CCR10 Is Important for the Development of Skin-Specific γδT Cells by Regulating Their Migration and Location
Open accessAbstract
Unlike conventional αβ T cells, which preferentially reside in secondary lymphoid organs for adaptive immune responses, various subsets of unconventional T cells, such as the γδ T cells with innate properties, preferentially reside in epithelial tissues as the first line of defense. However, mechanisms underlying their tissue-specific development are not well understood. We report in this paper that among different thymic T cell subsets fetal thymic precursors of the prototypic skin intraepithelial Vγ3+ T lymphocytes (sIELs) were selected to display a unique pattern of homing molecules, including a high level of CCR10 expression that was important for their development into sIELs. In fetal CCR10-knockout mice, the Vγ3+ sIEL precursors developed normally in the thymus but were defective in migrating into the skin. Although the earlier defect in skin-seeding by sIEL precursors was partially compensated for by their normal expansion in the skin of adult CCR10-knockout mice, the Vγ3+ sIELs displayed abnormal morphology and increasingly accumulated in the dermal region of the skin. These findings provide definite evidence that CCR10 is important in sIEL development by regulating the migration of sIEL precursors and their maintenance in proper regions of the skin and support the notion that unique homing properties of different thymic T cell subsets play an important role in their peripheral location.
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Homozygous CCR10-KO/EGFP-KI mice have dysregulated skin-resident T cells compared to heterozygous mice, characterized mostly by reduction of CD8+ and CD4+ αβT cells but not IL-17A+ αβT or γδT cells.
“Homozygous CCR10-KO/EGFP-KI (CCR10EGFP/EGFP, or CCR10−/− for simplicity) mice have dysregulated skin-resident T cells compared to heterozygous CCR10-KO/EGFP-KI (CCR10+/EGFP or CCR10+/−) mice, characterized mostly by the reduction of CD8+ and CD4+ αβT cells but not IL-17A+ αβT or γδT cells.20,22,23”
From Skin-resident T cells play an important role in controlling skin colonization of Candidozyma (Candida) auris (2026) · cites this paper as [22]
The Results sections on defective sIEL development and dermal accumulation report fewer epidermal Vγ3+ γδ T cells in CCR10-knockout mice and altered distribution of those cells within the skin—the opposite of the claim that γδ T cells were not reduced or dysregulated. The comparisons reported there are with wild-type controls, not heterozygous mice; these passages do not establish the claimed predominant loss of CD4+ and CD8+ αβ T cells. (LLM, conf=0.88)
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Cites
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984 · see citing works
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
Matloubian, M., Lo, C. G., Cinamon, G., Lesneski, M. J., Xu, Y., Brinkmann, V., Allende, M. L., Proia, R. L., & Cyster, J. G. (2004) · Nature · doi:10.1038/nature02284 · Cited by 2,581 · see citing works
Skin immune sentinels in health and disease
Nestle, F. O., Meglio, P. D., Qin, J., & Nickoloff, B. J. (2009) · Nature reviews. Immunology · doi:10.1038/nri2622 · Cited by 1,431 · see citing works
Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1
Treiner, E., Duban, L., Bahram, S., Radosavljevic, M., Wanner, V., Tilloy, F., Affaticati, P., Gilfillan, S., & Lantz, O. (2003) · Nature · doi:10.1038/nature01433 · Cited by 1,139 · see citing works
γδ Cells: A Right Time and a Right Place for a Conserved Third Way of Protection
Hayday, A. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.975 · Cited by 1,134 · see citing works
Regulation of Cutaneous Malignancy by γδ T Cells
Girardi, M., Oppenheim, D. E., Steele, C. R., Lewis, J. M., Glusac, E. J., Filler, R. B., Hobby, P., Sutton, B. J., Tigelaar, R. E., & Hayday, A. (2001) · Science · doi:10.1126/science.1063916 · Cited by 1,002 · see citing works
Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice
Arbonés, M. L., Ord, D. C., Ley, K. F., Ratech, H., Maynard-Curry, C., Otten, G., Capon, D. J., & Teddert, T. F. (1994) · Immunity · doi:10.1016/1074-7613(94)90076-0 · Cited by 831 · see citing works
CCL27–CCR10 interactions regulate T cell–mediated skin inflammation
Homey, B., Alenius, H. T., Müller, A., Soto, H., Bowman, E. P., Yuan, W., McEvoy, L. M., Lauerma, A., Assmann, T., Bünemann, E., et al. (2002) · Nature Medicine · doi:10.1038/nm0202-157 · Cited by 807 · see citing works
A Role for Skin γδ T Cells in Wound Repair
Jameson, J., Ugarte, K., Chen, N., Yachi, P. P., Fuchs, E. V., Boismenu, R., & Havran, W. L. (2002) · Science · doi:10.1126/science.1069639 · Cited by 639 · see citing works
Tilloy, F., Treiner, E., Park, S., Cordier, C., Lemonnier, F. A., de la Salle, H., Bendelac, A. S., Bonneville, M., & Lantz, O. J. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.12.1907 · Cited by 614 · see citing works
Luci, C., Reynders, A., Ivanov, I. I., Cognet, C., Chiche, L., Chasson, L., Hardwigsen, J., Anguiano, E., Banchereau, J., Chaussabel, D., et al. (2008) · Nature Immunology · doi:10.1038/ni.1681 · Cited by 551 · see citing works
Iwasaki, A. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141634 · Cited by 533 · see citing works
CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells
Morales, J., Homey, B., Vicari, A. P., Hudak, S. A., Oldham, E. R., Hedrick, J. A., Orozco, R., Copeland, N. G., Jenkins, N. A., McEvoy, L. M., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.25.14470 · Cited by 507 · see citing works
Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice.
Schön, M. P., Arya, A., Murphy, E. A., Adams, C. M., Strauch, U., Agace, W. W., Marsal, J., Donohue, J. P., Her, H., Beier, D. R., et al. (1999) · PubMed · Cited by 424 · see citing works
Mucosal T Lymphocyte Numbers Are Selectively Reduced in Integrin αE (CD103)-Deficient Mice
Schön, M. P., Arya, A., Murphy, E. A., Adams, C. M., Strauch, U., Agace, W. W., Marsal, J., Donohue, J. P., Her, H., Beier, D. R., et al. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.11.6641 · Cited by 399 · see citing works
Kunkel, E. J., Kim, C. H., Lazarus, N. H., Vierra, M. A., Soler, D. F., Bowman, E. P., & Butcher, E. C. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17244 · Cited by 348 · see citing works
Homey, B., Wang, W., Soto, H., Buchanan, M. E., Wiesenborn, A., Catron, D., Müller, A., McClanahan, T. K., Dieu‐Nosjean, M., Orozco, R., et al. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.7.3465 · Cited by 332 · see citing works
Identification of a Novel Chemokine (CCL28), which Binds CCR10 (GPR2)
Wang, W., Soto, H., Oldham, E. R., Buchanan, M. E., Homey, B., Catron, D., Jenkins, N. A., Copeland, N. G., Gilbert, D. J., Nguyen, N. T., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001461200 · Cited by 294 · see citing works
Boyden, L. M., Lewis, J. M., Barbee, S. D., Bas, A., Girardi, M., Hayday, A., Tigelaar, R. E., & Lifton, R. P. (2008) · Nature Genetics · doi:10.1038/ng.108 · Cited by 288 · see citing works
Strid, J., Roberts, S. J., Filler, R. B., Lewis, J. M., Kwong, B. Y., Schpero, W. L., Kaplan, D. H., Hayday, A., & Girardi, M. (2008) · Nature Immunology · doi:10.1038/ni1556 · Cited by 266 · see citing works
Lazarus, N. H., Kunkel, E. J., Johnston, B., Wilson, E., Youngman, K. R., & Butcher, E. C. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.7.3799 · Cited by 250 · see citing works
Hardy, R. R. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.5.2749 · Cited by 249 · see citing works
Role for CCR7 Ligands in the Emigration of Newly Generated T Lymphocytes from the Neonatal Thymus
Ueno, T., Hara, K., Willis, M. S., Malin, M., Höpken, U. E., Gray, D. H. D., Matsushima, K., Lipp, M., Springer, T. A., Boyd, R. L., et al. (2002) · Immunity · doi:10.1016/s1074-7613(02)00267-4 · Cited by 222 · see citing works
Resident Skin-specific γδ T Cells Provide Local, Nonredundant Regulation of Cutaneous Inflammation
