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Heme oxygenase-1 mediates BAY 11-7085 induced ferroptosis

Chang, Ling-Chu, Chiang, Shih-Kai, Chen, Shuen-Ei, Yu, Yung-Luen, Chou, Ruey-Hwang, Chang, Wei-Chao·2018·Cancer Letters
DOI 10.1016/j.canlet.2017.12.025
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Abstract

Ferroptosis is a form of oxidative cell death and has become a chemotherapeutic target for cancer treatment. BAY 11-7085 (BAY), which is a well-known IκBα inhibitor, suppressed viability in cancer cells via induction of ferroptotic death in an NF-κB-independent manner. Reactive oxygen species scavenging, relief of lipid peroxidation, replenishment of glutathione and thiol-containing agents, as well as iron chelation, rescued BAY-induced cell death. BAY upregulated a variety of Nrf2 target genes related to redox regulation, particularly heme oxygenase-1 (HO-1). Studies with specific inhibitors and shRNA interventions suggested that the hierarchy of induction is Nrf2-SLC7A11-HO-1. SLC7A11 inhibition by erastin, sulfasalazine, or shRNA interference sensitizes BAY-induced cell death. Overexperession of SLC7A11 attenuated BAY-inhibited cell viability. The ferroptotic process induced by hHO-1 overexpression further indicated that HO-1 is a key mediator of BAY-induced ferroptosis that operates through cellular redox regulation and iron accumulation. BAY causes compartmentalization of HO-1 into the nucleus and mitochondrion, and followed mitochondrial dysfunctions, leading to lysosome targeting for mitophagy. In this study, we first discovered that BAY induced ferroptosis via Nrf2-SLC7A11-HO-1 pathway and HO-1 is a key mediator by responding to the cellular redox status.

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Metadata

Authors
Chang, L.-C., Chiang, S.-K., Chen, S.-E., Yu, Y.-L., Chou, R.-H., & Chang, W.-C.
ORCID
Chang, Ling-Chu
Venue
Cancer Letters
Publisher
Elsevier BV
Published
2018-03
Volume
416
Pages
124-137
ISSN
0304-3835
DOI
10.1016/j.canlet.2017.12.025
Cited by
521
References
12
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
Ministry of Science and Technology of the Republic of China (104-2314-B-039-034, 105-2628-B-039-004-MY3)

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