Spatial oxygenation profiles in tumors during normo- and hyperbaric hyperoxia
Abstract
Background Inspiratory hyperoxia reduces tumor hypoxia, which is responsible for limited radiosensitivity of tumors. However, very little is known about the heterogeneity of intratumoral oxygenation during this supportive treatment. The study analyzes whether local hypoxia is still present during normobaric and hyperbaric inspiratory hyperoxia and whether the addition of CO2 to the inspiratory gas affects the spatial pO2 distribution.Material and methods Tumor oxygenation of experimental DS-sarcomas in rats was assessed by polarographic needle electrodes at 1 and 2 atm (bar) environmental pressure during pure O2 or carbogen (95 % O2 + 5 % CO2) breathing. Up to 320 individual pO2 measurements were performed in a strictly oriented grid resulting in an oxygenation profile in a horizontal tumor layer.Results In the experimental tumors used the oxygenation showed pronounced heterogeneities with closely adjacent hypoxic and oxygenated regions. This heterogeneity was still visible under normobaric hyperoxia where large confluent hypoxic regions were detectable. At 1 atm, the addition of CO2 improved tumor oxygenation significantly (at least in large tumors). At 2 atm, only very small local regions of hypoxia were detected. However, under this condition hypercapnia had no impact on tumor oxygenation.Conclusions The data show that even under hyperbaric hyperoxia, hypoxic regions are detectable despite the average pO2 increased by a factor of 100. The results also clearly indicate that the oxygenation pattern improves disproportionally with increasing environmental pressure.
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Atmospheric and hyperbaric hyperoxia can reduce the hypoxic area of tumors to varying degrees.
“Studies have shown that atmospheric and hyperbaric hyperoxia can reduce the hypoxic area of tumors to varying degrees.”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [300]
Cites
Radiobiology for the Radiologist.
(1974) · Annals of Internal Medicine · doi:10.7326/0003-4819-80-3-438_1 · Cited by 3,498 · see citing works
(1989) · PubMed · Cited by 3,343 · see citing works
Gray, L. H., Conger, A. D., Ebert, M., Hornsey, S., & Scott, O. C. A. (1953) · The British Journal of Radiology · doi:10.1259/0007-1285-26-312-638 · Cited by 2,158 · see citing works
Guidelines for the welfare and use of animals in cancer research
Workman, P., Aboagye, E. O., Balkwill, F. R., Balmain, A., Bruder, G., Chaplin, D. J., Double, J. A., Everitt, J. I., Farningham, D. A. H., Glennie, M. J., et al. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605642 · Cited by 1,449 · see citing works
Radiobiology for the Radiologist
Fry, R. J. M., & Hall, E. J. (1995) · Radiation Research · doi:10.2307/3579017 · Cited by 1,351 · see citing works
Vaupel, P. W., Schlenger, K., Knoop, C., & Höckel, M. (1991) · PubMed · Cited by 952 · see citing works
Self-citationImaging oxygenation of human tumours
Padhani, A. R., Krohn, K. A., Lewis, J. S., & Alber, M. L. (2006) · European Radiology · doi:10.1007/s00330-006-0431-y · Cited by 328 · see citing works
Brennan, D. J., Jirström, K., Kronblad, Å., Millikan, R. C., Landberg, G., Duffy, M. J., Rydén, L., Gallagher, W. M., & O’Brien, S. L. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0480 · Cited by 140 · see citing works
Correlations of noninvasive BOLD and TOLD MRI with pO2 and relevance to tumor radiation response
Hallac, R. R., Zhou, H., Pidikiti, R., Song, K. H., Stojadinović, S., Zhao, D., Solberg, T. D., Peschke, P., & Mason, R. P. (2013) · Magnetic Resonance in Medicine · doi:10.1002/mrm.24846 · Cited by 131 · see citing works
Kelleher, D. K., Mattheinsen, U., Thews, O., & Vaupel, P. W. (1996) · PubMed · Cited by 114 · see citing works
Self-citationThe mechanisms by which hyperbaric oxygen and carbogen improve tumour oxygenation
Brizel, D. M., Lin, S., Johnson, J., Brooks, J., Dewhirst, M. W., & Piantadosi, C. (1995) · British Journal of Cancer · doi:10.1038/bjc.1995.474 · Cited by 107 · see citing works
MR assessment of changes of tumor in response to hyperbaric oxygen treatment
Matsumoto, K., Bernardo, M., Subramanian, S., Choyke, P. L., Mitchell, J. B., Krishna, M. C., & Lizak, M. J. (2006) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20961 · Cited by 100 · see citing works
Bussink, J., Kaanders, J. H. A. M., Rijken, P. F. J. W., Raleigh, J. A., & van der Kogel, A. J. (2000) · Radiation Research · doi:10.1667/0033-7587(2000)153[0398:cibpah]2.0.co;2 · Cited by 94 · see citing works
Yaromina, A., Thames, H. D., Zhou, X., Hering, S., Eicheler, W., Dörfler, A., Leichtner, T., Zips, D., & Baumann, M. A. (2010) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2010.04.020 · Cited by 88 · see citing works
