MUC1 (CD227): a multi-tasked molecule

Essentials of Glycobiology

Varki, A. P., Cummings, R. D., Esko, J. D., Freeze, H. H., Stanley, P., Bertozzi, C. R., Hart, G. W., & Etzler, M. E. (1999) · Cited by 2,384

Mucins in cancer: function, prognosis and therapy

Kufe, D. W. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2761 · Cited by 1,433

Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin.

Gendler, S. J., Lancaster, C. A., Taylor‐Papadimitriou, J., Duhig, T., Peat, N., Burchell, J., Pemberton, L. F., Lalani, E., & Wilson, D. B. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77254-2 · Cited by 976

MUC1: a multifaceted oncoprotein with a key role in cancer progression

Nath, S., & Mukherjee, P. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.02.007 · Cited by 867

Monoclonal antibodies to epithelium‐specific components of the human milk fat globule membrane: Production and reaction with cells in culture

Taylor‐Papadimitriou, J., Peterson, J. A., Arklie, J., et al. (1981) · International Journal of Cancer · doi:10.1002/ijc.2910280104 · Cited by 603

Identification of the gastrointestinal and pancreatic cancer-associated antigen detected by monoclonal antibody 19-9 in the sera of patients as a mucin.

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Differential Reactivity of a Novel Monoclonal Antibody (DF3) with Human Malignant versus Benign Breast Tumors

Kufe, D. W., Inghirami, G., Abe, M., et al. (1984) · Hybridoma · doi:10.1089/hyb.1984.3.223 · Cited by 578

MUC1, The Renaissance Molecule

Gendler, S. J. (2001) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1011379725811 · Cited by 553

Expression of Tn, sialosyl-Tn, and T antigens in human colon cancer.

Itzkowitz, S., Yuan, M., Montgomery, C. K., Kjeldsen, T., Takahashi, H., Bigbee, W. L., & Kim, Y. S. (1989) · PubMed · Cited by 511

Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components.

Wesseling, J., van der Valk, S. W., Vos, H. L., et al. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.129.1.255 · Cited by 495

Monoclonal antibodies against human milk‐fat globule membranes detecting differentiation antigens of the mammary gland and its tumors

Hilkens, J., Buijs, F., Hilgers, J., et al. (1984) · International Journal of Cancer · doi:10.1002/ijc.2910340210 · Cited by 492

Development and characterization of breast cancer reactive monoclonal antibodies directed to the core protein of the human milk mucin.

Burchell, J., Gendler, S. J., Taylor‐Papadimitriou, J., et al. (1987) · PubMed · Cited by 477

Cell membrane-associated mucins and their adhesion-modulating property

Hilkens, J., Ligtenberg, M. J. L., Vos, H. L., & Litvinov, S. V. (1992) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(92)90315-z · Cited by 453

MUC1-C oncoprotein as a target in breast cancer: activation of signaling pathways and therapeutic approaches

Kufe, D. W. (2012) · Oncogene · doi:10.1038/onc.2012.158 · Cited by 452

Cloning and sequencing of a human pancreatic tumor mucin cDNA.

Lan, M. S., Batra, S. K., Qi, W., et al. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77255-4 · Cited by 437

MUC1 cell surface mucin is a critical element of the mucosal barrier to infection

McAuley, J., Lindén, S. K., Png, C. W., King, R. M., Pennington, H. L., Gendler, S. J., Florin, T. H., Hill, G. R., Korolik, V., & McGuckin, M. A. (2007) · Journal of Clinical Investigation · doi:10.1172/jci26705 · Cited by 437

Cell surface-associated mucins in signal transduction.

Singh, P., & Hollingsworth, M. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.07.006 · Cited by 434

Episialin, a carcinoma-associated mucin, is generated by a polymorphic gene encoding splice variants with alternative amino termini.

Ligtenberg, M. J., Vos, H. L., Gennissen, A. M. C., & Hilkens, J. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39399-8 · Cited by 369

Human milk mucin inhibits rotavirus replication and prevents experimental gastroenteritis.

