Integrin and microtubule crosstalk in the regulation of cellular processes
Open accessAbstract
Integrins engage components of the extracellular matrix, and in collaboration with other receptors, regulate signaling cascades that impact cell behavior in part by modulating the cell's cytoskeleton. Integrins have long been known to function together with the actin cytoskeleton to promote cell adhesion, migration, and invasion, and with the intermediate filament cytoskeleton to mediate the strong adhesion needed for the maintenance and integrity of epithelial tissues. Recent studies have shed light on the crosstalk between integrin and the microtubule cytoskeleton. Integrins promote microtubule nucleation, growth, and stabilization at the cell cortex, whereas microtubules regulate integrin activity and remodeling of adhesion sites. Integrin-dependent stabilization of microtubules at the cell cortex is critical to the establishment of apical-basal polarity required for the formation of epithelial tissues. During cell migration, integrin-dependent microtubule stabilization contributes to front-rear polarity, whereas microtubules promote the turnover of integrin-mediated adhesions. This review focuses on this interdependent relationship and its impact on cell behavior and function.
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The osteoclast cytoskeleton is made of four categories of filamentous structures and fulfills essential functions including cell adhesion, migration, contractility, division, vesicular transport, and bone resorption.
“The osteoclast cytoskeleton is made of filamentous structures that belong to one of four categories: polarized actin filaments; polarized microtubules; non-polarized intermediate filaments; or non-polarized septin filaments. The cytoskeleton fulfills essential functions including cell adhesion, migration, contractility, division, vesicular transport, and bone resorption [2,3,4,5,6].”
From Osteoclasts and Microgravity (2020) · cites this paper as [4]
The Introduction describes microtubules as polarized filaments involved in vesicular trafficking, migration, and mitosis. The section on adhesion-site turnover also links microtubules to cell adhesion and migration. Our copy does not establish the four-category classification for osteoclasts or the claimed roles in osteoclast contractility and bone resorption; page numbers were not provided. (LLM, conf=0.88)
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- Authors
- LaFlamme, S. E., Mathew-Steiner, S., Singh, N., Colello-Borges, D., & Nieves, B.
- Affiliations
- Albany Medical College (US)
- Corresponding author
- LaFlamme, Susan E.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2018-09-11
- Volume
- 75
- Issue
- 22
- Pages
- 4177-4185
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC6182340
- OpenAlex
- W2891539047
- Cited by
- 84
- References
- 87
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 7 · 2023: 8 · 2022: 16 · 2021: 12 · 2020: 18 · 2019: 9
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Cellular and Molecular Life Sciences (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- IUScholarWorks (Indiana University) (submittedVersion, cc-by-nc-nd)
- Purdue University Indianapolis (Indiana University) (submittedVersion, cc-by-nc-nd)
- PMC
- Funders
- National Institutes of Health (GM51540)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Keywords
- integrins, microtubules, cell cortex, microtubule stabilization, cell adhesion, cell migration, cell invasion, apical-basal polarity, front-rear polarity, integrin-mediated adhesion, cytoskeleton
- MeSH terms
- Cell Adhesion, Cell Movement, Microtubules, Signal Transduction, Integrins, Cell Polarity
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