Girardi, M., Lewis, J. M., Glusac, E. J., Filler, R. B., Geng, L., Hayday, A., & Tigelaar, R. E. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20012000 · Cited by 195 · see citing works
Development and selection of γδ T cells
Xiong, N., & Raulet, D. H. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2006.00478.x · Cited by 178 · see citing works
Self-citationSelection of the cutaneous intraepithelial γδ+ T cell repertoire by a thymic stromal determinant
Lewis, J. M., Girardi, M., Roberts, S. J., Barbee, S. D., Hayday, A., & Tigelaar, R. E. (2006) · Nature Immunology · doi:10.1038/ni1363 · Cited by 167 · see citing works
Yamagata, T., Mathis, D. J., & Benoist, C. O. (2004) · Nature Immunology · doi:10.1038/ni1070 · Cited by 163 · see citing works
Generation and Cyclic Remodeling of the Hair Follicle Immune System in Mice
Paus, R., van der Veen, C., Eichmüller, S. B., Kopp, T., Hagen, E., Müller‐Röver, S., & Hofmann, U. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00243.x · Cited by 141 · see citing works
Mallick, C. A., Lewis, J. M., Ehrlich, L. I. R., Owen, M. J., Tigelaar, R. E., & Hayday, A. (1998) · Science · doi:10.1126/science.279.5357.1729 · Cited by 118 · see citing works
An Indispensable Role for the Chemokine Receptor CCR10 in IgA Antibody-Secreting Cell Accumulation
Morteau, O., Gerard, C. J., Lu, B., Ghiran, S., Rits, M., Fujiwara, Y., Law, Y., Distelhorst, K., Nielsen, E. M., Hill, E. D., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.9.6309 · Cited by 117 · see citing works
Xiong, N., Kang, C., & Raulet, D. H. (2004) · Immunity · doi:10.1016/j.immuni.2004.06.008 · Cited by 111 · see citing works
Self-citationCD8+ recent thymic emigrants home to and efficiently repopulate the small intestine epithelium
Staton, T. L., Habtezion, A., Winslow, M. M., Sato, T., Love, P. E., & Butcher, E. C. (2006) · Nature Immunology · doi:10.1038/ni1319 · Cited by 109 · see citing works
Goldman, J., Spencer, D. M., & Raulet, D. H. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.177.3.729 · Cited by 105 · see citing works
Control of γδ T‐Cell Development
Raulet, D. H., Spencer, D. M., Hsiang, Y. H., Goldman, J., Bix, M., Liao, N., Zijlstra, M., Jaenisch, R., & Correa, I. (1991) · Immunological Reviews · doi:10.1111/j.1600-065x.1991.tb00592.x · Cited by 91 · see citing works
Creus, A. D., Beneden, K. V., Stevenaert, F., Debacker, V., Plum, J. R., & Leclercq, G. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.12.6486 · Cited by 81 · see citing works
Thymic differentiation of TCRαβ+ CD8αα+ IELs
Lambolez, F., Kronenberg, M., & Cheroutre, H. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2006.00488.x · Cited by 73 · see citing works
Sullivan, S., Bergstresser, P. R., Tigelaar, R. E., & Streilein, J. W. (1985) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12273454 · Cited by 70 · see citing works
Xiong, N., Kang, C., & Raulet, D. H. (2002) · Immunity · doi:10.1016/s1074-7613(02)00285-6 · Cited by 65 · see citing works
Self-citationMiyauchi, S., & Hashimoto, K. (1987) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12470379 · Cited by 55 · see citing works
Embryonic trafficking of γδ T cells to skin is dependent on E/P selectin ligands and CCR4
Jiang, X., Campbell, J. J., & Kupper, T. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912943107 · Cited by 54 · see citing works
Requirement of the IL-2 Receptor β Chain for the Development of Vγ3 Dendritic Epidermal T Cells
Kawai, K., Suzuki, H., Tomiyama, K., Minagawa, M., Mak, T. W., & Ohashi, P. S. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00214.x · Cited by 49 · see citing works
Development of Dendritic Epidermal T Cells with a Skewed Diversity of γδTCRs in Vδ1-Deficient Mice
Hara, H., Kishihara, K., Matsuzaki, G., Takimoto, H., Tsukiyama, T., Tigelaar, R. E., & Nomoto, K. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.7.3695 · Cited by 43 · see citing works
T Cell Receptor Specificity Is Critical for the Development of Epidermal γδ T Cells
