The DOI matches its Crossref record; 277 of the 277 references it cites were found in a registry or an index.
Diversity among POU transcription factors in chromatin recognition and cell fate reprogramming
Open accessAbstract
The POU (Pit-Oct-Unc) protein family is an evolutionary ancient group of transcription factors (TFs) that bind specific DNA sequences to direct gene expression programs. The fundamental importance of POU TFs to orchestrate embryonic development and to direct cellular fate decisions is well established, but the molecular basis for this activity is insufficiently understood. POU TFs possess a bipartite 'two-in-one' DNA binding domain consisting of two independently folding structural units connected by a poorly conserved and flexible linker. Therefore, they represent a paradigmatic example to study the molecular basis for the functional versatility of TFs. Their modular architecture endows POU TFs with the capacity to accommodate alternative composite DNA sequences by adopting different quaternary structures. Moreover, associations with partner proteins crucially influence the selection of their DNA binding sites. The plentitude of DNA binding modes confers the ability to POU TFs to regulate distinct genes in the context of different cellular environments. Likewise, different binding modes of POU proteins to DNA could trigger alternative regulatory responses in the context of different genomic locations of the same cell. Prominent POU TFs such as Oct4, Brn2, Oct6 and Brn4 are not only essential regulators of development but have also been successfully employed to reprogram somatic cells to pluripotency and neural lineages. Here we review biochemical, structural, genomic and cellular reprogramming studies to examine how the ability of POU TFs to select regulatory DNA, alone or with partner factors, is tied to their capacity to epigenetically remodel chromatin and drive specific regulatory programs that give cells their identities.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“We examined the expression patterns of several transcription factor families (Extended Data Fig. 13), including forkhead box (Fox), Krüppel-like factor (Klf), LIM homeobox (Lhx), NKX-homeodomain (Nkx), nuclear receptor (Nr), Paired box (Pax), POU domain (Pou), positive regulatory domain (Prdm), SRY-related HMG-box (Sox), and T-box (Tbx), all of which have been shown to have important roles in”
From A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain (2023) · cites this paper as [102]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Items 201–277 of 277
Reprogramming fibroblasts into induced pluripotent stem cells with Bmi1
Moon, J.-H., Heo, J. S., Kim, J. S., Jun, E. K., Lee, J. H., Kim, A., Kim, J., Whang, K. Y., Kang, Y., Yeo, S., et al. (2011) · Cell Research · doi:10.1038/cr.2011.107 · Cited by 120
Lillycrop, K. A., Budrahan, V. S., Lakin, N. D., Terrenghi, G., Wood, J. N., Polak, J. M., & Latchman, D. S. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.19.5093 · Cited by 116
Recognition of the surface of a homeo domain protein.Preprint
Pomerantz, J. L., Kristie, T. M., & Sharp, P. A. (1992) · Genes & Development · doi:10.1101/gad.6.11.2047 · Cited by 114
Small molecules enable OCT4-mediated direct reprogramming into expandable human neural stem cells
Zhu, S., Ambasudhan, R., Sun, W., Kim, H. J., Talantova, M. V., Wang, X., Zhang, M., Zhang, Y., Laurent, T., Parker, J., et al. (2013) · Cell Research · doi:10.1038/cr.2013.156 · Cited by 114
Molecular basis for the genome engagement by Sox proteins
