Mechanisms and consequences of intestinal dysbiosis

Microbiota regulates type 1 diabetes through Toll-like receptors

Burrows, M. P., Volchkov, P., Kobayashi, K. S., & Chervonsky, A. V. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1508740112 · Cited by 174

Comparative analyses of fecal microbiota in Tibetan and Chinese Han living at low or high altitude by barcoded 454 pyrosequencing

Li, L., & Zhao, X. (2015) · Scientific Reports · doi:10.1038/srep14682 · Cited by 167

Comorbidities, Exposure to Medications, and the Risk of Community-Acquired Clostridium difficile Infection: A Systematic Review and Meta-analysis

Furuya‐Kanamori, L., Stone, J., Clark, J. M., McKenzie, S. J., Yakob, L., Paterson, D. L., Riley, T. V., Doi, S. A. R., & Clements, A. (2014) · Infection Control and Hospital Epidemiology · doi:10.1017/ice.2014.39 · Cited by 163

High-Affinity Interaction between Gram-Negative Flagellin and a Cell Surface Polypeptide Results in Human Monocyte Activation

McDermott, P. F., Ciacci-Woolwine, F., Snipes, J. A., & Mizel, S. B. (2000) · Infection and Immunity · doi:10.1128/iai.68.10.5525-5529.2000 · Cited by 161

Sequencing the human microbiome in health and disease

Cox, M. J., Cookson, W. O. C. M., & Moffatt, M. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt398 · Cited by 159

Bile Acids and the Membrane Bile Acid Receptor TGR5—Connecting Nutrition and Metabolism

Thomas, C., Auwerx, J. H., & Schoonjans, K. (2008) · Thyroid · doi:10.1089/thy.2007.0255 · Cited by 155

Prevalence and Risk Factors for Asymptomatic Clostridium difficile Carriage

Alasmari, F. A., Seiler, S. M., Hink, T., Burnham, C. D., & Dubberke, E. R. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu258 · Cited by 152

Differences in Gut Metabolites and Microbial Composition and Functions between Egyptian and U.S. Children Are Consistent with Their Diets

Shankar, V., Gouda, M., Moncivaiz, J. D., Gordon, A., Reo, N. V., Hussein, L., & Paliy, O. (2017) · mSystems · doi:10.1128/msystems.00169-16 · Cited by 152

The role of toxin A and toxin B in the virulence of Clostridium difficile

Carter, G. P., Rood, J. I., & Lyras, D. (2011) · Trends in Microbiology · doi:10.1016/j.tim.2011.11.003 · Cited by 148

TLR5 Signaling Stimulates the Innate Production of IL-17 and IL-22 by CD3negCD127+ Immune Cells in Spleen and Mucosa

Maele, L. V., Carnoy, C., Cayet, D., Songhet, P., Dumoutier, L., Ferrero, I., Janot, L., Erard, F., Bertout, J., Léger, H., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000115 · Cited by 144

TLR4 signalling in the intestine in health and disease

Fukata, M., & Abreu, M. T. (2007) · Biochemical Society Transactions · doi:10.1042/bst0351473 · Cited by 142

Microcins in action: amazing defence strategies of Enterobacteria

Rebuffat, S. (2012) · Biochemical Society Transactions · doi:10.1042/bst20120183 · Cited by 137

A modified R-type bacteriocin specifically targeting Clostridium difficile prevents colonization of mice without affecting gut microbiota diversity

Gebhart, D., Lok, S., Clare, S., Tomas, M., Stares, M., Scholl, D., Donskey, C. J., Lawley, T. D., & Govoni, G. R. (2015) · mBio · doi:10.1128/mbio.02368-14 · Cited by 127

High‐fat Diet‐induced Intestinal Hyperpermeability is Associated with Increased Bile Acids in the Large Intestine of Mice

Murakami, Y., Tanabe, S., & Suzuki, T. (2015) · Journal of Food Science · doi:10.1111/1750-3841.13166 · Cited by 125

Culture-independent analysis of desulfovibrios in the human distal colon of healthy, colorectal cancer and polypectomized individuals

Scanlan, P. D., Shanahan, F., & Marchesi, J. R. (2009) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2009.00709.x · Cited by 124

Oral immunoglobulin for preventing necrotizing enterocolitis in preterm and low birth weight neonates

Foster, J. P., Seth, R., & Cole, M. J. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001816.pub3 · Cited by 111

Prebiotic supplementation in preterm neonates: Updated systematic review and meta-analysis of randomised controlled trials

Srinivasjois, R. M., Rao, S. C., & Patole, S. (2013) · Clinical Nutrition · doi:10.1016/j.clnu.2013.05.009 · Cited by 110

Escherichia coli Nissle 1917 in Ulcerative Colitis Treatment: Systematic Review and Meta-analysis

Losurdo, G., Iannone, A., Contaldo, A., Ierardi, E., Leo, A. D., & Principi, M. (2015) · Journal of Gastrointestinal and Liver Diseases · doi:10.15403/jgld.2014.1121.244.ecn · Cited by 109

High-protein diet modifies colonic microbiota and luminal environment but not colonocyte metabolism in the rat model: The increased luminal bulk connection

Liu, X., Blouin, J.-M., Santacruz, A., Lan, A., Andriamihaja, M., Wilkanowicz, S., Benetti, P.-H., Tomé, D., Sanz, Y., Blachier, F., et al. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00400.2013 · Cited by 103

Immunoglobulin-like domains on bacteriophage: weapons of modest damage?

