The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Mechanisms of viral mutation
Open accessAbstract
The remarkable capacity of some viruses to adapt to new hosts and environments is highly dependent on their ability to generate de novo diversity in a short period of time. Rates of spontaneous mutation vary amply among viruses. RNA viruses mutate faster than DNA viruses, single-stranded viruses mutate faster than double-strand virus, and genome size appears to correlate negatively with mutation rate. Viral mutation rates are modulated at different levels, including polymerase fidelity, sequence context, template secondary structure, cellular microenvironment, replication mechanisms, proofreading, and access to post-replicative repair. Additionally, massive numbers of mutations can be introduced by some virus-encoded diversity-generating elements, as well as by host-encoded cytidine/adenine deaminases. Our current knowledge of viral mutation rates indicates that viral genetic diversity is determined by multiple virus- and host-dependent processes, and that viral mutation rates can evolve in response to specific selective pressures.
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Cites
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“Experimental evidence supporting the joint effects of recombination and mutation rates in viral adaptability has been recently obtained using poliovirus polymerase mutants that individually alter replication fidelity or recombination rate [126].”
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Cited by
Markov, P. V., Ghafari, M., Beer, M., Lythgoe, K., Simmonds, P., Stilianakis, N. I., & Katzourakis, A. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-023-00878-2 · Cited by 1,179
SARS-CoV-2 evolution during treatment of chronic infection
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Directed Evolution: Methodologies and Applications
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Global Organization and Proposed Megataxonomy of the Virus World
Koonin, E. V., Dolja, V. V., Krupovic, M., Varsani, A., Wolf, Y. I., Yutin, N., Zerbini, F. M., & Kuhn, J. H. (2020) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00061-19 · Cited by 585
Optimizing oncolytic virotherapy in cancer treatment
Harrington, K., Freeman, D. J., Kelly, B., Harper, J., & Soria, J.-C. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0029-0 · Cited by 513
Metadata
- Authors
- Sanjuán, R., & Domingo-Calap, P.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2016-07-08
- Volume
- 73
- Issue
- 23
- Pages
- 4433-4448
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- OpenAlex
- W2461540377
- Cited by
- 947
- References
- 10
- FWCI
- 28.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
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