Cited by 98Genomics and Chromatin DynamicsPluripotent Stem Cells ResearchEpigenetics and DNA Methylation

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Diversity among POU transcription factors in chromatin recognition and cell fate reprogramming

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Malik, Vikas, Zimmer, Dennis, Jauch, Ralf·2018·Cellular and Molecular Life Sciences

DOI 10.1007/s00018-018-2748-5PMC PMC11105716

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Abstract

The POU (Pit-Oct-Unc) protein family is an evolutionary ancient group of transcription factors (TFs) that bind specific DNA sequences to direct gene expression programs. The fundamental importance of POU TFs to orchestrate embryonic development and to direct cellular fate decisions is well established, but the molecular basis for this activity is insufficiently understood. POU TFs possess a bipartite 'two-in-one' DNA binding domain consisting of two independently folding structural units connected by a poorly conserved and flexible linker. Therefore, they represent a paradigmatic example to study the molecular basis for the functional versatility of TFs. Their modular architecture endows POU TFs with the capacity to accommodate alternative composite DNA sequences by adopting different quaternary structures. Moreover, associations with partner proteins crucially influence the selection of their DNA binding sites. The plentitude of DNA binding modes confers the ability to POU TFs to regulate distinct genes in the context of different cellular environments. Likewise, different binding modes of POU proteins to DNA could trigger alternative regulatory responses in the context of different genomic locations of the same cell. Prominent POU TFs such as Oct4, Brn2, Oct6 and Brn4 are not only essential regulators of development but have also been successfully employed to reprogram somatic cells to pluripotency and neural lineages. Here we review biochemical, structural, genomic and cellular reprogramming studies to examine how the ability of POU TFs to select regulatory DNA, alone or with partner factors, is tied to their capacity to epigenetically remodel chromatin and drive specific regulatory programs that give cells their identities.

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Authors: Malik, V., Zimmer, D., & Jauch, R.
Affiliations: Chinese Academy of Sciences (CN)
Corresponding author: Jauch, Ralf
ORCID: Malik, Vikas
Jauch, Ralf
Venue: Cellular and Molecular Life Sciences
Publisher: Springer Science and Business Media LLC
Published: 2018-01-15
Volume: 75
Issue: 9
Pages: 1587-1612
ISSN: 1420-682X (ISSN-L)
1420-9071
DOI: 10.1007/s00018-018-2748-5
PMC: PMC11105716
OpenAlex: W2783784339
Cited by: 98
References: 277
Citations by year: 2026: 6 · 2025: 7 · 2024: 15 · 2023: 15 · 2022: 11 · 2021: 25 · 2020: 4 · 2019: 10 · 2018: 5
FWCI: 1.08
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Cellular and Molecular Life Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Funders: Ministry of Science and Technology of the People's Republic of China (2013DFE33080, 2016YFA0100700, 2017YFA0105103)
National Natural Science Foundation of China (31471238)
a 100 talent award of the Chinese Academy of Sciences (2014B030301058)
Science and Technology Planning Projects of Guangdong Province, China (2016A050503038)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords: POU transcription factors, Oct4, Brn2, Oct-6, DNA binding modes, chromatin remodeling, cellular reprogramming, pluripotency, transcription factor-DNA interaction, quaternary structure, epigenetic regulation, embryonic development
MeSH terms: Animals, Binding Sites, Cell Differentiation, Chromatin, Humans, Protein Binding, Transcription Factors, POU Domain Factors, Cellular Reprogramming

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Diversity among POU transcription factors in chromatin recognition and cell fate reprogramming

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