Yolken, R. H., Peterson, J. A., Vonderfecht, S. L., Fouts, E. T., Midthun, K., & Newburg, D. S. (1992) · Journal of Clinical Investigation · doi:10.1172/jci116078 · Cited by 346

Differentiation antigens expressed by epithelial cells in the lactating breast are also detectable in breast cancers

Arklie, J., Taylor‐Papadimitriou, J., Bodmer, W. F., et al. (1981) · International Journal of Cancer · doi:10.1002/ijc.2910280105 · Cited by 330

Human Endometrial Mucin MUC1 Is Up-Regulated by Progesterone and Down-Regulated In Vitro by the Human Blastocyst1

Meseguer, M., Aplin, J., Caballero-Campo, P., et al. (2001) · Biology of Reproduction · doi:10.1095/biolreprod64.2.590 · Cited by 327

Suppression of cellular aggregation by high levels of episialin.

Ligtenberg, M. J. L., Buijs, F., Vos, H. L., et al. (1992) · PubMed · Cited by 321

MUC1: A multifunctional cell surface component of reproductive tissue epithelia

Brayman, M. J., Thathiah, A., & Carson, D. D. (2004) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-2-4 · Cited by 313

Isolation and sequencing of a cDNA coding for the human DF3 breast carcinoma-associated antigen.

Siddiqui, J., Abe, M., Hayes, D. F., et al. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.7.2320 · Cited by 312

Interaction of the DF3/MUC1 Breast Carcinoma-associated Antigen and β-Catenin in Cell Adhesion

Yamamoto, M., Bharti, A. K., Li, Y., & Kufe, D. W. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.19.12492 · Cited by 308

Cloning of partial cDNA encoding differentiation and tumor-associated mucin glycoproteins expressed by human mammary epithelium.

Gendler, S. J., Burchell, J., Duhig, T., et al. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.17.6060 · Cited by 290

Cell-associated episialin is a complex containing two proteins derived from a common precursor.

Ligtenberg, M. J. L., Kruijshaar, L., Buijs, F., et al. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42677-4 · Cited by 278

Therapeutic vaccination with TG4010 and first-line chemotherapy in advanced non-small-cell lung cancer: a controlled phase 2B trial

Quoix, É., Ramlau, R., Westeel, V., Pápai, Z., Madroszyk, A., Riviere, A., Koralewski, P., Breton, J.-L., Stoelben, E., Braun, D., et al. (2011) · The Lancet Oncology · doi:10.1016/s1470-2045(11)70259-5 · Cited by 269

Antibody and T cell responses of patients with adenocarcinoma immunized with mannan-MUC1 fusion protein.

Karanikas, V., Hwang, L.-A., Pearson, J. M., et al. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119825 · Cited by 268

Human epithelial tumor antigen cDNA sequences

Wreschner, D. H., Hareuveni, M., Tsarfaty, I., et al. (1990) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1990.tb15511.x · Cited by 245

Mucin Dynamics in Intestinal Bacterial Infection

Lindén, S. K., Florin, T. H., & McGuckin, M. A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003952 · Cited by 242

A short sequence, within the amino acid tandem repeat of a cancer‐associated mucin, contains immunodominant epitopes

Burchell, J., Taylor‐Papadimitriou, J., Boshell, M., Gendler, S. J., & Duhig, T. (1989) · International Journal of Cancer · doi:10.1002/ijc.2910440423 · Cited by 230

MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer

Chaika, N. V., Gebregiworgis, T., Lewallen, M. E., Purohit, V., Radhakrishnan, P., Liu, X., Zhang, B., Mehla, K., Brown, R. B., Caffrey, T. C., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203339109 · Cited by 228

Molecular cloning and analysis of the mouse homologue of the tumor-associated mucin, MUC1, reveals conservation of potential O-glycosylation sites, transmembrane, and cytoplasmic domains and a loss of minisatellite-like polymorphism

