The DOI matches its Crossref record; 116 of the 116 references it cites were found in a registry or an index.
Vitamin D and molecular actions on the immune system: modulation of innate and autoimmunity
Open accessAbstract
Vitamin D has received increased attention recently for its pleiotropic actions on many chronic diseases. The importance of vitamin D on the regulation of cells of the immune system has gained increased appreciation over the past decade with the discovery of the vitamin D receptor (VDR) and key vitamin D metabolizing enzymes expressed by cells of the immune system. Animal studies, early epidemiologic and clinical studies have supported a potential role for vitamin D in maintaining immune system balance. The hormonal form of vitamin D up-regulates anti-microbial peptides, namely cathelicidin, to enhance clearance of bacteria at various barrier sites and in immune cells. Vitamin D modulates the adaptive immune system by direct effects on T cell activation and on the phenotype and function of antigen-presenting cells (APCs), particularly of DCs. The purpose of this manuscript is to review the molecular and clinical evidence for vitamin D as a modulator of the innate and adaptive immune system.
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Cites
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Cited by
Sunlight and Vitamin D: A global perspective for health
Wacker, M., & Holick, M. F. (2013) · Dermato-Endocrinology · doi:10.4161/derm.24494 · Cited by 1,156
International Consensus Statement on Allergy and Rhinology: Rhinosinusitis
Orlandi, R. R., Kingdom, T. T., Hwang, P. H., Smith, T. L., Alt, J. A., Baroody, F. M., Batra, P. S., Bernal‐Sprekelsen, M., Bhattacharyya, N., Chandra, R. K., et al. (2016) · International Forum of Allergy & Rhinology · doi:10.1002/alr.21695 · Cited by 892
Conversion from clinically isolated syndrome to multiple sclerosis: a large multicentre study
Kuhle, J., Disanto, G., Dobson, R., Adiutori, R., Bianchi, L., Topping, J., Bestwick, J., Meier, U.-C., Marta, M., Costa, G. D., et al. (2015) · Multiple Sclerosis Journal · doi:10.1177/1352458514568827 · Cited by 299
An Update on the Effects of Vitamin D on the Immune System and Autoimmune Diseases
Sîrbe, C., Rednic, S., Grama, A., & Pop, T. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179784 · Cited by 269
Ritterhouse, L. L., Crowe, S. R., Niewold, T. B., Kamen, D. L., Macwana, S. R., Roberts, V. C., Dedeke, A. B., Harley, J. B., Scofield, R. H., Guthridge, J. M., et al. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.148494 · Cited by 229
Self-citation
Metadata
- Authors
- Kamen, D. L., & Tangpricha, V.
- Venue
- Journal of Molecular Medicine
- Published
- 2010-02-01
- Volume
- 88
- Issue
- 5
- Pages
- 441-450
- ISSN
- 0946-2716 (ISSN-L)
- 1432-1440
- OpenAlex
- W2107306983
- Cited by
- 560
- References
- 116
- FWCI
- 24.23
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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