The DOI matches its Crossref record; 261 of the 261 references it cites were found in a registry or an index.
ROS signaling and redox biology in endothelial cells
Open accessAbstract
The purpose of this review is to provide an overview of redox mechanisms, sources and antioxidants that control signaling events in ECs. In particular, we describe which molecules are involved in redox signaling and how they influence the relationship between ECs and other vascular component with regard to angiogenesis. Recent and new tools to investigate physiological ROS signaling will be also discussed. Such findings are providing an overview of the ROS biology relevant for endothelial cells in the context of normal and pathological angiogenic conditions.
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“NOX5 also appears to modulate proliferation and cell migration processes (371, 719).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [719]
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Items 201–261 of 261
Pei, D., Song, Y., Yu, H., Hu, W., Du, Y., & Zhang, G. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05531.x · Cited by 64
Murdoch, C. E., Shuler, M. M., Haeussler, D. J., Kikuchi, R., Bearelly, P., Han, J., Watanabe, Y., Fuster, J. J., Walsh, K. X., Ho, Y.-S., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.517219 · Cited by 64
Langston, W., Chidlow, J. H., Booth, B. A., Barlow, S. C., Lefer, D. J., Patel, R. P., & Kevil, C. G. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.12.010 · Cited by 64
Wang, G., Qian, P., Jackson, F. R., Qian, G., & Wu, G. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.08.008 · Cited by 63
Dai, S., He, Y., Zhang, H., Yu, L., Wan, T., Xu, Z., Jones, D., Chen, H., & Wang, M. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.180349 · Cited by 63
Measuring Glutathione Redox Potential of HIV-1-infected Macrophages
Bhaskar, A., Munshi, M., Khan, S. Z., Fatima, S., Arya, R. S., Jameel, S., & Singh, A. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.588913 · Cited by 62
Catarzi, S., Biagioni, C., Giannoni, E., Favilli, F., Marcucci, T., Iantomasi, T., & VINCENZINI, M. T. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2005.03.004 · Cited by 62
Kaplan, N., Urao, N., Furuta, E., Kim, S.-J., Razvi, M., Nakamura, Y., McKinney, R. D., Poole, L. B., Fukai, T., & Ushio‐Fukai, M. (2011) · Free Radical Research · doi:10.3109/10715762.2011.602073 · Cited by 62
Nitric oxide, S‐Nitrosation, and endothelial permeability
Durán, W. N., Beuve, A. V., & Sánchez, F. A. (2013) · IUBMB Life · doi:10.1002/iub.1204 · Cited by 61
Tao, R., Wang, H., Hong, L.-J., Huang, J.-Y., Lu, Y., Liao, M.-H., Ye, W., Lu, N., Zhu, D.-Y., Huang, Q., et al. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5381 · Cited by 61
Uno, K., Prow, T. W., Bhutto, I. A., Yerrapureddy, A., McLeod, D. S., Yamamoto, M. P., Reddy, S. P., & Lutty, G. A. (2010) · Experimental Eye Research · doi:10.1016/j.exer.2009.12.012 · Cited by 60
Xi, G., Shen, X., Maile, L. A., Wai, C., Gollahon, K. A., & Clemmons, D. R. (2011) · Diabetes · doi:10.2337/db11-0990 · Cited by 60
A Highly Selective Fluorescent Probe for Visualization of Organic Hydroperoxides in Living Cells
Zhao, B. S., Liang, Y., Song, Y., Zheng, C., Hao, Z., & Chen, P. R. (2010) · Journal of the American Chemical Society · doi:10.1021/ja1071114 · Cited by 60
Reactive oxygen species downregulate glucose transport system in retinal endothelial cells
Fernandes, R., Hosoya, K., & Pereira, P. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00140.2010 · Cited by 59
Hellfritsch, J., Kirsch, J., Schneider, M., Fluege, T., Wortmann, M., Frijhoff, J., Dagnell, M., Fey, T., Esposito, I., Kölle, P., et al. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.5889 · Cited by 57