Spicer, A. P., Parry, G., Patton, S., et al. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98592-3 · Cited by 226

a Totally Synthetic, Self-Assembling, Adjuvant-Free MUC1 Glycopeptide Vaccine for Cancer Therapy

Huang, Z., Shi, L., Ma, J.-W., Sun, Z., Cai, H., Chen, Y., Zhao, Y., & Li, Y. (2012) · Journal of the American Chemical Society · doi:10.1021/ja211725s · Cited by 225

MCF7 Side Population Cells with Characteristics of Cancer Stem/Progenitor Cells Express the Tumor Antigen MUC1

Engelmann, K., Shen, H., & Finn, O. J. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2249 · Cited by 217

Initial clinical evaluation of an immunoradiometric assay for CA 19‐9 using the nci serum bank

Ritts, R. E., Villano, B. C. D., Go, V. L. W., Herberman, R. B., Klug, T. L., & Zurawski, V. R. (1984) · International Journal of Cancer · doi:10.1002/ijc.2910330310 · Cited by 209

Interaction between circulating galectin-3 and cancer-associated MUC1 enhances tumour cell homotypic aggregation and prevents anoikis

Zhao, Q., Barclay, M., Hilkens, J., Guo, X., Barrow, H., Rhodes, J. M., & Yu, L. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-154 · Cited by 207

The MUC1 SEA Module Is a Self-cleaving Domain

Levitin, F., Stern, O., Weiss, M., Gil-Henn, C., Ziv, R., Prokocimer, Z., Smorodinsky, N. I., Rubinstein, D. B., & Wreschner, D. H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506047200 · Cited by 204

Adhesion Receptors as Regulators of the Hematopoietic Process

Verfaillie, C. M. (1998) · Blood · doi:10.1182/blood.v92.8.2609 · Cited by 200

The epithelial tumor antigen MUC1 is expressed in hematological malignancies and is recognized by MUC1-specific cytotoxic T-lymphocytes.

Brossart, P., Schneider, A., Dill, P. E., Schammann, T., Grünebach, F., Wirths, S., Kanz, L., Bühring, H., & Brugger, W. (2001) · PubMed · Cited by 200

Structure and Biology of a Carcinoma-associated Mucin, MUC1

Gendler, S. J., Spicer, A. P., Lalani, E., et al. (1991) · American Review of Respiratory Disease · doi:10.1164/ajrccm/144.3_pt_2.s42 · Cited by 194

Oxidative/reductive conjugation of mannan to antigen selects for T1 or T2 immune responses.

Apostolopoulos, V., Pietersz, G. A., Loveland, B. E., Sandrin, M. S., & McKenzie, I. F. C. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.22.10128 · Cited by 189

Dependence on the MUC1-C Oncoprotein in Non–Small Cell Lung Cancer Cells

Raina, D. B., Kosugi, M., Ahmad, R., Panchamoorthy, G., Rajabi, H. N., Alam, M., Shimamura, T., Shapiro, G. I., Supko, J. G., Kharbanda, S. M., et al. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-10-1050 · Cited by 185

The MUC1 and Galectin-3 Oncoproteins Function in a MicroRNA-Dependent Regulatory Loop

Ramasamy, S., Duraisamy, S., Barbashov, S. F., Kawano, T., Kharbanda, S. M., & Kufe, D. W. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.031 · Cited by 181

Serum Galectin-2, -4, and -8 Are Greatly Increased in Colon and Breast Cancer Patients and Promote Cancer Cell Adhesion to Blood Vascular Endothelium

Barrow, H., Guo, X., Wandall, H. H., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-1462 · Cited by 181

Inhibition of adhesion of S-fimbriated Escherichia coli to buccal epithelial cells by human milk fat globule membrane components: a novel aspect of the protective function of mucins in the nonimmunoglobulin fraction