Hou, L., Srivastava, Y., & Jauch, R. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.08.005 · Cited by 113
Self-citationO-GlcNAc modifications regulate cell survival and epiboly during zebrafish development
Webster, D. M., Teo, C. F., Sun, Y., Włoga, D., Gay, S., Klonowski, K. D., Wells, L., & Dougan, S. T. (2009) · BMC Developmental Biology · doi:10.1186/1471-213x-9-28 · Cited by 112
Lineage conversion induced by pluripotency factors involves transient passage through an iPSC stage
Bar‐Nur, O., Verheul, C., Sommer, A. G., Brumbaugh, J., Schwarz, B. A., Lipchina, I., Huebner, A. J., Mostoslavsky, G., & Hochedlinger, K. (2015) · Nature Biotechnology · doi:10.1038/nbt.3247 · Cited by 109
Takeda, H., Matsuzaki, T., Oki, T., Miyagawa, T., & Amanuma, H. (1994) · Genes & Development · doi:10.1101/gad.8.1.45 · Cited by 109
Core Mediator structure at 3.4 Å extends model of transcription initiation complex
Nozawa, K., Schneider, T. R., & Cramer, P. (2017) · Nature · doi:10.1038/nature22328 · Cited by 108
Functions of the POU domain genes Skn-1a/i and Tst-1/Oct-6/SCIP in epidermal differentiation.Preprint
D, B. A. M., Weinberg, W. C., Rennekampff, O. H., McEvilly, R. J., Bermingham, J. R., Hooshmand, F., Vasilyev, V. B., Hansbrough, J. F., Pittelkow, M. R., Yuspa, S. H., et al. (1997) · Genes & Development · doi:10.1101/gad.11.14.1873 · Cited by 107
Dailey, L., Yuan, H., & Basilico, C. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.12.7758-7769.1994 · Cited by 107
Jauch, R., Aksoy, I., Hutchins, A. P., Ng, C. K. L., Tian, X. F., Chen, J., Palasingam, P., Robson, P., Stanton, L. W., & Kolatkar, P. R. (2011) · Stem Cells · doi:10.1002/stem.639 · Cited by 106
Self-citationAnabolic-androgenic steroids induce apoptotic cell death in adult rat ventricular myocytes
Zaugg, M., Jamali, N. Z., Lucchinetti, E., Xu, W., Alam, M., Shafiq, S. A., & Siddiqui, M. A. Q. (2001) · Journal of Cellular Physiology · doi:10.1002/1097-4652(2001)9999:9999 · Cited by 106
Ninkina, N. N., Stevens, G., Wood, J. N., & Richardson, W. D. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.14.3175 · Cited by 105
Phosphorylation regulates human OCT4
Brumbaugh, J., Hou, Z., Russell, J. D., Howden, S. E., Yu, P., Ledvina, A. R., Coon, J. J., & Thomson, J. A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1203874109 · Cited by 100
Swinstead, E. E., Paakinaho, V., Presman, D. M., & Hager, G. L. (2016) · BioEssays · doi:10.1002/bies.201600137 · Cited by 100
Tsai, S., Bouwman, B. A. M., Ang, Y.-S., Kim, S., Lee, D., Lemischka, I. R., & Rendl, M. (2011) · Stem Cells · doi:10.1002/stem.649 · Cited by 99
Nishimoto, M., Miyagi, S., Yamagishi, T., Sakaguchi, T., Niwa, H., Muramatsu, M., & Okuda, A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.12.5084-5094.2005 · Cited by 97
Chen, J., Chen, X., Li, M., Liu, X., Gao, Y., Kou, X., Zhao, Y., Zheng, W., Zhang, X., Huo, Y., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.01.013 · Cited by 94
O’Neill, E. A., & Kelly, T. J. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)35442-0 · Cited by 93
Poellinger, L., & Roeder, R. G. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.2.747-756.1989 · Cited by 92
Deciphering the Sox-Oct partner code by quantitative cooperativity measurements
Ng, C. K. L., Li, N. X., Chee, S., Prabhakar, S., Kolatkar, P. R., & Jauch, R. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks153 · Cited by 89
Self-citationGeneration of Induced Pluripotent Stem Cells from Human Adipose-Derived Stem Cells Without c-MYC
