neuroglia: in the Context of Cell Signalling
George, S., Hamblin, M. R., & Abrahamse, H. (2019) · Stem Cell Reviews and Reports · doi:10.1007/s12015-019-09917-z · Cited by 97
Cerium oxide nanoparticles inhibit differentiation of neural stem cells
Gliga, A. R., Edoff, K., Caputo, F., Källman, T., Blom, H., Karlsson, H. L., Ghibelli, L., Traversa, E., Ceccatelli, S., & Fadeel, B. (2017) · Scientific Reports · doi:10.1038/s41598-017-09430-8 · Cited by 84
MEIS transcription factors in development and disease
Schulte, D., & Geerts, D. (2019) · Development · doi:10.1242/dev.174706 · Cited by 73
RETRACTED: Risk-Associated Long Noncoding RNA FOXD3-AS1 Inhibits Neuroblastoma Progression by Repressing PARP1-Mediated Activation of CTCF
Zhao, X., Li, D., Huang, D., Song, H., Mei, H., Fang, E., Wang, X., Yang, F., Zheng, L., Huang, K., et al. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.12.017 · Cited by 73
Retracted
Neurogenesis, neuronal migration, and axon guidance
Accogli, A., Addour-Boudrahem, N., & Srour, M. (2020) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64150-2.00004-6 · Cited by 81
Retinoic acid rewires the adrenergic core regulatory circuitry of childhood neuroblastoma
Zimmerman, M. W., Durbin, A. D., He, S., Oppel, F., Shi, H., Tao, T., Li, Z., Berezovskaya, A., Liu, Y., Zhang, J., et al. (2021) · Science Advances · doi:10.1126/sciadv.abe0834 · Cited by 68
Organs to Cells and Cells to Organoids: The Evolution of in vitro Central Nervous System Modelling
Pacitti, D., Privolizzi, R., & Bax, B. E. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00129 · Cited by 66
Therapy resistance in neuroblastoma: Mechanisms and reversal strategies
Zhou, X., Wang, X., Li, N., Guo, Y. A., Yang, X., & Lei, Y. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1114295 · Cited by 56
Retinoic acid induces human gastruloids with posterior embryo-like structures
Hamazaki, N., Yang, W., Kubo, C. A., Qiu, C., Martin, B., Garge, R. K., Regalado, S. G., Nichols, E. K., Pendyala, S., Bradley, N., et al. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01487-8 · Cited by 56
Differential RA responsiveness directs formation of functionally distinct spermatogonial populations at the initiation of spermatogenesis in the mouse
Velte, E. K., Niedenberger, B. A., Serra, N. D., Singh, A., la Cruz, L. R.-D., Hermann, B. P., & Geyer, C. B. (2019) · Development · doi:10.1242/dev.173088 · Cited by 55
Suppression of ferroptosis by vitamin A or radical-trapping antioxidants is essential for neuronal development
Tschuck, J., Nair, V. P., Galhoz, A., Zaratiegui, C., Tai, H.-M., Ciceri, G., Rothenaigner, I., Tchieu, J. H., Stockwell, B. R., Studer, L., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-51996-1 · Cited by 58
Retinoic Acid-Signaling Regulates the Proliferative and Neurogenic Capacity of Müller Glia-Derived Progenitor Cells in the Avian Retina
Todd, L. J., Suarez, L., Quinn, C. H., & Fischer, A. J. (2017) · Stem Cells · doi:10.1002/stem.2742 · Cited by 53
Bioactive Lipid Signaling in Cardiovascular Disease, Development, and Regeneration
Wasserman, A. H., Venkatesan, M., & Aguirre, A. (2020) · Cells · doi:10.3390/cells9061391 · Cited by 50
DNA Double-Strand Breaks as Pathogenic Lesions in Neurological Disorders
Provasek, V. E., Mitra, J., Malojirao, V. H., & Hegde, M. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094653 · Cited by 54
Vitamin A Inhibits Development of Dextran Sulfate Sodium-Induced Colitis and Colon Cancer in a Mouse Model
