Stress-activated cap’n’collar transcription factors in aging and human disease

Staging of brain pathology related to sporadic Parkinson’s disease

Braak, H., Tredici, K. D., Rüb, U., de Vos, R. A. I., Jansen Steur, E. N. H., & Braak, E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00065-9 · Cited by 10,777 · see citing works

Aging: a theory based on free radical and radiation chemistry

Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works

Oxidative stress: oxidants and antioxidants

Sies, H. (1997) · Experimental Physiology · doi:10.1113/expphysiol.1997.sp004024 · Cited by 4,577 · see citing works

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999 · see citing works

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development · doi:10.1101/gad.13.1.76 · Cited by 3,634 · see citing works

Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway

Kensler, T. W., Wakabayashi, N., & Biswal, S. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.46.120604.141046 · Cited by 3,630 · see citing works

Targeting the KEAP1-NRF2 system to prevent kidney disease progression

Nezu, M., Suzuki, N., & Yamamoto, M. (2017) · American Journal of Nephrology · doi:10.1159/000475890 · Cited by 3,447 · see citing works

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

Bjørkøy, G., Lamark, T., Brech, A., Outzen, H., Perander, M., Øvervatn, A., Stenmark, H., & Johansen, T. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200507002 · Cited by 3,276 · see citing works

Oxidative Stress, Caloric Restriction, and Aging

Sohal, R. S., & Weindruch, R. H. (1996) · Science · doi:10.1126/science.273.5271.59 · Cited by 3,133 · see citing works

Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism

Bonifati, V., Rizzu, P., van Baren, M. J., Schaap, O., Breedveld, G. J., Krieger, E., Dekker, M. C. J., Squitieri, F., Ibáñez, P., Joosse, M., et al. (2003) · Science · doi:10.1126/science.1077209 · Cited by 2,800 · see citing works

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Kobayashi, A., Kang, M.-I., Okawa, H., Ohtsuji, M., Zenke, Y., Chiba, T., Igarashi, K., & Yamamoto, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.16.7130-7139.2004 · Cited by 2,224 · see citing works

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.

Komatsu, M., Waguri, S., Koike, M., Sou, Y.-S., Ueno, T., Hara, T., Mizushima, N., Iwata, J.-I., Ezaki, J., Murata, S., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.035 · Cited by 2,124 · see citing works

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Géloën, A., Even, P. C., Cervera, P., & Le Bouc, Y. (2003) · Nature · doi:10.1038/nature01298 · Cited by 2,109 · see citing works

Global burden of COPD: risk factors, prevalence, and future trends

Mannino, D. M., & Buist, A. S. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61380-4 · Cited by 2,077 · see citing works

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Dinkova-Kostova, A. T., Holtzclaw, W. D., Cole, R. N., Itoh, K., Wakabayashi, N., Katoh, Y., Yamamoto, M., & Talalay, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172398899 · Cited by 1,947 · see citing works

Redefining Oxidative Stress

Jones, D. P. (2006) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.8.1865 · Cited by 1,726 · see citing works

Nrf2–Keap1 defines a physiologically important stress response mechanism

Motohashi, H., & Yamamoto, M. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.09.003 · Cited by 1,725 · cited 1× · see citing works

Nrf2:INrf2 (Keap1) signaling in oxidative stress

Kaspar, J. W., Niture, S. K., & Jaiswal, A. K. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.07.035 · Cited by 1,646 · see citing works

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

Moi, P., Chan, K., Asunis, I., Cao, A., & Kan, Y. W. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.21.9926 · Cited by 1,607 · see citing works

Biochemistry of oxidative stress

Halliwell, B. B. (2007) · Biochemical Society Transactions · doi:10.1042/bst0351147 · Cited by 1,546 · see citing works

The plasticity of aging: insights from long-lived mutants

Kenyon, C. (2005) · Cell · doi:10.1016/j.cell.2005.02.002 · Cited by 1,338 · see citing works

Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex

Zhang, D. D., Lo, S., Cross, J. V., Templeton, D. J., & Hannink, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.24.10941-10953.2004 · Cited by 1,262 · see citing works

Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

Cullinan, S. B., Zhang, D. D., Hannink, M., Arvisais, E. W., Kaufman, R. J., & Diehl, J. A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.20.7198-7209.2003 · Cited by 1,233 · see citing works

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in <i>nrf2</i> transcription factor-deficient mice

Ramos-Gomez, M., Kwak, M.-K., Dolan, P. M., Itoh, K., Yamamoto, M., Talalay, P., & Kensler, T. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051618798 · Cited by 1,102 · see citing works

Mechanistic Studies of the Nrf2-Keap1 Signaling Pathway

Zhang, D. D. (2006) · Drug Metabolism Reviews · doi:10.1080/03602530600971974 · Cited by 1,091 · see citing works

Phosphorylation of Nrf2 at Ser-40 by Protein Kinase C Regulates Antioxidant Response Element-mediated Transcription*

Huang, H.-C., Nguyen, T., & Pickett, C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206911200 · Cited by 1,070 · see citing works

Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer

Singh, A., Misra, V., Thimmulappa, R. K., Lee, H., Ames, S., Hoque, M. O., Herman, J. G., Baylin, S. B., Sidransky, D., Gabrielson, E., et al. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030420 · Cited by 1,060 · see citing works

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase 1 gene

Radjendirane, V., & Jaiswal, A. K. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14960 · Cited by 1,034 · see citing works

Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke–induced emphysema in mice

Rangasamy, T., Cho, C. Y., Thimmulappa, R. K., Zhen, L., Srisuma, S., Kensler, T. W., Yamamoto, M. P., Petrache, I., Tuder, R. M., & Biswal, S. S. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21146 · Cited by 993 · see citing works

Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers

Wakabayashi, N., Dinkova-Kostova, A. T., Holtzclaw, W. D., Kang, M.-I., Kobayashi, A., Yamamoto, M., Kensler, T. W., & Talalay, P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307301101 · Cited by 986 · see citing works

The Keap1-BTB Protein Is an Adaptor That Bridges Nrf2 to a Cul3-Based E3 Ligase: Oxidative Stress Sensing by a Cul3-Keap1 Ligase

Cullinan, S. B., Gordan, J. D., Jin, J., Harper, J. W., & Diehl, J. A. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.19.8477-8486.2004 · Cited by 986 · see citing works

Oxidative and Electrophilic Stresses Activate Nrf2 through Inhibition of Ubiquitination Activity of Keap1

Kobayashi, A., Kang, M.-I., Watai, Y., Tong, K. I., Shibata, T., Uchida, K., & Yamamoto, M. P. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.26.1.221-229.2006 · Cited by 933 · see citing works

Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans

Tullet, J. M. A., Hertweck, M., An, J. H., Baker, J., Hwang, J. Y., Liu, S., Oliveira, R. P., Baumeister, R., & Blackwell, T. K. (2008) · Cell · doi:10.1016/j.cell.2008.01.030 · Cited by 923 · see citing works

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

Wakabayashi, N., Itoh, K., Wakabayashi, J., Motohashi, H., Noda, S., Takahashi, S., Imakado, S., KOTSUJI, T., Otsuka, F., Roop, D. R., et al. (2003) · Nature Genetics · doi:10.1038/ng1248 · Cited by 881 · see citing works

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

Hayes, J. D., & McMahon, M. J. (2009) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2008.12.008 · Cited by 870 · see citing works

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

Wang, X.-J., Sun, Z., Villeneuve, N. F., Zhang, S., Zhao, F., Li, Y., Chen, W., Yi, X., Zheng, W., Wondrak, G. T., et al. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn095 · Cited by 839 · see citing works

Longer lifespan, altered metabolism, and stress resistance in <i>Drosophila</i> from ablation of cells making insulin-like ligands

Broughton, S. J., Piper, M. D. W., Ikeya, T., Bass, T. M., Jacobson, J., Driege, Y., Martinez, P., Hafen, E., Withers, D. J., Leevers, S. J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405775102 · Cited by 822 · see citing works

DJ-1, a cancer- and Parkinson’s disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2

Clements, C. M., McNally, R. S., Conti, B. J., Mak, T. W., & Ting, J. P.-Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607260103 · Cited by 818 · see citing works

Coordinate Regulation of Glutathione Biosynthesis and Release by Nrf2-Expressing Glia Potently Protects Neurons from Oxidative Stress

Shih, A. Y., Johnson, D. A., Wong, G., Kraft, A. D., Jiang, L., Erb, H., Johnson, J. A., & Murphy, T. H. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03394.2003 · Cited by 786 · see citing works

Molecular mechanisms of Nrf2‐mediated antioxidant response

Li, W., & Kong, A. T. (2008) · Molecular Carcinogenesis · doi:10.1002/mc.20465 · Cited by 786 · see citing works

Identification of the NF-E2-related Factor-2-dependent Genes Conferring Protection against Oxidative Stress in Primary Cortical Astrocytes Using Oligonucleotide Microarray Analysis

Lee, J., Calkins, M. J., Chan, K., Kan, Y. W., & Johnson, J. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211558200 · Cited by 783 · see citing works

Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid

Suh, J. H., Shenvi, S. V., Dixon, B. M., Liu, H., Jaiswal, A. K., Liu, R.-M., & Hagen, T. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400282101 · Cited by 774 · see citing works

Expression of Nrf2 in Neurodegenerative Diseases

Ramsey, C. P., Glass, C. A., Montgomery, M. B., Lindl, K. A., Ritson, G. P., Chia, L. A., Hamilton, R. L., Chu, C. T., & Jordan-Sciutto, K. L. (2007) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/nen.0b013e31802d6da9 · Cited by 760 · see citing works

Keap1 Recruits Neh2 through Binding to ETGE and DLG Motifs: Characterization of the Two-Site Molecular Recognition Model

