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Cited by 15T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisDermatology and Skin Diseases

Epidermal resident γδ T cell development and function in skin

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Xu, Yingping, Dimitrion, Peter, Cvetkovski, Steven, Zhou, Li, Mi, Qing-Sheng·2021·Cellular and Molecular Life Sciences
DOI 10.1007/s00018-020-03613-9PMC PMC11073445
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Abstract

Epidermal resident γδ T cells, or dendritic epidermal T cells (DETCs) in mice, are a unique and conserved population of γδ T cells enriched in the epidermis, where they serve as the regulators of immune responses and sense skin injury. Despite the great advances in the understanding of the development, homeostasis, and function of DETCs in the past decades, the origin and the underlying molecular mechanisms remain elusive. Here, we reviewed the recent research progress on DETCs, including their origin and homeostasis in the skin, especially at transcriptional and epigenetic levels, and discuss the involvement of DETCs in skin diseases.

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  • In wild-type mice, the epidermal T cell compartment is dominated by a highly specialized γδ T cell subset termed dendritic epidermal T cells (DETCs).

    “In wild-type mice, the epidermal T cell compartment is dominated by a highly specialized γδ T cell subset termed dendritic epidermal T cells (DETCs) (29).”

    From Comparing Mouse and Human Tissue-Resident γδ T Cells (2022) · cites this paper as [29]

    The Abstract identifies DETCs as a unique γδ T-cell population enriched in the mouse epidermis, and the Introduction describes their specialized receptor and residence there. Neither passage establishes that DETCs dominate the epidermal T-cell compartment in wild-type mice. (LLM, conf=0.82)

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Authors
Xu, Y., Dimitrion, P., Cvetkovski, S., Zhou, L., & Mi, Q.-S.
Affiliations
Henry Ford Health (US)
Corresponding author
  • Zhou, Li
  • Mi, Qing-Sheng
ORCID
Venue
Cellular and Molecular Life Sciences
Publisher
Springer Science and Business Media LLC
Published
2020-08-17
Volume
78
Issue
2
Pages
573-580
ISSN
  • 1420-682X (ISSN-L)
  • 1420-9071
DOI
10.1007/s00018-020-03613-9
PMC
PMC11073445
OpenAlex
W3049349117
Cited by
15
References
5
Citations by year
2026: 3 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 4
FWCI
0.20
Type
journal article
Language
en
Open access
Licence
Locations
  • Cellular and Molecular Life Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Henry Ford Health System (T71016, T71017)
  • National Natural Science Foundation of China (81302603)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Keywords
dendritic epidermal T cells, γδ T cells, epidermis, T cell development, T cell homeostasis, T cell origin, epigenetic regulation, transcriptional regulation, skin diseases
MeSH terms
Intraepithelial Lymphocytes, Animals, Cell Differentiation, Disease Models, Animal, Epidermis, Humans, Skin, Skin Diseases, Thymus Gland, Yolk Sac, Epigenesis, Genetic, Mice

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