Okayasu, I., Hana, K., Nemoto, N., Yoshida, T., Saegusa, M., Yokota-Nakatsuma, A., Song, S., & Iwata, M. (2016) · BioMed Research International · doi:10.1155/2016/4874809 · Cited by 49
Reduce, reuse, recycle – Developmental signals in spinal cord regeneration
Cardozo, M. J., Mysiak, K. S., Becker, T., & Becker, C. G. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2017.05.011 · Cited by 55
The ancestral retinoic acid receptor was a low-affinity sensor triggering neuronal differentiation
Handberg-Thorsager, M., Gutierrez-Mazariegos, J., Arold, S. T., Nadendla, E. K., Bertucci, P. Y., Germain, P., Tomančák, P., Pierzchalski, K., Jones, J. W., Albalat, R., et al. (2018) · Science Advances · doi:10.1126/sciadv.aao1261 · Cited by 49
Research Progress in Vitamin A and Autism Spectrum Disorder
Liu, Z., Wang, J., Xu, Q., Hong, Q., Zhu, J., & Chi, X. (2021) · Behavioural Neurology · doi:10.1155/2021/5417497 · Cited by 49
Retinoic acid and depressive disorders: Evidence and possible neurobiological mechanisms
Hu, P., van Dam, A., Wang, Y., Lucassen, P. J., & Zhou, J.-N. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.02.013 · Cited by 48
Two Opposing Faces of Retinoic Acid: Induction of Stemness or Induction of Differentiation Depending on Cell-Type
Mezquita, B., & Mezquita, C. (2019) · Biomolecules · doi:10.3390/biom9100567 · Cited by 46
Retinoic acid-induced upregulation of miR-219 promotes the differentiation of embryonic stem cells into neural cells
Wu, H., Zhao, J., Fu, B., Yin, S., Song, C., Zhang, J., Zhao, S., & Zhang, Y. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.336 · Cited by 43
Roles of vitamins in stem cells
Godoy-Parejo, C., Deng, C., Zhang, Y., Liu, W., & Chen, G. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03352-6 · Cited by 45
Nanoencapsulation approaches for oral delivery of vitamin A
Resende, D., Lima, S. A. C., & Reis, S. (2020) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2020.111121 · Cited by 44
COIMMR: a computational framework to reveal the contribution of herbal ingredients against human cancer via immune microenvironment and metabolic reprogramming
Tian, S., Li, Y., Xu, J., Zhang, L., Zhang, J., Lu, J., Xu, X., Luan, X., Zhao, J., & Zhang, W. (2023) · Briefings in Bioinformatics · doi:10.1093/bib/bbad346 · Cited by 47
Chronic retinoic acid treatment suppresses adult hippocampal neurogenesis, in close correlation with depressive-like behavior
Hu, P., Wang, Y., Liu, J., Meng, F., Qi, X., Chen, L., van Dam, A., Joëls, M., Lucassen, P. J., & Zhou, J. (2016) · Hippocampus · doi:10.1002/hipo.22574 · Cited by 41
Administration of all‐transretinoic acid after experimental traumatic brain injury is brain protective
Hummel, R., Ulbrich, S., Appel, D., Li, S., Hirnet, T., Zander, S., Bobkiewicz, W., Gölz, C., & Schäfer, M. K. E. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15259 · Cited by 41
Transcriptional profiling of mESC-derived tendon and fibrocartilage cell fate switch
Kaji, D. A., Montero, A. M., Patel, R. S., & Huang, A. H. (2021) · Nature Communications · doi:10.1038/s41467-021-24535-5 · Cited by 44
A new advanced cellular model of functional cholinergic-like neurons developed by reprogramming the human SH-SY5Y neuroblastoma cell line
D’Aloia, A., Pastori, V., Blasa, S., Campioni, G., Peri, F., Sacco, E., Ceriani, M., Lecchi, M., & Costa, B. (2024) · Cell Death Discovery · doi:10.1038/s41420-023-01790-7 · Cited by 36
Antagonism between Gdf6a and retinoic acid pathways controls timing of retinal neurogenesis and growth of the eye in zebrafish
