Cited by 109Inflammasome and immune disordersNitric Oxide and Endothelin EffectsAdvanced Glycation End Products research

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Contribution of redox-dependent activation of endothelial Nlrp3 inflammasomes to hyperglycemia-induced endothelial dysfunction

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Chen, Yang, Wang, Lei, Pitzer, Ashley L., Li, Xiang, Li, Pin-Lan, Zhang, Yang·2016·Journal of Molecular Medicine

DOI 10.1007/s00109-016-1481-5PMC PMC5512566

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Abstract

Recent studies indicate that inflammasomes serve as intracellular machinery to initiate classical cytokine-mediated inflammatory responses and play a crucial role in the pathogenesis of cardiovascular diseases. However, whether or not the activation of endothelial inflammasomes directly causes cell dysfunction or tissue injury without recruitment of inflammatory cells is unknown. We explored the role of endothelial cell inflammasome activation in mediating tight junction disruption, a hallmark event of endothelial barrier dysfunction leading to endothelial hyperpermeability in diabetes. We used confocal microscopy to study the formation and activation of NOD-like receptor family pyrin domain containing-3 (Nlrp3) inflammasomes and expression of tight junction proteins in coronary arteries of streptozotocin-treated diabetic wild type and Nlrp3 gene-deleted mice. We found that Nlrp3 ablation prevented inflammasome activation and tight junction disassembly in the coronary arterial endothelium of diabetic mice. Similarly, Nlrp3 gene silencing prevented high glucose-induced down-regulation of tight junction proteins in cultured mouse vascular endothelial cells (MVECs). The high glucose-induced tight junction disruption and consequent endothelial permeability were attributed to increased release of the high mobility group box protein-1 (HMGB1), which is dependent on enhanced Nlrp3 inflammasome activity. Mechanistically, reducing reactive oxygen species (ROS) production abolished high glucose-induced inflammasome activation, tight junction disruption, and endothelial hyperpermeability in MVECs. Collectively, the ROS-dependent activation of endothelial Nlrp3 inflammasomes by hyperglycemia may be an important initiating mechanism to cause endothelial dysfunction. These effects could contribute to the early onset of endothelial injury in diabetes.Key message Endothelial tight junction disruption in diabetes requires Nlrp3 inflammasomes. High glucose activates Nlrp3 inflammasome in endothelial cells via ROS production. Activation of endothelial inflammasome by high glucose triggers release of HMGB1. Blockade of Nlrp3/HMGB1 axis inhibits high glucose-induced endothelial permeability.

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Authors: Chen, Y., Wang, L., Pitzer, A. L., Li, X., Li, P.-L., & Zhang, Y.
Affiliations: Guangzhou University of Chinese Medicine (CN)
Virginia Commonwealth University (US)
University of Houston (US)
Corresponding author: Zhang, Yang
ORCID: Chen, Yang
Wang, Lei
Li, Xiang
Li, Pin-Lan
Zhang, Yang
Venue: Journal of Molecular Medicine
Publisher: Springer Science and Business Media LLC
Published: 2016-10-25
Volume: 94
Issue: 12
Pages: 1335-1347
ISSN: 0946-2716 (ISSN-L)
1432-1440
DOI: 10.1007/s00109-016-1481-5
PMC: PMC5512566
OpenAlex: W2535421876
Cited by: 108
References: 59
Citations by year: 2026: 6 · 2025: 6 · 2024: 9 · 2023: 9 · 2022: 15 · 2021: 12 · 2020: 15 · 2019: 12 · 2018: 11 · 2017: 12 · 2016: 1
FWCI: 6.24
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Journal of Molecular Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (HL122937, HL122769, HL057244)
National Natural Science Foundation of China (81603587)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
Keywords: NLRP3 inflammasome, endothelial dysfunction, hyperglycemia, diabetes mellitus, tight junction disruption, endothelial hyperpermeability, reactive oxygen species, HMGB1, coronary endothelium, streptozotocin-induced diabetes, vascular endothelial cells, inflammasome activation
MeSH terms: NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Cell Line, Coronary Vessels, Diabetes Mellitus, Experimental, Endothelium, Vascular, Gene Expression Regulation, Humans, Hyperglycemia, Male, Mice, Inbred C57BL, Oxidation-Reduction, Permeability, Streptozocin, Reactive Oxygen Species, Mice, Knockout, Tight Junctions, HMGB1 Protein, RNA, Small Interfering, Endothelial Cells, Mice, Inflammasomes

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Contribution of redox-dependent activation of endothelial Nlrp3 inflammasomes to hyperglycemia-induced endothelial dysfunction

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