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Inflammatory responses and inflammation-associated diseases in organs

Open access
Chen, Linlin, Deng, Huidan, Cui, Hengmin, Fang, Jing, Zuo, Zhicai, Deng, Junliang, Li, Yinglun, Wang, Xun, Zhao, Ling·2018·Oncotarget

Abstract

// Linlin Chen 1, * , Huidan Deng 1, * , Hengmin Cui 1, 2 , Jing Fang 1, 2 , Zhicai Zuo 1, 2 , Junliang Deng 1, 2 , Yinglun Li 1, 2 , Xun Wang 1, 2 and Ling Zhao 1, 2 1 College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu 611130, China 2 Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu 611130, China * These authors contributed equally to this work Correspondence to: Hengmin Cui, email: cui580420@sicau.edu.cn Keywords: inflammation; inflammatory signaling pathways; chemokines; cytokines; organ diseases Received: April 19, 2017 Accepted: November 03, 2017 Published: December 14, 2017 ABSTRACT Inflammation is a biological response of the immune system that can be triggered by a variety of factors, including pathogens, damaged cells and toxic compounds. These factors may induce acute and/or chronic inflammatory responses in the heart, pancreas, liver, kidney, lung, brain, intestinal tract and reproductive system, potentially leading to tissue damage or disease. Both infectious and non-infectious agents and cell damage activate inflammatory cells and trigger inflammatory signaling pathways, most commonly the NF-κB, MAPK, and JAK-STAT pathways. Here, we review inflammatory responses within organs, focusing on the etiology of inflammation, inflammatory response mechanisms, resolution of inflammation, and organ-specific inflammatory responses.

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Metadata

Authors
Chen, L., Deng, H., Cui, H., Fang, J., Zuo, Z., Deng, J., Li, Y., Wang, X., & Zhao, L.
Venue
Oncotarget
Published
2017-12-14
Volume
9
Issue
6
Pages
7204-7218
ISSN
1949-2553 (ISSN-L)
OpenAlex
W2771472591
Cited by
5,143
References
26
FWCI
73.26
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Inflammatory responses and inflammation-associated diseases in organs. https://app.cochat.ai/papers/10.18632/oncotarget.23208
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Chen, L., Deng, H., Cui, H., Fang, J., Zuo, Z., Deng, J., Li, Y., Wang, X., & Zhao, L. (2018). Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. https://doi.org/10.18632/oncotarget.23208

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