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FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis.

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Pre–B-Cell Colony-enhancing Factor as a Potential Novel Biomarker in Acute Lung Injury

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Visfatin: A New Adipokine

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Crystal Structure of Visfatin/Pre-B Cell Colony-enhancing Factor 1/Nicotinamide Phosphoribosyltransferase, Free and in Complex with the Anti-cancer Agent FK-866

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Different Effects on Mitogenesis and Transformation of a Mutation at Tyrosine 1251 of the Insulin-like Growth Factor I Receptor

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The Adipokine Visfatin is Markedly Elevated in Obese Children

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Editorial: Visfatin—A True Or False Trail To Type 2 Diabetes Mellitus

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Common Polymorphisms in the Promoter of the Visfatin Gene (PBEF1) Influence Plasma Insulin Levels in a French-Canadian Population

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Consequences of OX40-OX40 ligand interactions in Langerhans cell function: enhanced contact hypersensitivity responses in OX40L-transgenic mice

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Is PBEF/visfatin/Nampt an authentic adipokine relevant to the metabolic syndrome?

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Adipokines in inflammation and metabolic disease

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Obesity and Its Metabolic Complications: The Role of Adipokines and the Relationship between Obesity, Inflammation, Insulin Resistance, Dyslipidemia and Nonalcoholic Fatty Liver Disease

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NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

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Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

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The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

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Circadian Control of the NAD ⁺ Salvage Pathway by CLOCK-SIRT1

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Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD ⁺ Biosynthesis

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NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism

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NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR

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Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome

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Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

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The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways

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Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

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Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt

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Adipokines and Insulin Resistance

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Kidney fibrosis: from mechanisms to therapeutic medicines

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Adipocytokines and the Metabolic Complications of Obesity

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Physiological and pathophysiological roles of NAMPT and NAD metabolism.

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Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD ⁺ Precursor Vitamins in Human Nutrition

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NAD+ homeostasis in health and disease

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Quantitative Analysis of NAD Synthesis-Breakdown Fluxes

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The single-cell transcriptomic landscape of early human diabetic nephropathy

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The dynamic regulation of NAD metabolism in mitochondria

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NAD+ metabolism, stemness, the immune response, and cancer

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Imaging cytosolic NADH-NAD(+) redox state with a genetically encoded fluorescent biosensor

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Circadian Rhythms and Metabolic Syndrome

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NAD(+) in aging: molecular mechanisms and translational implications

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Obesity: A Chronic Low-Grade Inflammation and Its Markers

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Adipokines in liver diseases #

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White Adipose Tissue as Endocrine Organ and Its Role in Obesity

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Insulin resistance in chronic kidney disease: a systematic review

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Streptozotocin–nicotinamide-induced diabetes in the rat. Characteristics of the experimental model

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Targeting Sirtuin 1 to Improve Metabolism: All You Need Is NAD+?

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Inflammation, a Link between Obesity and Cardiovascular Disease

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Extracellular vesicle-contained eNAMPT delays aging and extends lifespan in mice

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Nampt: linking NAD biology, metabolism and cancer

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Caloric restriction, SIRT1 and longevity

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Skeletal Muscle as an Endocrine Organ: The Role of Myokines in Exercise Adaptations

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Role of NAD+ in regulating cellular and metabolic signaling pathways

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Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases

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NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

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Seven sirtuins for seven deadly diseases ofaging

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Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle

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SIRT1 and energy metabolism

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Visfatin in overweight/obesity, type 2 diabetes mellitus, insulin resistance, metabolic syndrome and cardiovascular diseases: a meta‐analysis and systemic review

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Adipokines in nonalcoholic fatty liver disease

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Mechanisms of thrombosis in obesity

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Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication

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Protein acetylation in metabolism – metabolites and cofactors

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Metabolic effects of obesity: A review

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Age‐associated loss of Sirt1‐mediated enhancement of glucose‐stimulated insulin secretion in beta cell‐specific Sirt1‐overexpressing (BESTO) mice

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The secretory function of adipocytes in the physiology of white adipose tissue

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NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion

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Nicotinamide Mononucleotide, an Intermediate of NAD+ Synthesis, Protects the Heart from Ischemia and Reperfusion

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SIRT1-dependent regulation of chromatin and transcription: Linking NAD+ metabolism and signaling to the control of cellular functions

Zhang, T., & Kraus, W. L. (2009) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2009.10.022 · Cited by 306 · see citing works

Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: role of nicotinamide mononucleotide

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The Warburg Effect 97 Years after Its Discovery

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Pre-B cell colony-enhancing factor (PBEF)/visfatin: a novel mediator of innate immunity

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Skeletal muscle NAMPT is induced by exercise in humans

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Sirtuins at a glance

Nakagawa, T., & Guarente, L. (2011) · Journal of Cell Science · doi:10.1242/jcs.081067 · Cited by 289 · see citing works

Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1‐dependent adenosine monophosphate–activated kinase pathway