Ferrero, I., Wilson, A., Beermann, F., Held, W., & MacDonald, H. R. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.10.1473 · Cited by 43 · see citing works
Jensen, K. D. C., Shin, S., & Chien, Y. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900465 · Cited by 31 · see citing works
Characterization and TCR variable region gene use of mouse resident nasal γδ T lymphocytes
Kim, C., Witherden, D. A., & Havran, W. L. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0108050 · Cited by 11 · see citing works
Uche, U. N., Huber, C. R., Raulet, D. H., & Xiong, N. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901859 · Cited by 11 · see citing works
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γδ T cells in homeostasis and host defence of epithelial barrier tissues
Nielsen, M. M., Witherden, D. A., & Havran, W. L. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.101 · Cited by 479 · see citing works
γδ T cells: origin and fate, subsets, diseases and immunotherapy
Hu, Y., Hu, Q., Li, Y., Lu, L., Xiang, Z., Yin, Z., Kabelitz, D., & Wu, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01653-8 · Cited by 395 · see citing works
White, G. E., Iqbal, A. J., & Greaves, D. R. (2013) · Pharmacological Reviews · doi:10.1124/pr.111.005074 · Cited by 289 · see citing works
Intrathymic programming of effector fates in three molecularly distinct γδ T cell subtypes
Narayan, K., Sylvia, K., Malhotra, N., Yin, C., Martens, G. W., Vallerskog, T., Kornfeld, H., Xiong, N., Cohen, N. R., Brenner, M. B., et al. (2012) · Nature Immunology · doi:10.1038/ni.2247 · Cited by 199 · see citing works
Self-citationCai, Y., Xue, F., Fleming, C., Yang, J., Ding, C., Ma, Y., Liu, M., Zhang, H.-G., Zheng, J., Xiong, N., et al. (2014) · Nature Communications · doi:10.1038/ncomms4986 · Cited by 162 · see citing works
Self-citationKadow, S., Jux, B., Zahner, S. P., Wingerath, B., Chmill, S., Clausen, B. E., Hengstler, J. G., & Esser, C. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100912 · Cited by 146 · see citing works
Functions of skin-resident γδ T cells
MacLeod, A. S., & Havran, W. L. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0702-x · Cited by 132 · see citing works
CCR10 and its ligands in regulation of epithelial immunity and diseases
Xiong, N., Fu, Y., Hu, S., Xia, M., & Yang, J. (2012) · Protein & Cell · doi:10.1007/s13238-012-2927-3 · Cited by 117 · see citing works
Self-citationHuman αβ and γδ T Cells in Skin Immunity and Disease
Cruz, M. S., Diamond, A., Russell, A., & Jameson, J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01304 · Cited by 111 · see citing works
Xia, M., Hu, S., Fu, Y., Jin, W., Yi, Q., Matsui, Y., Yang, J., McDowell, M. A., Sarkar, S., Kalia, V., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.03.010 · Cited by 85 · see citing works
Self-citationBibliometric Analysis of Dendritic Epidermal T Cell (DETC) Research From 1983 to 2019
Deng, Z., Wang, H.-W., Chen, Z., & Wang, T. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00259 · Cited by 76 · see citing works
Mechanisms of T cell organotropism
Fu, H., Ward, E. J., & Marelli‐Berg, F. M. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2211-4 · Cited by 73 · see citing works
Skin γδ T Cells and Their Function in Wound Healing
Hu, W., Shang, R., Yang, J., Chen, C., Liu, Z., Liang, G., He, W., & Luo, G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.875076 · Cited by 72 · see citing works
Critical roles of chemokine receptor CCR10 in regulating memory IgA responses in intestines
Hu, S., Yang, K., Yang, J., Li, M., & Xiong, N. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100156108 · Cited by 64 · see citing works
Self-citationRegulation of intestinal IgA responses
Xiong, N., & Hu, S. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1892-4 · Cited by 58 · see citing works
Self-citationFujikado, N., Mann, A. O., Bansal, K., Romito, K., Ferré, E. M. N., Rosenzweig, S. D., Lionakis, M. S., Benoist, C. O., & Mathis, D. J. (2016) · Immunity · doi:10.1016/j.immuni.2016.10.023 · Cited by 58 · see citing works