Valdivia, L. E., Lamb, D. B., Horner, W., Wierzbicki, C., Tafessu, A., Williams, A. M., Gestri, G., Krasnow, A. M., Vleeshouwer-Neumann, T., Givens, M., et al. (2016) · Development · doi:10.1242/dev.130922 · Cited by 36
The PLAGL2/MYCN/miR-506-3p interplay regulates neuroblastoma cell fate and associates with neuroblastoma progression
Zhao, Z., Shelton, S. D., Oviedo, A., Baker, A. L., Bryant, C. P., Omidvarnia, S., & Du, L. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-1531-2 · Cited by 35
YAP Mediates Hair Cell Regeneration in Balance Organs of Chickens, But LATS Kinases Suppress Its Activity in Mice
Rudolf, M. A., Andreeva, A. Y., Kozlowski, M. M., Kim, C. E., Moskowitz, B. A., Anaya, A., Kelley, M. W., & Corwin, J. T. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.0306-20.2020 · Cited by 34
Rostrocaudal patterning and neural crest differentiation of human pre-neural spinal cord progenitors in vitro
Cooper, F., Gentsch, G. E., Mitter, R., Bouissou, C., Healy, L. E., Hernandez-Rodriguez, A. R., Smith, J. C., & Bernardo, A. S. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.02.018 · Cited by 34
Vitamin A and inflammatory bowel diseases: from cellular studies and animal models to human disease
Barbalho, S. M., Goulart, R. D. Á., & Batista, G. L. D. S. A. (2018) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2019.1543588 · Cited by 34
Impact of Cancer Stem Cells on Therapy Resistance in Gastric Cancer
Otaegi-Ugartemendia, M., Matheu, A., & Carrasco‐García, E. (2022) · Cancers · doi:10.3390/cancers14061457 · Cited by 32
New Insights Into the Roles of Retinoic Acid Signaling in Nervous System Development and the Establishment of Neurotransmitter Systems
Zieger, E., & Schubert, M. (2016) · International review of cytology · doi:10.1016/bs.ircmb.2016.09.001 · Cited by 32
Alternative Biotransformation of Retinal to Retinoic Acid or Retinol by an Aldehyde Dehydrogenase from Bacillus cereus
Hong, S., Ngo, H.-P.-T., Nam, H.-K., Kim, K.-R., Kang, L., & Oh, D. (2016) · Applied and Environmental Microbiology · doi:10.1128/aem.00848-16 · Cited by 31
Peptide Regulation of Cell Differentiation
Khavinson, V. K., Linkova, N. S., Diatlova, A., & Trofimova, S. (2019) · Stem Cell Reviews and Reports · doi:10.1007/s12015-019-09938-8 · Cited by 31
The potential of mechanistic information organised within the AOP framework to increase regulatory uptake of the developmental neurotoxicity (DNT) in vitro battery of assays
Sachana, M., Willett, C., Pistollato, F., & Bal‐Price, A. (2021) · Reproductive Toxicology · doi:10.1016/j.reprotox.2021.06.006 · Cited by 34
Maternal fat-soluble vitamins, brain development, and regulation of feeding behavior: an overview of research
Sánchez‐Hernández, D., Anderson, G. H., Poon, A. N., Pannia, E., Cho, C. E., Huot, P. S. P., & Kubant, R. (2016) · Nutrition Research · doi:10.1016/j.nutres.2016.09.009 · Cited by 30
High‐throughput identification of factors promoting neuronal differentiation of human neural progenitor cells in microscale 3D cell culture
Nierode, G. J., Gopal, S., Kwon, P. S., Clark, D. S., Schaffer, D. V., & Dordick, J. S. (2018) · Biotechnology and Bioengineering · doi:10.1002/bit.26839 · Cited by 30
Sonic Hedgehog-Gli1 Signaling and Cellular Retinoic Acid Binding Protein 1 Gene Regulation in Motor Neuron Differentiation and Diseases
Lin, Y., Lin, Y.-W., Nhieu, J., Zhang, X., & Wei, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114125 · Cited by 29
Protocol for mouse adult neural stem cell isolation and culture
Ahmed, A. K. M. A., Isaksen, T. J., & Yamashita, T. (2021) · STAR Protocols · doi:10.1016/j.xpro.2021.100522 · Cited by 29