Aoki, T., Ohnishi, H., Oda, Y., Tadokoro, M., Sasao, M., Kato, H., Hattori, K., & Ohgushi, H. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2009.0747 · Cited by 86
Required enhancer–matrin-3 network interactions for a homeodomain transcription program
Skowronska‐Krawczyk, D., Ma, Q., Schwartz, M., Scully, K. M., Li, W., Liu, Z., Taylor, H., Tollkühn, J., Ohgi, K. A., Notani, D., et al. (2014) · Nature · doi:10.1038/nature13573 · Cited by 83
Zhao, H., Li, Y., Jin, H., Xie, L., Liu, C., Jiang, F., Luo, Y., Yin, G.-W., Li, Y., Wang, J., et al. (2010) · Differentiation · doi:10.1016/j.diff.2010.03.002 · Cited by 82
Palasingam, P., Jauch, R., Ng, C. K. L., & Kolatkar, P. R. (2009) · Journal of Molecular Biology · doi:10.1016/j.jmb.2009.03.055 · Cited by 80
Self-citationThe Early Expansion and Evolutionary Dynamics of POU Class Genes
Gold, D. A., Gates, R. D., & Jacobs, D. K. (2014) · Molecular Biology and Evolution · doi:10.1093/molbev/msu243 · Cited by 77
Jauch, R., Ng, C. K. L., Narasimhan, K., & Kolatkar, P. R. (2011) · Biochemical Journal · doi:10.1042/bj20111768 · Cited by 73
Self-citationZhou, H., Yoshioka, T., & Nathans, J. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-07-02261.1996 · Cited by 73
Post‐translational modification of POU domain transcription factor Oct‐4 by SUMO‐1
Zhang, Z., Liao, B., Xu, M., & Jin, Y. (2007) · The FASEB Journal · doi:10.1096/fj.06-6914com · Cited by 72
Reprogramming of Trophoblast Stem Cells into Pluripotent Stem Cells by Oct4
Wu, T., Wang, H., He, J., Kang, L., Jiang, Y.-H., Liu, J., Zhang, Y., Kou, Z.-H., Liu, L., Zhang, X.-H., et al. (2011) · Stem Cells · doi:10.1002/stem.617 · Cited by 70
Dissecting the role of distinct OCT4-SOX2 heterodimer configurations in pluripotency
Tàpia, N., MacCarthy, C. M., Esch, D., Marthaler, A. G., Tiemann, U., Araúzo-Bravo, M. J., Jauch, R., Cojocaru, V., & Schöler, H. R. (2015) · Scientific Reports · doi:10.1038/srep13533 · Cited by 69
Self-citationChromatin scanning by dynamic binding of pioneer factors
Zaret, K. S., Lerner, J., & Iwafuchi-Doi, M. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.05.024 · Cited by 68
Structure of Smad1 MH1/DNA complex reveals distinctive rearrangements of BMP and TGF-β effectors
Baburajendran, N., Palasingam, P., Narasimhan, K., Sun, W., Prabhakar, S., Jauch, R., & Kolatkar, P. R. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq046 · Cited by 66
Self-citationAksoy, I., Jauch, R., Eras, V., Chng, W.-B. A., Chen, J., Divakar, U., Ng, C. K. L., Kolatkar, P. R., & Stanton, L. W. (2013) · Stem Cells · doi:10.1002/stem.1522 · Cited by 65
Self-citationReduced fertility in mice deficient for the POU protein sperm-1
Pearse, R. V., Drolet, D. W., Kalla, K. A., Hooshmand, F., Bermingham, J. R., & Rosenfeld, M. G. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7555 · Cited by 64
Efficient Generation of iPS Cells from Skeletal Muscle Stem Cells
Tan, K., Eminli, S., Hettmer, S., Hochedlinger, K., & Wagers, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026406 · Cited by 63
Models of global gene expression define major domains of cell type and tissue identity
Hutchins, A. P., Yang, Z., Li, Y., He, F., Fu, X., Wang, X., Li, D., Liu, K., He, J., Wang, Y., et al. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx054 · Cited by 63
Chemical approaches to cell reprogramming
Chen, Y., Liu, K., Tang, S., & Ding, S. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2014.09.006 · Cited by 59
Brn-5 is a divergent POU domain factor highly expressed in layer IV of the neocortex.