Tong, K. I., Katoh, Y., Kusunoki, H., Itoh, K., Tanaka, T., & Yamamoto, M. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.8.2887-2900.2006 · Cited by 759 · see citing works

BTB Protein Keap1 Targets Antioxidant Transcription Factor Nrf2 for Ubiquitination by the Cullin 3-Roc1 Ligase

Furukawa, M., & Xiong, Y. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.25.1.162-171.2005 · Cited by 746 · see citing works

PERK-dependent Activation of Nrf2 Contributes to Redox Homeostasis and Cell Survival following Endoplasmic Reticulum Stress

Cullinan, S. B., & Diehl, J. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314219200 · Cited by 739 · see citing works

Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer

Padmanabhan, B., Tong, K. I., Ohta, T., Nakamura, Y., Scharlock, M., Ohtsuji, M., Kang, M.-I., Kobayashi, A., Yokoyama, S., & Yamamoto, M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.01.013 · Cited by 735 · cited 1× · see citing works

Cancer related mutations in <i>NRF2</i> impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

Shibata, T., Ohta, T., Tong, K. I., Kokubu, A., Odogawa, R., Tsuta, K., Asamura, H., Yamamoto, M., & Hirohashi, S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806268105 · Cited by 728 · see citing works

High Sensitivity of Nrf2 Knockout Mice to Acetaminophen Hepatotoxicity Associated with Decreased Expression of ARE-Regulated Drug Metabolizing Enzymes and Antioxidant Genes

Enomoto, A. (2001) · Toxicological Sciences · doi:10.1093/toxsci/59.1.169 · Cited by 728 · see citing works

SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress responsePreprint

An, J. H., & Blackwell, T. K. (2003) · Genes & Development · doi:10.1101/gad.1107803 · Cited by 722 · see citing works

Mediators of Chronic Obstructive Pulmonary Disease

Barnes, P. J. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.4.2 · Cited by 710 · see citing works

Molecular basis for chemoprevention by sulforaphane: a comprehensive review

Juge, N., Mithen, R. F., & Τράκα, Μ. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6484-5 · Cited by 696 · see citing works

Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoeitin/MGDF in megakaryocyte development

Shivdasani, R. A., Rosenblatt, M., Zucker‐Franklin, D., Jackson, C. W., Hunt, P., Saris, C. J. M., & Orkin, S. H. (1995) · Cell · doi:10.1016/0092-8674(95)90531-6 · Cited by 687 · see citing works

Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila

Sykiotis, G. P., & Bohmann, D. (2008) · Developmental Cell · doi:10.1016/j.devcel.2007.12.002 · Cited by 675 · see citing works

Role of NRF2 in Protection Against Hyperoxic Lung Injury in Mice

Cho, H., Jedlicka, A., Reddy, S. P., Kensler, T. W., Yamamoto, M. P., Zhang, L.-Y., & Kleeberger, S. R. (2002) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.26.2.4501 · Cited by 660 · see citing works

The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes.

McMahon, M. J., Itoh, K., Yamamoto, M. P., Chanas, S. A., Henderson, C. J., McLellan, L. I., Wolf, C. R., Cavin, C., & Hayes, J. D. (2001) · PubMed · Cited by 657 · see citing works

Bach Proteins Belong to a Novel Family of BTB-Basic Leucine Zipper Transcription Factors That Interact with MafK and Regulate Transcription through the NF-E2 Site

Oyake, T., Itoh, K., Motohashi, H., Hayashi, N., Hoshino, H., Nishizawa, M., Yamamoto, M. P., & Igarashi, K. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.11.6083 · Cited by 656 · see citing works

Dual roles of Nrf2 in cancer

LAU, A., VILLENEUVE, N., Sun, Z., Wong, P. K., & Zhang, D. (2008) · Pharmacological Research · doi:10.1016/j.phrs.2008.09.003 · Cited by 645 · see citing works

Two neurons mediate diet-restriction-induced longevity in C. elegans

Bishop, N. A., & Guarente, L. (2007) · Nature · doi:10.1038/nature05904 · Cited by 643 · see citing works

NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development

Chan, K., Lu, R., Chang, J. C., & Kan, Y. W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13943 · Cited by 643 · see citing works

Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response

Chen, W., Sun, Z., Wang, X.-J., Jiang, T., Huang, Z., Fang, D., & Zhang, D. D. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.04.029 · Cited by 638 · see citing works

Hemoprotein Bach1 regulates enhancer availability of heme oxygenase‐1 gene

Sun, J., Hoshino, H., Takaku, K., Nakajima, O., Muto, A., Suzuki, H., Tashiro, S., Takahashi, S., Shibahara, S., Alam, J., et al. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf516 · Cited by 637 · see citing works

Erythroid transcription factor NF-E2 is a haematopoietic-specific basic–leucine zipper protein

Andrews, N. C., Erdjument‐Bromage, H., Davidson, M. B., Tempst, P., & Orkin, S. H. (1993) · Nature · doi:10.1038/362722a0 · Cited by 637 · see citing works

Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth

Ohta, T., Iijima, K., Miyamoto, M., Nakahara, I., Tanaka, H., Ohtsuji, M., Suzuki, T., Kobayashi, A., Yokota, J., Sakiyama, T., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5003 · Cited by 630 · see citing works

p62 Is a Common Component of Cytoplasmic Inclusions in Protein Aggregation Diseases

Zatloukal, K., Stumptner, C., Fuchsbichler, A., Heid, H., Schnoelzer, M., Kenner, L., Kleinert, R., Prinz, M., Aguzzi, A., & Denk, H. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64369-6 · Cited by 624 · see citing works

Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling

Lo, S., Li, X., Henzl, M. T., Beamer, L. J., & Hannink, M. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601243 · Cited by 604 · see citing works

Free Radical Theory of Aging: An Update: Increasing the Functional Life Span

HARMAN, D. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1354.003 · Cited by 601 · see citing works

Enhanced Expression of the Transcription Factor Nrf2 by Cancer Chemopreventive Agents: Role of Antioxidant Response Element-Like Sequences in the nrf2 Promoter

Kwak, M.-K., Itoh, K., Yamamoto, M. P., & Kensler, T. W. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.9.2883-2892.2002 · Cited by 597 · see citing works

The Nrf2–ARE Pathway

Johnson, J. A., Johnson, D. A., Kraft, A. D., Calkins, M. J., Jakel, R. J., Vargas, M. R., & Chen, P. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.036 · Cited by 588 · see citing works

Amyotrophic lateral sclerosis

Mitchell, J. D., & Borasio, G. D. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60944-1 · Cited by 583 · see citing works

Disruption of <i>Nrf2</i> enhances susceptibility to severe airway inflammation and asthma in mice

Rangasamy, T., Guo, J., Mitzner, W. A., Roman, J., Singh, A., Fryer, A. D., Yamamoto, M., Kensler, T. W., Tuder, R. M., Georas, S. N., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050538 · Cited by 580 · see citing works

Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson’s disease: Critical role for the astrocyte

Chen, P.-C., Vargas, M. R., Pani, A. K., Smeyne, R. J., Johnson, D. A., Kan, Y. W., & Johnson, J. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813361106 · Cited by 579 · see citing works

Nrf2 is essential for protection against acute pulmonary injury in mice

Chan, K., & Kan, Y. W. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12731 · Cited by 574 · see citing works

Nuclear Factor E2-Related Factor 2-Dependent Antioxidant Response Element Activation by tert -Butylhydroquinone and Sulforaphane Occurring Preferentially in Astrocytes Conditions Neurons against Oxidative Insult

Kraft, A. D., Johnson, D. A., & Johnson, J. A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3817-03.2004 · Cited by 541 · see citing works

Transcriptional Regulation of NF-E2 p45-related Factor (NRF2) Expression by the Aryl Hydrocarbon Receptor-Xenobiotic Response Element Signaling Pathway

Miao, W., Hu, L., Scrivens, P. J., & Batist, G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412081200 · Cited by 541 · see citing works

Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes

Kang, M.-I., Kobayashi, A., Wakabayashi, N., Kim, S.-G., & Yamamoto, M. P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308347100 · Cited by 536 · see citing works

Nrf2, a multi‐organ protector?

Lee, J., Li, J., Johnson, D. A., Stein, T. D., Kraft, A. D., Calkins, M. J., Jakel, R. J., & Johnson, J. A. (2005) · The FASEB Journal · doi:10.1096/fj.04-2591hyp · Cited by 532 · see citing works

Nrf2-Deficient Mice Have an Increased Susceptibility to Dextran Sulfate Sodium–Induced Colitis

Khor, T. O., Huang, M., Kwon, K. H., Chan, J. Y., Reddy, B. S., & Kong, A. T. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-3562 · Cited by 530 · see citing works

Glycogen Synthase Kinase-3β Inhibits the Xenobiotic and Antioxidant Cell Response by Direct Phosphorylation and Nuclear Exclusion of the Transcription Factor Nrf2

Salazar‐Roa, M., Rojo, A. I., Velasco, D., de Sagarra, R. M., & Cuadrado, A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513737200 · Cited by 523 · see citing works

Phosphorylation of Nrf2 at Ser40 by Protein Kinase C in Response to Antioxidants Leads to the Release of Nrf2 from INrf2, but Is Not Required for Nrf2 Stabilization/Accumulation in the Nucleus and Transcriptional Activation of Antioxidant Response Element-mediated NAD(P)H:Quinone Oxidoreductase-1 Gene Expression

Bloom, D. A., & Jaiswal, A. K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307633200 · Cited by 523 · see citing works

Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription

Katoh, Y., Itoh, K., Yoshida, E., Miyagishi, M., Fukamizu, A., & Yamamoto, M. P. (2001) · Genes to Cells · doi:10.1046/j.1365-2443.2001.00469.x · Cited by 521 · see citing works

