The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
The release of the adipocytokine visfatin is regulated by glucose and insulin
Open accessAbstract
Aims/hypothesis The novel insulin-mimetic adipocytokine visfatin has been linked to the metabolic syndrome, but its regulation has not been characterised to date. Since insulin-mimetic actions of visfatin may be part of the feedback regulation of glucose homeostasis, we hypothesised that visfatin concentrations are influenced by glucose or insulin blood levels in humans.Subjects, materials and methods In this randomised, double-blind, placebo-controlled crossover study, nine healthy male subjects (age 26+/-6 years) attended three different study days. On each day, systemic glucose concentrations of 5.0, 8.3 and 11.1 mmol/l were attained by stepwise increases in i.v. infusions of glucose, representing fasting and postprandial conditions. Visfatin plasma concentrations were studied during concomitant exogenous hyperinsulinaemia, inhibition of endogenous insulin production by somatostatin infusion, and placebo time control. Additionally, human adipocytes were cultured to study visfatin release and mRNA expression in vitro.Results Glucose concentrations of 8.3 and 11.1 mmol/l increased circulating visfatin from baseline concentrations of 0.5+/-0.0 ng/ml to 0.9+/-0.1 and 2.1+/-0.3 ng/ml, respectively (p<0.01). Glucose-induced elevation of visfatin was prevented by co-infusion of insulin or somatostatin (p<0.05). Cultured subcutaneous and visceral adipocytes released an equivalent amount of visfatin upon glucose-concentration- and time-dependent stimulation. Visfatin secretion involved the phosphatidylinositol 3-kinase (PI3-kinase) and protein kinase B (AKT) pathways. The mRNA expression pattern of visfatin was consistent with this altered protein release.Conclusions/interpretation Circulating visfatin concentrations are increased by hyperglycaemia. This effect is suppressed by exogenous hyperinsulinaemia or somatostatin infusion. Glucose signalling for visfatin release in adipocytes involves the PI3-kinase/AKT pathway.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“For example, metformin may alleviate abnormal visfatin levels in PCOS patients by increasing peripheral insulin sensitivity and thereby decreasing the IR-induced hyperinsulinemia, which, in turn, may lower visfatin secretion because insulin and glucose affect visfatin secretion via the phosphatidylinositol 3-kinase/protein kinase B pathway (55).”
From Circulating Adipokine Levels in Nonobese Women with Polycystic Ovary Syndrome and in Nonobese Control Women: A Systematic Review and Meta-Analysis (2021) · cites this paper as [55]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin
Fukuhara, A., Matsuda, M., Nishizawa, M., Segawa, K., Tanaka, M., Kishimoto, K., Matsuki, Y., Murakami, M., Ichisaka, T., Murakami, H., et al. (2005) · Science · doi:10.1126/science.1097243 · Cited by 1,906
RetractedLeptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
The hormone resistin links obesity to diabetes
Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755
A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes
Scherer, P. E., Williams, S. P., Fogliano, M., Baldini, G., & Lodish, H. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.26746 · Cited by 3,238
Kim, H. J., Park, S. Y., Choi, Y. J., Han, S. J., Lee, K. W., & Kim, D. J. (2013) · Hormone Research in Paediatrics · doi:10.1159/000348848 · Cited by 3,061
AdipoQ Is a Novel Adipose-specific Gene Dysregulated in Obesity
Hu, E., Liang, P., & Spiegelman, B. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.18.10697 · Cited by 2,261
Maeda, K., Okubo, K., Shimomura, I., Funahashi, T., Matsuzawa, Y., & Matsubara, K. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0587 · Cited by 2,081
Plasma Visfatin Concentrations and Fat Depot–Specific mRNA Expression in Humans
Berndt, J., Klöting, N., Kralisch, S., Kovacs, P. L., Faßhauer, M., Schön, M. R., Stümvoll, M., & Blüher, M. (2005) · Diabetes · doi:10.2337/diabetes.54.10.2911 · Cited by 733
Chen, M., Chung, F., Chang, D., Tsai, J. C. ‐., Huang, H.-F., Shin, S., & Lee, Y. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1475 · Cited by 660
Haider, D. G., Schindler, K., Schaller, G., Prager, G., Wolzt, M., & Ludvik, B. H. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2248 · Cited by 310
Self-citationSautin, Y. Y., Lu, M., Gaugler, A. C., Zhang, L., & Gluck, S. L. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.2.575-589.2005 · Cited by 221
