The DOI matches its Crossref record; 241 of the 241 references it cites were found in a registry or an index.
MUC1 (CD227): a multi-tasked molecule
Open accessAbstract
Mucin 1 (MUC1 [CD227]) is a high-molecular weight (>400 kDa), type I membrane-tethered glycoprotein that is expressed on epithelial cells and extends far above the glycocalyx. MUC1 is overexpressed and aberrantly glycosylated in adenocarcinomas and in hematological malignancies. As a result, MUC1 has been a target for tumor immunotherapeutic studies in mice and in humans. MUC1 has been shown to have anti-adhesive and immunosuppressive properties, protects against infections, and is involved in the oncogenic process as well as in cell signaling. In addition, MUC1 plays a key role in the reproductive tract, in the immune system (affecting dendritic cells, monocytes, T cells, and B cells), and in chronic inflammatory diseases. Evidence for all of these roles for MUC1 is discussed herein and demonstrates that MUC1 is truly a multitasked molecule.
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“MUC1 is a mucin glycoprotein overexpressed on some adenocarcinoma cells and is considered an important tumor surface marker, especially breast cancer. It has been used as a potential target for the treatment of breast cancer.250,251”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [250]
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Metadata
- Authors
- Apostolopoulos, V., Stojanovska, L., & Gargosky, S. E.
- Affiliations
- Victoria University (AU)
- Corresponding author
- Apostolopoulos, Vasso
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2015-08-21
- Volume
- 72
- Issue
- 23
- Pages
- 4475-4500
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC11113675
- OpenAlex
- W1199355021
- Cited by
- 138
- References
- 241
- Citations by year
- 2026: 13 · 2025: 18 · 2024: 18 · 2023: 11 · 2022: 9 · 2021: 12 · 2020: 15 · 2019: 10 · 2018: 16 · 2017: 9 · 2016: 6
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Victoria University Research Repository (Victoria University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- MUC1, mucin 1, aberrant glycosylation, cancer immunotherapy, immunosuppression, infection control, carcinogenesis, signal transduction, reproductive tract, dendritic cells, monocytes, T cells, B cells, chronic inflammatory diseases
- MeSH terms
- Amino Acid Sequence, Animals, Cell Communication, Epithelial Cells, Female, Gene Expression Regulation, Humans, Immunotherapy, Leukocytes, Male, Molecular Sequence Data, Pregnancy, Alternative Splicing, Mucin-1, Protein Isoforms, Mice, Host-Pathogen Interactions
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