Pathobiology of Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease

Yoshida, T., & Tuder, R. M. (2007) · Physiological Reviews · doi:10.1152/physrev.00048.2006 · Cited by 508 · see citing works

Dimerization of Substrate Adaptors Can Facilitate Cullin-mediated Ubiquitylation of Proteins by a “Tethering” Mechanism

McMahon, M. J., Thomas, N., Itoh, K., Yamamoto, M. P., & Hayes, J. D. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601119200 · Cited by 489 · see citing works

GSK-3β Acts Upstream of Fyn Kinase in Regulation of Nuclear Export and Degradation of NF-E2 Related Factor 2

Jain, A. K., & Jaiswal, A. K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611336200 · Cited by 484 · see citing works

Nrf2 Activation in Astrocytes Protects against Neurodegeneration in Mouse Models of Familial Amyotrophic Lateral Sclerosis

Vargas, M. R., Johnson, D. A., Sirkis, D. W., Messing, A., & Johnson, J. A. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4099-08.2008 · Cited by 479 · see citing works

Identification of Activating Transcription Factor 4 (ATF4) as an Nrf2-interacting Protein

He, C. H., Gong, P., Hu, B., Stewart, D., Choi, M. E., Choi, A. M. K., & Alam, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101198200 · Cited by 473 · see citing works

Two-site substrate recognition model for the Keap1-Nrf2 system: A hinge and latch mechanism

Tong, K. I., Kobayashi, A., Katsuoka, F., & Yamamoto, M. (2006) · Biological Chemistry · doi:10.1515/bc.2006.164 · Cited by 473 · see citing works

Genetic Alteration of Keap1 Confers Constitutive Nrf2 Activation and Resistance to Chemotherapy in Gallbladder Cancer

Shibata, T., Kokubu, A., Gotoh, M., Ojima, H., Ohta, T., Yamamoto, M. P., & Hirohashi, S. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.06.082 · Cited by 468 · see citing works

Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2

Eggler, A. L., Liu, G., Pezzuto, J. M., van Breemen, R. B., & Mesecar, A. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502402102 · Cited by 459 · see citing works

Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors

Motohashi, H., O'Connor, T., Katsuoka, F., Engel, J. D., & Yamamoto, M. P. (2002) · Gene · doi:10.1016/s0378-1119(02)00788-6 · Cited by 456 · see citing works

Different Electrostatic Potentials Define ETGE and DLG Motifs as Hinge and Latch in Oxidative Stress Response

Tong, K. I., Padmanabhan, B., Kobayashi, A., Shang, C., Hirotsu, Y., Yokoyama, S., & Yamamoto, M. P. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00753-07 · Cited by 447 · see citing works

The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress responsePreprint

Inoue, H., Hisamoto, N., An, J. H., Oliveira, R. D. P., Nishida, E., Blackwell, T. K., & Matsumoto, K. (2005) · Genes & Development · doi:10.1101/gad.1324805 · Cited by 443 · see citing works

Nrf2-induced antioxidant protection: A promising target to counteract ROS-mediated damage in neurodegenerative disease?

de Vries, H. E., Witte, M. E., Hondius, D., Rozemüller, A. J. M., Drukarch, B., Hoozemans, J. J. M., & van Horssen, J. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.09.001 · Cited by 432 · see citing works

JNK Signaling Confers Tolerance to Oxidative Stress and Extends Lifespan in Drosophila

Wang, M. C., Bohmann, D., & Jasper, H. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00323-x · Cited by 422 · see citing works

Nrf2 Enhances Cell Proliferation and Resistance to Anticancer Drugs in Human Lung Cancer

Homma, S., Ishii, Y., Morishima, Y., Yamadori, T., Matsuno, Y., Haraguchi, N., Kikuchi, N., Satoh, H., Sakamoto, T., Hizawa, N., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2822 · Cited by 417 · see citing works

Bach1 Competes with Nrf2 Leading to Negative Regulation of the Antioxidant Response Element (ARE)-mediated NAD(P)H:Quinone Oxidoreductase 1 Gene Expression and Induction in Response to Antioxidants

Dhakshinamoorthy, S., Jain, A. K., Bloom, D. A., & Jaiswal, A. K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500166200 · Cited by 414 · see citing works

Acetylation of Nrf2 by p300/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response

Sun, Z., Chin, Y. E., & Zhang, D. D. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01639-08 · Cited by 413 · see citing works

Control of Larval Development by Chemosensory Neurons in Caenorhabditis elegans

Bargmann, C. I., & Horvitz, H. R. (1991) · Science · doi:10.1126/science.2006412 · Cited by 405 · see citing works

Role of Nrf2 in the Regulation of CD36 and Stress Protein Expression in Murine Macrophages

Ishii, T., Itoh, K., Ruiz, E., Leake, D. S., Unoki‐Kubota, H., Yamamoto, M. P., & Mann, G. E. (2004) · Circulation Research · doi:10.1161/01.res.0000119171.44657.45 · Cited by 400 · see citing works

Heme oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1

Reichard, J. F., Motz, G. T., & Puga, A. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm638 · Cited by 393 · see citing works

Inhibition of 7,12-Dimethylbenz(a)anthracene-Induced Skin Tumorigenesis in C57BL/6 Mice by Sulforaphane Is Mediated by Nuclear Factor E2–Related Factor 2

Xu, C., Huang, M., Shen, G., Yuan, X., Lin, W., Khor, T. O., Conney, A. H., & Kong, A. T. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0300 · Cited by 379 · see citing works

PARK7, a Novel Locus for Autosomal Recessive Early-Onset Parkinsonism, on Chromosome 1p36

van Duijn, C. M., Dekker, M. C. J., Bonifati, V., Galjaard, R. H., Houwing‐Duistermaat, J. J., Snijders, P. J. L. M., Testers, L., Breedveld, G. J., Horstink, M. W. I. M., Sandkuijl, L. A., et al. (2001) · The American Journal of Human Genetics · doi:10.1086/322996 · Cited by 378 · see citing works

skn-1, a maternally expressed gene required to specify the fate of ventral blastomeres in the early C. elegans embryo

Bowerman, B. A., Eaton, B. A., & Priess, J. R. (1992) · Cell · doi:10.1016/0092-8674(92)90078-q · Cited by 374 · see citing works

RNAi -Mediated Silencing of Nuclear Factor Erythroid-2–Related Factor 2 Gene Expression in Non–Small Cell Lung Cancer Inhibits Tumor Growth and Increases Efficacy of Chemotherapy

Singh, A., Boldin‐Adamsky, S., Thimmulappa, R. K., Rath, S. K., Ashush, H., Coulter, J. B., Blackford, A. L., Goodman, S. N., Bunz, F., Watson, W. H., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1401 · Cited by 371 · see citing works

The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

Zipper, L. M., & Mulcahy, R. T. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206530200 · Cited by 366 · see citing works

Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1–Nrf2 regulatory pathway

Motohashi, H., Katsuoka, F., Engel, J. D., & Yamamoto, M. P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305902101 · Cited by 363 · see citing works

Phosphorylation of Nrf2 at Multiple Sites by MAP Kinases Has a Limited Contribution in Modulating the Nrf2-Dependent Antioxidant Response

Sun, Z., Huang, Z., & Zhang, D. D. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006588 · Cited by 362 · see citing works

The transcription factor NRF2 protects against pulmonary fibrosis

Cho, H., Reddy, S. P., Yamamoto, M. P., & Kleeberger, S. R. (2004) · The FASEB Journal · doi:10.1096/fj.03-1127fje · Cited by 355 · see citing works

Targeting Nrf2 with the triterpenoid CDDO- imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice

Sussan, T. E., Rangasamy, T., Blake, D. J., Malhotra, D., El-Haddad, H., Bedja, D., Yates, M. S., Kombairaju, P., Yamamoto, M., Liby, K. T., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804333106 · Cited by 346 · see citing works

Nrf2-deficient female mice develop lupus-like autoimmune nephritis11See Editorial by Byrd and Thomas, p. 1606.

Yoh, K., Itoh, K., Enomoto, A., Hirayama, A., Yamaguchi, N., Kobayashi, M., Morito, N., Kôyama, A., Yamamoto, M. P., & Takahashi, S. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.00939.x · Cited by 345 · see citing works

Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast.

Chan, J. Y., Han, X. L., & Kan, Y. W. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11371 · Cited by 342 · see citing works

Activation of Mitogen-activated Protein Kinase Pathways Induces Antioxidant Response Element-mediated Gene Expression via a Nrf2-dependent Mechanism

Yu, R., Chen, C., Mo, Y.-Y., Hebbar, V., Owuor, E. D., Tan, T., & Kong, A.-N. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004037200 · Cited by 341 · see citing works

Carcinogenicity and Modification of the Carcinogenic Response by bha, Bht, and Other Antioxidants

Ito, N., Fukushima, S., & Tsuda, H. (1985) · Critical Reviews in Toxicology · doi:10.3109/10408448509029322 · Cited by 341 · see citing works

Identification of the interactive interface and phylogenic conservation of the Nrf2‐Keap1 system

Kobayashi, M., Itoh, K., Suzuki, T., Osanai, H., Nishikawa, K., Katoh, Y., Takagi, Y., & Yamamoto, M. P. (2002) · Genes to Cells · doi:10.1046/j.1365-2443.2002.00561.x · Cited by 340 · see citing works

Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury

Marzec, J. M., Christie, J. D., Reddy, S. P., Jedlicka, A., Vuong, H., Lanken, P. N., Aplenc, R., Yamamoto, T., Yamamoto, M. P., Cho, H., et al. (2007) · The FASEB Journal · doi:10.1096/fj.06-7759com · Cited by 340 · see citing works

Keap1 Controls Postinduction Repression of the Nrf2-Mediated Antioxidant Response by Escorting Nuclear Export of Nrf2

