Implications of Hyperoxia over the Tumor Microenvironment: An Overview Highlighting the Importance of the Immune System
Open accessAbstract
Hyperoxia is used in order to counteract hypoxia effects in the TME (tumor microenvironment), which are described to boost the malignant tumor phenotype and poor prognosis. The reduction of tumor hypoxic state through the formation of a non-aberrant vasculature or an increase in the toxicity of the therapeutic agent improves the efficacy of therapies such as chemotherapy. Radiotherapy efficacy has also improved, where apoptotic mechanisms seem to be implicated. Moreover, hyperoxia increases the antitumor immunity through diverse pathways, leading to an immunopermissive TME. Although hyperoxia is an approved treatment for preventing and treating hypoxemia, it has harmful side-effects. Prolonged exposure to high oxygen levels may cause acute lung injury, characterized by an exacerbated immune response, and the destruction of the alveolar–capillary barrier. Furthermore, under this situation, the high concentration of ROS may cause toxicity that will lead not only to cell death but also to an increase in chemoattractant and proinflammatory cytokine secretion. This would end in a lung leukocyte recruitment and, therefore, lung damage. Moreover, unregulated inflammation causes different consequences promoting tumor development and metastasis. This process is known as protumor inflammation, where different cell types and molecules are implicated; for instance, IL-1β has been described as a key cytokine. Although current results show benefits over cancer therapies using hyperoxia, further studies need to be conducted, not only to improve tumor regression, but also to prevent its collateral damage.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
HBO promotes PD-1 Ab delivery and T-cell infiltration into the tumor parenchyma by depleting major components of the ECM, such as collagen and fibronectin.
“HBO also promoted PD‐1 Ab delivery and T‐cell infiltration into the tumor parenchyma by depleting major components of the ECM, such as collagen and fibronectin.”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [424]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709 · see citing works
limma powers differential expression analyses for RNA-sequencing and microarray studies
Ritchie, M. E., Phipson, B., Wu, D., Hu, Y., Law, C. W., Shi, W., & Smyth, G. K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv007 · Cited by 40,458 · see citing works
clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
Yu, G., Wang, L.-G., Han, Y., & He, Q.-Y. (2012) · OMICS: A Journal of Integrative Biology · doi:10.1089/omi.2011.0118 · Cited by 36,259 · see citing works
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219 · see citing works
A scaling normalization method for differential expression analysis of RNA-seq data
Robinson, M. D., & Oshlack, A. (2010) · Genome Biology · doi:10.1186/gb-2010-11-3-r25 · Cited by 7,876 · see citing works
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180 · see citing works
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
Forsythe, J. A., Jiang, B.-H., Iyer, N. V., Agani, F., Leung, S. W., Koos, R. D., & Semenza, G. L. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4604 · Cited by 3,981 · see citing works
Angiogenesis in life, disease and medicine
Carmeliet, P. (2005) · Nature · doi:10.1038/nature04478 · Cited by 3,494 · see citing works
NF-κB, inflammation, immunity and cancer: coming of age
Taniguchi, K., & Karin, M. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.142 · Cited by 2,679 · see citing works
Cellular and developmental control of O <sub>2</sub> homeostasis by hypoxia-inducible factor 1α
Iyer, N. V., Kotch, L. E., Agani, F., Leung, S. W., Laughner, E., Wenger, R. H., Gassmann, M., Gearhart, J. D., Lawler, A. M., Yu, A. Y., et al. (1998) · Genes & Development · doi:10.1101/gad.12.2.149 · Cited by 2,476 · see citing works
The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy
Thomlinson, R. H., & Gray, L. H. (1955) · British Journal of Cancer · doi:10.1038/bjc.1955.55 · Cited by 2,228 · see citing works
Inflammation 2010: New Adventures of an Old Flame
Medzhitov, R. M. (2010) · Cell · doi:10.1016/j.cell.2010.03.006 · Cited by 1,854 · see citing works
Semenza, G. L., Jiang, B.-H., Leung, S. W., Passantino, R., Concordet, J.-P., Maire, P., & Giallongo, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.51.32529 · Cited by 1,752 · see citing works
Salceda, S., & Caro, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.36.22642 · Cited by 1,674 · see citing works
The unique physiology of solid tumors: opportunities (and problems) for cancer therapy.
