The Intraepithelial T Cell Response to NKG2D-Ligands Links Lymphoid Stress Surveillance to Atopy
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Epidermal abrasion and T cells in the skin work together to drive the type of immune responses seen in allergy and asthma.
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TCR triggering alone is typically insufficient for full activation of innate-like T cells.
“However, TCR triggering alone is typically insufficient for the full activation of these cells (15)”
From NKG2D-mediated detection of metabolically stressed hepatocytes by innate-like T cells is essential for initiation of NASH and fibrosis (2023) · cites this paper as [15]
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- Authors
- Strid, J., Sobolev, O., Zafirova, B., Polic, B., & Hayday, A.
- Affiliations
- Guy's Hospital (GB)
- University of Rijeka (HR)
- Department of Histology and Embryology, University of Rijeka School of Medicine, Braće Branchetta 20, HR-51000 Rijeka, Croatia.
- Corresponding author
- Hayday, Adrian
- Venue
- Science
- Published
- 2011-12-02
- Volume
- 334
- Issue
- 6060
- Pages
- 1293-1297
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3842529
- OpenAlex
- W2014541274
- Cited by
- 155
- References
- 34
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 7 · 2022: 7 · 2021: 3 · 2020: 15 · 2019: 4 · 2018: 21 · 2017: 7 · 2016: 19 · 2015: 7 · 2014: 11 · 2013: 29 · 2012: 10
- FWCI
- 7.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Wellcome Trust (085780)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- NKG2D, NKG2D ligands, intraepithelial T cells, atopy, Th2 cells, tissue damage, carcinogenesis
- MeSH terms
- Animals, Epidermis, Hypersensitivity, Immediate, Ligands, Lymphoid Tissue, Membrane Proteins, Mice, Transgenic, Stress, Physiological, Up-Regulation, T-Lymphocyte Subsets, Receptors, Antigen, T-Cell, gamma-delta, Th2 Cells, Mice, NK Cell Lectin-Like Receptor Subfamily K
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