Differentiation enhances Zika virus infection of neuronal brain cells
Martín, C. S.-S., Li, T. Y., Bouquet, J., Streithorst, J. A., Yu, G., Paranjpe, A., & Chiu, C. Y. (2018) · Scientific Reports · doi:10.1038/s41598-018-32400-7 · Cited by 27
Impacts of vitamin A deficiency on biological rhythms: Insights from the literature
Guo, X., Wang, H., Xu, J., & Hua, H. M. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.886244 · Cited by 28
Neurogenic and Neuroprotective Potential of Stem/Stromal Cells Derived from Adipose Tissue
Figiel‐Dabrowska, A., Radoszkiewicz, K., Rybkowska, P., Krześniak, N. E., Sulejczak, D., & Sarnowska, A. (2021) · Cells · doi:10.3390/cells10061475 · Cited by 28
On the role of retinoic acid in virus induced inflammatory response in cornea
Jaggi, U., Varanasi, S. K., Bhela, S., & Rouse, B. T. (2018) · Microbes and Infection · doi:10.1016/j.micinf.2018.04.007 · Cited by 28
Treatment of human neuroblastoma cell line SH‐SY5Y with HSP27 siRNA tagged‐exosomes decreased differentiation rate into mature neurons
Shokrollahi, E., Nourazarian, A., Rahbarghazi‬, R., Salimi, L., Karbasforush, S., Khaksar, M., Salarinasab, S., Abhari, A., & Heidarzadeh, M. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28704 · Cited by 28
Age-Related Expression of a Repeat-Rich Intergenic Long Noncoding RNA in the Rat Brain
Kour, S., & Rath, P. C. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9634-z · Cited by 27
A Single-Cell Transcriptomic Analysis of the Mouse Hippocampus After Voluntary Exercise
Methi, A., Islam, M. R., Kaurani, L., Sakib, M. S., Krüger, D. M., Pena, T., Burkhardt, S., Liebetanz, D., & Fischer, A. (2024) · Molecular Neurobiology · doi:10.1007/s12035-023-03869-9 · Cited by 33
Disruption of mesoderm formation during cardiac differentiation due to developmental exposure to 13-cis-retinoic acid
Liu, Q., Bortle, K. V., Zhang, Y., Zhao, M., Zhang, J. Z., Geller, B. S., Gruber, J. J., Jiang, C., Wu, J. C., & Snyder, M. P. (2018) · Scientific Reports · doi:10.1038/s41598-018-31192-0 · Cited by 27
Retinoic acid signaling drives differentiation toward the absorptive lineage in colorectal cancer
Wester, R. A., van Voorthuijsen, L., Neikes, H. K., Dijkstra, J. J., Lamers, L. A., Frölich, S., van der Sande, M., Logie, C., Lindeboom, R. G. H., & Vermeulen, M. (2021) · iScience · doi:10.1016/j.isci.2021.103444 · Cited by 28
Tissue-Engineered Models of the Human Brain: State-of-the-Art Analysis and Challenges
Tarricone, G., Carmagnola, I., & Chiono, V. (2022) · Journal of Functional Biomaterials · doi:10.3390/jfb13030146 · Cited by 30
Electrospun decellularized extracellular matrix scaffolds promote the regeneration of injured neurons
Mungenast, L., Nieminen, R., Gaiser, C., Faia-Torres, A. B., Rühe, J., & Suter‐Dick, L. (2023) · Biomaterials and Biosystems · doi:10.1016/j.bbiosy.2023.100081 · Cited by 26
Characterization and therapeutic perspectives of differentiation-inducing therapy in malignant tumors
Zhu, K., Xia, Y.-R., Tian, X., He, Y.-C., Zhou, J., Han, R., Guo, H., Song, T., Chen, L., & Tian, X.-D. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1271381 · Cited by 17
Retinoic acid exerts neuroprotective effects against focal cerebral ischemia by preventing apoptotic cell death
Kang, J.-B., Park, D.-J., Shah, M.-A., & Koh, P. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135979 · Cited by 28
Combining phenotypic profiling and targeted RNA-Seq reveals linkages between transcriptional perturbations and chemical effects on cell morphology: Retinoic acid as an example