Brown, J. M., & Giaccia, A. J. (1998) · PubMed · Cited by 1,498 · see citing works
Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia
Carreau, A., Hafny‐Rahbi, B. E., Matejuk, A., Grillon, C., & Kieda, C. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01258.x · Cited by 1,246 · see citing works
Corzo, C. A., Condamine, T., Lu, L., Cotter, M. J., Youn, J.-I., Cheng, P., Cho, H.-I., Celis, E., Quiceno, D. G., Padhya, T., et al. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100587 · Cited by 1,173 · see citing works
VEGF-Induced Adult Neovascularization: Recruitment, Retention, and Role of Accessory Cells
Grunewald, M., Avraham, I., Dor, Y., Bachar-Lustig, E., Itin, A., Yung, S., Chimenti, S., Landsman, L., Abramovitch, R., & Keshet, E. (2006) · Cell · doi:10.1016/j.cell.2005.10.036 · Cited by 1,125 · see citing works
A2A adenosine receptor protects tumors from antitumor T cells
Ohta, A., Gorelik, E., Prasad, S. J., Ronchese, F., Lukashev, D. E., Wong, M. K. K., Huang, X., Caldwell, S. A., Liu, K., Smith, P. T., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605251103 · Cited by 1,066 · see citing works
Defining normoxia, physoxia and hypoxia in tumours—implications for treatment response
McKeown, S. R. (2014) · The British Journal of Radiology · doi:10.1259/bjr.20130676 · Cited by 1,050 · see citing works
IL-1 is required for tumor invasiveness and angiogenesis
Voronov, E., Shouval, D. S., Krelin, Y., Cagnano, E., Benharroch, D., Iwakura, Y., Dinarello, C. A., & Apte, R. N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0437939100 · Cited by 1,023 · see citing works
Tu, S., Bhagat, G., Cui, G., Takaishi, S., Kurt‐Jones, E. A., Rickman, B. H., Betz, K. S., Penz-Österreicher, M., Björkdahl, O., Fox, J. G., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.10.011 · Cited by 815 · see citing works
A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells
Barsoum, I. B., Smallwood, C. A., Siemens, D. R., & Graham, C. H. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-0992 · Cited by 767 · see citing works
VEGFs and receptors involved in angiogenesis versus lymphangiogenesis
Lohela, M. K., Bry, M., Tammela, T., & Alitalo, K. K. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.12.012 · Cited by 731 · see citing works
Developmental and Pathological Angiogenesis
Chung, A. S., & Ferrara, N. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154002 · Cited by 722 · see citing works
Synnestvedt, K., Furuta, G. T., Comerford, K. M., Louis, N. A., Karhausen, J., Eltzschig, H. K., Hansen, K. R., Thompson, L. F., & Colgan, S. P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15337 · Cited by 679 · see citing works
Synnestvedt, K., Furuta, G. T., Comerford, K. M., Louis, N., Karhausen, J., Eltzschig, H. K., Hansen, K. R., Thompson, L. F., & Colgan, S. P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215337 · Cited by 660 · see citing works
Immunological mechanisms of the antitumor effects of supplemental oxygenation
Hatfield, S. M., Kjaergaard, J., Lukashev, D., Schreiber, T. H., Belikoff, B., Abbott, R., Sethumadhavan, S., Philbrook, P., Ko, K., Cannici, R., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa1260 · Cited by 600 · see citing works
Graham, K., & Unger, E. C. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s140462 · Cited by 581 · see citing works
Clambey, E. T., McNamee, E. N., Westrich, J. A., Glover, L. E., Campbell, E. L., Jedlicka, P., de Zoeten, E. F., Cambier, J. C., Stenmark, K. R., Colgan, S. P., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202366109 · Cited by 560 · see citing works
Physiological and pathological responses to hypoxia
Michiels, C. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63747-9 · Cited by 559 · see citing works