de Moraes, M. S., da Costa, P. E., Batista, W. L., Paschoalin, T., Curcio, M. F., Borges, R. E., Taha, M. O., Fonseca, F. V., Stern, A., & Monteiro, H. P. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.06.011 · Cited by 54
Regulation of cardiovascular cellular processes by S-nitrosylation
Schulman, I. H., & Hare, J. M. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.04.002 · Cited by 52
Targeting the Reversibly Oxidized Protein Tyrosine Phosphatase Superfamily
Boivin, B., Yang, M. W. O., & Tonks, N. K. (2010) · Science Signaling · doi:10.1126/scisignal.3137pl2 · Cited by 51
Interaction of NADPH oxidase 1 with Toll-like receptor 2 induces migration of smooth muscle cells
Lee, J. H., Joo, J. H., Kim, J., Lim, H. J., Kim, S. A., Curtiss, L. K., Seong, J. K., Cui, W., Yabe‐Nishimura, C., & Bae, Y. S. (2013) · Cardiovascular Research · doi:10.1093/cvr/cvt107 · Cited by 51
Abdelsaid, M. A., Matragoon, S., & El‐Remessy, A. B. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4761 · Cited by 50
Visualization of Intracellular Hydrogen Peroxide with HyPer, a Genetically Encoded Fluorescent Probe
Mishina, N. M., Markvicheva, K. N., Bilan, D. S., Matlashov, M. E., Shirmanova, M. V., Liebl, D., Schultz, C., Lukyanov, S., & Belousov, V. V. (2013) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-405883-5.00003-x · Cited by 49
NADPH oxidase 4 promotes cardiac microvascular angiogenesis after hypoxia/reoxygenation in vitro
Wang, J., Hong, Z., Zeng, C., Yu, Q., & Wang, H. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.01.027 · Cited by 48
Pro‐inflammatory angiogenesis is mediated by p38 MAP kinase
Gangaraju, R., Kamocka, M. M., Marin, A., Suckow, M. A., Wolter, W. R., Badve, S., Sanjeevaiah, A. R., Pumiglia, K. M., Rosen, E. D., & Clauss, M. A. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22404 · Cited by 46
Zhuang, J., Jiang, T.-X., Lü, D., Luo, Y., Zheng, C., Feng, J., Yang, D., Chen, C., & Yan, X. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.04.007 · Cited by 46
Li, Q., Fu, G.-B., Zheng, J.-T., He, J., Niu, X.-B., Chen, Q.-D., Yin, Y., Qian, X., Xu, Q., Wang, M., et al. (2013) · Biochimica et Biophysica Acta · doi:10.1016/j.bbamcr.2013.09.018 · Cited by 45
Frijhoff, J., Dagnell, M., Augsten, M., Beltrami, E., Giorgio, M., & Östman, A. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.12.022 · Cited by 43
Kuang, L., Feng, J., He, G., & Jing, T. (2013) · International Journal of Biological Sciences · doi:10.7150/ijbs.5887 · Cited by 43
Dang-li, R., HeKong, W., JiQin, L., Zhang, M., & WenCheng, Z. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-1013-0 · Cited by 43
Dymkowska, D., Drabarek, B., Podszywalow‐Bartnicka, P., Szczepanowska, J., & Zabłocki, K. (2013) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2013.11.008 · Cited by 42
Tipping off endothelial tubes: nitric oxide drives tip cells
Priya, M. K., Sahu, G., Soto‐Pantoja, D. R., Goldy, N., Sundaresan, A. M., Jadhav, V. S., BARATHKUMAR, T. R., Saran, U., Ali, B. M. J., Roberts, D. D., et al. (2014) · Angiogenesis · doi:10.1007/s10456-014-9455-0 · Cited by 42
Pi, X., Xie, L., Portbury, A. L., Kumar, S., Lockyer, P. P., Li, X., & Patterson, C. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.303733 · Cited by 42
Molecular Characterization of Reactive Oxygen Species in Systemic and Pulmonary Hypertension
Zuo, L., Rose, B. A., Roberts, W. J., He, F., & Banes‐Berceli, A. K. L. (2014) · American Journal of Hypertension · doi:10.1093/ajh/hpt292 · Cited by 41
Bretón‐Romero, R., Acín‐Pérez, R., Rodríguez‐Pascual, F., Molledo, M. M., Brandes, R. P., Rial, E., Enríquez, J. A., & Lamas, S. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.07.003 · Cited by 39
Stacey, M. M., Vissers, M. C. M., & Winterbourn, C. C. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4348 · Cited by 39
