Non‐steroidal anti‐inflammatory drugs (NSAIDs) in Alzheimer's disease: old and new mechanisms of action

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

VANE, J. R. (1971) · Nature New Biology · doi:10.1038/newbio231232a0 · Cited by 8,605 · see citing works

Inflammation and Alzheimer’s disease

Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514 · see citing works

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., et al. (1999) · Science · doi:10.1126/science.286.5440.735 · Cited by 3,876 · see citing works

The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation

Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J., & Glass, C. K. (1998) · Nature · doi:10.1038/34178 · Cited by 3,525 · see citing works

PPAR-γ agonists inhibit production of monocyte inflammatory cytokines

Jiang, C., Ting, A. T., & Seed, B. (1998) · Nature · doi:10.1038/34184 · Cited by 2,899 · see citing works

Cyclooxygenase in biology and disease

Dubois, R. N., Abramson, S. B., Crofford, L., Gupta, R., Simon, L. S., Putte, L., & Lipsky, P. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.12.1063 · Cited by 2,606 · see citing works

Inflammatory Blockade Restores Adult Hippocampal Neurogenesis

Monje, M. L., Toda, H., & Palmer, T. D. (2003) · Science · doi:10.1126/science.1088417 · Cited by 2,426 · see citing works

Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

Bard, F., Cannon, C., Barbour, R., Burke, R.-L., Games, D., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., et al. (2000) · Nature Medicine · doi:10.1038/78682 · Cited by 2,012 · see citing works

COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression

Chandrasekharan, N. V., Dai, H., Roos, K. L. T., Evanson, N. K., Tomsik, J., Elton, T. S., & Simmons, D. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162468699 · Cited by 1,989 · see citing works

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(84)91209-9 · Cited by 1,693 · see citing works

Inflammation is detrimental for neurogenesis in adult brain

Ekdahl, C. T., Claasen, J.-H., Bonde, S., Kokaia, Z., & Lindvall, O. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2234031100 · Cited by 1,559 · see citing works

A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity

Weggen, S., Eriksen, J. L., Das, P., Sagi, S. A., Wang, R., Pietrzik, C. U., Findlay, K. A., Smith, T. E., Murphy, M. P., Bulter, T., et al. (2001) · Nature · doi:10.1038/35102591 · Cited by 1,388 · see citing works

Inflammation in Neurodegenerative Disease—A Double-Edged Sword

Wyss-Coray, T., & Mucke, L. (2002) · Neuron · doi:10.1016/s0896-6273(02)00794-8 · Cited by 1,235 · see citing works

Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

in 't Veld, B. A., Ruitenberg, A., Hofman, A., Launer, L. J., van Duijn, C. M., Stijnen, T., Breteler, M. M. B., & Stricker, B. H. C. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010178 · Cited by 1,196 · see citing works

Risk of Alzheimer's disease and duration of NSAID use

Stewart, W. F., Kawas, C., Corrada, M., & Metter, E. J. (1997) · Neurology · doi:10.1212/wnl.48.3.626 · Cited by 1,132 · see citing works

Peroxisome Proliferator-activated Receptors α and γ Are Activated by Indomethacin and Other Non-steroidal Anti-inflammatory Drugs

Lehmann, J. M., Lenhard, J. M., Oliver, B. B., Ringold, G. M., & Kliewer, S. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.6.3406 · Cited by 1,110 · see citing works

Ibuprofen Suppresses Plaque Pathology and Inflammation in a Mouse Model for Alzheimer's Disease

Lim, G. P., Yang, F., Chu, T., Chen, P., Beech, W. K., Teter, B., Tran, T., Ubeda, O. J., Ashe, K. H., Frautschy, S. A., et al. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-15-05709.2000 · Cited by 876 · see citing works

Cyclooxygenase-1 and Cyclooxygenase-2 Selectivity of Widely Used Nonsteroidal Anti-Inflammatory Drugs

Cryer, B., & Feldman, M. L. (1998) · The American Journal of Medicine · doi:10.1016/s0002-9343(98)00091-6 · Cited by 771 · see citing works

Neuroprotection by Aspirin and Sodium Salicylate Through Blockade of NF-κB Activation

Grilli, M., Pizzi, M., Memo, M., & Spano, P. (1996) · Science · doi:10.1126/science.274.5291.1383 · Cited by 751 · see citing works

Cyclooxygenase‐independent actions of cyclooxygenase inhibitors

Tegeder, I., Pfeilschifter, J. M., & Geißlinger, G. (2001) · The FASEB Journal · doi:10.1096/fj.01-0390rev · Cited by 748 · see citing works

Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils

Khoury, J. E., Hickman, S. E., Thomas, C. A., Cao, L., Silverstein, S. C., & Loike, J. D. (1996) · Nature · doi:10.1038/382716a0 · Cited by 727 · see citing works

Early Phenotypic Changes in Transgenic Mice That Overexpress Different Mutants of Amyloid Precursor Protein in Brain

Moechars, D., Dewachter, I., Lorent, K., Reversé, D., Baekelandt, V., Naidu, A., Tesseur, I., Spittaels, K., Haute, C. V. D., Checler, F., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.10.6483 · Cited by 668 · see citing works

Microglial Cells Internalize Aggregates of the Alzheimer's Disease Amyloid β-Protein Via a Scavenger Receptor

Paresce, D. M., Ghosh, R. N., & Maxfield, F. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80187-7 · Cited by 663 · see citing works

NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo

Eriksen, J. L., Sagi, S. A., Smith, T. E., Weggen, S., Das, P., McLendon, D. C., Ozols, V. V., Jessing, K. W., Zavitz, K. H., Koo, E. H., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18162 · Cited by 634 · see citing works