Inflammation Induces Myeloid-Derived Suppressor Cells that Facilitate Tumor Progression
Bunt, S. K., Sinha, P., Clements, V. K., Leips, J., & Ostrand‐Rosenberg, S. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.1.284 · Cited by 539 · see citing works
Benita, Y., Kikuchi, H., Smith, A. D., Zhang, M. Q., Chung, D. C., & Xavier, R. J. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp425 · Cited by 469 · see citing works
Vascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1): a dual regulator for angiogenesis
Shibuya, M. (2006) · Angiogenesis · doi:10.1007/s10456-006-9055-8 · Cited by 443 · see citing works
Adenosine Receptors: Expression, Function and Regulation
Sheth, S., Brito, R., Mukherjea, D., Rybak, L. P., & Ramkumar, V. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15022024 · Cited by 404 · see citing works
Interactions between mitochondrial reactive oxygen species and cellular glucose metabolism
Liemburg-Apers, D. C., Willems, P. H. G. M., Koopman, W. J. H., & Grefte, S. (2015) · Archives of Toxicology · doi:10.1007/s00204-015-1520-y · Cited by 391 · see citing works
Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF high neutrophils
Engblom, C., Pfirschke, C., Žilionis, R., Martins, J. D. S., Bos, S. A., Courties, G., Rickelt, S., Sévère, N., Baryawno, N., Faget, J., et al. (2017) · Science · doi:10.1126/science.aal5081 · Cited by 388 · see citing works
Glucose Catabolism in Cancer Cells
Mathupala, S. P., Rempel, A., & Pedersen, P. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m108181200 · Cited by 374 · see citing works
Ortega, M. A., Fraile‐Μartinez, O., Montero, C. G., Callejón-Peláez, E., Sáez, M. A., Álvarez-Mon, M. Á., García‐Honduvilla, N., Monserrat, J., Álvarez‐Mon, M., Buján, J., et al. (2021) · Medicina · doi:10.3390/medicina57090864 · Cited by 306 · see citing works
Singer, M., Young, P. J., Laffey, J. G., Asfar, P., Taccone, F. S., Skrifvars, M. B., Meyhoff, C. S., & Radermacher, P. (2021) · Critical Care · doi:10.1186/s13054-021-03815-y · Cited by 293 · see citing works
Hoefflin, R., Harlander, S., Schäfer, S., Metzger, P., Kuo, F., Schönenberger, D., Adlesic, M., Peighambari, A., Seidel, P., Chen, C.-Y., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17873-3 · Cited by 292 · see citing works
FOXP3+ regulatory T cells and their functional regulation
Li, Z., Li, D., Tsun, A., & Li, B. (2015) · Cellular & Molecular Immunology · doi:10.1038/cmi.2015.10 · Cited by 290 · see citing works
Reactive oxygen species: a volatile driver of field cancerization and metastasis
Liao, Z., Chua, D., & Tan, N. S. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0961-y · Cited by 284 · see citing works
Why not treat human cancer with interleukin-1 blockade?
Dinarello, C. A. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9229-0 · Cited by 280 · see citing works
Takahashi, H., Sakakura, K., Kudo, T., Toyoda, M., Kaira, K., Oyama, T., & Chikamatsu, K. (2016) · Oncotarget · doi:10.18632/oncotarget.14374 · Cited by 260 · see citing works
Nazareth, M. R., Broderick, L., Simpson-Abelson, M. R., Kelleher, R. J., Yokota, S. J., & Bankert, R. B. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.9.5552 · Cited by 259 · see citing works
HIF-1 in cancer therapy: two decade long story of a transcription factor
Soni, S., & Padwad, Y. S. (2017) · Acta Oncologica · doi:10.1080/0284186x.2017.1301680 · Cited by 251 · see citing works
edgeR for Differential RNA-seq and ChIP-seq Analysis: An Application to Stem Cell Biology
Nikolayeva, O., & Robinson, M. D. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-0512-6_3 · Cited by 231 · see citing works