Schroten, H., Hanisch, F. G., Plogmann, R., Hacker, J. H., Uhlenbruck, G., Nobis‐Bosch, R., & Wahn, V. (1992) · Infection and Immunity · doi:10.1128/iai.60.7.2893-2899.1992 · Cited by 180

Identification ofPseudomonas aeruginosaflagellin as an adhesin for Muc1 mucin

Lillehoj, E. P., Kim, B. T., & Kim, K. C. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00383.2001 · Cited by 180

KL-6, a Human MUC1 Mucin, Is Chemotactic for Human Fibroblasts

Hirasawa, Y., Kohno, N., Yokoyama, A., Inoue, Y., Abe, M., & Hiwada, K. (1997) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.17.4.2253 · Cited by 179

Human MUC1 Carcinoma Antigen Regulates Intracellular Oxidant Levels and the Apoptotic Response to Oxidative Stress

Yin, L., Li, Y., Ren, J., Kuwahara, H., & Kufe, D. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301987200 · Cited by 175

Circulating Galectin-3 Promotes Metastasis by Modifying MUC1 Localization on Cancer Cell Surface

Zhao, Q., Guo, X., Nash, G. B., Stone, P. C., Hilkens, J., Rhodes, J. M., & Yu, L. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1096 · Cited by 174

MUC1 Mucin Is a Negative Regulator of Toll-Like Receptor Signaling

Ueno, K., Koga, T., Kato, K., Golenbock, D. T., Gendler, S. J., Kai, H., & Kim, K. C. (2007) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0336rc · Cited by 172

The Mechanism of Unresponsiveness to Circulating Tumor Antigen MUC1 Is a Block in Intracellular Sorting and Processing by Dendritic Cells

Hiltbold, E. M., Vlad, A., Ciborowski, P. S., Watkins, S. C., & Finn, O. J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.7.3730 · Cited by 167

Mucins in the pathogenesis of breast cancer: Implications in diagnosis, prognosis and therapy

Mukhopadhyay, P., Chakraborty, S., Ponnusamy, M. P., et al. (2011) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2011.01.001 · Cited by 166

Serum sialyl Tn as an independent predictor of poor prognosis in patients with epithelial ovarian cancer.

Kobayashi, H., Terao, T., & Kawashima, Y. (1992) · Journal of Clinical Oncology · doi:10.1200/jco.1992.10.1.95 · Cited by 162

High Density O-Glycosylation on Tandem Repeat Peptide from Secretory MUC1 of T47D Breast Cancer Cells

Müller, S., Alving, K., Peter‐Katalinić, J., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.26.18165 · Cited by 160

The C-type lectin MGL expressed by dendritic cells detects glycan changes on MUC1 in colon carcinoma

Saeland, E., van Vliet, S. J., Bäckström, M., van den Berg, V. C. M., Geijtenbeek, T. B. H., Meijer, G. A., & van Kooyk, Y. (2006) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-006-0274-z · Cited by 156

Expression of MUC1 mucin on activated human T cells: implications for a role of MUC1 in normal immune regulation.

Agrawal, B., Krantz, M. J., Parker, J., et al. (1998) · PubMed · Cited by 154

MUC1/episialin: a critical barrier in the female reproductive tract

DeSouza, M. M., Surveyor, G. A., Price, R. E., et al. (2000) · Journal of Reproductive Immunology · doi:10.1016/s0165-0378(99)00046-7 · Cited by 153

Tyrosine phosphorylation of the MUC1 breast cancer membrane proteins Cytokine receptor‐like molecules

Zrihan‐Licht, S., Baruch, A., Elroy‐Stein, O., et al. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)01251-2 · Cited by 153

Macrophage–tumour cell interactions: identification of MUC1 on breast cancer cells as a potential counter‐receptor for the macrophage‐restricted receptor, sialoadhesin

Nath, Hartnell, Happerfield, et al. (1999) · Immunology · doi:10.1046/j.1365-2567.1999.00827.x · Cited by 146

