The DOI matches its Crossref record; 327 of the 327 references it cites were found in a registry or an index.
Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis
Open accessAbstract
Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an abnormal fibrotic response involving vast areas of the lungs. Given the poor knowledge of the mechanisms underpinning IPF onset and progression, a better understanding of the cellular processes and molecular pathways involved is essential for the development of effective therapies, currently lacking. Besides a number of established IPF-associated risk factors, such as cigarette smoking, environmental factors, comorbidities, and viral infections, several other processes have been linked with this devastating disease. Apoptosis, senescence, epithelial-mesenchymal transition, endothelial-mesenchymal transition, and epithelial cell migration have been shown to play a key role in IPF-associated tissue remodeling. Moreover, molecules, such as chemokines, cytokines, growth factors, adenosine, glycosaminoglycans, non-coding RNAs, and cellular processes including oxidative stress, mitochondrial dysfunction, endoplasmic reticulum stress, hypoxia, and alternative polyadenylation have been linked with IPF development. Importantly, strategies targeting these processes have been investigated to modulate abnormal cellular phenotypes and maintain tissue homeostasis in the lung. This review provides an update regarding the emerging cellular and molecular mechanisms involved in the onset and progression of IPF.
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Idiopathic Pulmonary Fibrosis: An Update on Pathogenesis
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Inhibition of ferroptosis and iron accumulation alleviates pulmonary fibrosis in a bleomycin model
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Metadata
- Authors
- Phan, T. H. G., Paliogiannis, P., Nasrallah, G. K., Giordo, R., Eid, A. H., Fois, A. G., Zinellu, A., Mangoni, A. A., & Pintus, G.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2020-11-17
- Volume
- 78
- Issue
- 5
- Pages
- 2031-2057
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- OpenAlex
- W3101332344
- Cited by
- 351
- References
- 327
- FWCI
- 24.50
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Phan, T. H. G., Paliogiannis, P., Nasrallah, G. K., Giordo, R., Eid, A. H., Fois, A. G., Zinellu, A., Mangoni, A. A., & Pintus, G. (2021). Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis. Cellular and Molecular Life Sciences. https://doi.org/10.1007/s00018-020-03693-7
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