Nonsteroidal Anti-inflammatory Drugs and the Risk of Parkinson Disease

Chen, H., Zhang, S. M., Hernán, M. Á., Schwarzschild, M. A., Willett, W. C., Colditz, G. A., Speizer, F. E., & Ascherio, A. (2003) · Archives of Neurology · doi:10.1001/archneur.60.8.1059 · Cited by 630 · see citing works

Estrogen reduces neuronal generation of Alzheimer β-amyloid peptides

Xu, H., Gouras, G. K., Greenfield, J. P., Vincent, B., Näslund, J., Mazzarelli, L., Fried, G., Jovanovic, J. N., Seeger, M., Relkin, N. R., et al. (1998) · Nature Medicine · doi:10.1038/nm0498-447 · Cited by 557 · see citing works

The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs

Reid, G., Wielinga, P. R., Zelcer, N., van der Heijden, I., Kuil, A., de Haas, M., Wijnholds, J., & Borst, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1033060100 · Cited by 531 · see citing works

Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies

Etminan, M., Gill, S., & Samii, A. (2003) · BMJ · doi:10.1136/bmj.327.7407.128 · Cited by 511 · see citing works

Inflammatory Mechanisms in Alzheimer's Disease: Inhibition of β-Amyloid-Stimulated Proinflammatory Responses and Neurotoxicity by PPARγ Agonists

Combs, C. K., Johnson, D. E., Karlo, J. C., Cannady, S. B., & Landreth, G. E. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-02-00558.2000 · Cited by 483 · see citing works

Inflammatory processes in Alzheimer's disease

McGeer, E. G., & McGeer, P. L. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(03)00124-6 · Cited by 473 · see citing works

Anti-Inflammatory Drug Therapy Alters β-Amyloid Processing and Deposition in an Animal Model of Alzheimer's Disease

Yan, Q., Zhang, J., Liu, H., Babu-Khan, S., Vassar, R., Biere, A. L., Citron, M., & Landreth, G. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-20-07504.2003 · Cited by 469 · see citing works

The development of COX2 inhibitors

Flower, R. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1034 · Cited by 460 · see citing works

Serum insulin-like growth factor I regulates brain amyloid-β levels

Carro, E., Trejo, J. L., Gómez‐Isla, T., LeRoith, D., & Torres‐Alemán, I. (2002) · Nature Medicine · doi:10.1038/nm793 · Cited by 448 · see citing works

Serum insulin-like growth factor I regulates brain amyloid-β levels

Carro, E., Jl, T., Gómez‐Isla, T., LeRoith, D., & Torres‐Alemán, I. (2002) · Nature Medicine · doi:10.1038/nm1202-793 · Cited by 442 · see citing works

Transthyretin sequesters amyloid beta protein and prevents amyloid formation.

Schwarzman, A. L., Gregori, L. L., Vitek, M. P., Lyubski, S., Strittmatter, W. J., Enghilde, J. J., Bhasin, R., Silverman, J. M., Weisgraber, K. H., & Coyle, P. K. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.18.8368 · Cited by 410 · see citing works

Neuroinflammation in Alzheimer's disease and prion disease

Eikelenboom, P., Bate, C., van Gool, W. A., Hoozemans, J. J. M., Rozemüller, A. J. M., Veerhuis, R., & Williams, A. (2002) · Glia · doi:10.1002/glia.10146 · Cited by 402 · see citing works

Rofecoxib

Reines, S. A., Block, G. A., Morris, J. C., Liu, G., Nessly, M. L., Lines, C. R., Norman, B., & Baranak, C. C. (2004) · Neurology · doi:10.1212/wnl.62.1.66 · Cited by 378 · see citing works

Inhibition of thromboxane formation in vivo and ex vivo: implications for therapy with platelet inhibitory drugs

Reilly, I., & FitzGerald, G. (1987) · Blood · doi:10.1182/blood.v69.1.180.bloodjournal691180 · Cited by 374 · see citing works

Cyclooxygenase-selective inhibition of prostanoid formation: transducing biochemical selectivity into clinical read-outs

Patrono, C., Patrignani, P., & Rodríguez, L. A. G. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200113418 · Cited by 362 · see citing works

Nonsteroidal Anti-Inflammatory Drugs and Peroxisome Proliferator-Activated Receptor-γ Agonists Modulate Immunostimulated Processing of Amyloid Precursor Protein through Regulation of β-Secretase

Sastre, M., Dewachter, I., Landreth, G. E., Willson, T. M., Klockgether, T., LEUVEN, F. V., & Heneka, M. T. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-30-09796.2003 · Cited by 359 · see citing works

Inhibition of thromboxane formation in vivo and ex vivo: implications for therapy with platelet inhibitory drugs

Reilly, I., & FitzGerald, G. (1987) · Blood · doi:10.1182/blood.v69.1.180.180 · Cited by 356 · see citing works

Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer's disease

Hauss‐Wegrzyniak, B., Dobrzański, P., Stoehr, J. D., & Wenk, G. L. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01215-8 · Cited by 337 · see citing works

Microglial Activation and β-Amyloid Deposit Reduction Caused by a Nitric Oxide-Releasing Nonsteroidal Anti-Inflammatory Drug in Amyloid Precursor Protein Plus Presenilin-1 Transgenic Mice

Jantzen, P. T., Connor, K. E., DiCarlo, G., Wenk, G. L., Wallace, J. L., Rojiani, A. M., Coppola, D., Morgan, D., & Gordon, M. N. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-06-02246.2002 · Cited by 337 · see citing works