Direct Targeting of the Mucin 1 Oncoprotein Blocks Survival and Tumorigenicity of Human Breast Carcinoma Cells

Raina, D. B., Ahmad, R., Joshi, M. D., Li, Y., Wu, Z., Kawano, T., Vasir, B., Avigan, D., Kharbanda, S. M., & Kufe, D. W. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0854 · Cited by 145

CA 15–3: A Prognostic Marker in Breast Cancer

Duffy, M. J., Shering, S. G., Sherry, F., McDermott, E. W. M., & O’Higgins, N. J. (2000) · The International Journal of Biological Markers · doi:10.1177/172460080001500410 · Cited by 142

Inhibition of gastric mucin synthesis by Helicobacter pylori

Byrd, J. C., Yunker, C. K., Xu, Q., Sternberg, L. R., & Bresalier, R. S. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70360-x · Cited by 141

Induction of HLA-A2-restricted CTLs to the mucin 1 human breast cancer antigen

Apostolopoulos, V., Karanikas, V., Haurum, J. S., et al. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.11.5211 · Cited by 138

Contribution of the MUC1 tandem repeat and cytoplasmic tail to invasive and metastatic properties of a pancreatic cancer cell line.

Kohlgraf, K. G., Gawron, A. J., Higashi, M., et al. (2003) · PubMed · Cited by 138

Cutting Edge: Enhanced Pulmonary Clearance of Pseudomonas aeruginosa by Muc1 Knockout Mice

Lu, W., Hisatsune, A., Koga, T., Kato, K., Kuwahara, I., Lillehoj, E. P., Chen, W. H., Cross, A. S., Gendler, S. J., Gewirtz, A. T., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.7.3890 · Cited by 137

Recombinant MUC1 Probe Authentically Reflects Cell-specific O-Glycosylation Profiles of Endogenous Breast Cancer Mucin

Müller, S., & Hanisch, F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202921200 · Cited by 136

Cellular Mucins: Targets for Immunotherapy

Apostolopoulos, V., & McKenzie, I. F. C. (2017) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v37.i2-6.110 · Cited by 134

Immunological and structural features of the protein core of human polymorphic epithelial mucin

Price, M. R., Hudecz, F., O'Sullivan, C., et al. (1990) · Molecular Immunology · doi:10.1016/0161-5890(90)90089-i · Cited by 131

Muc-1 Core Protein Is Expressed on Multiple Myeloma Cells and Is Induced by Dexamethasone

Treon, S. P., Mollick, J. A., Urashima, M., et al. (1999) · Blood · doi:10.1182/blood.v93.4.1287 · Cited by 125

Expression of MUC-1 Epitopes on Normal Bone Marrow: Implications for the Detection of Micrometastatic Tumor Cells

Brugger, W., Bühring, H., Grünebach, F., et al. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.5.1535 · Cited by 125

Biophysical characterization of one-, two-, and three-tandem repeats of human mucin (muc-1) protein core.

Fontenot, J. D., Tjandra, N., Bu, D., et al. (1993) · PubMed · Cited by 124

Aberrant RNA splicing and its functional consequences in cancer cells

Fackenthal, J. D., & Godley, L. A. (2008) · Disease Models & Mechanisms · doi:10.1242/dmm.000331 · Cited by 122

MUC1-induced alterations in a lipid metabolic gene network predict response of human breast cancers to tamoxifen treatment

Pitroda, S. P., Khodarev, N. N., Beckett, M. A., Kufe, D. W., & Weichselbaum, R. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812029106 · Cited by 121

MUC1 Is a Counter-Receptor for Myelin-Associated Glycoprotein (Siglec-4a) and Their Interaction Contributes to Adhesion in Pancreatic Cancer Perineural Invasion

Swanson, B. J., McDermott, K. M., Singh, P. K., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2483 · Cited by 120

The breast cancer-associated MUC1 gene generates both a receptor and its cognate binding protein.