Go, Y., Son, D. J., Park, H., Orr, M. L., Li, H., Takabe, W., Kumar, S., Kang, D. W., Kim, C. W., Jo, H., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108346 · Cited by 38
Zhou, H., Liu, L., Zhang, Y., Huang, Y., Tao, Y., Zhang, S., Su, J., Tang, Y., Guo, Z., Hu, R., et al. (2013) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12068 · Cited by 37
Tian, J., Hou, Y., Lü, Q., Wiseman, D. A., Fonseca, F. V., Elms, S. C., Fulton, D. J., & Black, S. M. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.03.023 · Cited by 35
Direct Sensing of Endothelial Oxidants by Vascular Endothelial Growth Factor Receptor-2 and c-Src
Lee, M. M., Choy, W. C., & Abid, M. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028454 · Cited by 34
Thioredoxin-Interacting Protein Mediates Nuclear–to–Plasma Membrane Communication
Spindel, O. N., Chen, Y., & Berk, B. C. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.244681 · Cited by 34
Role of Plasma Membrane Caveolae/Lipid Rafts in VEGF-Induced Redox Signaling in Human Leukemia Cells
Caliceti, C., Zambonin, L., Rizzo, B., Fiorentini, D., Sega, F. V. D., Hrelia, S., & Prata, C. (2014) · BioMed Research International · doi:10.1155/2014/857504 · Cited by 32
Mondol, A. S., Tonks, N. K., & Kamata, T. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.11.005 · Cited by 32
Kang, D. H., Lee, D. J., Kim, J., Lee, J. Y., Kim, H., Kwon, K., Taylor, W. R., Jo, H., & Kang, S. W. (2013) · Circulation · doi:10.1161/circulationaha.113.001725 · Cited by 32
Control of angiogenesis dictated by picomolar superoxide levels
Bir, S. C., Shen, X., Kavanagh, T. J., Kevil, C. G., & Pattillo, C. B. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.05.015 · Cited by 30
Speciale, A., Anwar, S., Ricciardi, E., Chirafisi, J., Saija, A., & Cimino, F. (2011) · Toxicology Letters · doi:10.1016/j.toxlet.2011.09.017 · Cited by 30
In Vivo Imaging of H2O2 Production in Drosophila
Barata, A. G., & Dick, T. P. (2013) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-405883-5.00004-1 · Cited by 29
Goy, C., Czypiorski, P., Altschmied, J., Jakob, S., Rabanter, L. L., Brewer, A. C., Ale‐Agha, N., Dyballa‐Rukes, N., Shah, A. M., & Haendeler, J. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.03.005 · Cited by 28
Reactive oxygen species cause endothelial dysfunction in chronic flow overload
Lu, X., Guo, X., Wassall, C. D., Kemple, M. D., Unthank, J. L., & Kassab, G. S. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00786.2009 · Cited by 27
Kalwa, H., Sartoretto, J. L., Martinelli, R., Romero, N., Steinhorn, B. S., Tao, M., Ozaki, C. K., Carman, C. V., & Michel, T. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1320854111 · Cited by 27
Sugiyama, T., & Michel, T. M. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00767.2009 · Cited by 26
Kolossov, V. L., Leslie, M. T., Chatterjee, A., Sheehan, B. M., Kenis, P. J. A., & Gaskins, H. R. (2012) · Experimental Biology and Medicine · doi:10.1258/ebm.2012.011436 · Cited by 25
The role of CD40L and VEGF in the modulation of angiogenesis and inflammation
Chakrabarti, S., Rizvi, M. A., Morin, K. M., Garg, R., & Freedman, J. E. (2010) · Vascular Pharmacology · doi:10.1016/j.vph.2010.05.003 · Cited by 23
Chen, B., Wang, W., Shen, T., & Qi, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076226 · Cited by 22
The Rho GTPase Rac1 is required for recycling endosome-mediated secretion of TNF in macrophages
Stanley, A. C., Wong, C. X., Micaroni, M., Venturato, J., Khromykh, T., Stow, J. L., & Lacy, P. (2014) · Immunology & Cell Biology · doi:10.1038/icb.2013.90 · Cited by 21 · cited 1×
“TNF-a has been shown to both be secreted by endothelial cells and to induce intracellular ROS formation possibly via Rac/ NADPH oxidase [178].”
