Circulating leptin levels are not associated with cardiovascular morbidity and mortality in women with diabetes: a prospective cohort study.
Open accessAbstract
Aims/hypothesis Leptin, an adipocyte-secreted hormone, plays an important role in regulating neuroendocrine and immune function as well as insulin resistance and metabolism. Our objective was to examine the relationship between leptin levels and cardiovascular morbidity and overall mortality in women with type 2 diabetes.Subjects and methods This prospective cohort study included 1,194 women with a confirmed diagnosis of type 2 diabetes, who provided a blood sample at baseline in 1989-1990. Participants were followed for 12 years for the development of health outcomes including cardiovascular disease (CVD) events as well as total mortality.Results There were 218 new CVD events and 228 deaths from all causes. Cox proportional hazards analysis was used to estimate the relative risks (RRs) for each quintile level of leptin compared with the lowest quintile. Leptin levels were positively associated with several CVD risk factors including BMI and inflammatory markers, but were not independently associated with the incidence of CVD or total mortality in women with diabetes. The multivariate RRs (95% CIs) for CVD across the quintiles of leptin were 0.96 (0.61-1.53), 0.99 (0.61-1.61), 1.04 (0.63-1.71), 1.02 (0.59-1.75) (p for trend = 0.83).Conclusions/interpretation Although circulating leptin levels are associated with obesity and inflammatory markers, they are not significantly related to the risk of CVD or mortality in women with diabetes.
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In leptin-sufficient obese subjects with type 2 diabetes, administration of r-metHuLeptin for 4 or 16 wk resulted in high pharmacologic leptin concentrations but did not activate the tumor necrosis factor alpha system or increase cytokines or inflammatory markers above the normal range.
“However, in leptin-sufficient obese subjects with type 2 diabetes, the administration of r-metHuLeptin for 4 or 16 wk resulted in high pharmacologic leptin concentrations but did not activate the tumor necrosis factor a system or increase cytokines or inflammatory markers above the normal range.”
From Leptin in humans: lessons from translational research (2009) · cites this paper as [32]
These data support a permissive role for leptin in the regulation of the immune system but do not support an etiopathogenic role for leptin in proinflammatory states associated with leptin excess such as obesity.
“These data support a permissive role for leptin in the regulation of the immune system but do not support an etiopathogenic role for leptin in proinflammatory states associated with leptin excess such as obesity (32).”
From Leptin in humans: lessons from translational research (2009) · cites this paper as [32]
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Adipose tissue dysfunction in obesity, diabetes, and vascular diseases
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- Authors
- Brennan, A. M., Li, T. Y., Kelesidis, I., Gavrila, A., Hu, F. B., & Mantzoros, C. S.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Mantzoros, C. S.
- Venue
- Diabetologia
- Published
- 2007-03-20
- Volume
- 50
- Issue
- 6
- Pages
- 1178-1185
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2048083112
- Cited by
- 54
- References
- 31
- Citations by year
- 2026: 1 · 2023: 2 · 2020: 2 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 5 · 2014: 6 · 2013: 3 · 2012: 5
- FWCI
- 4.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- Beth Israel Deaconess Medical Center
- National Institutes of Health
- National Heart, Lung, and Blood Institute (HL 65582, R01HL065582)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK058845, DK 58785, DK58845, P30DK040561)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- leptin, type 2 diabetes, women, cardiovascular disease, cardiovascular mortality, cardiovascular morbidity, adipokines, obesity, inflammatory markers, insulin resistance
- MeSH terms
- Adult, Aged, Blood Specimen Collection, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Female, Humans, Life Style, Middle Aged, Prospective Studies, Surveys and Questionnaires, Risk Factors, Cohort Studies, Body Mass Index, Survival Analysis, Leptin
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