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Neoadjuvant chemoradiation therapy with gemcitabine/cisplatin and surgery versus immediate surgery in resectable pancreatic cancer: Results of the first prospective randomized phase II trial.
Open accessAbstract
BACKGROUND: In nonrandomized trials, neoadjuvant treatment was reported to prolong survival in patients with pancreatic cancer. As neoadjuvant chemoradiation is established for the treatment of rectal cancer we examined the value of neoadjuvant chemoradiotherapy in pancreatic cancer in a randomized phase II trial. Radiological staging defining resectability was basic information prior to randomization in contrast to adjuvant therapy trials resting on pathological staging. PATIENTS AND METHODS: Patients with resectable adenocarcinoma of the pancreatic head were randomized to primary surgery (Arm A) or neoadjuvant chemoradiotherapy followed by surgery (Arm B), which was followed by adjuvant chemotherapy in both arms. A total of 254 patients were required to detect a 4.33-month improvement in median overall survival (mOS). RESULTS: The trial was stopped after 73 patients; 66 patients were eligible for analysis. Twenty nine of 33 allocated patients received chemoradiotherapy. Radiotherapy was completed in all patients. Chemotherapy was changed in 3 patients due to toxicity. Tumor resection was performed in 23 vs. 19 patients (A vs. B). The R0 resection rate was 48% (A) and 52% (B, P = 0.81) and (y)pN0 was 30% (A) vs. 39% (B, P = 0.44), respectively. Postoperative complications were comparable in both groups. mOS was 14.4 vs. 17.4 months (A vs. B; intention-to-treat analysis; P = 0.96). After tumor resection, mOS was 18.9 vs. 25.0 months (A vs. B; P = 0.79). CONCLUSION: This worldwide first randomized trial for neoadjuvant chemoradiotherapy in pancreatic cancer showed that neoadjuvant chemoradiation is safe with respect to toxicity, perioperative morbidity, and mortality. Nevertheless, the trial was terminated early due to slow recruiting and the results were not significant. ISRCTN78805636; NCT00335543.
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Therapeutic developments in pancreatic cancer: current and future perspectives
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Neoadjuvant therapy for pancreatic cancer
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Chemotherapy and tumor microenvironment of pancreatic cancer
Liu, Q., Liao, Q., & Zhao, Y. (2017) · Cancer Cell International · doi:10.1186/s12935-017-0437-3 · Cited by 120
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Metadata
- Authors
- Golcher, H., Brunner, T. B., Witzigmann, H., Marti, L., Bechstein, W.-O., Bruns, C., Jungnickel, H., Schreiber, S., Grabenbauer, G. G., Meyer, T., Merkel, S., Fietkau, R., & Hohenberger, W.
- Venue
- Strahlentherapie und Onkologie
- Published
- 2014-09-25
- Volume
- 191
- Issue
- 1
- Pages
- 7-16
- ISSN
- 0179-7158 (ISSN-L)
- 1439-099X
- OpenAlex
- W592682419
- Cited by
- 324
- References
- 37
- FWCI
- 9.91
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Golcher, H., Brunner, T. B., Witzigmann, H., Marti, L., Bechstein, W.-O., Bruns, C., Jungnickel, H., Schreiber, S., Grabenbauer, G. G., Meyer, T., Merkel, S., Fietkau, R., & Hohenberger, W. (2015). Neoadjuvant chemoradiation therapy with gemcitabine/cisplatin and surgery versus immediate surgery in resectable pancreatic cancer: Results of the first prospective randomized phase II trial. Strahlentherapie und Onkologie. https://doi.org/10.1007/s00066-014-0737-7
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