D, B. A. M., Schonemann, M. D., Pearse, R. V., Jenné, K. J., Sugarman, J., & Rosenfeld, M. G. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49475-1 · Cited by 58
Selective influence of Sox2 on POU transcription factor binding in embryonic and neural stem cells
Mistri, T. K., Devasia, A. G., Chu, L. T., Ng, W. P., Halbritter, F., Colby, D., Martynoga, B., Tomlinson, S. R., Chambers, I., Robson, P., et al. (2015) · EMBO Reports · doi:10.15252/embr.201540467 · Cited by 58
Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA interaction
Klaus, M., Prokoph, N., Girbig, M., Wang, X., Huang, Y., Srivastava, Y., Hou, L., Narasimhan, K., Kolatkar, P. R., François, M., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw130 · Cited by 55
Self-citationDailey, L., Yuan, H., & Basilico, C. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.12.7758 · Cited by 55
Highly Cooperative Homodimerization Is a Conserved Property of Neural POU Proteins
Rhee, J. M., Gruber, C. A., Brodie, T. B., Trieu, M., & Turner, E. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.51.34196 · Cited by 54
Structural Basis for the SOX-Dependent Genomic Redistribution of OCT4 in Stem Cell Differentiation
Merino, F., Ng, C. K. L., Veerapandian, V., Schöler, H. R., Jauch, R., & Cojocaru, V. (2014) · Structure · doi:10.1016/j.str.2014.06.014 · Cited by 51
Self-citationSperm 1: a POU-domain gene transiently expressed immediately before meiosis I in the male germ cell.
D, B. A. M., Pearse, R. V., Schlegel, P. N., Cichon, Z., Schonemann, M. D., Bardin, C. W., & Rosenfeld, M. G. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11084 · Cited by 51
Homoeo boxes, POU proteins and the limits to promiscuity
Robertson, M. (1988) · Nature · doi:10.1038/336522a0 · Cited by 47
DNA-PK phosphorylation sites on Oct-1 promote cell survival following DNA damage
Schild‐Poulter, C., Shih, A., Tantin, D. R., Yarymowich, N. C., Soubeyrand, S., Sharp, P. A., & Haché, R. J. G. (2007) · Oncogene · doi:10.1038/sj.onc.1210165 · Cited by 47
Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers
Baburajendran, N., Jauch, R., Tan, C. Y. Z., Narasimhan, K., & Kolatkar, P. R. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr500 · Cited by 44
Self-citationTakayama, Y., & Clore, G. M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100050108 · Cited by 42
Changing POU dimerization preferences converts Oct6 into a pluripotency inducer
Jerabek, S., Ng, C. K., Wu, G., Arauzo‐Bravo, M. J., Kim, K., Esch, D., Malik, V., Chen, Y., Velychko, S., MacCarthy, C. M., et al. (2017) · The EMBO Reports · doi:10.15252/embr.201642958 · Cited by 42
Self-citationNarasimhan, K., Pillay, S., Huang, Y.-H., Jayabal, S., Udayasuryan, B., Veerapandian, V., Kolatkar, P. R., Cojocaru, V., Pervushin, K. V., & Jauch, R. (2015) · Nucleic Acids Research · doi:10.1093/nar/gku1390 · Cited by 39
Self-citationPoellinger, L., & Roeder, R. G. (1989) · Molecular and Cellular Biology · doi:10.1128/mcb.9.2.747 · Cited by 38
Combinatorial binding of transcription factors in the pluripotency control regions of the genomePreprint
Ferraris, L., Stewart, A. P., Kang, J., DeSimone, A. M., Gemberling, M. P., Tantin, D. R., & Fairbrother, W. G. (2011) · Genome Research · doi:10.1101/gr.115824.110 · Cited by 37
Dynamic Regulation of Oct1 during Mitosis by Phosphorylation and Ubiquitination
Kang, J., Goodman, B., Zheng, Y., & Tantin, D. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023872 · Cited by 36