Morgun, E. I., & Vorotelyak, E. A. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.581697 · Cited by 56 · see citing works
Wu, Q., Chen, J., Chen, Y., Cai, L., Wang, X.-Z., Guo, W.-H., & Zheng, J. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0267-9 · Cited by 53 · see citing works
CCL27/CCL28–CCR10 Chemokine Signaling Mediates Migration of Lymphatic Endothelial Cells
Karnezis, T., Farnsworth, R. H., Harris, N. C., Williams, S. P., Caesar, C., Byrne, D. J., Herle, P., Macheda, M. L., Shayan, R., Zhang, Y., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-1858 · Cited by 50 · see citing works
Yang, J., Hu, S., Zhao, L., Kaplan, D. H., Perdew, G. H., & Xiong, N. (2016) · Nature Immunology · doi:10.1038/ni.3312 · Cited by 49 · see citing works
Self-citationCutting Edge: Intrinsic Programming of Thymic γδT Cells for Specific Peripheral Tissue Localization
Jin, Y., Xia, M., Saylor, C. M., Narayan, K., Kang, J., Wiest, D. L., Wang, Y., & Xiong, N. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002781 · Cited by 48 · see citing works
Self-citationOrphan chemoattractant receptor GPR15 mediates dendritic epidermal T‐cell recruitment to the skin
Lahl, K., Sweere, J. M., Pan, J., & Butcher, E. C. (2014) · European Journal of Immunology · doi:10.1002/eji.201444628 · Cited by 47 · see citing works
Cowan, J. E., Jenkinson, W. E., & Anderson, G. (2015) · European Journal of Immunology · doi:10.1002/eji.201445108 · Cited by 46 · see citing works
The Role of Tissue-resident γδ T Cells in Stress Surveillance and Tissue Maintenance
Johnson, M. D., Witherden, D. A., & Havran, W. L. (2020) · Cells · doi:10.3390/cells9030686 · Cited by 44 · see citing works
γδ T Cell Homing to Skin and Migration to Skin-Draining Lymph Nodes Is CCR7 Independent
Vrieling, M., Santema, W. J., Rhijn, I. V., Rutten, V. P. M. G., & Koets, A. P. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101972 · Cited by 42 · see citing works
CCL27 is a crucial regulator of immune homeostasis of the skin and mucosal tissues
Davila, M. L., Xu, M., Huang, C., Gaddes, E. R., Winter, L., Cantorna, M. T., Wang, Y., & Xiong, N. (2022) · iScience · doi:10.1016/j.isci.2022.104426 · Cited by 37 · see citing works
Self-citationThe aryl hydrocarbon receptor in innate T cell immunity
Stange, J., & Veldhoen, M. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0389-1 · Cited by 34 · see citing works
γδ T cell migration: Separating trafficking from surveillance behaviors at barrier surfaces
Fischer, M., Golovchenko, N. B., & Edelblum, K. L. (2020) · Immunological Reviews · doi:10.1111/imr.12915 · Cited by 34 · see citing works
Chen, C., Meng, Z., Ren, H., Zhao, N., Shang, R., He, W., & Hao, J. (2021) · Burns & Trauma · doi:10.1093/burnst/tkab009 · Cited by 33 · see citing works
Cross-talk between intraepithelial γδ T cells and epithelial cells
Witherden, D. A., & Havran, W. L. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.0213101 · Cited by 32 · see citing works
Molecular aspects of epithelial γδ T cell regulation
Witherden, D. A., & Havran, W. L. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.03.005 · Cited by 30 · see citing works
Li, C., Xu, M., Coyne, J., Wang, W.-B., Davila, M. L., Wang, Y., & Xiong, N. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.05.044 · Cited by 30 · see citing works
Self-citationXu, M., Li, C. R., Yang, J., Ye, A., Yan, L., Yeoh, B. S., Shi, L. S., Kim, Y. S., Kang, J., Vijay–Kumar, M., et al. (2022) · Science Immunology · doi:10.1126/sciimmunol.abe0584 · Cited by 25 · see citing works
Self-citationT lymphocyte trafficking: molecules and mechanisms
Marelli‐Berg, F. M. (2012) · Frontiers in bioscience · doi:10.2741/4111 · Cited by 24 · see citing works
Close link between development and function of gamma−delta T cells
Shibata, K. (2012) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2012.00435.x · Cited by 23 · see citing works
Ovine skin-recirculating γδ T cells express IFN-γ and IL-17 and exit tissue independently of CCR7