Novel anti-inflammatory therapy for Parkinson's disease

Gao, H., Liu, B., Zhang, W., & Hong, J. (2003) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(03)00176-7 · Cited by 324 · see citing works

Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß ₄₂ by Inhibiting Rho

Zhou, Y., Su, Y., Li, B., Liu, F., Ryder, J. W., Wu, X., Gonzalez-DeWhitt, P. A., Gelfanova, V., Hale, J. E., May, P. C., et al. (2003) · Science · doi:10.1126/science.1090154 · Cited by 316 · see citing works

Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer’s disease

Matsuoka, Y., Picciano, M., Malester, B., LaFrancois, J., Zehr, C., Daeschner, J. M., Olschowka, J. A., Fonseca, M. I., O’Banion, M. K., Tenner, A. J., et al. (2001) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64085-0 · Cited by 303 · see citing works

Evidence That Nonsteroidal Anti-inflammatory Drugs Decrease Amyloid β42 Production by Direct Modulation of γ-Secretase Activity

Weggen, S., Eriksen, J. L., Sagi, S. A., Pietrzik, C. U., Ozols, V. V., Fauq, A. H., Golde, T. E., & Koo, E. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303592200 · Cited by 280 · see citing works

Elevated CSF prostaglandin E 2 levels in patients with probable AD

Montine, T. J., Sidell, K. R., Crews, B. C., Markesbery, W. R., Marnett, L. J., Roberts, L. J., & Morrow, J. D. (1999) · Neurology · doi:10.1212/wnl.53.7.1495 · Cited by 278 · see citing works

Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: Facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors

Kalgutkar, A. S. S., Crews, B. C., Rowlinson, S. W., Marnett, A. B., Kozak, K. R., Remmel, R. P., & Marnett, L. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.2.925 · Cited by 252 · see citing works

Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging

Mackenzie, I. R. A., & Munoz, D. G. (1998) · Neurology · doi:10.1212/wnl.50.4.986 · Cited by 244 · see citing works

A classification of NSAIDs according to the relative inhibition of cyclooxygenase isoenzymes

Frölich, J. C. (1997) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(96)01017-6 · Cited by 243 · see citing works

Ibuprofen effects on Alzheimer pathology and open field activity in APPsw transgenic mice

Lim, G. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00299-8 · Cited by 224 · see citing works

Molecular mechanism of neurodegeneration induced by Alzheimer’s β-amyloid protein: channel formation and disruption of calcium homeostasis

Kawahara, M., & Kuroda, Y. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00370-1 · Cited by 221 · see citing works

Meloxican: Influence on arachidonic acid metabolism

Engelhardt, G., Bögel, R., Schnitzler, C., & Utzmann, R. (1996) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)02110-8 · Cited by 218 · see citing works

Increased Expression of Cyclooxygenases and Peroxisome Proliferator-Activated Receptor-γ in Alzheimer's Disease Brains

Kitamura, Y., Shimohama, S., Koike, H., Kakimura, J., Matsuoka, Y., Nomura, Y., Gebicke‐Haerter, P. J., & Taniguchi, T. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9981 · Cited by 208 · see citing works

Oligomerization and Toxicity of β-Amyloid-42 Implicated in Alzheimer's Disease

El‐Agnaf, O. M. A., Mahil, D. S., PATEL, B. P., & Austen, B. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3051 · Cited by 196 · see citing works

Neuronal Cyclooxygenase 2 Expression in the Hippocampal Formation as a Function of the Clinical Progression of Alzheimer Disease

Ho, L., Purohit, D. P., Haroutunian, V. H., Luterman, J. D., Willis, F., Näslund, J., Buxbaum, J. D., Mohs, R. C., Aisen, P. S. S., & Pasinetti, G. M. (2001) · Archives of Neurology · doi:10.1001/archneur.58.3.487 · Cited by 196 · see citing works

Polymorphisms in Inflammatory Genes and the Risk of Alzheimer Disease

McGeer, P. L. (2001) · Archives of Neurology · doi:10.1001/archneur.58.11.1790 · Cited by 192 · see citing works

Neuroprotective effects of non‐steroidal anti‐inflammatory drugs by direct scavenging of nitric oxide radicals

Asanuma, M., Nishibayashi-Asanuma, S., Miyazaki, I., Kohno, M., & Ogawa, N. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00205.x · Cited by 190 · see citing works

Cyclooxygenase-1 in Human Alzheimer and Control Brain: Quantitative Analysis of Expression by Microglia and CA3 Hippocampal Neurons

Yermakova, A., Rollins, J., Callahan, L. M., Rogers, J., & O’Banion, M. K. (1999) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199911000-00003 · Cited by 187 · see citing works

Complement activation by neurofibrillary tangles in Alzheimer's disease

Shen, Y., Lue, L.-F., Yang, L.-B., Roher, A., Kuo, Y.-M., Strohmeyer, R., Goux, W. J., Lee, V., Johnson, G. V. W., Webster, S. D., et al. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01842-0 · Cited by 185 · see citing works

Oligomerization of Endogenous and Synthetic Amyloid β-Protein at Nanomolar Levels in Cell Culture and Stabilization of Monomer by Congo Red

Podlisny, M. B., Walsh, D. M., Amarante, P., Ostaszewski, B. L., Stimson, E. R., Maggio, J. E., Teplow, D. B., & Selkoe, D. J. (1998) · Biochemistry · doi:10.1021/bi972029u · Cited by 181 · see citing works