Quantitative profiling of selective Sox/POU pairing on hundreds of sequences in parallel by Coop-seq
Chang, Y. K., Srivastava, Y., Hu, C., Joyce, A. P., Yang, X., Zuo, Z., Havranek, J. J., Stormo, G. D., & Jauch, R. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw1198 · Cited by 36
Self-citationSolution structure of the Oct-1 POU homeodomain determined by NMR and restrained molecular dynamics
Cox, M., van Tilborg, P. J. A., de Laat, W. L., Boelens, R., van Leeuwen, H. C., van der Vliet, P. C., & Kaptein, R. (1995) · Journal of Biomolecular NMR · doi:10.1007/bf00417488 · Cited by 35
Niwa, H., Nakamura, A., Urata, M., Shirae‐Kurabayashi, M., Kuraku, S., Russell, S. R. H., & Ohtsuka, S. (2016) · BMC Evolutionary Biology · doi:10.1186/s12862-016-0755-4 · Cited by 35
The POU-er of gene nomenclature
Frankenberg, S., Frank, D., Harland, R. M., Johnson, A. D., Nichols, J., Niwa, H., Schöler, H. R., Tanaka, E. M., Wylie, C., & Brickman, J. M. (2014) · Development · doi:10.1242/dev.108407 · Cited by 34
Novel Variants of Oct-3/4 Gene Expressed in Mouse Somatic Cells
Mizuno, N., & Kosaka, M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802992200 · Cited by 31
A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues
Wey, E., Lyons, G. E., & Schäfer, B. W. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.tb18676.x · Cited by 30
Differential activity by DNA-induced quarternary structures of POU transcription factors
Reményi, A., Tomilin, A. N., Schöler, H. R., & Wilmanns, M. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01164-4 · Cited by 29
The many roads to Rome: induction of neural precursor cells from fibroblasts
Lujan, E., & Wernig, M. (2012) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2012.07.002 · Cited by 28
Regulation of Oct1/Pou2f1 transcription activity by O ‐GlcNAcylation
Kang, J., Shen, Z., Lim, J., Handa, H., Wells, L., & Tantin, D. R. (2013) · The FASEB Journal · doi:10.1096/fj.12-220897 · Cited by 28
Merino, F., Bouvier, B., & Cojocaru, V. (2015) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004287 · Cited by 27
Critical POU domain residues confer Oct4 uniqueness in somatic cell reprogramming
Jin, W., Wang, L., Zhu, F., Tan, W., Lin, W., Chen, D., Sun, Q., & Xia, Z. (2016) · Scientific Reports · doi:10.1038/srep20818 · Cited by 27
OBF1 enhances transcriptional potential of Oct1
Lins, K., Reményi, A., Tomilin, A. N., Massa, S., Wilmanns, M., Matthias, P., & Schöler, H. R. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg199 · Cited by 25
Crystal structure of the dimeric Oct6 (POU3f1) POU domain bound to palindromic MORE DNA
Jauch, R., Choo, S. H., Ng, C. K. L., & Kolatkar, P. R. (2010) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.22916 · Cited by 23
Self-citationFunctional interplay between the RK motif and linker segment dictates Oct4–DNA recognition
Kong, X., Liu, J., Li, L., Yue, L., Zhang, L., Jiang, H., Xie, X., & Luo, C. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv323 · Cited by 18
Hanke, J. H., Landolfi, N. F., Tucker, P. W., & Capra, J. D. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.10.3560 · Cited by 18
Morita, E. H., Shirakawa, M., Kyogoku, Y., Hayashi, F., & Imagawa, M. (1995) · Protein Science · doi:10.1002/pro.5560040412 · Cited by 18
Nieto, L., Joseph, G., Stella, A., Henri, P., Burlet‐Schiltz, O., Monsarrat, B., Clottes, E., & Érard, M. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2007.04.072 · Cited by 17
Structure of human Brn-5 transcription factor in complex with CRH gene promoter
