Rosiglitazone modifies the adipogenic potential of human muscle satellite cells
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Aims/hypothesis Satellite cells are responsible for postnatal skeletal muscle regeneration. It has been demonstrated that mouse satellite cells behave as multipotent stem cells. We studied the differentiation capacities of human satellite cells and evaluated the effect of the insulin sensitiser rosiglitazone, a well known peroxisome proliferative activated receptor gamma (PPARG) agonist, on their adipogenic conversion.Subjects, materials and methods We obtained human satellite cells from human muscle biopsies of healthy subjects by single-fibre isolation and cultured them under myogenic, osteogenic and adipogenic conditions. Moreover, we compared the morphological features and the adipose-specific gene expression profiling, as assessed by quantitative PCR, between adipocytes differentiated from human satellite cells and those obtained from the stromal vascular fraction of human visceral fat.Results We proved by morphological analysis, mRNA expression and immunohistochemistry that human satellite cells are able to differentiate into myotubes, adipocytes and osteocytes. The addition of rosiglitazone to the adipogenic medium strongly activated PPARG expression and enhanced adipogenesis in human satellite cells, but did not in itself trigger the complete adipogenic programme. Moreover, we observed a decrease in wingless-type MMTV integration site family member 10B and an upregulation of growth differentiation factor 8 expression, both being independent of PPARG activation.Conclusions/interpretation Human satellite cells possess a clear adipogenic potential that could explain the presence of mature adipocytes within skeletal muscle in pathological conditions such as obesity, type 2 diabetes and ageing-related sarcopenia. Rosiglitazone treatment, while enhancing adipogenesis, induces a more favourable pattern of adipocytokine expression in satellite-derived fat cells. This could partially counteract the worsening effect of intermuscular adipose tissue depots on muscle insulin sensitivity.
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In obesity, satellite cells acquire adipocyte features, expressing adipocyte-specific genes and accumulating lipids, with a likely effect that favors myosteatosis.
“In obesity, satellite cells acquire adipocyte features, expressing adipocyte-specific genes and accumulating lipids, with a likely effect that favors myosteatosis [128–130].”
From The critical role of oxidative stress in sarcopenic obesity (2021) · cites this paper as [130]
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Additional file 7 of MYOD1 inhibits avian adipocyte differentiation via miRNA-206/KLF4 axis
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Additional file 8 of MYOD1 inhibits avian adipocyte differentiation via miRNA-206/KLF4 axis
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Additional file 1 of MYOD1 inhibits avian adipocyte differentiation via miRNA-206/KLF4 axis
Wang, Z., Zhao, Q., Li, X., Yin, Z., Chen, S., Wu, S., Yang, N., & Hou, Z. (2021) · Figshare · doi:10.6084/m9.figshare.14544717
Additional file 9 of MYOD1 inhibits avian adipocyte differentiation via miRNA-206/KLF4 axis
Wang, Z., Zhao, Q., Li, X., Yin, Z., Chen, S., Wu, S., Yang, N., & Hou, Z. (2021) · Figshare · doi:10.6084/m9.figshare.14544741
Additional file 5 of MYOD1 inhibits avian adipocyte differentiation via miRNA-206/KLF4 axis
Wang, Z., Zhao, Q., Li, X., Yin, Z., Chen, S., Wu, S., Yang, N., & Hou, Z. (2021) · Figshare · doi:10.6084/m9.figshare.14544729
Additional file 4 of MYOD1 inhibits avian adipocyte differentiation via miRNA-206/KLF4 axis
Wang, Z., Zhao, Q., Li, X., Yin, Z., Chen, S., Wu, S., Yang, N., & Hou, Z. (2021) · Figshare · doi:10.6084/m9.figshare.14544726
Additional file 3 of MYOD1 inhibits avian adipocyte differentiation via miRNA-206/KLF4 axis
Wang, Z., Zhao, Q., Li, X., Yin, Z., Chen, S., Wu, S., Yang, N., & Hou, Z. (2021) · Figshare · doi:10.6084/m9.figshare.14544723
Additional file 10 of MYOD1 inhibits avian adipocyte differentiation via miRNA-206/KLF4 axis
Wang, Z., Zhao, Q., Li, X., Yin, Z., Chen, S., Wu, S., Yang, N., & Hou, Z. (2021) · Figshare · doi:10.6084/m9.figshare.14544714
Additional file 2 of MYOD1 inhibits avian adipocyte differentiation via miRNA-206/KLF4 axis
Wang, Z., Zhao, Q., Li, X., Yin, Z., Chen, S., Wu, S., Yang, N., & Hou, Z. (2021) · Figshare · doi:10.6084/m9.figshare.14544720
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Muscle in fat trouble: The rise of IMAT in metabolic and musculoskeletal disease
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- Authors
- De Coppi, P., Milan, G., Scarda, A., Boldrin, L., Centobene, C., Piccoli, M., Pozzobon, M., Pilon, C., Pagano, C., Gamba, P., & Vettor, R.
- Affiliations
- University of Padua (IT)
- Corresponding author
- Milan, G.
- Venue
- Diabetologia
- Published
- 2006-06-24
- Volume
- 49
- Issue
- 8
- Pages
- 1962-1973
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W1976711948
- Cited by
- 81
- References
- 48
- Citations by year
- 2026: 2 · 2025: 3 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 4 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 4 · 2015: 3 · 2014: 2 · 2013: 6 · 2012: 4
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Update notices
- correction (2025-08-19)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Regione del Veneto
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- rosiglitazone, satellite cells, adipogenesis, skeletal muscle regeneration, multipotent stem cells, Wnt10b, myostatin, adipokines, intermuscular adipose tissue, skeletal muscle insulin sensitivity, obesity, type 2 diabetes, sarcopenia
- MeSH terms
- Rosiglitazone, Adolescent, Adult, Biopsy, Child, Female, Humans, Hypoglycemic Agents, Male, Muscle, Skeletal, Muscle Fibers, Skeletal, Satellite Cells, Skeletal Muscle, Thiazolidinediones, Adipogenesis
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