Hatfield, S. M., Kjaergaard, J., Lukashev, D., Belikoff, B., Schreiber, T. H., Sethumadhavan, S., Abbott, R., Philbrook, P., Thayer, M., Shujia, D., et al. (2014) · Journal of Molecular Medicine · doi:10.1007/s00109-014-1189-3 · Cited by 211 · see citing works
Wang, Y., Yin, K., Tian, J., Xia, X., Ma, J., Tang, X., Xu, H., & Wang, S. (2019) · Advanced Science · doi:10.1002/advs.201901278 · Cited by 211 · see citing works
The Role of IL-1β in the Early Tumor Cell–Induced Angiogenic Response
Carmi, Y., Dotan, S., Rider, P., Kaplanov, I., White, M. R., Baron, R., Abutbul, S., Huszar, M., Dinarello, C. A., Apte, R. N., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1202769 · Cited by 209 · see citing works
Interfering with Tumor Hypoxia for Radiotherapy Optimization
Telarović, I., Wenger, R. H., & Pruschy, M. N. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02000-x · Cited by 196 · see citing works
Chen, L., Huang, C., Li, Y., Deng, W., Mao, L., Wu, L., Zhang, W., Zhang, L., & Sun, Z. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2720-9 · Cited by 154 · see citing works
Neutrophil elastase in the tumor microenvironment
Lerman, I., & Hammes, S. R. (2017) · Steroids · doi:10.1016/j.steroids.2017.11.006 · Cited by 149 · see citing works
Immunosuppressive activity of cancer-associated fibroblasts in head and neck squamous cell carcinoma
Takahashi, H., Sakakura, K., Kawabata‐Iwakawa, R., Rokudai, S., Toyoda, M., Nishiyama, M., & Chikamatsu, K. (2015) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-015-1742-0 · Cited by 146 · see citing works
Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils
Mahiddine, K., Blaisdell, A., Ma, S., Créquer-Grandhomme, A., Lowell, C. A., & Erlebacher, A. (2019) · Journal of Clinical Investigation · doi:10.1172/jci130952 · Cited by 140 · see citing works
miARma-Seq: a comprehensive tool for miRNA, mRNA and circRNA analysis
Andrés‐León, E., Núñez‐Torres, R., & Rojas, A. M. (2016) · Scientific Reports · doi:10.1038/srep25749 · Cited by 139 · see citing works
Hyperbaric Oxygen Therapy for Malignancy: A Review
Daruwalla, J., & Christophi, C. (2006) · World Journal of Surgery · doi:10.1007/s00268-006-0190-6 · Cited by 129 · see citing works
Kobayashi, S., Zimmermann, H., & Millhorn, D. E. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.740621.x · Cited by 128 · see citing works
Adenosine and its receptors as therapeutic targets: An overview
Sachdeva, S., & Gupta, M. (2012) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2012.05.011 · Cited by 126 · see citing works
Molecular mechanisms underlying hyperoxia acute lung injury
Dias-Freitas, F., Coimbra, C. M., & Roncon‐Albuquerque, R. (2016) · Respiratory Medicine · doi:10.1016/j.rmed.2016.08.010 · Cited by 120 · see citing works
Rijpkema, M., Kaanders, J. H. A. M., Joosten, F. B. M., et al. (2002) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(02)02825-0 · Cited by 116 · see citing works
Ni, Y.-N., Wang, Y., Liang, B., et al. (2019) · BMC Pulmonary Medicine · doi:10.1186/s12890-019-0810-1 · Cited by 106 · see citing works
Ribatti, D., Solimando, A. G., & Pezzella, F. (2021) · Cancers · doi:10.3390/cancers13143433 · Cited by 99 · see citing works
Mohr, T. T., Haudek‐Prinz, V. J., Slany, A., Grillari, J., Micksche, M., & Gerner, C. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179065 · Cited by 93 · see citing works
Souto, J. C., Vila, L., & Brú, A. (2009) · Medicinal Research Reviews · doi:10.1002/med.20185 · Cited by 90 · see citing works
Wu, X. G., Zhu, Y., Huang, W., Li, J., Zhang, B., Li, Z., & Yang, X. (2018) · Advanced Science · doi:10.1002/advs.201700859 · Cited by 88 · see citing works
Beneficial and detrimental role of adenosine signaling in diseases and therapy