Geherin, S. A., Lee, M. H., Wilson, R. P., & Debes, G. F. (2013) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2013.06.008 · Cited by 23 · see citing works
Wang, W., Lin, Y., Zhao, L., Liao, C., Zhang, Y., Davila, M. L., Sun, J., Chen, Y., & Xiong, N. (2023) · Nature Immunology · doi:10.1038/s41590-022-01399-5 · Cited by 19 · see citing works
Self-citationZhao, L., Hu, S., Davila, M. L., Yang, J., Lin, Y., Albanese, J. M., Lo, Y., Wang, Y., Kennett, M. J., Liu, Q., et al. (2020) · Mucosal Immunology · doi:10.1038/s41385-020-0333-3 · Cited by 17 · see citing works
Self-citationMigration of γδ T cells in steady-state conditions
Shekhar, S., Milling, S. W. F., & Yang, X. (2012) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2012.03.016 · Cited by 17 · see citing works
Nakamura, K., White, A. J., Parnell, S. M., Lane, P. J. L., Jenkinson, E. J., Jenkinson, W. E., & Anderson, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074019 · Cited by 17 · see citing works
Bernal‐Alferes, B., Gómez-Mosqueira, R., Ortega-Tapia, G. T., Burgos‐Vargas, R., Garcı́a-Latorre, E., Domínguez‐López, M. L., & Romero‐López, J. P. (2023) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiad046 · Cited by 16 · see citing works
Unraveling Immune-Epithelial Interactions in Skin Homeostasis and Injury.
Mansfield, K. P., & Naik, S. (2020) · PubMed Central · Cited by 15 · see citing works
Interaction between γδTCR signaling and the E protein‐Id axis in γδ T cell development
Anderson, M. K., & Selvaratnam, J. S. (2020) · Immunological Reviews · doi:10.1111/imr.12924 · Cited by 15 · see citing works
Epidermal resident γδ T cell development and function in skin
Xu, Y., Dimitrion, P., Cvetkovski, S., Zhou, L., & Mi, Q.-S. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03613-9 · Cited by 15 · see citing works
Yang, J., Restori, K. H., Xu, M., Song, E. H., Zhao, L., Hu, S., Lyu, P., Wang, W., & Xiong, N. (2020) · iScience · doi:10.1016/j.isci.2020.101014 · Cited by 15 · see citing works
Self-citationFu, Y., Yang, J., & Xiong, N. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502662 · Cited by 14 · see citing works
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Thelen, F., & Witherden, D. A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01656 · Cited by 13 · see citing works
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Plužarić, V., Štefanić, M., Mihalj, M., Levak, M. T., Muršić, I., Glavaš‐Obrovac, L., Petřek, M., Balogh, P., & Tokić, S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.572924 · Cited by 13 · see citing works
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Rhoiney, M., Alvizo, C. R., & Jameson, J. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2300153 · Cited by 11 · see citing works
Role of Dendritic Epidermal T Cells in Cutaneous Carcinoma
Xiang, J., Qiu, M., & Zhang, H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01266 · Cited by 11 · see citing works
Hu, S., & Xiong, N. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202261 · Cited by 11 · see citing works
Self-citationIbusuki, A., Kawai, K., Nitahara, A., Argüello, R. J., & Kanekura, T. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1361139 · Cited by 9 · see citing works
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Wang, J., Pajulas, A., Fu, Y., Adom, D., Zhang, W., Nelson, A. S., Spandau, D. F., & Kaplan, M. H. (2022) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2022.03.012 · Cited by 9 · see citing works
Sezin, T., Jegodzinski, L., Meyne, L., Gupta, Y., Mousavi, S., Ludwig, R. J., Zillikens, D., & Sadik, C. D. (2021) · European Journal of Immunology · doi:10.1002/eji.202048887 · Cited by 8 · see citing works
Yao, Y., Liu, Q., Martin, C. E., Yin, C., Dong, Z., Mi, Q., & Zhou, L. (2017) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2017.08.023 · Cited by 8 · see citing works
One Size Does Not Fit All: Diversifying Immune Function in the Skin
Naik, S. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2100758 · Cited by 8 · see citing works