Nyffeler, J., Willis, C. M., Harris, F. R., Word, L. J., Judson, R., Everett, L. J., & Harrill, J. (2022) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2022.116032 · Cited by 25
Synergy of Nanotopography and Electrical Conductivity of PEDOT/PSS for Enhanced Neuronal Development
Bianchi, M., Guzzo, S., Lunghi, A., Greco, P., Pisciotta, A., Murgia, M., Carnevale, G., Fadiga, L., & Biscarini, F. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c15278 · Cited by 25
Promoting axonal regeneration through exosomes: An update of recent findings on exosomal PTEN and mTOR modifiers
Tang, B. L. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.10.008 · Cited by 26
Methods used to achieve different levels of the neuronal differentiation process in SH‐SY5Y and Neuro2a cell lines: An integrative review
dos Santos, M. G., Gomes, J. R., & Costa, M. D. M. (2023) · Cell Biology International · doi:10.1002/cbin.12093 · Cited by 23
Mouse Neural Stem Cell Differentiation and Human Adipose Mesenchymal Stem Cell Transdifferentiation Into Neuron- and Oligodendrocyte-like Cells With Myelination Potential
Santos, A. K., Gomes, K. N., Parreira, R. C., Scalzo, S., Pinto, M. C. X., Santiago, H. C., Birbrair, A., Sack, U., Ulrich, H., & Resende, R. R. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10218-7 · Cited by 24
Estrogen‐related receptor gamma regulates dopaminergic neuronal phenotype by activating GSK 3β/ NFAT signaling in SH ‐ SY 5Y cells
Lim, J., Choi, H., & Choi, H. J. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13085 · Cited by 23
Developmental neurotoxicity induced by glutaraldehyde in neuron/astrocyte co-cultured cells and zebrafish
Oh, H., Yoo, D., Park, S., Lee, S., & Kim, W. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.113891 · Cited by 22
P2X7 receptor isoform B is a key drug resistance mediator for neuroblastoma
Arnaud-Sampaio, V. F., Bento, C. A., Glaser, T., Adinolfi, E., Ulrich, H., & Lameu, C. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.966404 · Cited by 23
Longitudinal scRNA-seq analysis in mouse and human informs optimization of rapid mouse astrocyte differentiation protocols
Frazel, P. W., Labib, D., Fisher, T., Brosh, R., Pirjanian, N., Marchildon, A. E., Boeke, J. D., Fossati, V., & Liddelow, S. A. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01424-2 · Cited by 24
Nuclear hormone receptors control fundamental processes of human fetal neurodevelopment: Basis for endocrine disruption assessment
Koch, K., Schlüppmann, K., Hüsken, S., Stark, L. M., Förster, N., Masjosthusmann, S., Klose, J., Dönmez, A., & Fritsche, E. (2025) · Environment International · doi:10.1016/j.envint.2025.109400 · Cited by 21
Esrrb is a cell-cycle-dependent associated factor balancing pluripotency and XEN differentiation
Levy, S. H., Cohen, S. F., Arnon, L., Lahav, S., Awawdy, M., Alajem, A., Bavli, D., Sun, X., Buganim, Y., & Ram, O. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.04.016 · Cited by 17
A CYPome-wide study reveals new potential players in the pathogenesis of Parkinson’s disease
Hartz, P., Fehlmann, T., Wagenpfeil, G., Unger, M. M., & Bernhardt, R. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1094265 · Cited by 21
Roles of Retinoic Acid Signaling in Shaping the Neuronal Architecture of the Developing Amphioxus Nervous System
Zieger, E., Candiani, S., Garbarino, G., Croce, J. C., & Schubert, M. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0727-8 · Cited by 20
Nuclear RXRα and RXRβ receptors exert distinct and opposite effects on RA-mediated neuroblastoma differentiation