Liu, H., & Xia, Y. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00350.2015 · Cited by 85 · see citing works
Raa, A., Stansberg, C. T., Steen, V. M., Bjerkvig, R., Reed, R. K., & Stuhr, L. E. B. (2007) · BMC Cancer · doi:10.1186/1471-2407-7-23 · Cited by 77 · see citing works
Hajizadeh, F., Ardebili, S. M., Moornani, M. B., Masjedi, A., Atyabi, F., Kiani, M., Namdar, A., Karpisheh, V., Izadi, S., Baradaran, B., et al. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173235 · Cited by 75 · see citing works
Sundström, P., Stenstad, H., Langenes, V., Ahlmanner, F., Theander, L., Ndah, T. G., Fredin, K., Börjesson, L., Gustavsson, B. G., Bastid, J., et al. (2016) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-15-0050 · Cited by 73 · see citing works
Antihypoxic oxygenation agents with respiratory hyperoxia to improve cancer immunotherapy
Hatfield, S. M., & Sitkovsky, M. V. (2020) · Journal of Clinical Investigation · doi:10.1172/jci137554 · Cited by 73 · see citing works
Guimbellot, J. S., Erickson, S. W., Mehta, T. S., Wen, H., Page, G. P., Sorscher, E. J., & Hong, J. S. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-15 · Cited by 72 · see citing works
Lee, Y.-H., Bae, H. C., Noh, K. H., Song, K.-H., Ye, S.-K., Mao, C.-P., Lee, K.-M., Wu, T.-C., & Kim, T. W. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-1979 · Cited by 64 · see citing works
Argentiero, A., Solimando, A. G., Krebs, M., Leone, P., Susca, N., Brunetti, O., Racanelli, V., Vacca, A., & Silvestris, N. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051594 · Cited by 63 · see citing works
Kim, J., Koh, Y., Kim, D., Ahn, Y., Kim, T. M., Han, S., Oh, D., Lee, S., Im, S., Kim, T., et al. (2013) · Cancer Research and Treatment · doi:10.4143/crt.2013.45.4.325 · Cited by 60 · see citing works
MicroRNA‐31‐5p enhances the Warburg effect via targeting FIH
Zhu, B., Cao, X., Zhang, W., Pan, G., Yi, Q., Zhong, W., & Yan, D. (2018) · The FASEB Journal · doi:10.1096/fj.201800803r · Cited by 55 · see citing works
Moen, I., Tronstad, K. J., Kolmannskog, O., Salvesen, G. S., Reed, R. K., & Stuhr, L. E. (2009) · BMC Cancer · doi:10.1186/1471-2407-9-446 · Cited by 49 · see citing works
Inflammation, but not hypoxia, mediated HIF-1α activation depends on COX-2
Stasinopoulos, I. A., O’Brien, D. R., & Bhujwalla, Z. M. (2009) · Cancer Biology & Therapy · doi:10.4161/cbt.8.1.7079 · Cited by 49 · see citing works
License to Kill: When iNKT Cells Are Granted the Use of Lethal Cytotoxicity
Díaz‐Basabe, A., Strati, F., & Facciotti, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113909 · Cited by 45 · see citing works
Hyperoxia resensitizes chemoresistant human glioblastoma cells to temozolomide
Sun, S., Lee, D., Lee, N. P. Y., Pu, J. K.-S., Wong, T., Lui, W., Fung, C. F., & Leung, G. (2012) · Journal of Neuro-Oncology · doi:10.1007/s11060-012-0923-3 · Cited by 44 · see citing works
Barratt, S. L., Blythe, T., Ourradi, K., Jarrett, C., Welsh, G. I., Bates, D. O., & Millar, A. (2018) · Respiratory Research · doi:10.1186/s12931-017-0711-x · Cited by 44 · see citing works
Chaudhry, S. I., Hooper, S., Nye, E., Williamson, P., Harrington, K., & Sahai, E. (2013) · Oncogene · doi:10.1038/onc.2012.91 · Cited by 43 · see citing works
Pringle, K. G., Kind, K. L., Thompson, J. G., & Roberts, C. T. (2007) · Placenta · doi:10.1016/j.placenta.2007.05.009 · Cited by 38 · see citing works
Pulmonary Natural Killer T Cells Play an Essential Role in Mediating Hyperoxic Acute Lung Injury
Nowak-Machen, M., Schmelzle, M., Hanidziar, D., et al. (2013) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0180oc · Cited by 38 · see citing works
Xu, Y., Kong, X., Li, J., Cui, T., Wei, Y., Xu, J., Zhu, Y., & Zhu, X. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.690496 · Cited by 38 · see citing works