Baruch, A., Hartmann, M.-L., Yoeli, M., et al. (1999) · PubMed · Cited by 118

Generation of ligand‐receptor alliances by “SEA” module‐mediated cleavage of membrane‐associated mucin proteins

Wreschner, D. H., McGuckin, M. A., Williams, S. J., Baruch, A., Yoeli-Lerner, M., Ziv, R., Okun, L., Zaretsky, J. Z., Smorodinsky, N. I., Keydar, I., et al. (2002) · Protein Science · doi:10.1110/ps.16502 · Cited by 116

Abnormalities in Mucin Gene Expression in Crohnʼs Disease

Buisine, M., Desreumaux, P., Debailleul, V., Gambiez, L. P., Geboes, K., Ectors, N., Delescaut, M.-P., Degand, P., Aubert, J., Colombel, J., et al. (1999) · Inflammatory Bowel Diseases · doi:10.1097/00054725-199902000-00004 · Cited by 115

RNA Interference Suppression of MUC1 Reduces the Growth Rate and Metastatic Phenotype of Human Pancreatic Cancer Cells

Tsutsumida, H., Swanson, B. J., Singh, P. K., Caffrey, T. C., Kitajima, S., Goto, M., Yonezawa, S., & Hollingsworth, M. A. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1197 · Cited by 115

Ocular Mucin Gene Expression Levels as Biomarkers for the Diagnosis of Dry Eye Syndrome

Corrales, R. M., Narayanan, S., Fernández, I., et al. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-7655 · Cited by 110

Altered expression and allelic association of the hypervariable membrane mucin MUC1 in Helicobacter pylori gastritis

Vinall, L. E., King, M., Novelli, M. R., Green, C. A., Daniels, G. L., Hilkens, J., Sarner, M., & Swallow, D. M. (2002) · Gastroenterology · doi:10.1053/gast.2002.34157 · Cited by 110

Monoclonal antibodies reactive with mucin expressed in breast cancer

Xing, P., Tjandra, J. J., Stacker, S. A., et al. (1989) · Immunology and Cell Biology · doi:10.1038/icb.1989.29 · Cited by 110

Cellular Mucins: Targets for Immunotherapy

Apostolopoulos, V., & McKenzie, I. F. C. (1994) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v14.i3-4.40 · Cited by 108

Human Tumor Antigen MUC1 Is Chemotactic for Immature Dendritic Cells and Elicits Maturation but Does Not Promote Th1 Type Immunity

Carlos, C. A., Dong, H., Howard, O. M. Z., Oppenheim, J. J., Hanisch, F., & Finn, O. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.3.1628 · Cited by 105

Release of Membrane-Associated Mucins from Ocular Surface Epithelia

Blalock, T. D., Spurr-Michaud, S. J., Tisdale, A. S., & Gipson, I. K. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-1081 · Cited by 105

Galectin-3 regulates MUC1 and EGFR cellular distribution and EGFR downstream pathways in pancreatic cancer cells

Merlin, J., Stechly, L., de Beauce, S., Monté, D., Leteurtre, E., SEUNINGEN, I. V., Huet, G., & Pigny, P. (2011) · Oncogene · doi:10.1038/onc.2010.631 · Cited by 105

Structure, Function and Gene Expression of Epithelial Mucins

Seregni, E. C., Botti, C., Massaron, S., Lombardo, C., Capobianco, A. M. L., Bogni, A., & Bombardieri, E. (1997) · Tumori Journal · doi:10.1177/030089169708300301 · Cited by 103

Inhibition of the MUC1-C oncoprotein induces multiple myeloma cell death by down-regulating TIGAR expression and depleting NADPH

Yin, L., Kosugi, M., & Kufe, D. W. (2011) · Blood · doi:10.1182/blood-2011-07-369686 · Cited by 97

Report on the first international workshop on carcinoma‐associated mucins

Taylor‐Papadimitriou, J. (1991) · International Journal of Cancer · doi:10.1002/ijc.2910490102 · Cited by 97

