Changes to the Intestinal Microbiome With Parenteral Nutrition: Review of a Murine Model and Potential Clinical Implications
Abstract
Parenteral nutrition (PN) dependence, while life sustaining, carries a significant risk of septic complications associated with epithelial barrier dysfunction and translocation of gut-derived microbiota. Increasing evidence suggests that PN-associated changes in the intestinal microbiota play a central role in the breakdown of the intestinal epithelial barrier. This review outlines the clinical and experimental evidence of epithelial barrier dysfunction with PN, the role of gut inflammatory dysregulation in driving this process, and the role of the intestinal microbiome in modulating inflammation in the gut and systemically. The article summarizes the most current work of our laboratory and others and describes many of the laboratory findings behind our current understanding of the PN enteral environment. Understanding the interaction between nutrient delivery, the intestinal microbiome, and PN-associated complications may lead to the development of novel therapies to enhance safety and quality of life for patients requiring PN.
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In a rodent model, depriving animals of enteral nutrition significantly alters intestinal bacterial colonization and causes defects in specific mucosal immunity.
“in a rodent model, depriving animals of enteral nutrition (e.g., parenteral nutrition – intravenous nourishment) significantly alters intestinal bacterial colonization (e.g., increases levels of Proteobacteria (Demehri et al., 2015)) and causes defects in specific mucosal immunity (e.g., lowered secretory IgA levels).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Demehri et al., 2015
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- Authors
- Demehri, F. R., Barrett, M., & Teitelbaum, D. H.
- Affiliations
- Michigan Medicine (US)
- Corresponding author
- Teitelbaum, Daniel H.
- Venue
- Nutrition in Clinical Practice
- Publisher
- Wiley
- Published
- 2015-09-30
- Volume
- 30
- Issue
- 6
- Pages
- 798-806
- ISSN
- 0884-5336 (ISSN-L)
- 1941-2452
- OpenAlex
- W2190920297
- Cited by
- 53
- References
- 88
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 8 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 8 · 2018: 6 · 2017: 7 · 2016: 4
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nutrition in Clinical Practice (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- parenteral nutrition, gut microbiota, epithelial barrier dysfunction, intestinal barrier integrity, sepsis, intestinal inflammation, systemic inflammation
- MeSH terms
- Gastrointestinal Microbiome, Animals, Disease Models, Animal, Humans, Inflammation, Parenteral Nutrition, Mice
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