Cited by 234Diabetes and associated disordersDiabetes Management and ResearchDiabetes, Cardiovascular Risks, and Lipoproteins

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The incidence of Type I diabetes has not increased but shifted to a younger age at diagnosis in the 0–34 years group in Sweden 1983 to 1998

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and the Swedish Childhood Diabetes Study Group, Pundziute-Lyckå, A., Dahlquist, G., Nyström, L., Arnqvist, H., Björk, E., Blohmé, G., Bolinder, J., Eriksson, J., Sundkvist, G., Östman, J.·2002·Diabetologia

DOI 10.1007/s00125-002-0845-2

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Abstract

Aims/hypothesis To analyse the incidence of Type I (insulin-dependent) diabetes mellitus in the 0-34 years age group in Sweden 1983-1998.Methods Incidence and cumulative incidence per 100 000 and Poisson regression analysis of age-period effects was carried out using 11 751 cases from two nation-wide prospective registers.Results Incidence (95%-CI) was 21.4 (20.8-21.9) in men and 17.1 (16.6-17.5) in women between 0 and 34 years of age. In boys aged 0-14 and girls aged 0-12 years the incidence increased over time, but it tended to decrease at older age groups, especially in men. Average cumulative incidence at 35 years was 748 in men and 598 in women. Cumulative incidence in men was rather stable during four 4-year periods (736, 732, 762, 756), while in women it varied more (592, 542, 617, 631). In males aged 0-34 years, the incidence did not vary between the 4-year periods ( p=0.63), but time changes among the 3-year age groups differed ( p<0.001). In females the incidence between the periods varied ( p<0.001), being lower in 1987-1990 compared to 1983-1986, but time changes in the age groups did not differ ( p=0.08). For both sexes median age at diagnosis was higher in 1983-1986 than in 1995-1998 ( p<0.001) (15.0 and 12.5 years in males; 11.9 and 10.4 in females, respectively).Conclusion/interpretation During a 16-year period the incidence of Type I diabetes did not increase in the 0-34 years age group in Sweden, while median age at diagnosis decreased. A shift to younger age at diagnosis seems to explain the increasing incidence of childhood Type I diabetes.

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Is the ‘Accelerator Hypothesis’ worthy of our attention?
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Method
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Pineda-Trujillo, N., Rodriguez‐Acevedo, A. J., Rodriguez‐Acevedo, A. J., Ruiz‐Linares, A., Bedoya, G., Rivera, A., & Alfaro, J. (2017) · Journal of Endocrinological Investigation · doi:10.1007/s40618-017-0797-5 · Cited by 5
Epidemiology of Type 1 Diabetes
Stene, L. C., & Tuomilehto, J. O. (2024) · Wiley eBooks · doi:10.1002/9781119697473.ch4 · Cited by 6
The Incidence of Type 1 Diabetes in Sweden During 2008–2021
Abed, Y. A., Rawshani, A., Rawshani, A., Eliasson, B., Masri, M. A., Lernfelt, G., Novák, D., Pestalozzi, J., & Henningsson, M. (2025) · Acta Paediatrica · doi:10.1111/apa.70226 · Cited by 4
“It has been suggested that the overnutrition of children is a possible explanation for the shift of age at diagnosis [25], and the ‘accelerator hypothesis’ suggests that obesity and higher growth velocity in children result in higher insulin resistance, resulting in greater stress on the β cells.”
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“Furthermore many reports showed that older male adults of European origin (≥15 to 40 years of age) are more likely to develop T1DM than females of similar age and geographic location with an approximate 3:2 male to female ratio [28-30].”
Background
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Background
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(2012) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/97816080536121120101 · Cited by 3
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Trend of type 1 diabetes mellitus in boys and girls under 14 years of age in Belgrade in the period from 1992 to 2017: Joinpoint regression analysis
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Type 1 diabetes mellitus in children
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Authors: and the Swedish Childhood Diabetes Study Group, Pundziute-Lyckå, A., Dahlquist, G., Nyström, L., Arnqvist, H., Björk, E., Blohmé, G., Bolinder, J., Eriksson, J., Sundkvist, G., & Östman, J.
Affiliations: Umeå University (SE)
Linköping University (SE)
Uppsala University Hospital (SE)
Karolinska Institutet (SE)
Skåne University Hospital (SE)
ORCID: Arnqvist, H.
Bolinder, J.
Eriksson, J.
Venue: Diabetologia
Publisher: Springer Science and Business Media LLC
Published: 2002-05-08
Volume: 45
Issue: 6
Pages: 783-791
ISSN: 0012-186X (ISSN-L)
1432-0428
DOI: 10.1007/s00125-002-0845-2
OpenAlex: W1996624137
Cited by: 234
References: 40
Citations by year: 2025: 3 · 2024: 2 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 5 · 2017: 7 · 2016: 9 · 2015: 10 · 2014: 13 · 2013: 12 · 2012: 12
FWCI: 8.22
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Diabetologia (publishedVersion)
PubMed (publishedVersion)
Lund University Publications (Lund University) (submittedVersion)
Funders: Medical Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: type 1 diabetes, incidence trends, age at diagnosis, pediatric diabetes, sex differences, Sweden, diabetes registry, cumulative incidence
MeSH terms: Adolescent, Adult, Child, Child, Preschool, Diabetes Mellitus, Type 1, Female, Humans, Infant, Male, Regression Analysis, Sex Characteristics, Sweden, Time Factors, Incidence, Poisson Distribution, Age of Onset, Age Distribution

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The incidence of Type I diabetes has not increased but shifted to a younger age at diagnosis in the 0–34 years group in Sweden 1983 to 1998

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