Sun, Z., Zhang, S., Chan, J. Y., & Zhang, D. D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00630-07 · Cited by 332 · see citing works

The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin

Hayes, J. D., Chanas, S. A., Henderson, C. J., McMahon, M. J., Sun, C., Moffat, G. J., Wolf, C. R., & Yamamoto, M. P. (2000) · Biochemical Society Transactions · doi:10.1042/bst0280033 · Cited by 321 · see citing works

Nrf1 and Nrf2 Play Distinct Roles in Activation of Antioxidant Response Element-dependent Genes

Ohtsuji, M., Katsuoka, F., Kobayashi, A., Aburatani, H., Hayes, J. D., & Yamamoto, M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804597200 · Cited by 317 · see citing works

Generation of a Stable Antioxidant Response Element–Driven Reporter Gene Cell Line and Its Use to Show Redox-Dependent Activation of Nrf2 by Cancer Chemotherapeutic Agents

Wang, X. J., Hayes, J. D., & Wolf, C. R. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-2298 · Cited by 317 · see citing works

Atypical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress

Numazawa, S., Ishikawa, M., Yoshida, A., Tanaka, S., & Yoshida, T. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00043.2003 · Cited by 316 · see citing works

Hemin-induced Activation of the Thioredoxin Gene by Nrf2

Kim, Y. C., Masutani, H., Yamaguchi, Y., Itoh, K., Yamamoto, M. P., & Yodoi, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100103200 · Cited by 313 · see citing works

Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha

Wang, X. J., Hayes, J. D., Henderson, C. J., & Wolf, C. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709483104 · Cited by 310 · see citing works

Mechanism of Action of Sulforaphane: Inhibition of p38 Mitogen-Activated Protein Kinase Isoforms Contributing to the Induction of Antioxidant Response Element–Mediated Heme Oxygenase-1 in Human Hepatoma HepG2 Cells

Keum, Y., Yu, S., Chang, P. P.-J., Yuan, X., Kim, J. H., Xu, C., Han, J., Agarwal, A., & Kong, A. T. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3513 · Cited by 305 · see citing works

PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

Lo, S.-C., & Hannink, M. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.02.014 · Cited by 300 · see citing works

Deficiency of the Nrf1 and Nrf2 Transcription Factors Results in Early Embryonic Lethality and Severe Oxidative Stress

Leung, L., Kwong, M., Hou, S., Lee, C., & Chan, J. Y. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308439200 · Cited by 299 · see citing works

Molecular Cloning and Functional Characterization of a New Cap'n' Collar Family Transcription Factor Nrf3

Kobayashi, A., Ito, E., Toki, T., Kogame, K., Takahashi, S., Igarashi, K., Hayashi, N., & Yamamoto, M. P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.10.6443 · Cited by 299 · see citing works

Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust

Aoki, Y., Sato, H., Nishimura, N., Takahashi, S., Itoh, K., & Yamamoto, M. (2001) · Toxicology and Applied Pharmacology · doi:10.1006/taap.2001.9176 · Cited by 297 · see citing works

The transcriptional programme of antibody class switching involves the repressor Bach2

Muto, A., Tashiro, S., Nakajima, O., Hoshino, H., Takahashi, S., Sakoda, E., Ikebe, D., Yamamoto, M. P., & Igarashi, K. (2004) · Nature · doi:10.1038/nature02596 · Cited by 292 · see citing works

Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes

Yates, M. S., Tauchi, M., Katsuoka, F., Flanders, K. C., Liby, K. T., Honda, T., Gribble, G. W., Johnson, D. A., Johnson, J. A., Burton, N. C., et al. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0516 · Cited by 292 · see citing works

Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene

Dhakshinamoorthy, S., & Jaiswal, A. K. (2001) · Oncogene · doi:10.1038/sj.onc.1204506 · Cited by 290 · see citing works

Down-Regulated NF-E2–Related Factor 2 in Pulmonary Macrophages of Aged Smokers and Patients with Chronic Obstructive Pulmonary Disease

Suzuki, M., Betsuyaku, T., Ito, Y., Nagai, K., Nasuhara, Y., Kaga, K., Kondo, S., & Nishimura, M. (2008) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0424oc · Cited by 286 · see citing works

Genetic Evidence that Small Maf Proteins Are Essential for the Activation of Antioxidant Response Element-Dependent Genes

Katsuoka, F., Motohashi, H., Ishii, T., Aburatani, H., Engel, J. D., & Yamamoto, M. P. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.18.8044-8051.2005 · Cited by 283 · see citing works

Role of a Mitogen-activated Protein Kinase Pathway in the Induction of Phase II Detoxifying Enzymes by Chemicals

Yu, R., Lei, W., Mandlekar, S., Weber, M. J., Der, C. J., Wu, J., & Kong, A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.39.27545 · Cited by 281 · see citing works

Targeted disruption of the ubiquitous CNC‐bZIP transcription factor, Nrf‐1, results in anemia and embryonic lethality in mice

Chan, J. Y., Kwong, M., Lu, R., Chang, J., Wang, B., Yen, T. S. B., & Kan, Y. W. (1998) · The EMBO Journal · doi:10.1093/emboj/17.6.1779 · Cited by 277 · see citing works

Enhancing Expression of Nrf2-Driven Genes Protects the Blood–Brain Barrier after Brain Injury

Zhao, J., Moore, A. N., Redell, J. B., & Dash, P. K. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1683-07.2007 · Cited by 274 · see citing works

Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging

Hyun, D.-H., Emerson, S. S., Jo, D.-G., Mattson, M. P., & de Cabo, R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608008103 · Cited by 267 · see citing works

Impaired liver regeneration in Nrf2 knockout mice: role of ROS‐mediated insulin/IGF‐1 resistance

Beyer, T. A., Xu, W., Teupser, D., Keller, U. A. D., Bugnon, P., Hildt, E., Thiery, J., Kan, Y. W., & Werner, S. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601950 · Cited by 267 · see citing works

Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2

Xu, C., Yuan, X., Pan, Z., Shen, G., Kim, J. H., Yu, S., Khor, T. O., Li, W., Ma, J., & Kong, A. T. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0497 · Cited by 265 · see citing works

Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues

Wang, R., An, J., Ji, F., Jiao, H., Sun, H., & Zhou, D. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.06.004 · Cited by 261 · see citing works

Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: effect of chemical structure and stress signals

Chen, C., Pung, D., Leong, V., Hebbar, V., Shen, G., Nair, S., Li, W., & Kong, A.-N. T. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.07.021 · Cited by 260 · see citing works

Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration

Ramesh Babu, J., Lamar Seibenhener, M., Peng, J., Strom, A., Kemppainen, R., Cox, N., Zhu, H., Wooten, M. C., Diaz‐Meco, M. T., Moscat, J., et al. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05340.x · Cited by 258 · see citing works

The electrophile counterattack response: Protection against neoplasia and toxicity

Prestera, T., Zhang, Y., Spencer, S. R., Wilczak, C. A., & Talalay, P. (1993) · Advances in Enzyme Regulation · doi:10.1016/0065-2571(93)90024-8 · Cited by 256 · see citing works

Nuclear factor erythroid 2-related factor 2 protects against beta amyloid

Kanninen, K. M., Malm, T., Jyrkkänen, H.-K., Goldsteins, G., Keksa-Goldsteine, V., Tanila, H., Yamamoto, M. P., Ylä‐Herttuala, S., Levonen, A., & Koıstınaho, J. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.07.010 · Cited by 256 · see citing works

Nrf2-mediated protection against 6-hydroxydopamine

Jakel, R. J., Townsend, J. A., Kraft, A. D., & Johnson, J. A. (2007) · Brain Research · doi:10.1016/j.brainres.2007.01.131 · Cited by 252 · see citing works

Crystal Structure of the Kelch Domain of Human Keap1

Li, X., Zhang, D. D., Hannink, M., & Beamer, L. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410073200 · Cited by 249 · see citing works

Transcription factor Nrf2 plays a pivotal role in protection against elastase-induced pulmonary inflammation and emphysema

Ishii, Y., Itoh, K., Morishima, Y., Kimura, T., Kiwamoto, T., IIzuka, T., Hegab, A. E., Hosoya, T., Nomura, A., Sakamoto, T., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.10.6968 · Cited by 248 · see citing works

Protection from mitochondrial complex II inhibition <i>in vitro</i> and <i>in vivo</i> by Nrf2-mediated transcription

Calkins, M. J., Jakel, R. J., Johnson, D. A., Chan, K., Kan, Y. W., & Johnson, J. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408487101 · Cited by 247 · see citing works

Multiorgan Autoimmune Inflammation, Enhanced Lymphoproliferation, and Impaired Homeostasis of Reactive Oxygen Species in Mice Lacking the Antioxidant-Activated Transcription Factor Nrf2

Ma, Q., Battelli, L. A., & Hubbs, A. F. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.051113 · Cited by 246 · see citing works

Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents

Zhao, J., Kobori, N., Aronowski, J. A., & Dash, P. K. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.09.065 · Cited by 245 · see citing works

Role of phase 2 enzyme induction in chemoprotection by dithiolethiones

Kwak, M.-K., Egner, P. A., Dolan, P. M., Ramos‐Gómez, M., Groopman, J. D., Itoh, K., Yamamoto, M. P., & Kensler, T. W. (2001) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(01)00190-7 · Cited by 241 · see citing works

GSK‐3β down‐regulates the transcription factor Nrf2 after oxidant damage: relevance to exposure of neuronal cells to oxidative stress

Rojo, A. I., de Sagarra, M. R., & Cuadrado, A. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05124.x · Cited by 241 · see citing works

Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (−/−) mice

Hu, R., XU, C., Shen, G., JAIN, M., Khor, T. O., Gopalkrishnan, A., LIN, W., REDDY, B., CHAN, J., & KONG, A. (2006) · Cancer Letters · doi:10.1016/j.canlet.2005.11.050 · Cited by 241 · see citing works

Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction

Pearson, K. J., Lewis, K. N., Price, N. L., Chang, J. W., Perez, E., Cascajo, M. V., Tamashiro, K. L., Poosala, S., Csiszár, A., Ungvari, Z. I., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712162105 · Cited by 238 · see citing works

Keap1 Regulates the Oxidation-Sensitive Shuttling of Nrf2 into and out of the Nucleus via a Crm1-Dependent Nuclear Export Mechanism

Velichkova, M., & Hasson, T. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.11.4501-4513.2005 · Cited by 237 · see citing works

Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3

An, J. H., Vranas, K. C., Lucke, M., Inoue, H., Hisamoto, N., Matsumoto, K., & Blackwell, T. K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508105102 · Cited by 236 · see citing works

Chronic obstructive pulmonary disease

Calverley, P. M. A., & Walker, P. (2019) · CRC Press eBooks · doi:10.1201/9781315365176-10 · Cited by 235 · see citing works

A strategy for cancer prevention: Stimulation of the Nrf2-ARE signaling pathway

Zhang, Y., & Gordon, G. (2004) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.885.3.7 · Cited by 231 · see citing works

Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR‐32 neuroblastoma cells

Apopa, P. L., He, X., & Ma, Q. (2008) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.20212 · Cited by 230 · see citing works

Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging

Meulener, M. C., Xu, K., Thomson, L., Ischiropoulos, H., & Bonini, N. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601891103 · Cited by 230 · see citing works

Phosphatidylinositol 3-Kinase, Not Extracellular Signal-regulated Kinase, Regulates Activation of the Antioxidant-Responsive Element in IMR-32 Human Neuroblastoma Cells

Lee, J., Hanson, J. M., Chu, W. A., & Johnson, J. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100734200 · Cited by 227 · see citing works

Transcription Factor Nrf2 Protects the Brain From Damage Produced by Intracerebral Hemorrhage

Zhao, X., Sun, G., Zhang, J., Strong, R., Dash, P. K., Kan, Y. W., Grotta, J. C., & Aronowski, J. A. (2007) · Stroke · doi:10.1161/strokeaha.107.486506 · Cited by 227 · see citing works

Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1

Aikawa, Y., Morimoto, K., Yamamoto, T., Chaki, H., Hashiramoto, A., Narita, H., Hirono, S., & Shiozawa, S. (2008) · Nature Biotechnology · doi:10.1038/nbt1412 · Cited by 226 · see citing works

Imbalanced secondary mucosal antioxidant response in inflammatory bowel disease

Kruidenier, L., Kuiper, I., van Duijn, W., Mieremet-Ooms, M. A. C., van Hogezand, R. A., Lamers, C. B. H. W., & Verspaget, H. W. (2003) · The Journal of Pathology · doi:10.1002/path.1408 · Cited by 224 · see citing works

Keap1, the Sensor for Electrophiles and Oxidants that Regulates the Phase 2 Response, Is a Zinc Metalloprotein

Dinkova‐Kostova, A. T., Holtzclaw, W. D., & Wakabayashi, N. (2005) · Biochemistry · doi:10.1021/bi047434h · Cited by 220 · see citing works

Impaired Nuclear Nrf2 Translocation Undermines the Oxidative Stress Response in Friedreich Ataxia

Paupe, V., Dassa, E. P., Gonçalves, S., Auchère, F., Lönn, M. E., Holmgren, A., & Rustin, P. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004253 · Cited by 218 · see citing works

Age-Accelerated Atherosclerosis Correlates With Failure to Upregulate Antioxidant Genes

Collins, A. R., Lyon, C. J., Xia, X., Liu, J. Z., Tangirala, R. K., Yin, F., Boyadjian, R., Bikineyeva, A. T., Praticò, D., Harrison, D. G., et al. (2009) · Circulation Research · doi:10.1161/circresaha.108.188771 · Cited by 214 · see citing works

BRG1 Interacts with Nrf2 To Selectively Mediate <i>HO-1</i> Induction in Response to Oxidative Stress

Zhang, J., Ohta, T., Maruyama, A., Hosoya, T., Nishikawa, K., Maher, J. M., Shibahara, S., Itoh, K., & Yamamoto, M. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00700-06 · Cited by 213 · see citing works

A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity

Nioi, P., & Nguyen, T. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.08.051 · Cited by 212 · see citing works

Molecular mechanism of human Nrf2 activation and degradation: Role of sequential phosphorylation by protein kinase CK2

Pi, J., Bai, Y., Reece, J. M., Williams, J. G., Liu, D., Freeman, M. L., Fahl, W. E., Shugar, D., Liu, J., Qu, W., et al. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.001 · Cited by 212 · see citing works

Chronic obstructive pulmonary disease

Calverley, P. M. A., & Walker, P. P. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14416-9 · Cited by 209 · see citing works

The Nrf2-ARE Signalling Pathway: Promising Drug Target to Combat Oxidative Stress in Neurodegenerative Disorders

Muiswinkel, F. L. V., & Kuiperij, H. B. (2005) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007054038238 · Cited by 207 · see citing works

An Auto-regulatory Loop between Stress Sensors INrf2 and Nrf2 Controls Their Cellular Abundance

Lee, O.-H., Jain, A. K., Papusha, V. Z., & Jaiswal, A. K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706517200 · Cited by 205 · see citing works

Small Maf (MafG and MafK) Proteins Negatively Regulate Antioxidant Response Element-mediated Expression and Antioxidant Induction of the NAD(P)H:Quinone Oxidoreductase1 Gene

Dhakshinamoorthy, S., & Jaiswal, A. K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003531200 · Cited by 205 · see citing works

Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2.

Shivdasani, R. A., & Orkin, S. H. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8690 · Cited by 204 · see citing works

Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice

Ramos‐Gómez, M. (2003) · Carcinogenesis · doi:10.1093/carcin/24.3.461 · Cited by 200 · see citing works

Mutant SOD1 alters the motor neuronal transcriptome: implications for familial ALS

Kirby, J., Halligan, E. P., Baptista, M. J., Allen, S., Heath, P. R., Holden, H. M., Barber, S. C., Loynes, C. A., Wood-Allum, C. A., Lunec, J., et al. (2005) · Brain · doi:10.1093/brain/awh503 · Cited by 200 · see citing works

PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex

Lo, S.-C., & Hannink, M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606539200 · Cited by 199 · see citing works

The Nrf2 transcription factor protects from toxin-induced liver injury and fibrosis

Xu, W., Hellerbrand, C., Köhler, U. A., Bugnon, P., Kan, Y., Werner, S., & Beyer, T. A. (2008) · Laboratory Investigation · doi:10.1038/labinvest.2008.75 · Cited by 198 · see citing works

Multiple Nuclear Localization Signals Function in the Nuclear Import of the Transcription Factor Nrf2

Theodore, M., Kawai, Y., Yang, J., Kleshchenko, Y. Y., Reddy, S. P., Villalta, F., & Arinze, I. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709040200 · Cited by 197 · see citing works

Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2‐deficient mice upon dextran sulfate treatment

Osburn, W. O., Karim, B. O., Dolan, P. M., Liu, G., Yamamoto, M. P., Huso, D. L., & Kensler, T. W. (2007) · International Journal of Cancer · doi:10.1002/ijc.22943 · Cited by 197 · see citing works

Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema

Goven, D., Boutten, A., Leçon-Malas, V., Marchal-Sommé, J., Amara, N., Crestani, B., Fournier, M., Lesèche, G., Soler, P., Boczkowski, J., et al. (2008) · Thorax · doi:10.1136/thx.2007.091181 · Cited by 196 · see citing works

A genomic screen for activators of the antioxidant response element

Liu, Y., Kern, J. T., Walker, J. R., Johnson, J. A., Schultz, P. G., & Luesch, H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700898104 · Cited by 196 · see citing works

Regulation of Nrf2 Transactivation Domain Activity

Shen, G., Hebbar, V., Nair, S., Xu, C., Li, W., Lin, W., Keum, Y.-S., Han, J., Gallo, M. A., & Kong, A.-N. T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401368200 · Cited by 194 · see citing works

Nuclear Factor-Eythroid 2–Related Factor 2 Prevents Alcohol-Induced Fulminant Liver Injury

Lamlé, J., Marhenke, S., Borlak, J. T., von Wasielewski, R., Eriksson, C. J. P., Geffers, R., Manns, M. P., Yamamoto, M. P., & Vogel, A. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.01.011 · Cited by 193 · see citing works

Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response in Caenorhabditis elegans.