BackgroundHydrogen Peroxide Signaling Mediator in the Activation of p38 MAPK in Vascular Endothelial Cells
Bretón‐Romero, R., & Lamas, S. (2013) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-405881-1.00003-3 · Cited by 20
Bouzigues, C., Nguyen, T., Ramodiharilafy, R. O., Claeson, A. A., Tharaux, P., & Alexandrou, A. (2014) · Chemistry & Biology · doi:10.1016/j.chembiol.2014.02.020 · Cited by 19
Takagi, Y., Kikuta, K., Moriwaki, T., Aoki, T., Nozaki, K., Hashimoto, N., & Miyamoto, S. (2011) · Surgical Neurology International · doi:10.4103/2152-7806.80356 · Cited by 17
Abraham, B. G., Santala, V. P., Tkachenko, N. V., & Karp, M. T. (2014) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-014-8165-1 · Cited by 16
Tsirmoula, S., Λάμπρου, Μ., Hatziapostolou, M., Kieffer, N., & Papadimitriou, Ε. (2015) · Microvascular Research · doi:10.1016/j.mvr.2015.01.001 · Cited by 14
Burgoyne, J. R., & Eaton, P. (2013) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-405881-1.00007-0 · Cited by 13
In Vivo Imaging of Nitric Oxide and Hydrogen Peroxide in Cardiac Myocytes
Sartoretto, J. L., Kalwa, H., Romero, N., & Michel, T. M. (2013) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-405881-1.00004-5 · Cited by 7
Zhao, B. S., Zhang, G., Zeng, S., He, C., & Chen, P. R. (2013) · Integrative Biology · doi:10.1039/c3ib40209f · Cited by 5
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Metadata
- Authors
- Panieri, E., & Santoro, M. M.
- Affiliations
- University of Turin (IT)
- Vlaams Instituut voor Biotechnologie (BE)
- Corresponding author
- Santoro, Massimo M.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2015-05-14
- Volume
- 72
- Issue
- 17
- Pages
- 3281-3303
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC11113497
- OpenAlex
- W347357337
- Cited by
- 168
- References
- 261
- Citations by year
- 2026: 21 · 2025: 10 · 2024: 9 · 2023: 17 · 2022: 13 · 2021: 17 · 2020: 15 · 2019: 15 · 2018: 14 · 2017: 14 · 2016: 20 · 2015: 2
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Funders
- Fondazione Telethon (GGP10195)
- European Research Council (CoG - 647057)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- reactive oxygen species, redox signaling, endothelial cells, antioxidants, angiogenesis, oxidative stress, vascular component
- MeSH terms
- Animals, Humans, Mitochondria, Oxidation-Reduction, Signal Transduction, Protein Tyrosine Phosphatases, Reactive Oxygen Species, Neovascularization, Physiologic, NADPH Oxidases, Endothelial Cells
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