Girardi, C. S., Rostirolla, D. C., Lini, F. J. M., Brum, P. O., Delgado, J., Ribeiro, C. T., Teixeira, A. A., Peixoto, D. O., Heimfarth, L., Kunzler, A., et al. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.11.014 · Cited by 21
NSC ‐34 motor neuron‐like cells are sensitized to ferroptosis upon differentiation
Martinez, A. M., Mirkovic, J., Stanisz, Z., Patwari, F. S., & Yang, W. S. (2018) · FEBS Open Bio · doi:10.1002/2211-5463.12577 · Cited by 22
Modeling Bainbridge-Ropers Syndrome in Xenopus laevis Embryos
Lichtig, H., Artamonov, A., Polevoy, H., Reid, C. D., Bielas, S. L., & Frank, D. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00075 · Cited by 21
Development of differentiation modulators and targeted agents for treating neuroblastoma
Jin, Z., Lu, Y., Wu, Y., Che, J., & Dong, X. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112818 · Cited by 20
Impact of vitamin deficiency on microbiota composition and immunomodulation: relevance to autistic spectrum disorders
Ribeiro, R., Nicoli, J. R., Santos, G., & dos Santos, J. L. (2019) · Nutritional Neuroscience · doi:10.1080/1028415x.2019.1660485 · Cited by 26
Super-enhancer associated core regulatory circuits mediate susceptibility to retinoic acid in neuroblastoma cells
Gomez, R. L., Woods, L. M., Ramachandran, R., Tayoun, A. N. A., Philpott, A., & Ali, F. R. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.943924 · Cited by 19
RNA Polymerase II transcription independent of TBP in murine embryonic stem cells
Kwan, J. Z. J., Nguyen, T. F., Uzozie, A. C., Budzyński, M. A., Cui, J. H., Lee, J. M., Petegem, F. V., Lange, P. F., & Teves, S. S. (2023) · eLife · doi:10.7554/elife.83810 · Cited by 19
Establishing and maintaining Hox profiles during spinal cord development
Miller, A., & Dasen, J. S. (2023) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2023.03.014 · Cited by 22
Generation of iPSC-derived human forebrain organoids assembling bilateral eye primordia
Gabriel, E., Albanna, W., Pasquini, G., Ramani, A., Josipović, N., Mariappan, A., Riparbelli, M. G., Callaini, G., Karch, C. M. M., Goureau, O., et al. (2023) · Nature Protocols · doi:10.1038/s41596-023-00814-x · Cited by 21
The retinoic acid family-like nuclear receptor SmRAR identified by single-cell transcriptomics of ovarian cells controls oocyte differentiation in Schistosoma mansoni
Moescheid, M. F., Lu, Z., Soria, C. L. D., Quack, T., Puckelwaldt, O., Holroyd, N. E., Holzaepfel, P., Haeberlein, S., Rinaldi, G., Berriman, M., et al. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae1228 · Cited by 21
Retinoic acid attenuates ischemic injury-induced activation of glial cells and inflammatory factors in a rat stroke model
Kang, J.-B., Son, H.-K., Shah, M.-A., & Koh, P. (2024) · PLoS ONE · doi:10.1371/journal.pone.0300072 · Cited by 19
Postnatal Ablation of Synaptic Retinoic Acid Signaling Impairs Cortical Information Processing and Sensory Discrimination in Mice
Park, E., Tjia, M., Zuo, Y., & Chen, L. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.3028-17.2018 · Cited by 18
An optimized method for neuronal differentiation of embryonic stem cells in vitro
Li, Y., Mao, X., Xianyi, Z., Su, Y.-T., Zhou, X., Shi, K., & Zhao, S. (2019) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2019.108486 · Cited by 18
New Insights into the Control of Cell Fate Choices and Differentiation by Retinoic Acid in Cranial, Axial and Caudal Structures
Draut, H., Liebenstein, T., & Begemann, G. (2019) · Biomolecules · doi:10.3390/biom9120860 · Cited by 18
SHANK2 mutations impair apoptosis, proliferation and neurite outgrowth during early neuronal differentiation in SH-SY5Y cells