Andrés‐León, E., & Rojas, A. M. (2018) · Methods · doi:10.1016/j.ymeth.2018.09.002 · Cited by 37 · see citing works
Hyperbaric Oxygen for Radiation Necrosis of the Brain
Co, J. L., Moraes, M. V. D., Katznelson, R., et al. (2019) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/cjn.2019.290 · Cited by 37 · see citing works
Zhang, X., He, C., Sun, Y., Liu, X., Chen, Y., Chen, C., Yan, R., Fan, T., Yang, T., Lu, Y., et al. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.04.021 · Cited by 37 · see citing works
Zou, D., Li, J., Fan, Q., Zheng, X., Deng, J., & Wang, S. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27382 · Cited by 36 · see citing works
Qian, X., Zhang, Q., Shao, N., Shan, Z., Cheang, T., Zhang, Z., Su, Q., Wang, S., & Lin, Y. (2019) · Europe PMC (PubMed Central) · Cited by 36 · see citing works
Effect of normobaric oxygen on tumor radiosensitivity: Fractionated studies
Rojas, A., Carl, U. M., & Reghebi, K. (1990) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(90)90059-s · Cited by 34 · see citing works
Hyperoxygenation as a Therapeutic Supplement for Treatment of Triple Negative Breast Cancer
Mast, J. M., & Kuppusamy, P. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00527 · Cited by 34 · see citing works
Spatial oxygenation profiles in tumors during normo- and hyperbaric hyperoxia
Thews, O., & Vaupel, P. (2015) · Strahlentherapie und Onkologie · doi:10.1007/s00066-015-0867-6 · Cited by 33 · see citing works
Chen, C., Tang, Q., Zhang, Y., et al. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-0891-4 · Cited by 32 · see citing works
Potential of hyperbaric oxygen in urological diseases
Tanaka, T., Minami, A., Uchida, J., & Nakatani, T. (2019) · International Journal of Urology · doi:10.1111/iju.14015 · Cited by 27 · see citing works
Reeb, P., Bramardi, S. J., & Steibel, J. P. (2015) · PLoS ONE · doi:10.1371/journal.pone.0132310 · Cited by 26 · see citing works
Thomlinson, R. H. (1977) · Journal of Clinical Pathology · doi:10.1136/jcp.s3-11.1.105 · Cited by 25 · see citing works
Stem Cell Transcriptional Networks
(2014) · Methods in molecular biology · doi:10.1007/978-1-4939-0512-6 · Cited by 25 · see citing works
Normobaric hyperoxia inhibits the progression of lung cancer by inducing apoptosis
Kim, S. W., Kim, I. K., Ha, J. H., Yeo, C. D., Kang, H. H., Kim, J. W., & Lee, S. H. (2018) · Experimental Biology and Medicine · doi:10.1177/1535370218774737 · Cited by 25 · see citing works
Hanidziar, D., Nakahori, Y., Cahill, L. A., Gallo, D. J., Keegan, J. W., Nguyen, J. P., Otterbein, L. E., Lederer, J. A., & Robson, S. C. (2020) · Scientific Reports · doi:10.1038/s41598-020-61489-y · Cited by 23 · see citing works
Huang, D., Fang, F., & Xu, F. (2016) · PubMed · Cited by 22 · see citing works
Advances in Normobaric Hyperoxia Brain Protection in Experimental Stroke
Chen, Z., Ding, Y., Ji, X., et al. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00050 · Cited by 22 · see citing works
Role of hyperoxic treatment in cancer
Kim, S. W., Kim, I. K., & Lee, S. H. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220921547 · Cited by 20 · see citing works
Lee, H. Y., Kim, I. K., Lee, H. I., Lee, H. Y., Kang, H. S., Yeo, C. D., Kang, H. H., Moon, H. S., & Lee, S. H. (2018) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2016.334 · Cited by 19 · see citing works
Argentiero, A., Solimando, A. G., Krebs, M., et al. (2020) · Preprints.org · doi:10.20944/preprints202004.0181.v1 · Cited by 19 · see citing works
Jiang, M., Yin, X., Qin, B., Xuan, S., Yuan, X., Yin, H., Zhu, C., Li, X., Yang, J., Du, Y., et al. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.9b00663 · Cited by 15 · see citing works