Bussink, J., Kaanders, J. H., Rijken, P. F. J. W., et al. (1999) · Radiotherapy and Oncology · doi:10.1016/s0167-8140(99)00010-9 · Cited by 66 · see citing works
Improved Recurrence-Free Survival with ARCON for Anemic Patients with Laryngeal Cancer
Janssens, G. O. R. J., Rademakers, S. E., Terhaard, C. H. J., Doornaert, P., Bijl, H. P., van den Ende, P. L. A., Chin, A., Takes, R. P., de Bree, R., Hoogsteen, I. J., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1730 · Cited by 47 · see citing works
Hoskin, P., Rojas, A. M., Saunders, M. I., et al. (2008) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2008.10.001 · Cited by 44 · see citing works
de Figueiredo, B. H., Zacharatou, C., Galland-Girodet, S., et al. (2014) · Strahlentherapie und Onkologie · doi:10.1007/s00066-014-0752-8 · Cited by 40 · see citing works
Ding, Y., Mason, R. P., McColl, R. W., Yuan, Q., Hallac, R. R., Sims, R. D., & Weatherall, P. T. (2013) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.24006 · Cited by 37 · see citing works
Shi, Y., Lee, C. S., Wu, J., et al. (2005) · Head & Neck · doi:10.1002/hed.20169 · Cited by 36 · see citing works
Thews, O., Kelleher, D. K., & Vaupel, P. W. (2002) · Radiotherapy and Oncology · doi:10.1016/s0167-8140(01)00401-7 · Cited by 35 · see citing works
Self-citationHou, H. G., Dong, R., Li, H., Williams, B. B., Lariviere, J. P., Hekmatyar, S. K., Kauppinen, R. A., Khan, N. I., & Swartz, H. M. (2011) · Journal of Magnetic Resonance · doi:10.1016/j.jmr.2011.09.043 · Cited by 34 · see citing works
Oxygenation Measurements in Head and Neck Cancers during Hyperbaric Oxygenation
Becker, A., Kuhnt, T., Liedtke, H., et al. (2002) · Strahlentherapie und Onkologie · doi:10.1007/s00066-002-0892-0 · Cited by 33 · see citing works
Relevant parameters for describing the oxygenation status of solid tumors.
Thews, O., & Vaupel, P. W. (1996) · PubMed · Cited by 30 · see citing works
Self-citationHoskin, P., Rojas, A. M., Phillips, H., et al. (2005) · Cancer · doi:10.1002/cncr.21048 · Cited by 27 · see citing works
Janssens, G. O. R. J., van Bockel, L. W., Doornaert, P., Bijl, H. P., van den Ende, P. L. A., de Jong, M. A., van den Broek, G. B., Verbist, B. M., Terhaard, C. H. J., Span, P. N., et al. (2014) · European Journal of Cancer · doi:10.1016/j.ejca.2013.12.012 · Cited by 27 · see citing works
Rademakers, S. E., Hoogsteen, I. J., Rijken, P. F. J. W., et al. (2013) · Head & Neck · doi:10.1002/hed.23569 · Cited by 23 · see citing works
Hypoxia-regulated gene expression and prognosis in loco-regional gastroesophageal cancer
Winther, M., Alsner, J., Tramm, T., et al. (2013) · Acta Oncologica · doi:10.3109/0284186x.2013.818247 · Cited by 22 · see citing works
Borges, A., López‐Larrubia, P., Marques, J. M. B., et al. (2011) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2959 · Cited by 17 · see citing works
Müller, A., Remmele, S., Wenningmann, I., Clusmann, H., Träber, F., Flacke, S., König, R., Gieseke, J., Willinek, W. A., Schild, H. H., et al. (2010) · European Radiology · doi:10.1007/s00330-010-1948-7 · Cited by 14 · see citing works
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Hypoxia signaling in cancer: Implications for therapeutic interventions
Zhuang, Y., Liu, K., He, Q., Gu, X., Jiang, C., & Wu, J. (2023) · MedComm · doi:10.1002/mco2.203 · Cited by 119 · see citing works
Qin, S., Xu, Y., Li, H., Chen, H., & Yuan, Z. (2022) · Biomaterials Science · doi:10.1039/d1bm00317h · Cited by 56 · see citing works
Herrera-Campos, A. B., Zamudio-Martinez, E., Delgado-Bellido, D., Fernández-Cortés, M., Montuenga, L. M., Oliver, F. J., & Garcia-Diaz, A. (2022) · Cancers · doi:10.3390/cancers14112740 · Cited by 17 · see citing works
- Authors
- Thews, O., & Vaupel, P.
- Affiliations
- Martin Luther University Halle-Wittenberg (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Corresponding author
- Thews, Oliver
- Venue
- Strahlentherapie und Onkologie
- Published
- 2015-07-02
- Volume
- 191
- Issue
- 11
- Pages
- 875-882
- ISSN
- 0179-7158 (ISSN-L)
- 1439-099X
- OpenAlex
- W2332566592
- Cited by
- 33
- References
- 30
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 7 · 2022: 6 · 2021: 4 · 2018: 4 · 2017: 1 · 2016: 4 · 2015: 3
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Strahlentherapie und Onkologie (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM (Technical University of Munich) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
- Physical Sciences › Mathematics › Modeling and Simulation › Mathematical Biology Tumor Growth
- Keywords
- tumor hypoxia, hyperbaric hyperoxia, normobaric hyperoxia, carbogen, hypercapnia, sarcoma, radiosensitization
- MeSH terms
- Animals, Carcinosarcoma, Hyperbaric Oxygenation, Male, Oxygen, Oxygen Consumption, Tissue Distribution, Rats, Sprague-Dawley, Rats
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