Fraser, J. S., Maxwell, K. L., & Davidson, A. R. (2007) · Current Opinion in Microbiology · doi:10.1016/j.mib.2007.05.018 · Cited by 102

Escherichia coli K99 binds to N-glycolylsialoparagloboside and N-glycolyl-GM3 found in piglet small intestine

Kyogashima, M., Ginsburg, V., & Krivan, H. C. (1989) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(89)90042-8 · Cited by 102

Serum nitric oxide metabolites in subjects with metabolic syndrome

Zahediasl, S., Ghasemi, A., & Azizi, F. (2008) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2008.08.076 · Cited by 90

Structural insights into bacterial recognition of intestinal mucins

Etzold, S., & Juge, N. (2014) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2014.07.002 · Cited by 89

TNF-alpha Activates MUC2 Transcription via NF-kappaB but Inhibits via JNK Activation

Ahn, D. H., Crawley, S., Hokari, R., Kato, S., Yang, S. C., Li, J., & Kim, Y. (2005) · Cellular Physiology and Biochemistry · doi:10.1159/000083636 · Cited by 84

Non-Steroidal Anti-Inflammatory Drug-Induced Enteropathy

Lim, Y. J., & Yang, C. (2012) · Clinical Endoscopy · doi:10.5946/ce.2012.45.2.138 · Cited by 80

Space Environmental Factor Impacts upon Murine Colon Microbiota and Mucosal Homeostasis

Ritchie, L. E., Taddeo, S. S., Weeks, B. R., Lima, F., Bloomfield, S. A., Azcárate-Peril, M. A., Zwart, S. R., Smith, S. M., & Turner, N. D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125792 · Cited by 80

The effects of the microbiota on the host immune system

Karczewski, J., Poniedziałek, B., Adamski, Z., & Rzymski, P. (2014) · Autoimmunity · doi:10.3109/08916934.2014.938322 · Cited by 73

Vasoactive intestinal peptide upregulates MUC2 intestinal mucin via CREB/ATF1

Hokari, R., Lee, H., Crawley, S., Yang, S. C., Gum, J. R., Miura, S., & Kim, Y. S. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00142.2005 · Cited by 68

Changes seen in gut bacteria content and distribution with obesity: causation or association?

Bell, D. S. H. (2015) · Postgraduate Medicine · doi:10.1080/00325481.2015.1098519 · Cited by 67

Toll-like receptor 4 activation increases Akt phosphorylation in colon cancer cells.

Doan, H. Q., Bowen, K. A., Jackson, L. A., & Evers, B. M. (2009) · PubMed · Cited by 67

A novelO-linked glycan modulatesCampylobacter jejunimajor outer membrane protein-mediated adhesion to human histo-blood group antigens and chicken colonization

Mahdavi, J., Pirinççioğlu, N., Oldfield, N. J., Carlsohn, E., Stoof, J., Aslam, A., Self, T. J., Cawthraw, S. A., Petrovska, L., Colborne, N., et al. (2014) · Open Biology · doi:10.1098/rsob.130202 · Cited by 64

Colonic bacterial metabolism of corticosteroids

Yadav, V., Gaisford, S., Merchant, H. A., & Basit, A. W. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.09.007 · Cited by 63

Reduced microbial diversity and high numbers of one single Escherichia coli strain in the intestine of colitic mice

Wohlgemuth, S., Haller, D., Blaut, M., & Loh, G. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.01883.x · Cited by 54

Thusin, a Novel Two-Component Lantibiotic with Potent Antimicrobial Activity against Several Gram-Positive Pathogens

Xin, B., Zheng, J., Liu, H., Li, J., Ruan, L., Peng, D., Sajid, M., & Sun, M. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01115 · Cited by 54

Changes to the Intestinal Microbiome With Parenteral Nutrition: Review of a Murine Model and Potential Clinical Implications

Demehri, F. R., Barrett, M., & Teitelbaum, D. H. (2015) · Nutrition in Clinical Practice · doi:10.1177/0884533615609904 · Cited by 53

Drug metabolome of the Simvastatin formed by human intestinal microbiota in vitro

Aura, A., Mattila, I. M., Hyötyläinen, T., Gopalacharyulu, P. V., Bounsaythip, C., Orešič, M., & Oksman‐Caldentey, K. (2010) · Molecular BioSystems · doi:10.1039/c0mb00023j · Cited by 50

Rifaximin in the treatment of inflammatory bowel disease

Guslandi, M. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i42.4643 · Cited by 50

Akkermansia muciniphila

Cani, P. D., & Everard, A. (2014) · médecine/sciences · doi:10.1051/medsci/20143002003 · Cited by 48