Unsicker, C., Cristian, F.-B., von Hahn, M., Eckstein, V., Rappold, G., & Berkel, S. (2021) · Scientific Reports · doi:10.1038/s41598-021-81241-4 · Cited by 21
Aligned contiguous microfiber platform enhances neural differentiation of embryonic stem cells
Liu, Z., & Hu, Z. (2018) · Scientific Reports · doi:10.1038/s41598-018-24522-9 · Cited by 19
Role of miR-124 in the regulation of retinoic acid-induced Neuro-2A cell differentiation
You, Q., Dong, S., Han, Y., Pi, R., Du, Y.-J., & Dong, S.-Z. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.270417 · Cited by 18
Effects of all-trans and 9-cis retinoic acid on differentiating human neural stem cells in vitro
Kubíčková, B., Martinkova, S., Bohačiaková, D., Nezvedová, M., Liu, R., Brózman, O., Spáčil, Z., & Hilscherová, K. (2023) · Toxicology · doi:10.1016/j.tox.2023.153461 · Cited by 18
All-Trans Retinoic Acid Induces Expression of a Novel Intergenic Long Noncoding RNA in Adult rat Primary Hippocampal Neurons
Kour, S., & Rath, P. C. (2015) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0671-x · Cited by 18
Retinoic acid signaling and neurogenic niche regulation in the developing peripheral nervous system of the cephalochordate amphioxus
Zieger, E., Garbarino, G., Robert, N. S. M., Yu, J., Croce, J. C., Candiani, S., & Schubert, M. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2734-3 · Cited by 17
Carbachol, along with calcium, indicates new strategy in neural differentiation of human adipose tissue-derived mesenchymal stem cells in vitro
Masoumi, N., Ghollasi, M., Halabian, R., Eftekhari, E., & Ghiasi, M. (2023) · Regenerative Therapy · doi:10.1016/j.reth.2023.04.001 · Cited by 18
Cellular Lipidome Changes during Retinoic Acid (RA)-Induced Differentiation in SH-SY5Y Cells: A Comprehensive In Vitro Model for Assessing Neurotoxicity of Contaminants
Camdzic, M., Aga, D. S., & Atilla‐Gokcumen, G. E. (2023) · Environment & Health · doi:10.1021/envhealth.3c00022 · Cited by 16
Rapid human‐derived iPSC osteogenesis combined with three‐dimensionally printed Ti6Al4V scaffolds for the repair of bone defects
Yu, L., Yong, Y., Zhang, B., Bai, X., Fei, Q., & Zhang, L. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29788 · Cited by 17

Authors: Janesick, A., Wu, S. C., & Blumberg, B.
Affiliations: University of California, Irvine (US)
Corresponding author: Blumberg, Bruce
ORCID: Janesick, Amanda
Wu, Stephanie Cherie
Blumberg, Bruce
Venue: Cellular and Molecular Life Sciences
Publisher: Springer Science and Business Media LLC
Published: 2015-01-06
Volume: 72
Issue: 8
Pages: 1559-1576
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s00018-014-1815-9
PMC: PMC11113123
OpenAlex: W2117145998
Cited by: 295
References: 268
Citations by year: 2026: 15 · 2025: 37 · 2024: 30 · 2023: 36 · 2022: 25 · 2021: 44 · 2020: 31 · 2019: 24 · 2018: 22 · 2017: 16 · 2016: 13 · 2015: 2
FWCI: 2.22
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
Funders: National Science Foundation
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: retinoic acid signaling, neuronal differentiation, primary neurogenesis, retinoic acid receptor, proneural transcription factors, vitamin A deficiency, dedifferentiation, tumor differentiation
MeSH terms: Animals, Antigens, Neoplasm, Antineoplastic Agents, Humans, Neoplasms, Neurons, Tretinoin, Signal Transduction, Receptors, Retinoic Acid, Cell Cycle Proteins, Neurogenesis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Retinoic acid signaling and neuronal differentiation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks