The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis
Open accessAbstract
The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes secretion of the proinflammatory cytokines interleukin 1beta (IL-1beta) and IL-18, as well as 'pyroptosis', a form of cell death induced by bacterial pathogens. Members of the Nod-like receptor family, including NLRP1, NLRP3 and NLRC4, and the adaptor ASC are critical components of the inflammasome that link microbial and endogenous 'danger' signals to caspase-1 activation. Several diseases are associated with dysregulated activation of caspase-1 and secretion of IL-1beta. Thus, understanding inflammasome pathways may provide insight into disease pathogenesis that might identify potential targets for therapeutic intervention.
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Pyroptosis is often, if not always, associated with IL-1β and IL18 secretion, and mediates robust pro-inflammatory effects.
“pyroptosis is often (if not always) associated with IL-1β and IL18 secretion, and hence mediates robust pro-inflammatory effects [614, 615].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [615]
The inflammasome complex mediates activation of caspase-1, which triggers secretion of proinflammatory cytokines IL-1β and IL-18 as well as pyroptosis.
“In detail, the inflammasomes complex mediates the activation of caspase-1 which, in turn, triggers the secretion of the proinflammatory cytokines interleukin-1β (IL-1β) and interleukin-18 (IL-18) as well as pyroptosis, a form of programmed cell death [117].”
From Gut Microbiota and Cancer: From Pathogenesis to Therapy (2019) · cites this paper as [117]
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- Authors
- Franchi, L., Eigenbrod, T., Muñoz-Planillo, R., & Nuñez, G.
- Affiliations
- University of Michigan (US)
- ORCID
- Eigenbrod, Tatjana
- Venue
- Nature Immunology
- Published
- 2009-02-17
- Volume
- 10
- Issue
- 3
- Pages
- 241-247
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- PMC
- PMC2820724
- OpenAlex
- W1987535382
- Cited by
- 1,834
- References
- 101
- Citations by year
- 2026: 49 · 2025: 98 · 2024: 118 · 2023: 124 · 2022: 148 · 2021: 127 · 2020: 140 · 2019: 95 · 2018: 87 · 2017: 101 · 2016: 80 · 2015: 87 · 2014: 91 · 2013: 115 · 2012: 114
- FWCI
- 9.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Arthritis Foundation
- National Institute of Allergy and Infectious Diseases (R01AI064748, R01AI063331)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR052756)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Keywords
- inflammasome, caspase-1 activation, IL-1β, IL-18, pyroptosis, NOD-like receptors, NLRP1, NLRP3, NLRC4, innate immunity, pathogenesis, therapeutic target
- MeSH terms
- NLR Proteins, NLR Family, Pyrin Domain-Containing 3 Protein, Calcium-Binding Proteins, Carrier Proteins, Humans, Uric Acid, Caspase 1, Adaptor Proteins, Signal Transducing, Apoptosis Regulatory Proteins, CARD Signaling Adaptor Proteins, Interleukin-1beta, Protein Interaction Domains and Motifs
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