The immunity–diet–microbiota axis in the development of metabolic syndrome

Brandsma, E. T., Houben, T., Fu, J., Shiri‐Sverdlov, R., & Hofker, M. H. (2015) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000154 · Cited by 48

The Interaction Between Celiac Disease and Intestinal Microbiota

Losurdo, G., Principi, M., Iannone, A., Ierardi, E., & Leo, A. D. (2016) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000682 · Cited by 45

TGF-β Signaling in Dendritic Cells Governs Colonic Homeostasis by Controlling Epithelial Differentiation and the Luminal Microbiota

Ihara, S., Hirata, Y., Serizawa, T., Suzuki, N., Sakitani, K., Kinoshita, H., Hayakawa, Y., Nakagawa, H., Ijichi, H., Tateishi, K., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502548 · Cited by 42

Helicobacter pylori infection and normal colorectal mucosa–adenomatous polyp–adenocarcinoma sequence: a meta‐analysis of 27 case–control studies

Wang, F., Sun, M. Y., Shi, S., & Lv, Z. S. (2013) · Colorectal Disease · doi:10.1111/codi.12290 · Cited by 35

The role of stress in colicin regulation

Ghazaryan, L., Tonoyan, L., Al‐Ashhab, A., Soares, M. I. M., & Gillor, O. (2014) · Archives of Microbiology · doi:10.1007/s00203-014-1017-8 · Cited by 32

The problem of nitrogen disposal in the obese

Alemany, M. (2012) · Nutrition Research Reviews · doi:10.1017/s0954422411000163 · Cited by 31

Where genes meet environment—integrating the role of gut luminal contents, immunity and pancreas in type 1 diabetes

Scott, F. W., Pound, L. D., Patrick, C., Eberhard, C. E., & Crookshank, J. A. (2016) · Translational research · doi:10.1016/j.trsl.2016.09.001 · Cited by 24

Improving metabolic flux estimation via evolutionary optimization for convex solution space

Chen, J., Zheng, H., Liu, H., Junqing, N., Liu, J., Shen, T., Rui, B., & Shi, Y. (2007) · Bioinformatics · doi:10.1093/bioinformatics/btm050 · Cited by 11

EUBIOTIC MEDICINE

Galdston, I. (1944) · Science · doi:10.1126/science.100.2587.76 · Cited by 3

Eubiotic Medicine

Galdston, I. (1944) · Science · doi:10.1126/science.100.2587.76-a · Cited by 2

Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review

Di Vincenzo, F., Del Gaudio, A., Petito, V., Lopetuso, L. R., & Scaldaferri, F. (2024) · Internal and Emergency Medicine · doi:10.1007/s11739-023-03374-w · Cited by 1,498

The interplay between gut microbiota, short-chain fatty acids, and implications for host health and disease

Hays, K. E., Pfaffinger, J. M., & Ryznar, R. J. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2393270 · Cited by 541

Layered defense: how mucus and tight junctions seal the intestinal barrier

Capaldo, C., Powell, D. N., & Kalman, D. (2017) · Journal of Molecular Medicine · doi:10.1007/s00109-017-1557-x · Cited by 387

Role of Microbiota-Gut-Brain Axis in Regulating Dopaminergic Signaling

Hamamah, S., Aghazarian, A., Nazaryan, A., Hajnal, A. S., & Covașă, M. (2022) · Biomedicines · doi:10.3390/biomedicines10020436 · Cited by 327

Gut Microbiota Dysbiosis: Pathogenesis, Diseases, Prevention, and Therapy

Shen, Y., Fan, N., Ma, S., Cheng, X., Yang, X., & Wang, G. (2025) · MedComm · doi:10.1002/mco2.70168 · Cited by 404

Pathogenic role of the gut microbiota in gastrointestinal diseases

Nagao‐Kitamoto, H., Kitamoto, S., Kuffa, P., & Kamada, N. (2016) · Intestinal Research · doi:10.5217/ir.2016.14.2.127 · Cited by 178

Relationship between intestinal microbiota, diet and biological systems: an integrated view

Ferreira, R. D. S., Mendonça, L. A. B. M., Ribeiro, C. F. A., Calças, N. C., Guimarães, R. D. C. A., do Nascimento, V. A., Freitas, K. D. C., Carvalho, C. M. E., de Castro, A. P., & Franco, O. L. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1836605 · Cited by 46

Gut dysbacteriosis and intestinal disease: mechanism and treatment

Meng, X., ZHANG, G., Cao, H., Yu, D., Fang, X., de Vos, W. M., & Wu, H. (2020) · Journal of Applied Microbiology · doi:10.1111/jam.14661 · Cited by 130

Disbiosis en la microbiota intestinal

Moreno, X. (2024) · Revista GEN · doi:10.61155/gen.v76i1.602

The intestinal microbiota: its role in health and disease

Biedermann, L., & Rogler, G. (2015) · European Journal of Pediatrics · doi:10.1007/s00431-014-2476-2 · Cited by 227