Sulindac Sulfide Is a Noncompetitive γ-Secretase Inhibitor That Preferentially Reduces Aβ42 Generation

Takahashi, Y., Hayashi, I., Tominari, Y., Rikimaru, K., Morohashi, Y., Kan, T., Natsugari, H., Fukuyama, T., Tomita, T., & Iwatsubo, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301619200 · Cited by 179 · see citing works

Selected Non-steroidal Anti-inflammatory Drugs and Their Derivatives Target γ-Secretase at a Novel Site

Beher, D., Clarke, E. E., Wrigley, J. D. J., Martin, A. C. L., Nadin, A. J., Churcher, I., & Shearman, M. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404937200 · Cited by 177 · see citing works

In vitro detection of (S)-naproxen and ibuprofen binding to plaques in the Alzheimer’s brain using the positron emission tomography molecular imaging probe 2-(1-{6-[(2-[18F]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile

Agdeppa, E. D., Kepe, V., Petri, A., Satyamurthy, N., Liu, J., Huang, S. C., Small, G. W., Cole, G. M., & Barrio, J. R. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00907-7 · Cited by 172 · see citing works

Anti-inflammatory actions of peroxisome proliferator-activated receptor gamma agonists in Alzheimer's disease

Landreth, G. E. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00296-2 · Cited by 169 · see citing works

Alzheimer's disease: treatments in discovery and development

Citron, M. (2002) · Nature Neuroscience · doi:10.1038/nn940 · Cited by 164 · see citing works

Chronic Brain Inflammation Results in Cell Loss in the Entorhinal Cortex and Impaired LTP in Perforant Path-Granule Cell Synapses

Hauss‐Wegrzyniak, B., Lynch, M. A., Vraniak, P., & Wenk, G. L. (2002) · Experimental Neurology · doi:10.1006/exnr.2002.7966 · Cited by 143 · see citing works

The effects of a novel NSAID on chronic neuroinflammation are age dependent☆

Hauss‐Wegrzyniak, B., Vraniak, P., & Wenk, G. L. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00028-7 · Cited by 141 · see citing works

Selective inhibition of Aβ42 production by NSAID R‐enantiomers

Morihara, T., Chu, T., Ubeda, O. J., Beech, W. K., & Cole, G. M. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01195.x · Cited by 138 · see citing works

Evidence for caspase‐mediated cleavage of AMPA receptor subunits in neuronal apoptosis and Alzheimer's disease

Chan, S. L., Griffin, W. S. T., & Mattson, M. P. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19990801)57:3 · Cited by 137 · see citing works

Peroxisome Proliferator-Activated Receptor-γ Is a Target of Nonsteroidal Anti-Inflammatory Drugs Mediating Cyclooxygenase-Independent Inhibition of Lung Cancer Cell Growth

Wick, M. J., Hurteau, G., Dessev, C., et al. (2002) · Molecular Pharmacology · doi:10.1124/mol.62.5.1207 · Cited by 137 · see citing works

Cyclooxygenase-2 Promotes Amyloid Plaque Deposition in a Mouse Model of Alzheimer's Disease Neuropathology

Xiang, Z., Ho, L., Yemul, S., Zhao, Z., Pompl, P. N., Kelley, K. A., Dang, A., Qing, W., Teplow, D. B., & Pasinetti, G. M. (2002) · Gene Expression · doi:10.3727/000000002783992352 · Cited by 135 · see citing works

Studies of Aβ Pharmacodynamics in the Brain, Cerebrospinal Fluid, and Plasma in Young (Plaque-Free) Tg2576 Mice Using the γ-Secretase Inhibitor N2-[(2 S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7 S)-5-methyl-6-oxo-6,7-dihydro-5 H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY-411575)

Lanz, T. A., Hosley, J. D., Adams, W. J., & Merchant, K. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.060715 · Cited by 130 · see citing works

The disordered neuronal cytoskeleton in Alzheimer's disease

Lee, V. M. ‐., & Trojanowski, J. Q. (1992) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(92)90034-i · Cited by 129 · see citing works

Sulindac sulfide inhibits Ras signaling

Herrmann, C., Block, C., Geisen, C., Haas, K., Weber, C. K., Winde, G., Möröy, T., & Müller, O. (1998) · Oncogene · doi:10.1038/sj.onc.1202085 · Cited by 129 · see citing works

Aspirin and non-steroidal anti-inflammatory drugs inhibit amyloid-β aggregation

Thomas, T., Nadackal, T. G., & Thomas, K. (2001) · Neuroreport · doi:10.1097/00001756-200110290-00024 · Cited by 127 · see citing works

Aβ42-lowering Nonsteroidal Anti-inflammatory Drugs Preserve Intramembrane Cleavage of the Amyloid Precursor Protein (APP) and ErbB-4 Receptor and Signaling through the APP Intracellular Domain

Weggen, S., Eriksen, J. L., Sagi, S. A., Pietrzik, C. U., Golde, T. E., & Koo, E. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304824200 · Cited by 127 · see citing works

COX-2 as a multifunctional neuronal modulator

Bazan, N. G. (2001) · Nature Medicine · doi:10.1038/86477 · Cited by 125 · see citing works

Generation and Regulation of β‐Amyloid Peptide Variants by Neurons

Gouras, G. K., Xu, H., Jovanovic, J. N., Buxbaum, J. D., Wang, R., Greengard, P., Relkin, N. R., & Gandy, S. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.71051920.x · Cited by 122 · see citing works