Kahn, N., Rea, S. L., Moyle, S. S., Kell, A. M., & Johnson, T. (2008) · Biochemical Journal · doi:10.1042/bj20070521 · Cited by 192 · see citing works

Multivalent DNA Binding Complex Generated by Small Maf and Bach1 as a Possible Biochemical Basis for β-Globin Locus Control Region Complex

Igarashi, K., Hoshino, H., Muto, A., Suwabe, N., Nishikawa, S., Nakauchi, H., & Yamamoto, M. P. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.19.11783 · Cited by 191 · see citing works

Potent Protection against Aflatoxin-Induced Tumorigenesis through Induction of Nrf2-Regulated Pathways by the Triterpenoid 1-[2-Cyano-3-,12-Dioxooleana-1,9(11)-Dien-28-Oyl]Imidazole

Yates, M. S., Kwak, M.-K., Egner, P. A., Groopman, J. D., Bodreddigari, S., Sutter, T. R., Baumgartner, K. J., Roebuck, B. D., Liby, K. T., Yore, M. M., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3823 · Cited by 191 · see citing works

Identification of Bach2 as a B-cell-specific partner for small maf proteins that negatively regulate the immunoglobulin heavy chain gene 3′ enhancer

Muto, A., Hoshino, H., Madisen, L., Yanai, N., Obinata, M., Karasuyama, H., Hayashi, N., Nakauchi, H., Yamamoto, M., Groudine, M., et al. (1998) · The EMBO Journal · doi:10.1093/emboj/17.19.5734 · Cited by 190 · see citing works

Genetics of Aging in Caenorhabditis elegans

Antebi, A. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030129 · Cited by 188 · see citing works

In vivo modulation of the Parkinsonian phenotype by Nrf2

Burton, N. C., Kensler, T. W., & Guilarte, T. R. (2006) · NeuroToxicology · doi:10.1016/j.neuro.2006.07.019 · Cited by 187 · see citing works

The WD40 Repeat Protein WDR-23 Functions with the CUL4/DDB1 Ubiquitin Ligase To Regulate Nuclear Abundance and Activity of SKN-1 in Caenorhabditis elegans

Choe, K. P., Przybysz, A. J., & Strange, K. B. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01811-08 · Cited by 186 · see citing works

Differential expressions of antioxidant status in aging rats: the role of transcriptional factor Nrf2 and MAPK signaling pathway

Shih, P., & Yen, G. (2006) · Biogerontology · doi:10.1007/s10522-006-9033-y · Cited by 185 · see citing works

Arsenic-induced malignant transformation of human keratinocytes: Involvement of Nrf2

Pi, J., Diwan, B. A., Sun, Y., Liu, J., Qu, W., He, Y., Stýblo, M., & Waalkes, M. P. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.05.020 · Cited by 181 · see citing works

Nuclear Erythroid 2-Related Factor 2-Antioxidative Response Element Signaling Pathway in Motor Cortex and Spinal Cord in Amyotrophic Lateral Sclerosis

Sarlette, A., Krampfl, K., Grothe, C., Neuhoff, N. V., Dengler, R., & Petri, S. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31818b4906 · Cited by 179 · see citing works

Modulation of nuclear factor E2-related factor 2–mediated gene expression in mice liver and small intestine by cancer chemopreventive agent curcumin

Shen, G., Xu, C., Hu, R., Jain, M. R., Gopalkrishnan, A., Nair, S., Huang, M., Chan, J. Y., & Kong, A. T. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0293 · Cited by 179 · see citing works

Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

Łoboda, A., Damulewicz, M., Pyza, E., Józkowicz, A., & Dulak, J. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2223-0 · Cited by 2,654 · see citing works

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

Hayes, J. D., & Dinkova‐Kostova, A. T. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.02.002 · Cited by 2,158 · see citing works

Selective autophagy mediated by autophagic adapter proteins

Johansen, T., & Lamark, T. (2011) · Autophagy · doi:10.4161/auto.7.3.14487 · Cited by 1,730 · see citing works

The Biology of Proteostasis in Aging and Disease

Labbadia, J., & Morimoto, R. I. (2015) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-033955 · Cited by 1,472 · see citing works

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

Lei, G., Zhang, Y., Koppula, P., Liu, X., Zhang, J., Lin, S. H., Ajani, J. A., Xiao, Q., Liao, Z., Wang, H., et al. (2020) · Cell Research · doi:10.1038/s41422-019-0263-3 · Cited by 1,318 · see citing works

Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease

Ngo, V., & Duennwald, M. L. (2022) · Antioxidants · doi:10.3390/antiox11122345 · Cited by 1,130 · see citing works

Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer

Koppula, P., Zhang, Y., Zhuang, L., & Gan, B. (2018) · 癌症：英文版 · doi:10.1186/s40880-018-0288-x · Cited by 932 · see citing works

Regulation of Nrf2—an update

Niture, S. K., Khatri, R., & Jaiswal, A. K. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.02.008 · Cited by 873 · see citing works

AMP-Activated Protein Kinase (AMPK) Controls the Aging Process via an Integrated Signaling Network

Salminen, A., & Kaarniranta, K. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2011.12.005 · Cited by 860 · see citing works

Oxidative stress response and Nrf2 signaling in aging

Zhang, H., Davies, K. J. A., & Forman, H. J. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.05.036 · Cited by 804 · see citing works

Small Molecule Modulators of <scp>K</scp> eap1‐ <scp>N</scp> rf2‐ <scp>ARE</scp> Pathway as Potential Preventive and Therapeutic Agents

Magesh, S., Chen, Y., & Hu, L. (2012) · Medicinal Research Reviews · doi:10.1002/med.21257 · Cited by 760 · see citing works

Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease

Ruiz, S., Pérgola, P. E., Zager, R. A., & Vaziri, N. D. (2013) · Kidney International · doi:10.1038/ki.2012.439 · Cited by 722 · see citing works

How do nutritional antioxidants really work: Nucleophilic tone and para-hormesis versus free radical scavenging in vivo

Forman, H. J., Davies, K. J. A., & Ursini, F. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.05.045 · Cited by 707 · see citing works

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

Robida-Stubbs, S., Glover-Cutter, K., Lamming, D. W., Mizunuma, M., Narasimhan, S. D., Neumann-Haefelin, E., Sabatini, D. M., & Blackwell, T. K. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.007 · Cited by 648 · see citing works

SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans

Blackwell, T. K., Steinbaugh, M. J., Hourihan, J. M., Ewald, C. Y., & Isik, M. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.008 · Cited by 622 · see citing works

Structural basis of Keap1 interactions with Nrf2

Canning, P., Sorrell, F. J., & Bullock, A. N. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.05.034 · Cited by 605 · see citing works

Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer

Liu, X., Olszewski, K. L., Zhang, Y., Lim, E. W., Shi, J., Zhang, X., Zhang, J., Lee, H., Koppula, P., Lei, G., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0496-x · Cited by 599 · see citing works

Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha

Chorley, B. N., Campbell, M. R., Wang, X., Karaca, M., Sambandan, D., Bangura, F., Xue, P., Pi, J., Kleeberger, S. R., & Bell, D. A. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks409 · Cited by 557 · see citing works

Cancer Chemoprevention Mechanisms Mediated Through the Keap1–Nrf2 Pathway

Hayes, J. D., McMahon, M. J., Chowdhry, S., & Dinkova‐Kostova, A. T. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3221 · Cited by 540 · see citing works

Regulation of proteasome assembly and activity in health and disease

Rousseau, A., & Bertolotti, A. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0040-z · Cited by 510 · see citing works

Nox enzymes and new thinking on reactive oxygen: A double-edged sword revisited

Lambeth, J. D., & Neish, A. S. (2014) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-012513-104651 · Cited by 495 · see citing works

Oxidative Stress in Ageing and Chronic Degenerative Pathologies: Molecular Mechanisms Involved in Counteracting Oxidative Stress and Chronic Inflammation

Leyane, T. S., Jere, S. W., & Houreld, N. N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137273 · Cited by 510 · see citing works

A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers

Koppula, P., Lei, G., Zhang, Y., Yan, Y., Mao, C., Kondiparthi, L., Shi, J., Liu, X., Horbath, A. D., Das, M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29905-1 · Cited by 478 · see citing works

Antioxidant response elements: Discovery, classes, regulation and potential applications

Raghunath, A., Sundarraj, K., Raju, N., Arfuso, F., Bian, J., Kumar, A. P., Sethi, G., & Perumal, E. (2018) · Redox Biology · doi:10.1016/j.redox.2018.05.002 · Cited by 470 · see citing works

Regulation of proteasome activity in health and disease

Schmidt, M., & Finley, D. J. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.08.012 · Cited by 461 · see citing works

Molecular Biology of Atherosclerosis

Hopkins, P. N. (2013) · Physiological Reviews · doi:10.1152/physrev.00004.2012 · Cited by 456 · see citing works

SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

Olagnier, D. P., Farahani, E., Thyrsted, J., Blay‐Cadanet, J., Herengt, A., Idorn, M., Hait, A. S., Hernáez, B., Knudsen, A., Iversen, M. B., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18764-3 · Cited by 449 · see citing works

Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

McMahon, M. J., Lamont, D. J., Beattie, K. A., & Hayes, J. D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1007387107 · Cited by 445 · see citing works

Nrf2–MafG heterodimers contribute globally to antioxidant and metabolic networks

Hirotsu, Y., Katsuoka, F., Funayama, R., Nagashima, T., Nishida, Y., Nakayama, K., Engel, J. D., & Yamamoto, M. P. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks827 · Cited by 431 · see citing works

Macrophages and Iron Metabolism

Soares, M. P., & Hamza, I. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.016 · Cited by 401 · see citing works

Green leaf volatile production by plants: a meta‐analysis

Ameye, M., Allmann, S., Verwaeren, J., Smagghe, G. J., Haesaert, G., Schuurink, R. C., & Audenaert, K. (2017) · New Phytologist · doi:10.1111/nph.14671 · Cited by 395 · see citing works

Disease tolerance and immunity in host protection against infection

Soares, M. P., Teixeira, L., & Moita, L. F. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2016.136 · Cited by 376 · see citing works

Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosisPreprint

Wu, T., Zhao, F. L., Gao, B., Tan, C., Yagishita, N., Nakajima, T., Wong, P. K., Chapman, E., Fang, D., & Zhang, D. D. (2014) · Genes & Development · doi:10.1101/gad.238246.114 · Cited by 355 · see citing works

Anti‐ageing active ingredients from herbs and nutraceuticals used in traditional Chinese medicine: pharmacological mechanisms and implications for drug discovery

Shen, C., Jiang, J., Yang, L., Wang, D., & Zhu, W. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13631 · Cited by 345 · see citing works

Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity

Ewald, C. Y., Landis, J. N., Abate, J. P., Murphy, C. T., & Blackwell, T. K. (2014) · Nature · doi:10.1038/nature14021 · Cited by 337 · see citing works

Repression of the Heat Shock Response Is a Programmed Event at the Onset of Reproduction

Labbadia, J. P., & Morimoto, R. I. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.06.027 · Cited by 330 · see citing works

Pharmacological Targeting of the Transcription Factor Nrf2 at the Basal Ganglia Provides Disease Modifying Therapy for Experimental Parkinsonism

Jaźwa, A., Rojo, A. I., Innamorato, N. G., Hesse, M., Fernández‐Ruíz, J., & Cuadrado, A. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3731 · Cited by 329 · see citing works

Nrf2—a therapeutic target for the treatment of neurodegenerative diseases

Johnson, D. A., & Johnson, J. A. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.07.147 · Cited by 328 · see citing works

Acute exercise stress activates Nrf2/ARE signaling and promotes antioxidant mechanisms in the myocardium

Muthusamy, V. R., Kannan, S., Sadhaasivam, K., Gounder, S. S., Davidson, C. J., Boeheme, C., Hoidal, J. R., Wang, L., & Rajasekaran, N. S. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.10.440 · Cited by 316 · see citing works

The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate

Koppula, P., Zhang, Y., Shi, J., Li, W., & Gan, B. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.798405 · Cited by 302 · see citing works

The Role of Nrf2 Activity in Cancer Development and Progression

Zimța, A., Cenariu, D., Irimie, A., Magdo, L., Nabavi, S. M., Atanasov, A. G., & Berindan‐Neagoe, I. (2019) · Cancers · doi:10.3390/cancers11111755 · Cited by 298 · see citing works

Transcriptional regulation of xenobiotic detoxification in DrosophilaPreprint

Misra, J. R., Horner, M. A., Lam, G., & Thummel, C. S. (2011) · Genes & Development · doi:10.1101/gad.17280911 · Cited by 283 · see citing works

Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming

Olagnier, D., Brandtoft, A. M., Gunderstofte, C., Villadsen, N. L., Krapp, C., Thielke, A. L., Laustsen, A., Peri, S., Hansen, A. L., Bonefeld, L., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05861-7 · Cited by 282 · see citing works

Discovery of Vinyl Sulfones as a Novel Class of Neuroprotective Agents toward Parkinson’s Disease Therapy

Woo, S. Y., Kim, J. H., Moon, M. K., Han, S. H., Yeon, S. K., Choi, J., Jang, B. K., Song, H. J., Kang, Y. G., Kim, J. W., et al. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm401788m · Cited by 268 · see citing works

α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease

Lastres‐Becker, I., Ulusoy, A., Innamorato, N. G., Şahin, G., Rábano, A., Kirik, D., & Cuadrado, A. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds143 · Cited by 264 · see citing works

Proteomic Analysis of Ubiquitin Ligase KEAP1 Reveals Associated Proteins That Inhibit NRF2 Ubiquitination

Hast, B. E., Goldfarb, D., Mulvaney, K. M., Hast, M. A., Siesser, P. F., Yan, F., Hayes, D. N., & Major, M. B. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4400 · Cited by 259 · see citing works

Protein damage, repair and proteolysis

Chondrogianni, N., Petropoulos, I., Grimm, S., Georgila, K., Catalgol, B., Friguet, B., Grune, T., & Gonos, E. S. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.09.001 · Cited by 254 · see citing works

A Versatile ΦC31 Based Reporter System for Measuring AP-1 and Nrf2 Signaling in Drosophila and in Tissue Culture

Chatterjee, N., & Bohmann, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034063 · Cited by 254 · see citing works

Molecular chaperones and proteostasis regulation during redox imbalance

Niforou, K., Cheimonidou, C., & Trougakos, I. P. (2014) · Redox Biology · doi:10.1016/j.redox.2014.01.017 · Cited by 250 · see citing works

Roles of Oxidative Stress and Nrf2 Signaling in Pathogenic and Non-Pathogenic Cells: A Possible General Mechanism of Resistance to Therapy

Hammad, M., Raftari, M., Cesário, R., Salma, R., Godoy, P. R. D. V., Emami, S. N., & Haghdoost, S. (2023) · Antioxidants · doi:10.3390/antiox12071371 · Cited by 245 · see citing works

NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis

Widenmaier, S. B., Snyder, N., Nguyen, T. B., Arduini, A., Lee, G. Y., Arruda, A. P., Saksi, J., Bartelt, A., & Hotamışlıgil, G. S. (2017) · Cell · doi:10.1016/j.cell.2017.10.003 · Cited by 229 · see citing works

Sulforaphane reactivates cellular antioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress

Kubo, E., Chhunchha, B., Singh, P., Sasaki, H., & Singh, D. P. (2017) · Scientific Reports · doi:10.1038/s41598-017-14520-8 · Cited by 231 · see citing works

Transcriptional regulation of xenobiotic detoxification genes in insects - An overview

Amezian, D., Nauen, R., & Goff, G. L. (2021) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2021.104822 · Cited by 231 · see citing works

The Keap1-Nrf2 system and diabetes mellitus

Uruno, A., Yagishita, Y., & Yamamoto, M. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.12.012 · Cited by 231 · see citing works

Mechanism of the Nrf2/Keap1/ARE signaling system

Tkachev, V., Брониславовна, М. Е., & Зенков, Н. К. (2011) · Biochemistry (Moscow) · doi:10.1134/s0006297911040031 · Cited by 228 · see citing works

Genetic Analysis of Cytoprotective Functions Supported by Graded Expression of Keap1

Taguchi, K., Maher, J. M., Suzuki, T., Kawatani, Y., Motohashi, H., & Yamamoto, M. P. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01591-09 · Cited by 225 · see citing works

Molecular and Chemical Regulation of the Keap1-Nrf2 Signaling Pathway

Keum, Y., & Choi, B. Y. (2014) · Molecules · doi:10.3390/molecules190710074 · Cited by 224 · see citing works

Reactive Oxygen Production Induced by the Gut Microbiota: Pharmacotherapeutic Implications

Jones, R. M., Mercante, J. W., & Neish, A. S. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712799828283 · Cited by 228 · see citing works

HO-1 Induction in Cancer Progression: A Matter of Cell Adaptation

Nitti, M., Piras, S., Marinari, U. M., Moretta, L., Pronzato, M. A., & Furfaro, A. L. (2017) · Antioxidants · doi:10.3390/antiox6020029 · Cited by 222 · see citing works

NRF2 targeting: a promising therapeutic strategy in chronic obstructive pulmonary disease

Boutten, A., Goven, D., Artaud-Macari, É., Boczkowski, J., & Bonay, M. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.02.006 · Cited by 223 · see citing works

Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence

Steinbaugh, M. J., Narasimhan, S. D., Robida-Stubbs, S., Mazzeo, L. E. M., Dreyfuss, J. M., Hourihan, J. M., Raghavan, P., Operaña, T. N., Esmaillie, R., & Blackwell, T. K. (2015) · eLife · doi:10.7554/elife.07836 · Cited by 213 · see citing works

Insect ATP-Binding Cassette (ABC) Transporters: Roles in Xenobiotic Detoxification and Bt Insecticidal Activity

Wu, C., Chakrabarty, S., Jin, M., Liu, K., & Xiao, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112829 · Cited by 219 · see citing works

p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition

Radhakrishnan, S. K., den Besten, W., & Deshaies, R. J. (2014) · eLife · doi:10.7554/elife.01856 · Cited by 211 · see citing works

The role of the antioxidant and longevity-promoting Nrf2 pathway in metabolic regulation

Sykiotis, G. P., Habeos, I. G., Samuelson, A. V., & Bohmann, D. (2010) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32834136f2 · Cited by 214 · see citing works

Naringenin protects against 6-OHDA-induced neurotoxicity via activation of the Nrf2/ARE signaling pathway

Lou, H., Xu, J., Wei, X., Shi, H., Ren, D., & Zhang, X. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.11.026 · Cited by 212 · see citing works

Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis

Neymotin, A., Calingasan, N. Y., Wille, E. J., Naseri, N., Petri, S., Damiano, M. G., Liby, K. T., Risingsong, R., Sporn, M. B., Beal, M. F., et al. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.03.027 · Cited by 212 · see citing works

A systems view of epithelial–mesenchymal transition signaling states

Thomson, S., Petti, F., Sujka-Kwok, I., Mercado, P., Bean, J. M., Monaghan, M., Seymour, S. L., Argast, G. M., Epstein, D. M., & Haley, J. D. (2010) · Clinical & Experimental Metastasis · doi:10.1007/s10585-010-9367-3 · Cited by 210 · see citing works

Keratin 16 regulates innate immunity in response to epidermal barrier breach

Lessard, J. C., Piña-Paz, S., Rotty, J. D., Hickerson, R. P., Kaspar, R. L., Balmain, A., & Coulombe, P. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1309576110 · Cited by 206 · see citing works

An Overview of the Nrf2/ARE Pathway and Its Role in Neurodegenerative Diseases

Zgórzyńska, E., Dziedzic, B., & Walczewska, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179592 · Cited by 207 · see citing works

Nrf2: Molecular and epigenetic regulation during aging

Silva‐Palacios, A., Ostolga-Chavarría, M., Zazueta, C., & Königsberg, M. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.06.003 · Cited by 195 · see citing works

Tissue damage control in disease tolerance

Soares, M. P., Gozzelino, R., & Weis, S. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.08.001 · Cited by 187 · see citing works

Nrf2-A regulator of keratinocyte redox signaling

Schäfer, M., & Werner, S. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.04.018 · Cited by 192 · see citing works

NRF2 Activation in Cancer: From DNA to Protein

Cloer, E. W., Goldfarb, D., Schrank, T. P., Weissman, B. E., & Major, M. B. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-2723 · Cited by 182 · see citing works

Nrf2 links epidermal barrier function with antioxidant defense

Schäfer, M., Farwanah, H., Willrodt, A., Huebner, A. J., Sandhoff, K., Roop, D. R., Hohl, D., Bloch, W., & Werner, S. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201200219 · Cited by 186 · see citing works

Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis

Castillo-Quan, J. I., Li, L., Kinghorn, K. J., Ivanov, D. K., Tain, L. S., Slack, C., Kerr, F., Nespital, T., Thornton, J. M., Hardy, J., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.03.041 · Cited by 186 · see citing works

The transcription factor NF‐E2‐related Factor 2 (Nrf2): a protooncogene?