Dong, D. F., Fu, Y., Chen, F., Zhang, J., Jia, H., Li, J., Wang, H., & Wen, J. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11700 · Cited by 14 · see citing works
Lee, K., Kim, D., & Kim, W. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.02.113 · Cited by 13 · see citing works
Protein kinase D1 regulates hypoxic metabolism through HIF-1α and glycolytic enzymes incancer cells
Chen, J., Cui, B., Fan, Y., Li, X., Li, Q., Du, Y., Feng, Y., & Zhang, P. (2018) · Oncology Reports · doi:10.3892/or.2018.6479 · Cited by 12 · see citing works
Myeloid derived suppressor cells and the release of micro-metastases from dormancy
Khadge, S., Cole, K., & Talmadge, J. E. (2021) · Clinical & Experimental Metastasis · doi:10.1007/s10585-021-10098-8 · Cited by 12 · see citing works
Chen, Y., Li, H., Chen, D., et al. (2021) · Digestive Diseases and Sciences · doi:10.1007/s10620-021-07202-z · Cited by 9 · see citing works
Vélez, J., Silva, L. M. R., Gärtner, U., Daugschies, A., Mazurek, S., Hermosilla, C. R., & Taubert, A. (2021) · Biology · doi:10.3390/biology10100963 · Cited by 9 · see citing works
Ristescu, I., Tiron, C. E., Tiron, A., & Grigoraș, I. (2021) · Biomedicines · doi:10.3390/biomedicines9091213 · Cited by 7 · see citing works
Protumor effects of proinflammatory mediators in breast cancer
Sirotković-Skerlev, M., Kulić, A., Bradić, L., et al. (2012) · Hrčak Portal of scientific journals of Croatia (University Computing Centre) · Cited by 4 · see citing works
Aphale, R., & Shah, S. M. (2020) · Indian Journal of Surgery · doi:10.1007/s12262-020-02601-4 · Cited by 2 · see citing works
Chen, Y., Li, H., Chen, D., et al. (2020) · doi:10.21203/rs.2.18624/v2 · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Hypoxia signaling in cancer: Implications for therapeutic interventions
Zhuang, Y., Liu, K., He, Q., Gu, X., Jiang, C., & Wu, J. (2023) · MedComm · doi:10.1002/mco2.203 · Cited by 119 · see citing works
- Authors
- Herrera-Campos, A. B., Zamudio-Martinez, E., Delgado-Bellido, D., Fernández-Cortés, M., Montuenga, L. M., Oliver, F. J., & Garcia-Diaz, A.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Instituto de Parasitología y Biomedicina López Neyra, CSIC, 18016 Granada, Spain
- Navarre Institute of Health Research (ES)
- Corresponding author
- Oliver, F. Javier
- Venue
- Cancers
- Publisher
- MDPI AG
- Published
- 2022-05-31
- Volume
- 14
- Issue
- 11
- Pages
- 2740
- ISSN
- 2072-6694 (ISSN-L)
- PMC
- PMC9179641
- OpenAlex
- W4281946594
- Cited by
- 17
- References
- 118
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 7 · 2023: 4 · 2022: 2
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cancers (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Agencia Estatal de Investigación, Spanish Ministry of Economy and Competitiveness (SAF2012–40011-C02–01, SAF2015–70520-R, RTI2018–098968-B-I00, RTICC RD12/0036/0026, PID2019-104867RB-I00/AEI/, CIBERONC ISCIII CB16/12/00421, CB16/12/00273, P10-CTS-0662)
- Instituto de Salud Carlos III—Fondo Europeo de Desarrollo Regional (SAF2012–40011-C02–01, SAF2015–70520-R, RTI2018–098968-B-I00, RTICC RD12/0036/0026, PID2019-104867RB-I00/AEI/, CIBERONC ISCIII CB16/12/00421, CB16/12/00273, P10-CTS-0662)
- Junta de Andalucía (SAF2012–40011-C02–01, SAF2015–70520-R, RTI2018–098968-B-I00, RTICC RD12/0036/0026, PID2019-104867RB-I00/AEI/, CIBERONC ISCIII CB16/12/00421, CB16/12/00273, P10-CTS-0662)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- hyperoxia, tumor microenvironment, tumor hypoxia, antitumor immunity, reactive oxygen species, acute lung injury, IL-1β, chemotherapy efficacy, radiotherapy, apoptosis, metastasis, cytokine production
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