The Cytoplasmic Tail of MUC1: A Very Busy Place

Carson, D. D. (2008) · Science Signaling · doi:10.1126/scisignal.127pe35 · Cited by 97

Bovine Muc1 inhibits binding of enteric bacteria to Caco-2 cells

Parker, P., Sando, L., Pearson, R., Kongsuwan, K., Tellam, R., & Smith, S. C. (2009) · Glycoconjugate Journal · doi:10.1007/s10719-009-9269-2 · Cited by 96

Bacterial conjunctivitis in Muc1 null mice.

Kardon, R., Price, R. E., Julian, J. A., et al. (1999) · PubMed · Cited by 95

Recombinant Tumor-Associated MUC1 Glycoprotein Impairs the Differentiation and Function of Dendritic Cells

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Progression of Pancreatic Adenocarcinoma Is Significantly Impeded with a Combination of Vaccine and COX-2 Inhibition

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Regulated expression of MUC1 epithelial antigen in erythropoiesis

Rughetti, A., Biffoni, M., Pierelli, L., et al. (2003) · British Journal of Haematology · doi:10.1046/j.1365-2141.2003.04038.x · Cited by 25

Targeting the Intracellular MUC1 C-terminal Domain Inhibits Proliferation and Estrogen Receptor Transcriptional Activity in Lung Adenocarcinoma Cells

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MUC1-positive circulating tumor cells and MUC1 protein predict chemotherapeutic efficacy in the treatment of metastatic breast cancer

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Altered glycosylation of mucin glycoproteins in colonic neoplasia

Kim, Y. S. (1992) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240501117 · Cited by 24

Detection of mammary serum antigen in sera from breast cancer patients using monoclonal antibody 3E1.2.

Stacker, S. A., Thompson, C. H., Sacks, N. P. M., et al. (1988) · PubMed · Cited by 22

Terminal differentiation of chronic myelogenous leukemia cells is induced by targeting of the MUC1-C oncoprotein

Li, Y., Ahmad, R., Kosugi, M., Kawano, T., Avigan, D., Stone, R. M., Kharbanda, S. M., & Kufe, D. W. (2010) · Cancer Biology & Therapy · doi:10.4161/cbt.10.5.12584 · Cited by 22

MUC1-C Oncoprotein Blocks Terminal Differentiation of Chronic Myelogenous Leukemia Cells by a ROS-Mediated Mechanism

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Smart nanoparticles for cancer therapy

Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073

Diagnosis and management of resistant hypertension: state of the art

Wei, F.-F., Zhang, Z.-Y., Huang, Q.-F., & Staessen, J. A. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0006-6 · Cited by 39

The influence of luteolin on expression of epithelial MUC1 mucin in human skin fibroblasts

Wosek, J., Radziejewska, I., & Andrulewicz, E. (2016) · Progress in Health Sciences · doi:10.5604/01.3001.0009.5050

Expression of Different Glycoforms of Membrane Mucin(MUC1) and Secretory Mucin (MUC2, MUC5AC and MUC6) in Pancreatic Neoplasms

Horinouchi, M., Nagata, K., Nakamura, A., et al. (2003) · ACTA HISTOCHEMICA ET CYTOCHEMICA · doi:10.1267/ahc.36.443 · Cited by 45

Role of epithelial mucins during airway infection

Kim, K. C. (2011) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2011.12.003 · Cited by 94

Mucins of the eye

Uebermuth, C. (1999) · Der Ophthalmologe · doi:10.1007/s003470050453 · Cited by 1

Mucin genes have different expression patterns in healthy and diseased upper airway mucosa

Martínez‐Antón, A., DeBolós, C., Garrido, M., Roca‐Ferrer, J., Barranco, C., Alobid, I., Xaubet, A., Picado, C., & Mullol, J. (2006) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2006.02451.x · Cited by 109