Immune-Epithelial Cell Interactions during Epidermal Regeneration, Repair, and Inflammatory Diseases
Schmitter-Sánchez, A. D., & Park, S. (2024) · International Journal of Stem Cells · doi:10.15283/ijsc23107 · Cited by 6 · see citing works
Early, M. A., Schroeder, W. G., Unnithan, R., Gilchrist, J. M., Müller, W. A., & Schenkel, A. R. (2017) · PeerJ · doi:10.7717/peerj.3555 · Cited by 6 · see citing works
The role of γδ T cells and CAR-γδ T cell therapy in autoimmune diseases
Wang, T., Wang, H., Lv, R., Wen, C., Wang, M., & Huang, L. (2025) · Autoimmunity Reviews · doi:10.1016/j.autrev.2025.103883 · Cited by 5 · see citing works
Role of non-canonical T cells in homeostasis and pathology
Топтыгина, А. П. (2023) · Medical Immunology (Russia) · doi:10.15789/1563-0625-ron-2918 · Cited by 4 · see citing works
Chemokine receptors in primary and secondary lymphoid tissues
Cordero, H. (2024) · International review of cytology · doi:10.1016/bs.ircmb.2023.11.003 · Cited by 4 · see citing works
Gamma delta T cells: Multifaceted mediators in pregnancy and the pathogenesis of miscarriage
Xu, Q., Chen, L., Dai, J., Chung, J. P. W., Wang, C. C., Liao, A., & Zhang, T. (2025) · International review of cytology · doi:10.1016/bs.ircmb.2025.09.001 · Cited by 2 · see citing works
Xie, J., Yan, L., Kadosh, D., & Xiong, N. (2026) · iScience · doi:10.1016/j.isci.2026.115862 · Cited by 1 · see citing works
Self-citationSong, E. H., Garcia, J., & Xiong, N. (2024) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2024.09.001 · Cited by 1 · see citing works
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Stoenchev, K. V., & Pennington, D. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-374279-7.05009-8
Kawai, K. (2016) · Springer eBooks · doi:10.1007/978-4-431-55855-2_6
Li, C. R., Lin, Y., Wang, W., Xu, M., Zhang, N., & Xiong, N. (2022) · European Journal of Immunology · doi:10.1002/eji.202249793
Self-citationSong, E. H., Xu, M., Yang, J., Xiao, Y., Griffith, A. V., & Xiong, N. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2100870
Self-citationStructure and Function of TCRγδ Receptors
Sanchez, G. S., Papadopoulou, M., & Vermijlen, D. (2024) · Elsevier eBooks · doi:10.1016/b978-0-128-24465-4.00056-9
Gamma delta (γδ) T cells: origin, phenotype, functions
Соколов, Д. И. (2025) · Medical Immunology (Russia) · doi:10.15789/1563-0625-gdt-3160
Early life determinants of skin-resident T cells
Wang, W., & Xiong, N. (2025) · Trends in Immunology · doi:10.1016/j.it.2025.10.011
Self-citationCCL27 regulates immune responses and angiogenesis in skin wound healing process
Huang, C., Kumar, M., Yan, L., & Xiong, N. (2026) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2026.02.004
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Mallu, A. C. T., Phinney, N. Z., Lupo, F., & Coffelt, S. B. (2026) · Trends in Immunology · doi:10.1016/j.it.2026.02.009
- Authors
- Jin, Y., Xia, M., Sun, A., Saylor, C. M., & Xiong, N.
- Affiliations
- Pennsylvania State University (US)
- Corresponding author
- Xiong, Na
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-11
- Volume
- 185
- Issue
- 10
- Pages
- 5723-5731
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- PMC
- PMC3037513
- OpenAlex
- W2157669539
- Cited by
- 74
- References
- 46
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 2 · 2020: 13 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 6 · 2015: 3 · 2014: 3 · 2013: 6 · 2012: 5
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01AI071043)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- CCR10, γδ T cells, thymic selection, T cell migration, skin colonization
- MeSH terms
- Animals, Cell Differentiation, Cell Movement, Cell Separation, Flow Cytometry, Microscopy, Fluorescence, Skin, T-Lymphocyte Subsets, Receptors, Antigen, T-Cell, gamma-delta, Mice, Knockout, Reverse Transcriptase Polymerase Chain Reaction, Mice, Receptors, CCR10
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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