Pereira, J. H., & Kim, S. (2009) · Journal of Structural Biology · doi:10.1016/j.jsb.2009.05.003 · Cited by 15
Toward directed reprogramming through exogenous factors
Lin, C., Chen, Y., & Ding, S. (2013) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2013.06.002 · Cited by 14
Functional role of position 22 in the homeodomain of Brn-3 transcription factors
Dawson, S. J., Palmer, R., Morris, P. J., & Latchman, D. S. (1998) · Neuroreport · doi:10.1097/00001756-199807130-00029 · Cited by 10
Reprogramming cells with synthetic proteins
Jauch, R., Yang, X., & Malik, V. (2014) · Asian Journal of Andrology · doi:10.4103/1008-682x.145433 · Cited by 7
Self-citationHigh-Resolution Dissection of Conducive Reprogramming Trajectory to Ground State PluripotencyPreprint
Zviran, A., Mor, N., Rais, Y., Gingold, H., Peles, S., Chomsky, E., Viukov, S. V., Buenrostro, J. D., Weinberger, L., Manor, Y. S., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/184135 · Cited by 5
Cited by
Sorted by citations
A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain
Yao, Z., van Velthoven, C. T. J., Kunst, M., Zhang, M., McMillen, D., Lee, C., Jung, W., Goldy, J., Abdelhak, A., Aitken, M., et al. (2023) · Nature · doi:10.1038/s41586-023-06812-z · Cited by 1,203
Regulation of immune responses by tuft cells
Schneider, C., O’Leary, C. E., & Locksley, R. M. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0176-x · Cited by 278
Tuft Cells—Systemically Dispersed Sensory Epithelia Integrating Immune and Neural Circuitry
O’Leary, C. E., Schneider, C., & Locksley, R. M. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042718-041505 · Cited by 172
OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage
Wu, X., He, X., Ipsaro, J. J., Huang, Y., Preall, J. B., Ng, D., Shue, Y. T., Sage, J., Egeblad, M., Joshua‐Tor, L., et al. (2022) · Nature · doi:10.1038/s41586-022-04842-7 · Cited by 93
Malik, V., Glaser, L. V., Zimmer, D., Velychko, S., Weng, M., Holzner, M., Arend, M., Chen, Y., Srivastava, Y., Veerapandian, V., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11054-7 · Cited by 72
Self-citation
Metadata
- Authors
- Malik, V., Zimmer, D., & Jauch, R.
- Affiliations
- Chinese Academy of Sciences (CN)
- Corresponding author
- Jauch, Ralf
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2018-01-15
- Volume
- 75
- Issue
- 9
- Pages
- 1587-1612
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC11105716
- OpenAlex
- W2783784339
- Cited by
- 98
- References
- 277
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 15 · 2023: 15 · 2022: 11 · 2021: 25 · 2020: 4 · 2019: 10 · 2018: 5
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Funders
- Ministry of Science and Technology of the People's Republic of China (2013DFE33080, 2016YFA0100700, 2017YFA0105103)
- National Natural Science Foundation of China (31471238)
- a 100 talent award of the Chinese Academy of Sciences (2014B030301058)
- Science and Technology Planning Projects of Guangdong Province, China (2016A050503038)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- POU transcription factors, Oct4, Brn2, Oct-6, DNA binding modes, chromatin remodeling, cellular reprogramming, pluripotency, transcription factor-DNA interaction, quaternary structure, epigenetic regulation, embryonic development
- MeSH terms
- Animals, Binding Sites, Cell Differentiation, Chromatin, Humans, Protein Binding, Transcription Factors, POU Domain Factors, Cellular Reprogramming
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
