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Cited by 18Extracellular vesicles in diseaseMesenchymal stem cell researchNanoparticle-Based Drug Delivery

EVs vs. EVs: MSCs and Tregs as a source of invisible possibilities

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Heydari, Zahra, Peshkova, Maria, Gonen, Zeynep Burcin, Coretchi, Ianos, Eken, Ahmet, Yay, Arzu Hanım, Dogan, Muhammet Ensar, Gokce, Nuriye +12 more·2023·Journal of Molecular Medicine
DOI 10.1007/s00109-022-02276-2PMC PMC9759062
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Abstract

Extracellular vesicles (EVs) are produced by various cells and exist in most biological fluids. They play an important role in cell-cell signaling, immune response, and tumor metastasis, and also have theranostic potential. They deliver many functional biomolecules, including DNA, microRNAs (miRNA), messenger RNA (mRNA), long non-coding RNA (lncRNA), lipids, and proteins, thus affecting different physiological processes in target cells. Decreased immunogenicity compared to liposomes or viral vectors and the ability to cross through physiological barriers such as the blood-brain barrier make them an attractive and innovative option as diagnostic biomarkers and therapeutic carriers. Here, we highlighted two types of cells that can produce functional EVs, namely, mesenchymal stem/stromal cells (MSCs) and regulatory T cells (Tregs), discussing MSC/Treg-derived EV-based therapies for some specific diseases including acute respiratory distress syndrome (ARDS), autoimmune diseases, and cancer.

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  • MSC-EVs carry RNAs, proteins, lipids, and immunomodulatory factors.

    “MSC-EVs carry a high-tech load of RNAs, proteins, lipids, and immunomodulatory factors [60].”

    From From signaling pathways to clinical trials: mesenchymal stem cells as multimodal regenerative architects in liver cirrhosis therapy (2025) · cites this paper as [60]

  • MSCs secrete MMP-2 and MMP-9, which degrade the triple-helical domain of collagen I and III into fragments phagocytosed by macrophages.

    “Additionally, MSCs exert robust matrix-modifying effects through the secretion of MMPs, specifically MMP-2 (gelatinase A) and MMP-9 (gelatinase B), which possess characteristic proteolytic activity towards fibrillar collagens that constitute the fibrotic scar tissue [60]. The enzymes degrade the triple-helical domain of collagen types I and III into smaller fragments that are subsequently phagocyt”

    From From signaling pathways to clinical trials: mesenchymal stem cells as multimodal regenerative architects in liver cirrhosis therapy (2025) · cites this paper as [60]

    The Cancer > Functionalized MSC-EVs section discusses MMP-14 regulation, not secretion of MMP-2 or MMP-9. The ARDS/ALI section mentions macrophage polarization but not phagocytosis of collagen fragments. Searches for MMP-2, collagen types I and III, and phagocytosed collagen found no passage addressing the claimed mechanism; page numbers were unavailable. (LLM, conf=0.74)

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Cited by

Sorted by citations

Authors
Heydari, Z., Peshkova, M., Gonen, Z. B., Coretchi, I., Eken, A., Yay, A. H., Dogan, M. E., Gokce, N., Akalin, H., Kosheleva, N., Galea-Abdusa, D., Ulinici, M., Vorojbit, V., Shpichka, A., Groppa, S., Vosough, M., Todiras, M., Butnaru, D., Ozkul, Y., & Timashev, P.
Affiliations
  • Sechenov University (RU)
  • Erciyes University (TR)
  • Nicolae Testemițanu State University of Medicine and Pharmacy (MD)
  • Royan Institute (IR)
Corresponding author
  • Vosough, Massoud
  • Timashev, Peter
ORCID
Venue
Journal of Molecular Medicine
Publisher
Springer Science and Business Media LLC
Published
2022-12-17
Volume
101
Issue
1-2
Pages
51-63
ISSN
  • 0946-2716 (ISSN-L)
  • 1432-1440
DOI
10.1007/s00109-022-02276-2
PMC
PMC9759062
OpenAlex
W4311718428
Cited by
18
References
1
Citations by year
2026: 4 · 2025: 7 · 2024: 2 · 2023: 5
FWCI
0.36
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Molecular Medicine (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ministry of Science and Higher Education of the Russian Federation (075-15-2021-951)
  • ERA.Net (21.80013.8007.2M)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
extracellular vesicles, mesenchymal stem cells, regulatory T cells, cell-derived vesicles, microRNA, long non-coding RNA, biomarkers, acute respiratory distress syndrome, autoimmune disease, cancer, cell-to-cell communication, immunotherapy
MeSH terms
Extracellular Vesicles, Proteins, MicroRNAs, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells

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