Mechanisms of ß-Amyloid Neurotoxicity: Perspectives of Pharmacotherapy

Harkany, T., Ábrahám, I. M., Kónya, C., Nyakas, C. J., Zarándi, M., Penke, B., & Luiten, P. G. M. (2000) · Reviews in the Neurosciences · doi:10.1515/revneuro.2000.11.4.329 · Cited by 122 · see citing works

Apolipoprotein E, transthyretin and actin in the CSF of Alzheimer's patients: relation with the senile plaques and cytoskeleton biochemistry

Merched, A. J., Sérot, J., Visvikis‐Siest, S., Aguillon, D., Faure, G. C., & Siest, G. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00234-8 · Cited by 111 · see citing works

Reduced prealbumin (transthyretin) in CSF of severely demented patients with Alzheimer's disease

Riisøen, H. (1988) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1988.tb03687.x · Cited by 111 · see citing works

Amyloid Precursor Protein and Amyloid β Peptide in Human Platelets

Skovronsky, D., Lee, V. M. ‐., & Praticò, D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006285200 · Cited by 110 · see citing works

Activation of peroxisome proliferator-activated receptor isoforms and inhibition of prostaglandin H2 synthases by ibuprofen, naproxen, and indomethacin11Abbreviations: AA, arachidonic acid; ACO, acyl-CoA oxidase; COX; cyclooxygenase; NSAIDs, nonsteroidal anti-inflammatory drugs; PGHS, prostaglandin endoperoxide H synthase; PPP, platelet-poor plasma; PRP, platelet-rich plasma; PPAR, peroxisome proliferator-activated receptor; PPRE, peroxisome proliferator response element; and CoA coenzyme A.

Jaradat, M., Wongsud, B., Phornchirasilp, S., Rangwala, S. M., Shams, G. E.-D. A. M., Sutton, M., Romstedt, K. J., Noonan, D. J., & Feller, D. R. (2001) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00822-x · Cited by 110 · see citing works

Meloxican: Influence on arachidonic acid metabolism

Engelhardt, G., Bögel, R., Schnitzer, C., & Utzmann, R. (1996) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)02111-6 · Cited by 109 · see citing works

Downregulation of neuronal cyclooxygenase-2 expression in end stage Alzheimer's disease

Yermakova, A. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00303-7 · Cited by 108 · see citing works

Cyclooxygenase (COX)-2 and cell cycle activity in a transgenic mouse model of Alzheimer's Disease neuropathology

Xiang, Z. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00282-2 · Cited by 107 · see citing works

Inflammation and cerebral amyloidosis are disconnected in an animal model of Alzheimer's disease

Quinn, J. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(03)00037-7 · Cited by 102 · see citing works

Presenilins are not required for Aβ42 production in the early secretory pathway

Wilson, C., Doms, R. W., Zheng, H., & Lee, V. M. ‐. (2002) · Nature Neuroscience · doi:10.1038/nn898 · Cited by 99 · see citing works

Modulation of β‐amyloid metabolism by non‐steroidal anti‐inflammatory drugs in neuronal cell cultures

Gasparini, L., Rusconi, L., Xu, H., Soldato, P. D., & Ongini, E. (2003) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02154.x · Cited by 97 · see citing works

Indomethacin Reverses the Microglial Response to Amyloid β-Protein

Netland, E. E., Newton, J. L., Majocha, R. E., & Tate, B. A. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00047-5 · Cited by 93 · see citing works

Ibuprofen Decreases Cytokine-Induced Amyloid Beta Production in Neuronal Cells

Blasko, I., Apochal, A., Boeck, G., Hartmann, T., Grubeck‐Loebenstein, B., & Ransmayr, G. N. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0451 · Cited by 92 · see citing works

Putative Cyclooxygenase-3 Expression in Rat Brain Cells

Kis, B., Snipes, J. A., Isse, T., Nagy, K. A., & Busija, D. W. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000090681.07515.81 · Cited by 92 · see citing works

Yin and Yang: complement activation and regulation in Alzheimer’s disease

Shen, Y., & Meri, S. (2003) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2003.08.001 · Cited by 89 · see citing works

Attenuation of chronic neuroinflammation by a nitric oxide‐releasing derivative of the antioxidant ferulic acid

Wenk, G. L., McGann-Gramling, K. R., Hauss‐Wegrzyniak, B., Ronchetti, D., Maucci, R., Rosi, S., Gasparini, L., & Ongini, E. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02359.x · Cited by 85 · see citing works

Metabolism of Alzheimer beta-amyloid precursor protein: regulation by protein kinase A in intact cells and in a cell-free system.

Xu, H., Sweeney, D. A., Greengard, P., & Gandy, S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.4081 · Cited by 84 · see citing works

Cyclooxygenase-2 Expression by Nonsteroidal Anti-inflammatory Drugs in Human Airway Smooth Muscle Cells: Role of Peroxisome Proliferator-Activated Receptors

Pang, L., Nie, M., Corbett, L. M., & Knox, A. J. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.2.1043 · Cited by 81 · see citing works

Non-steroidal Anti-inflammatory Drugs Stimulate Secretion of Non-amyloidogenic Precursor Protein

Avramovich‐Tirosh, Y., Amit, T., & Youdim, M. B. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201308200 · Cited by 81 · see citing works

The selective cyclooxygenase-2 inhibitor rofecoxib suppresses brain inflammation and protects cholinergic neurons from excitotoxic degeneration in vivo

Scali, C., Giovannini, M. G., Prosperi, C., Bellucci, A., Pepeu, G., & Casamenti, F. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00839-4 · Cited by 79 · see citing works

Clinical pharmacokinetics of nonsteroidal anti-inflammatory drugs in the cerebrospinal fluid

Bannwarth, B., Netter, P., Pourel, J., Royer, R., & Gaucher, A. (1989) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(89)90140-6 · Cited by 76 · see citing works

The Non-cyclooxygenase Targets of Non-steroidal Anti-inflammatory Drugs, Lipoxygenases, Peroxisome Proliferator-activated Receptor, Inhibitor of κB Kinase, and NFκB, Do Not Reduce Amyloid β42 Production

Sagi, S. A., Weggen, S., Eriksen, J. L., Golde, T. E., & Koo, E. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303588200 · Cited by 76 · see citing works

β-Amyloid Production, Aggregation, and Clearance as Targets for Therapy in Alzheimer's Disease

Felice, F. G. D., & Ferreira, S. T. (2002) · Cellular and Molecular Neurobiology · doi:10.1023/a:1021832302524 · Cited by 75 · see citing works

Peripheral administration of novel anti-inflammatories can attenuate the effects of chronic inflammation within the CNS

Hauss‐Wegrzyniak, B., Willard, L. B., Soldato, P. D., Pepeu, G., & Wenk, G. L. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01081-6 · Cited by 75 · see citing works

Toxicity of human THP-1 monocytic cells towards neuron-like cells is reduced by non-steroidal anti-inflammatory drugs (NSAIDs)

Klegeris, A., Walker, D. G., & McGeer, P. L. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(99)00014-3 · Cited by 75 · see citing works

Effect of Anti-inflammatory Medications on Neuropathological Findings in Alzheimer Disease

Halliday, G. M., Shepherd, C. E., McCann, H., Reid, W. G. J., Grayson, D. A., Broe, G. A., & Kril, J. J. (2000) · Archives of Neurology · doi:10.1001/archneur.57.6.831 · Cited by 72 · see citing works

Cyclooxygenase-3 Gene Expression in Alzheimer Hippocampus and in Stressed Human Neural Cells

Cui, J.-G., Kuroda, H., Chandrasekharan, N. V., Peláez, R. P., Simmons, D. L., Bazan, N. G., & Lukiw, W. J. (2004) · Neurochemical Research · doi:10.1023/b:nere.0000035809.70905.8a · Cited by 65 · see citing works

Stereoselective disposition of ibuprofen enantiomers in human cerebrospinal fluid.

Bannwarth, B., Lapicque, F., Péhourcq, F., et al. (1995) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1995.tb05783.x · Cited by 61 · see citing works

Brain inflammatory reaction in an animal model of neuronal degeneration and its modulation by an anti‐inflammatory drug: implication in Alzheimer's disease

Scali, C., Prosperi, C., Vannucchi, M. G., Pepeu, G., & Casamenti, F. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00075.x · Cited by 58 · see citing works

Apolipoproteins E3 and E4 induce, and transthyretin prevents accumulation of the Alzheimer's β-amyloid peptide in cultured vascular smooth muscle cells

Mazur‐Kolecka, B., Frackowiak, J., & Wı́sniewski, H. M. (1995) · Brain Research · doi:10.1016/0006-8993(95)00873-o · Cited by 57 · see citing works

Mechanisms to prevent the toxicity of chronic neuroinflammation on forebrain cholinergic neurons

Wenk, G. L., McGann, K., Mencarelli, A., Hauss‐Wegrzyniak, B., Soldato, P. D., & Fiorucci, S. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00523-9 · Cited by 56 · see citing works

Pharmacologic Agents Associated with a Preventive Effect on Alzheimer's Disease: A Review of the Epidemiologic Evidence

Veld, B. A. I. (2002) · Epidemiologic Reviews · doi:10.1093/epirev/mxf001 · Cited by 56 · see citing works

Cyclooxygenases and Central Nervous System Inflammation

Schwab, J. M., & Schluesener, H. J. (2003) · Archives of Neurology · doi:10.1001/archneur.60.4.630 · Cited by 50 · see citing works

Neuroprotective efficacy of nimesulide against hippocampal neuronal damage following transient forebrain ischemia

Candelario‐Jalil, E., Álvarez, D., González-Falcón, A., Garcia-Cabrera, M., Martı́nez-Sánchez, G., Merino, N., Giuliani, A., & León, O. S. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)02422-6 · Cited by 49 · see citing works

Quantitative Volumetric Analyses of Brain Magnetic Resonance Imaging from Rat with Chronic Neuroinflammation

Hauss‐Wegrzyniak, B., Galons, J., & Wenk, G. L. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7469 · Cited by 47 · see citing works

The influence of brain inflammation upon neuronal adenosine A2Breceptors

Rosi, S., McGann, K., Hauss‐Wegrzyniak, B., et al. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01825.x · Cited by 45 · see citing works

Cyclooxygenases in Central Nervous System Diseases

Graham, S. H., & Hickey, R. W. (2003) · Archives of Neurology · doi:10.1001/archneur.60.4.628 · Cited by 45 · see citing works

beta-Amyloid Aggregation Inhibitors for the Treatment of Alzheimer Disease Dream or Reality?