Shelton, P. M., & Jaiswal, A. K. (2012) · The FASEB Journal · doi:10.1096/fj.12-217257 · Cited by 185 · see citing works

Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3

Hayes, J. D., Chowdhry, S., Dinkova‐Kostova, A. T., & Sutherland, C. D. (2015) · Biochemical Society Transactions · doi:10.1042/bst20150011 · Cited by 185 · see citing works

Nrf2 Represses FGF21 During Long-Term High-Fat Diet–Induced Obesity in Mice

Chartoumpekis, D. V., Ziros, P. G., Psyrogiannis, A. I., Papavassiliou, A. G., Kyriazopoulou, V. E., Sykiotis, G. P., & Habeos, I. G. (2011) · Diabetes · doi:10.2337/db11-0112 · Cited by 184 · see citing works

NADPH debt drives redox bankruptcy: SLC7A11/xCT-mediated cystine uptake as a double-edged sword in cellular redox regulation

Liu, X., Zhang, Y., Zhuang, L., Olszewski, K. L., & Gan, B. (2020) · Genes & Diseases · doi:10.1016/j.gendis.2020.11.010 · Cited by 184 · see citing works

The Nrf2/ARE Pathway: A Promising Target to Counteract Mitochondrial Dysfunction in Parkinson's Disease

Tüfekçi, K. U., Bayin, E. C., Genç, Ş., & Genç, K. (2011) · Parkinson s Disease · doi:10.4061/2011/314082 · Cited by 181 · see citing works

Chronic oxidative stress promotes H2AX protein degradation and enhances chemosensitivity in breast cancer patients

Gruosso, T., Mieulet, V., Cardon, M., Bourachot, B., Kieffer, Y., Devun, F., Dubois, T., Dutreix, M., Vincent‐Salomon, A., Miller, K. M., et al. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201505891 · Cited by 179 · see citing works

RNAi Screening Implicates a SKN-1–Dependent Transcriptional Response in Stress Resistance and Longevity Deriving from Translation Inhibition

Wang, J., Robida-Stubbs, S., Tullet, J. M. A., Rual, J.-F. M., Vidal, M., & Blackwell, T. K. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001048 · Cited by 167 · see citing works

Bach2 maintains T cells in a naive state by suppressing effector memory-related genes

Tsukumo, S.-I., Unno, M., Muto, A., Takeuchi, A., Kometani, K., Kurosaki, T., Igarashi, K., & Saito, T. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1306691110 · Cited by 168 · see citing works

Endoplasmic reticulum stress and Nrf2 signaling in cardiovascular diseases

Cominacini, L., Mozzini, C., Garbin, U., Pasini, A., Stranieri, C., Solani, E., Vallerio, P., Tinelli, I. A., & Pasini, A. F. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.05.027 · Cited by 175 · see citing works

Impaired Transcriptional Activity of Nrf2 in Age-Related Myocardial Oxidative Stress Is Reversible by Moderate Exercise Training

Gounder, S. S., Kannan, S., Devadoss, D., Miller, C. J., Whitehead, K. S., Odelberg, S. J., Firpo, M. A., Paine, R., Hoidal, J. R., Abel, E. D., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045697 · Cited by 171 · see citing works

Regulation of Nrf2 by phosphorylation: Consequences for biological function and therapeutic implications

Liu, T., Lv, Y., Zhao, J., You, Q., & Jiang, Z. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.03.034 · Cited by 172 · see citing works

Targeting Nrf2-Mediated Gene Transcription by Extremely Potent Synthetic Triterpenoids Attenuate Dopaminergic Neurotoxicity in the MPTP Mouse Model of Parkinson's Disease

Kaidery, N. A., Banerjee, R., Yang, L., Smirnova, N. A., Hushpulian, D. M., Liby, K. T., Williams, C. R., Yamamoto, M. P., Kensler, T. W., Ratan, R. R., et al. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4491 · Cited by 172 · see citing works

Nrf2 as regulator of innate immunity: A molecular Swiss army knife!

Battino, M. A., Giampieri, F., Pistollato, F., Sureda, A., de Oliveira, M. R., Pittalà, V., Fallarino, F., Nabavi, S. F., Atanasov, A. G., & Nabavi, S. M. (2017) · Biotechnology Advances · doi:10.1016/j.biotechadv.2017.12.012 · Cited by 168 · see citing works

Nrf2 Promotes Keratinocyte Proliferation in Psoriasis through Up-Regulation of Keratin 6, Keratin 16, and Keratin 17

Yang, L., Fan, X., Cui, T., Dang, E., & Wang, G. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.05.015 · Cited by 169 · see citing works

Nrf2 Suppresses Oxidative Stress and Inflammation in App Knock-In Alzheimer’s Disease Model Mice

Uruno, A., Matsumaru, D., Ryoke, R., Saito, R., Kadoguchi, S., Saigusa, D., Saito, T., Saido, T. C., Kawashima, R., & Yamamoto, M. P. (2020) · Molecular and Cellular Biology · doi:10.1128/mcb.00467-19 · Cited by 166 · see citing works

Nrf2-Mediated Fibroblast Reprogramming Drives Cellular Senescence by Targeting the Matrisome

Hiebert, P., Wietecha, M. S., Cangkrama, M., Haertel, E., Mavrogonatou, E., Stumpe, M., Steenbock, H., Grossi, S., Beer, H., Angel, P. E., et al. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.06.012 · Cited by 166 · see citing works

Nrf2 activation in the treatment of neurodegenerative diseases: a focus on its role in mitochondrial bioenergetics and function

Esteras, N., Dinkova‐Kostova, A. T., & Abramov, A. Y. (2016) · Biological Chemistry · doi:10.1515/hsz-2015-0295 · Cited by 161 · see citing works

Proanthocyanidins against Oxidative Stress: From Molecular Mechanisms to Clinical Applications

Yang, L., Xian, D., Xiong, X., Lai, R., Song, J., & Zhong, J. (2018) · BioMed Research International · doi:10.1155/2018/8584136 · Cited by 160 · see citing works

Role of impaired Nrf2 activation in the pathogenesis of oxidative stress and inflammation in chronic tubulo-interstitial nephropathy

Aminzadeh, M. A., Nicholas, S. B., Norris, K. C., & Vaziri, N. D. (2013) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gft022 · Cited by 156 · see citing works

Specific SKN-1/Nrf Stress Responses to Perturbations in Translation Elongation and Proteasome Activity

Li, X., Matilainen, O., Jin, C., Glover-Cutter, K. M., Holmberg, C. I., & Blackwell, T. K. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002119 · Cited by 152 · see citing works

Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance

Cui, M., Atmanli, A., Morales, M. G., Tan, W. H., Chen, K., Xiao, X., Xu, L., Liu, N., Bassel‐Duby, R., & Olson, E. N. (2021) · Nature Communications · doi:10.1038/s41467-021-25653-w · Cited by 148 · see citing works

Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease

Kerr, F., Sofola-Adesakin, O., Ivanov, D. K., Gatliff, J., Perez‐Nievas, B. G., Bertrand, H. C., Martinez, P., Callard, R., Snoeren, I., Cochemé, H. M., et al. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006593 · Cited by 146 · see citing works

Oxidative Stress in Cardiovascular Diseases: Involvement of Nrf2 Antioxidant Redox Signaling in Macrophage Foam Cells Formation

Ooi, B. K., Goh, B. H., & Yap, W. H. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112336 · Cited by 144 · see citing works

Transcription factors, CncC and Maf, regulate expression of CYP6BQ genes responsible for deltamethrin resistance in Tribolium castaneum

Kalsi, M., & Palli, S. R. (2015) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2015.08.002 · Cited by 141 · see citing works

Regulation of Drosophila lifespan by JNK signaling

Biteau, B., Karpac, J., Hwangbo, D., & Jasper, H. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.11.003 · Cited by 138 · see citing works

Preserving transcriptional stress responses as an anti‐aging strategy

Cheng, Y., Pitoniak, A., Wang, J., & Bohmann, D. (2021) · Aging Cell · doi:10.1111/acel.13297 · Cited by 14 · see citing works

Mechanisms and functions of Nrf2 signaling in Drosophila

Pitoniak, A., & Bohmann, D. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.020 · Cited by 123 · see citing works

SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans

Blackwell, T. K., Steinbaugh, M. J., Hourihan, J. M., Ewald, C. Y., & Isik, M. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.008 · Cited by 622 · see citing works

Declining signal dependence of <scp>N</scp> rf2‐ <scp>M</scp> af <scp>S</scp> ‐regulated gene expression correlates with aging phenotypes

Rahman, M. M., Sykiotis, G. P., Nishimura, M., Bodmer, R., & Bohmann, D. (2013) · Aging Cell · doi:10.1111/acel.12078 · Cited by 100 · see citing works

Drosophila Nrf2/Keap1 Mediated Redox Signaling Supports Synaptic Function and Longevity and Impacts on Circadian Activity

Spiers, J. G., Breda, C., Robinson, S., Giorgini, F., & Steinert, J. R. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00086 · Cited by 41 · see citing works