The DOI matches its Crossref record; 185 of the 185 references it cites were found in a registry or an index.
Insect antimicrobial peptides: potential weapons to counteract the antibiotic resistance
Open accessAbstract
Misuse and overuse of antibiotics have contributed in the last decades to a phenomenon known as antibiotic resistance which is currently considered one of the principal threats to global public health by the World Health Organization. The aim to find alternative drugs has been demonstrated as a real challenge. Thanks to their biodiversity, insects represent the largest class of organisms in the animal kingdom. The humoral immune response includes the production of antimicrobial peptides (AMPs) that are released into the insect hemolymph after microbial infection. In this review, we have focused on insect immune responses, particularly on AMP characteristics, their mechanism of action and applications, especially in the biomedical field. Furthermore, we discuss the Toll, Imd, and JAK-STAT pathways that activate genes encoding for the expression of AMPs. Moreover, we focused on strategies to improve insect peptides stability against proteolytic susceptibility such as D-amino acid substitutions, N-terminus modification, cyclization and dimerization.
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Cites
1 retracted
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RetractedUCSF Chimera—A visualization system for exploratory research and analysis
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Antimicrobial peptides of multicellular organisms
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Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
Brogden, K. A. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1098 · Cited by 5,829
Inflammatory responses and inflammation-associated diseases in organs
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Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies
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Cited by
Stenvinkel, P., Shiels, P. G., & Johnson, R. J. (2023) · Journal of Environmental Management · doi:10.1016/j.jenvman.2022.116981 · Cited by 14
Biomimetics provides lessons from nature for contemporary ways to improve human health
Stenvinkel, P., Avesani, C. M., Gordon, L. J., Schalling, M., & Shiels, P. G. (2021) · Journal of Clinical and Translational Science · doi:10.1017/cts.2021.790 · Cited by 11
Metadata
- Authors
- Manniello, M. D., Moretta, A., Salvia, R., Scieuzo, C., Lucchetti, D., Vogel, H., Sgambato, A., & Falabella, P.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2021-02-17
- Volume
- 78
- Issue
- 9
- Pages
- 4259-4282
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- OpenAlex
- W3132791108
- Cited by
- 259
- References
- 185
- FWCI
- 25.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Manniello, M. D., Moretta, A., Salvia, R., Scieuzo, C., Lucchetti, D., Vogel, H., Sgambato, A., & Falabella, P. (2021). Insect antimicrobial peptides: potential weapons to counteract the antibiotic resistance. Cellular and Molecular Life Sciences. https://doi.org/10.1007/s00018-021-03784-z
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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