Talaga, P. E. (2001) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557013407098 · Cited by 44 · see citing works

Post-transcriptional Contribution of a cAMP-dependent Pathway to the Formation of α- and β/γ-Secretases-Derived Products of βAPP Maturation in Human Cells Expressing Wild-type and Swedish Mutated βAPP

Marambaud, P., Chevallier, N., Ancolio, K., & Checler, F. (1998) · Molecular Medicine · doi:10.1007/bf03401766 · Cited by 42 · see citing works

Cellular Cofactors for Amyloid β-Peptide-Induced Cell Stress

Yan, S. D., Roher, A. E., Schmidt, A. M., & Stern, D. M. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65452-1 · Cited by 39 · see citing works

Cellular and molecular basis of b-amyloid precursor protein metabolism (Y2K update)

Jeffrey, P. G. (2000) · Frontiers in bioscience · doi:10.2741/greenfield · Cited by 38 · see citing works

Comparison between Flurbiprofen and its Nitric Oxide-Releasing Derivatives HCT-1026 and NCX-2216 on Aβ(1-42)-Induced Brain Inflammation and Neuronal Damage in the Rat

Prosperi, C., Scali, C., Barba, M. C., Bellucci, A., Giovannini, M. G., Pepeu, G., & Casamenti, F. (2004) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463200401700312 · Cited by 35 · see citing works

Regulation of APP Synthesis and Secretion by Neuroimmunophilin Ligands and Cyclooxygenase Inhibitors

Lee, R. K. K., & Wurtman, R. J. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06934.x · Cited by 33 · see citing works

Gastric Tolerability and Prolonged Prostaglandin Inhibition in the Brain with a Nitric Oxide-Releasing Flurbiprofen Derivative, NCX-2216 [3-[4-(2-Fluoro-α-methyl-[1,1′-biphenyl]-4-acetyloxy)-3-methoxyphenyl]-2-propenoic acid 4-nitrooxy butyl ester]

Wallace, J. L., Muscará, M. N., Nucci, G. D., Zamunér, S. R., Cirino, G., Soldato, P. D., & Ongini, E. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.063453 · Cited by 33 · see citing works

Transthyretin gene in Alzheimer's disease patients

Palha, J. A., Moreira, P., Wısnıewskı, T., Frangione, B., & Saraiva, M. J. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12334-x · Cited by 30 · see citing works

Cellular and molecular basis of beta-amyloid precursor protein metabolism

Xu, H. (1998) · Frontiers in bioscience · doi:10.2741/a283 · Cited by 30 · see citing works

Diffusion of arylpropionate non‐steroidal anti‐inflammatory drugs into the cerebrospinal fluid: a quantitative structure–activity relationship approach

Péhourcq, F., Matoga, M., & Bannwarth, B. (2004) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2004.00201.x · Cited by 29 · see citing works

Rapid impact of ?-amyloid on Paxillin in a neural cell line

Berg, M. M., Krafft, G. A., & Klein, W. L. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19971215)50:6 · Cited by 26 · see citing works

Role of tumour necrosis factor-α and inducible nitric oxide synthase in the prevention of nitro-flurbiprofen small intestine toxicity

Bertrand, V., Guimbaud, R., Sogni, P., Lamrani-Ghaouti, A., Mauprivez, C., Giroud, J. P., Couturier, D., Chauvelot‐Moachon, L., & Chaussade, S. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00550-0 · Cited by 25 · see citing works

Inhibition of cell transformation by sulindac sulfide is confined to specific oncogenic pathways

Gala, M. K., Sun, R., & Yang, V. W. (2002) · Cancer Letters · doi:10.1016/s0304-3835(01)00716-9 · Cited by 21 · see citing works

NO-Flurbiprofen Attenuates Excitotoxin-Induced Brain Inflammation, and Releases Nitric Oxide in the Brain

Prosperi, C., Scali, C., Pepeu, G., & Casamenti, F. (2001) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.86.230 · Cited by 21 · see citing works

Arachidonate Metabolites Affect the Secretion of an N-Terminal Fragment of Alzheimer′s Disease Amyloid Precursor Protein

Kinouchi, T., Ono, Y., Sorimachi, H., et al. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1576 · Cited by 21 · see citing works

Pharmacokinetic and pharmacodynamic aspects of the ideal COX-2 inhibitor: a pharmacologist's perspective.

Brune, K., & Neubert, A. (2002) · PubMed · Cited by 17 · see citing works

Binding of Amyloid Beta-Protein to Intracellular Brain Proteins in Rat and Human

Ray, I., Chauhan, A., Wı́sniewski, H. M., Węgiel, J., Kim, K. S., & Chauhan, V. P. S. (1998) · Neurochemical Research · doi:10.1023/a:1020744216699 · Cited by 16 · see citing works

Nonsteroidal antiinflammatory drugs inhibiting prostanoid efflux: As easy as ABC?

Warner, T. D., & Mitchell, J. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1733826100 · Cited by 16 · see citing works

P4-214 A nitric oxide-releasing derivative of the antioxidant ferulic acid, NCX 2057, attenuates chronic neuroinflammation in rat

Ongini, E., McGann-Gramling, K. R., Hauss‐Wegrzyniak, B., et al. (2004) · Neurobiology of Aging · doi:10.1016/s0197-4580(04)81772-x · Cited by 11 · see citing works

Influence of Molecular Lipophilicity on the Diffusion of Arylpropionate Non-steroidal Anti-inflammatory Drugs into the Cerebrospinal Fluid

Matoga, M., Péhourcq, F., Lagrange, F., et al. (2011) · Arzneimittelforschung · doi:10.1055/s-0031-1300446 · Cited by 11 · see citing works

Interactions of Aβ with Endogenous Anti-Inflammatory Agents: A Basis for Chronic Neuroinflammation in Alzheimer's Disease

Janciauskiene, S. M., Sun, Y., & Wright, H. T. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0519 · Cited by 7 · see citing works

Effects of Rofecoxib or Naproxen vs Placebo on Alzheimer Disease Progression: A Randomized Controlled Trial