Wang, P., Xu, T., Guan, Y., Tian, W., Viollet, B., Rui, Y., Zhai, Q., Su, D., & Miao, C. (2011) · Annals of Neurology · doi:10.1002/ana.22236 · Cited by 288 · see citing works

Slc12a8 is a nicotinamide mononucleotide transporter

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Revisiting the adipocyte: a model for integration of cytokine signaling in the regulation of energy metabolism

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Adipose tissue and its role in organ crosstalk

Romacho, T., Elsen, M., Röhrborn, D., & Eckel, J. (2014) · Acta Physiologica · doi:10.1111/apha.12246 · Cited by 278 · see citing works

The Cardiomyocyte Circadian Clock: Emerging Roles in Health and Disease

Durgan, D. J., & Young, M. E. (2010) · Circulation Research · doi:10.1161/circresaha.109.209957 · Cited by 277 · see citing works

Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes

Braidy, N., Berg, J., Clement, J., Khorshidi, F., Poljak, A., Jayasena, T., Grant, R., & Sachdev, P. S. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7269 · Cited by 286 · see citing works

Adipokines in obesity

Leal, V. D. O., & Mafra, D. (2013) · Clinica Chimica Acta · doi:10.1016/j.cca.2013.02.003 · Cited by 275 · see citing works

Adipokines – removing road blocks to obesity and diabetes therapy

Blüher, M. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.01.005 · Cited by 273 · see citing works

NAD metabolism: Implications in aging and longevity

Yaku, K., Okabe, K., & Nakagawa, T. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.05.006 · Cited by 269 · see citing works

Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging

Stein, L. R., & Imai, S. (2014) · The EMBO Journal · doi:10.1002/embj.201386917 · Cited by 265 · see citing works

NAD + Metabolism in Cardiac Health, Aging, and Disease

Abdellatif, M., Sedej, S., & Kroemer, G. (2021) · Circulation · doi:10.1161/circulationaha.121.056589 · Cited by 262 · see citing works

Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) as a therapeutic strategy in cancer

Sampath, D., Zabka, T. S., Misner, D. L., O’Brien, T., & Dragovich, P. S. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.02.004 · Cited by 258 · see citing works

Depression and type 2 diabetes: Inflammatory mechanisms of a psychoneuroendocrine co-morbidity

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Human SGBS Cells – a Unique Tool for Studies of Human Fat Cell Biology

Fischer‐Posovszky, P., Newell, F., Wabitsch, M., & Tornqvist, H. E. (2008) · Obesity Facts · doi:10.1159/000145784 · Cited by 248 · see citing works

Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes

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NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response

Wang, B., Hasan, M. K., Alvarado, E., Yuan, H., Wu, H., & Chen, W. (2010) · Oncogene · doi:10.1038/onc.2010.468 · Cited by 244 · see citing works

SIRT1-Mediated eNAMPT Secretion from Adipose Tissue Regulates Hypothalamic NAD+ and Function in Mice

Yoon, M. J., Yoshida, M., Johnson, S., Takikawa, A., Usui, I., Tobe, K., Nakagawa, T., Yoshino, J., & Imai, S. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.04.002 · Cited by 242 · see citing works

Pharmacological Inhibition of Nicotinamide Phosphoribosyltransferase/Visfatin Enzymatic Activity Identifies a New Inflammatory Pathway Linked to NAD

Busso, N., Karababa, M., Nobile, M., Rolaz, A., Gool, F. V., Gallí, M., Léo, O., So, A. K.-L., & Smedt, T. D. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002267 · Cited by 244 · see citing works

NAD+ homeostasis in human health and disease

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Nicotinamide Phosphoribosyltransferase (Nampt): A Link Between NAD Biology, Metabolism, and Diseases

Imai, S. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209787185814 · Cited by 235 · see citing works

Mitochondrial Metabolism, Sirtuins, and AgingPreprint

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Macrophages provide a transient muscle stem cell niche via NAMPT secretion

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The importance of NAMPT / NAD / SIRT1 in the systemic regulation of metabolism and ageing

Imai, S., & Yoshino, J. (2013) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12171 · Cited by 232 · see citing works

Enzymes in the NAD+ Salvage Pathway Regulate SIRT1 Activity at Target Gene Promoters

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The Small Molecule GMX1778 Is a Potent Inhibitor of NAD ⁺ Biosynthesis: Strategy for Enhanced Therapy in Nicotinic Acid Phosphoribosyltransferase 1-Deficient Tumors

Watson, M., Roulston, A., Bélec, L., Billot, X., Marcellus, R., Bédard, D., Bernier, C., Branchaud, S., Chan, H., Dairi, K., et al. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00112-09 · Cited by 229 · see citing works

Leptin, resistin and visfatin: the missing link between endocrine metabolic disorders and immunity

Al-Suhaimi, E. A., & Shehzad, A. (2013) · European journal of medical research · doi:10.1186/2047-783x-18-12 · Cited by 233 · see citing works

