Synthesis and evaluation of anti-inflammatory and analgesic activity of some substituted thiazolyl and thaizolidinonyl tetrahydronapthalene derivatives
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THN-fused C3-spirooxindoles should possess good druglikeness because THN and spirooxindole derivatives are privileged drug-like architectures.
“We started with THN54, 55, 56, 57, 58, 59, 60, 61 and spirooxindole derivatives62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72 because they are privileged drug-like architectures, so the resulting THN-fused C3-spirooxindoles should possess good druglikeness (Fig. 2C).”
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Wang, B., Peng, F., Huang, W., Zhou, J., Zhang, N., Sheng, J., Haruehanroengra, P., He, G., & Han, B. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.12.013 · Cited by 73 · see citing works
- Authors
- Haiba, M. E., Abd El-Karim, S. S., Gouhar, R. S., El-Zahar, M. I., & El-Awdan, S. A.
- Affiliations
- King Saud University (SA)
- National Research Centre (EG)
- Venue
- Medicinal Chemistry Research
- Published
- 2014-01-31
- Volume
- 23
- Issue
- 7
- Pages
- 3418-3435
- ISSN
- 1054-2523 (ISSN-L)
- 1554-8120
- OpenAlex
- W2136697762
- Cited by
- 19
- References
- 31
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Medicinal Chemistry Research (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis and biological activity
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis of Tetrazole Derivatives
- Keywords
- thiazole derivatives, thiazolidinone derivatives, anti-inflammatory activity, analgesic activity, indomethacin comparison, ulcerogenicity, gastrointestinal safety, drug synthesis
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