Cited by 53Clinical Nutrition and GastroenterologyGut microbiota and healthGastrointestinal motility and disorders

Changes to the Intestinal Microbiome With Parenteral Nutrition: Review of a Murine Model and Potential Clinical Implications

Demehri, Farokh R., Barrett, Meredith, Teitelbaum, Daniel H.·2015·Nutrition in Clinical Practice

Abstract

Parenteral nutrition (PN) dependence, while life sustaining, carries a significant risk of septic complications associated with epithelial barrier dysfunction and translocation of gut-derived microbiota. Increasing evidence suggests that PN-associated changes in the intestinal microbiota play a central role in the breakdown of the intestinal epithelial barrier. This review outlines the clinical and experimental evidence of epithelial barrier dysfunction with PN, the role of gut inflammatory dysregulation in driving this process, and the role of the intestinal microbiome in modulating inflammation in the gut and systemically. The article summarizes the most current work of our laboratory and others and describes many of the laboratory findings behind our current understanding of the PN enteral environment. Understanding the interaction between nutrient delivery, the intestinal microbiome, and PN-associated complications may lead to the development of novel therapies to enhance safety and quality of life for patients requiring PN.

Integrity signals

Registry

Crossref · 10.1177/0884533615609904

Cites

88 of 88 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In a rodent model, depriving animals of enteral nutrition significantly alters intestinal bacterial colonization and causes defects in specific mucosal immunity.

    “in a rodent model, depriving animals of enteral nutrition (e.g., parenteral nutrition – intravenous nourishment) significantly alters intestinal bacterial colonization (e.g., increases levels of Proteobacteria (Demehri et al., 2015)) and causes defects in specific mucosal immunity (e.g., lowered secretory IgA levels).”

    From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Demehri et al., 2015

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Demehri, F. R., Barrett, M., & Teitelbaum, D. H.
Affiliations
Michigan Medicine (US)
Corresponding author
Teitelbaum, Daniel H.
Venue
Nutrition in Clinical Practice
Publisher
Wiley
Published
2015-09-30
Volume
30
Issue
6
Pages
798-806
ISSN
  • 0884-5336 (ISSN-L)
  • 1941-2452
OpenAlex
W2190920297
Cited by
53
References
88
Citations by year
2026: 2 · 2025: 3 · 2024: 8 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 8 · 2018: 6 · 2017: 7 · 2016: 4
FWCI
0.73
Type
journal article
Language
en
Open access
closed
Locations
  • Nutrition in Clinical Practice (publishedVersion)
  • PubMed (publishedVersion)
  • Deep Blue (University of Michigan) (submittedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
parenteral nutrition, gut microbiota, epithelial barrier dysfunction, intestinal barrier integrity, sepsis, intestinal inflammation, systemic inflammation
MeSH terms
Gastrointestinal Microbiome, Animals, Disease Models, Animal, Humans, Inflammation, Parenteral Nutrition, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review