Cited by 168Redox biology and oxidative stressNitric Oxide and Endothelin EffectsAngiogenesis and VEGF in Cancer

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ROS signaling and redox biology in endothelial cells

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Panieri, Emiliano, Santoro, Massimo M.·2015·Cellular and Molecular Life Sciences

DOI 10.1007/s00018-015-1928-9PMC PMC11113497

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Abstract

The purpose of this review is to provide an overview of redox mechanisms, sources and antioxidants that control signaling events in ECs. In particular, we describe which molecules are involved in redox signaling and how they influence the relationship between ECs and other vascular component with regard to angiogenesis. Recent and new tools to investigate physiological ROS signaling will be also discussed. Such findings are providing an overview of the ROS biology relevant for endothelial cells in the context of normal and pathological angiogenic conditions.

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Authors: Panieri, E., & Santoro, M. M.
Affiliations: University of Turin (IT)
Vlaams Instituut voor Biotechnologie (BE)
Corresponding author: Santoro, Massimo M.
ORCID: Panieri, Emiliano
Santoro, Massimo M.
Venue: Cellular and Molecular Life Sciences
Publisher: Springer Science and Business Media LLC
Published: 2015-05-14
Volume: 72
Issue: 17
Pages: 3281-3303
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s00018-015-1928-9
PMC: PMC11113497
OpenAlex: W347357337
Cited by: 168
References: 261
Citations by year: 2026: 21 · 2025: 10 · 2024: 9 · 2023: 17 · 2022: 13 · 2021: 17 · 2020: 15 · 2019: 15 · 2018: 14 · 2017: 14 · 2016: 20 · 2015: 2
FWCI: 1.61
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
Padua Research Archive (University of Padova) (submittedVersion)
Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
Funders: Fondazione Telethon (GGP10195)
European Research Council (CoG - 647057)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords: reactive oxygen species, redox signaling, endothelial cells, antioxidants, angiogenesis, oxidative stress, vascular component
MeSH terms: Animals, Humans, Mitochondria, Oxidation-Reduction, Signal Transduction, Protein Tyrosine Phosphatases, Reactive Oxygen Species, Neovascularization, Physiologic, NADPH Oxidases, Endothelial Cells

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