Aisen, P. S., Schafer, K. A., Grundman, M., Pfeiffer, E., Sano, M., Davis, K. L., Farlow, M. R., Jin, S., Thomas, R. G., Thal, L. J., et al. (2003) · JAMA · doi:10.1001/jama.289.21.2819 · Cited by 5 · see citing works

Mammalian nicotinic acetylcholine receptors: from structure to function

Albuquerque, E. X., Pereira, E. F. R., Alkondon, M., & Rogers, S. W. (2009) · Physiological Reviews · doi:10.1152/physrev.00015.2008 · Cited by 1,724 · see citing works

Protective effects of NSAIDs on the development of Alzheimer disease

Vlad, S. C., Miller, D. R., Kowall, N. W., & Felson, D. T. (2008) · Neurology · doi:10.1212/01.wnl.0000311269.57716.63 · Cited by 535 · see citing works

Tau and neuroinflammation in Alzheimer’s disease: interplay mechanisms and clinical translation

Chen, Y., & Yu, Y. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02853-3 · Cited by 516 · see citing works

Modulation of inflammation in brain: A matter of fat

Farooqui, A. A., Horrocks, L. A., & Farooqui, T. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04371.x · Cited by 460 · see citing works

Neuroinflammation: Implications for the Pathogenesis and Molecular Diagnosis of Alzheimer's Disease

Rojo, L. E., Fernández, J. A., Maccioni, A. A., Jimenez, J. M., & Maccioni, R. B. (2008) · Archives of Medical Research · doi:10.1016/j.arcmed.2007.10.001 · Cited by 351 · see citing works

Amyloid beta-induced glycogen synthase kinase 3β phosphorylated VDAC1 in Alzheimer's disease: Implications for synaptic dysfunction and neuronal damage

Reddy, P. H. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.06.012 · Cited by 147 · see citing works

Can herbs provide a new generation of drugs for treating Alzheimer’s disease?

Anekonda, T. S., & Reddy, P. H. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.09.001 · Cited by 140 · see citing works

Role of natural products for the treatment of Alzheimer’s disease

Noori, T., Dehpour, A. R., Sureda, A., Sobarzo-Sanchez, E., & Shirooie, S. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.173974 · Cited by 141 · see citing works

No advantage of Aβ₄₂-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies

Szekely, C. A., Green, R. C., Breitner, J. C. S., Østbye, T., Beiser, A. S., Corrada, M. M., Dodge, H. H., Ganguli, M., Kawas, C. H., Kuller, L. H., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000313933.17796.f6 · Cited by 121 · see citing works

Neuroinflammation: a potential therapeutic target

Craft, J. M., Watterson, D. M., & Van Eldik, L. J. (2005) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.9.5.887 · Cited by 116 · see citing works

Molecular targets of non-steroidal anti-inflammatory drugs in neurodegenerative diseases

Lleo, A., Galea, E., & Sastre, M. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6516-1 · Cited by 93 · see citing works

Ibuprofen modifies cognitive disease progression in an Alzheimer’s mouse model

Van Dam, D., Coen, K., & De Deyn, P. (2010) · Journal of Psychopharmacology · doi:10.1177/0269881108097630 · Cited by 45 · see citing works

Pharmacokinetics of Cromolyn and Ibuprofen in Healthy Elderly Volunteers

Brazier, D., Perry, R., Keane, J., Barrett, K., & Elmaleh, D. R. (2017) · Clinical Drug Investigation · doi:10.1007/s40261-017-0549-5 · Cited by 31 · see citing works

Novel Blood Biomarkers that Correlate with Cognitive Performance and Hippocampal Volumetry: Potential for Early Diagnosis of Alzheimer’s Disease

Hudd, F., Shiel, A., Harris, M., Bowdler, P., McCann, B., Tsivos, D., Wearn, A., Knight, M., Kauppinen, R., Coulthard, E., et al. (2019) · Journal of Alzheimer's Disease · doi:10.3233/jad-180879 · Cited by 26 · see citing works

Synthesis and evaluation of anti-inflammatory and analgesic activity of some substituted thiazolyl and thaizolidinonyl tetrahydronapthalene derivatives

Haiba, M. E., Abd El-Karim, S. S., Gouhar, R. S., El-Zahar, M. I., & El-Awdan, S. A. (2014) · Medicinal Chemistry Research · doi:10.1007/s00044-014-0926-z · Cited by 19 · see citing works

Response of Osteoarthritis to Ibuprofen or Flurbiprofen

Mena, H. R., Ehrlich, G. E., Giansiracusa, J. E., et al. (1976) · Journal of International Medical Research · doi:10.1177/030006057600400302 · Cited by 20 · see citing works

A Controlled Clinical Study Comparing Sulindac with Ibuprofen and Aspirin in the Treatment of Musculoskeletal Diseases

Oyemade, G. A. A., & Onadeko, B. O. (1979) · Journal of International Medical Research · doi:10.1177/030006057900700615 · Cited by 3 · see citing works

Adhesion formation and uterine tube healing in the rabbit: A controlled study of the effects of ibuprofen and flurbiprofen

Jarrett, J. C., & Dawood, M. Y. (1986) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(86)90142-0 · Cited by 12 · see citing works

Double-blind comparison of flurbiprofen and sulindac for the treatment of osteoarthritis

Brown, B. L., Johnson, J. H., & Hearron, M. S. (1986) · The American Journal of Medicine · doi:10.1016/0002-9343(86)90126-9 · Cited by 117 · see citing works

A comparison of sulindac with ibuprofen in the management of rheumatoid arthritis.

BURRY, H. C., & Witherington, L. (1979) · PubMed · Cited by 4 · see citing works