The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.
Regulatory network of miRNA on its target: coordination between transcriptional and post-transcriptional regulation of gene expression
Open accessAbstract
MicroRNAs (miRNAs) are a class of endogenous small noncoding RNAs that participate in a majority of biological processes via regulating target gene expression. The post-transcriptional repression through miRNA seed region binding to 3' UTR of target mRNA is considered as the canonical mode of miRNA-mediated gene regulation. However, emerging evidence suggests that other regulatory modes exist beyond the canonical mechanism. In particular, the function of intranuclear miRNA in gene transcriptional regulation is gradually revealed, with evidence showing their contribution to gene silencing or activating. Therefore, miRNA-mediated regulation of gene transcription not only expands our understanding of the molecular mechanism underlying miRNA regulatory function, but also provides new evidence to explain its ability in the sophisticated regulation of many bioprocesses. In this review, mechanisms of miRNA-mediated gene transcriptional and post-transcriptional regulation are summarized, and the synergistic effects among these actions which form a regulatory network of a miRNA on its target are particularly elaborated. With these discussions, we aim to emphasize the importance of miRNA regulatory network on target gene regulation and further highlight the potential application of the network mode in the achievement of a more effective and stable modulation of the target gene expression.
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“it has become apparent that 5′ UTRs, coding sequences, and promoters also can be targeted for repression.229”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [229]
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“Traditionally it was thought that the miRNAs targeted the 3′ UTRs of transcripts but it has become apparent that 5′ UTRs, coding sequences, and promoters also can be targeted for repression.(229) Because miRNAs have imperfect sequence recognition, they may bind to multiple target genes and modulate their expression.”
Background
Metadata
- Authors
- Pu, M., Chen, J., Tao, Z., Miao, L., Qi, X., Wang, Y., & Ren, J.
- Affiliations
- Chinese Academy of Sciences (CN)
- Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences (CN)
- Corresponding author
- Ren, Jin
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2018-10-29
- Volume
- 76
- Issue
- 3
- Pages
- 441-451
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC11105547
- OpenAlex
- W2899058989
- Cited by
- 500
- References
- 82
- Citations by year
- 2026: 48 · 2025: 59 · 2024: 83 · 2023: 73 · 2022: 91 · 2021: 77 · 2020: 53 · 2019: 14
- FWCI
- 3.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- microRNA, microRNA target regulation, transcriptional regulation, post-transcriptional regulation, 3' UTR binding, miRNA seed region, gene silencing, gene activation, regulatory networks, gene expression modulation
- MeSH terms
- Gene Expression Regulation, Humans, Protein Processing, Post-Translational, Transcriptional Activation, Drug Delivery Systems, Gene Silencing, MicroRNAs
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