NAD Metabolism in Cancer Therapeutics

Yaku, K., Okabe, K., Hikosaka, K., & Nakagawa, T. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00622 · Cited by 229 · see citing works

Implications of altered NAD metabolism in metabolic disorders

Okabe, K., Yaku, K., Tobe, K., & Nakagawa, T. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-019-0527-8 · Cited by 223 · see citing works

NAMPT is essential for the G-CSF–induced myeloid differentiation via a NAD+–sirtuin-1–dependent pathway

Skokowa, J., Lan, D., Thakur, B. K., Wang, F., Gupta, K., Cario, G., Brechlin, A. M., Schambach, A., Hinrichsen, L., Meyer, G., et al. (2009) · Nature Medicine · doi:10.1038/nm.1913 · Cited by 218 · see citing works

The human NAD metabolome: Functions, metabolism and compartmentalization

Nikiforov, A. A., Kulikova, V., & Ziegler, M. (2015) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2015.1028612 · Cited by 214 · see citing works

Extracellular Nampt Promotes Macrophage Survival via a Nonenzymatic Interleukin-6/STAT3 Signaling Mechanism

Li, Y., Zhang, Y., Dorweiler, B., Cui, D., Wang, T., Woo, C. W., Brunkan, C. S., Wolberger, C., Imai, S., & Tabas, I. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805866200 · Cited by 212 · see citing works

NAMPT and NAPRT: Two Metabolic Enzymes With Key Roles in Inflammation

Audrito, V., Messana, V. G., & Deaglio, S. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00358 · Cited by 209 · see citing works

Adipokines as novel modulators of lipid metabolism

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The role of adipokines in β-cell failure of type 2 diabetes

Dunmore, S., & Brown, J. E. P. (2012) · Journal of Endocrinology · doi:10.1530/joe-12-0278 · Cited by 205 · see citing works

Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia

Audrito, V., Serra, S., Brusa, D., Mazzola, F., Arruga, F., Vaisitti, T., Coscia, M., Maffei, R., Rossi, D., Wang, T., et al. (2014) · Blood · doi:10.1182/blood-2014-07-589069 · Cited by 199 · see citing works

Regulation of Cartilage-specific Gene Expression in Human Chondrocytes by SirT1 and Nicotinamide Phosphoribosyltransferase

Dvir‐Ginzberg, M., Gagarina, V., Lee, E. J., & Hall, D. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803196200 · Cited by 201 · see citing works

The NAD World: A New Systemic Regulatory Network for Metabolism and Aging—Sirt1, Systemic NAD Biosynthesis, and Their Importance

Imai, S. (2009) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-008-9041-4 · Cited by 200 · see citing works

Hepatic NAD+ deficiency as a therapeutic target for non‐alcoholic fatty liver disease in ageing

Zhou, C., Yang, X., Hua, X., Liu, J., Fan, M.-B., Li, G., Song, J., Xu, T., Li, Z., Guan, Y., et al. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13513 · Cited by 198 · see citing works

Leucocytes are a major source of circulating nicotinamide phosphoribosyltransferase (NAMPT)/pre-B cell colony (PBEF)/visfatin linking obesity and inflammation in humans

Friebe, D., Neef, M., Kratzsch, J., Erbs, S., Dittrich, K., Garten, A., Petzold-Quinque, S., Blüher, S., Reinehr, T., Stümvoll, M., et al. (2011) · Diabetologia · doi:10.1007/s00125-010-2042-z · Cited by 198 · see citing works

Visfatin/Nampt: An Adipokine with Cardiovascular Impact

Romacho, T., Sánchez‐Ferrer, C. F., & Peiró, C. (2013) · Mediators of Inflammation · doi:10.1155/2013/946427 · Cited by 198 · see citing works

Nampt/PBEF/Visfatin: A New Player in β Cell Physiology and in Metabolic Diseases?

Tanaka, T., & Nabeshima, Y. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.004 · Cited by 26 · see citing works

The regulation of nicotinamide adenine dinucleotide biosynthesis by Nampt/PBEF/visfatin in mammals

Revollo, J. R., Grimm, A. A., & Imai, S. (2007) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32801b3c8f · Cited by 310 · see citing works

Progress in functional research of nicotinamide phosphoribosyltransferase

He-li, D. (2009) · International Journal of Internal Medicine

Nampt: linking NAD biology, metabolism and cancer

Garten, A., Petzold-Quinque, S., Körner, A., Imai, S., & Kieß, W. (2008) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2008.10.004 · Cited by 399 · see citing works

Expression and Regulation of Nampt in Human Islets

Kover, K. L., Tong, P. Y., Watkins, D. J., Clements, M. A., Stehno‐Bittel, L., Novikova, L., Bittel, D., Kibiryeva, N., Stuhlsatz, J., Yan, Y., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058767 · Cited by 47 · see citing works