Plasma Ghrelin Concentrations Are Not Regulated by Glucose or Insulin
Schaller, G., Schmidt, A., Pleiner, J., Woloszczuk, W., Wolzt, M., & Luger, A. (2003) · Diabetes · doi:10.2337/diabetes.52.1.16 · Cited by 204
Self-citationHormonal regulation of the novel adipocytokine visfatin in 3T3-L1 adipocytes
Kralisch, S., Klein, J. C., Lössner, U., Blüher, M., Paschke, R., Stümvoll, M., & Faßhauer, M. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.06211 · Cited by 165
Interleukin-6 is a negative regulator of visfatin gene expression in 3T3-L1 adipocytes
Kralisch, S., Klein, J. C., Lössner, U., Blüher, M., Paschke, R., Stümvoll, M., & Faßhauer, M. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00090.2005 · Cited by 161
Yaworsky, K., Somwar, R., Ramlal, T., Tritschler, H., & Klip, A. (2000) · Diabetologia · doi:10.1007/s001250050047 · Cited by 134
Klöting, N., & Klöting, I. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.05.058 · Cited by 90
Taylor, R., Soos, M. A., Wells, A., Argyraki, M., & Siddle, K. (1987) · Biochemical Journal · doi:10.1042/bj2420123 · Cited by 66
Somatostatin Is Expressed and Secreted by Human Adipose Tissue upon Infection and Inflammation
Seboek, D., Linscheid, P., Zulewski, H., Langer, I., Christ‐Crain, M., Keller, U. B., & Müller-Stich, B. P. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0271 · Cited by 41
Sandqvist, M., Eriksson, J. W., & Jansson, P. (2001) · Diabetes · doi:10.2337/diabetes.50.10.2344 · Cited by 31
Tardif, A., Julien, N., Chiasson, J., & Coderre, L. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00134.2002 · Cited by 30
Myou, S., Leff, A. R., Myo, S., Boetticher, E., Meliton, A. Y., Lambertino, A., Liu, J., Xu, C., Muñoz, N. M., & Zhu, X. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.8.4399 · Cited by 26
Chang-Hui, L., Yen-Ju, H., & Lin, Y. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.10.054 · Cited by 21
Effect of whole blood on insulin adsorption onto intravenous infusion systems
Kerchner, J., Colaluca, D. M., & Juhl, R. P. (1980) · American Journal of Health-System Pharmacy · doi:10.1093/ajhp/37.10.1323 · Cited by 17
Cited by
Sorted by citations
Mechanisms linking obesity with cardiovascular disease
Van Gaal, L. F., Mertens, I. L., & De Block, C. E. (2006) · Nature · doi:10.1038/nature05487 · Cited by 2,814
Pancreatic regulation of glucose homeostasis.
Röder, P. V., Wu, B., Liu, Y., & Han, W. (2016) · Experimental & Molecular Medicine · doi:10.1038/emm.2016.6 · Cited by 985
Nampt/PBEF/Visfatin Regulates Insulin Secretion in β Cells as a Systemic NAD Biosynthetic Enzyme
Revollo, J. R., Körner, A., Mills, K. F., Satoh, A., Wang, T., Garten, A., Dasgupta, B., Sasaki, Y., Wolberger, C., Townsend, R. R., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.003 · Cited by 911
Physiological and pathophysiological roles of NAMPT and NAD metabolism.
Garten, A., Schuster, S., Penke, M., Gorski, T., de Giorgis, T., & Kiess, W. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.117 · Cited by 708
Obesity: A Chronic Low-Grade Inflammation and Its Markers
Khanna, D., Khanna, S., Khanna, P., Kahar, P., & Patel, B. M. (2022) · Cureus · doi:10.7759/cureus.22711 · Cited by 567
Metadata
- Authors
- Haider, D. G., Schaller, G., Kapiotis, S., Maier, C., Luger, A., & Wolzt, M.
- Affiliations
- Medical University of Vienna (AT)
- Corresponding author
- Wolzt, M.
- ORCID
- Wolzt, M.
- Venue
- Diabetologia
- Published
- 2006-05-31
- Volume
- 49
- Issue
- 8
- Pages
- 1909-1914
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W1985941542
- Cited by
- 258
- References
- 23
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 12 · 2022: 8 · 2021: 9 · 2020: 8 · 2019: 5 · 2018: 9 · 2017: 5 · 2016: 11 · 2015: 18 · 2014: 14 · 2013: 20 · 2012: 14
- FWCI
- 18.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- 8th European Congress of Endocrinology incorporating the British Endocrine Societies
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- visfatin, adipokines, glucose homeostasis, hyperinsulinemia, hyperglycemia, somatostatin, adipocytes, PI3K/Akt signaling, insulin signaling, metabolic syndrome
- MeSH terms
- Insulin Secretion, Adult, Blood Glucose, Double-Blind Method, Glucose, Humans, Hyperinsulinism, Infusions, Intravenous, Insulin, Male, Placebos, Reference Values, Somatostatin, Cytokines, Adipocytes, Cross-Over Studies, Nicotinamide Phosphoribosyltransferase
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
