Cited by 1,410Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityAdipose Tissue and Metabolism

Adipose tissue dysfunction in obesity, diabetes, and vascular diseases

Hajer, G. R., van Haeften, T. W., Visseren, F. L.J.·2008·European Heart Journal

Abstract

The classical perception of adipose tissue as a storage place of fatty acids has been replaced over the last years by the notion that adipose tissue has a central role in lipid and glucose metabolism and produces a large number of hormones and cytokines, e.g. tumour necrosis factor-alpha, interleukin-6, adiponectin, leptin, and plasminogen activator inhibitor-1. The increased prevalence of excessive visceral obesity and obesity-related cardiovascular risk factors is closely associated with the rising incidence of cardiovascular diseases and type 2 diabetes mellitus. This clustering of vascular risk factors in (visceral) obesity is often referred to as metabolic syndrome. The close relationship between an increased quantity of visceral fat, metabolic disturbances, including low-grade inflammation, and cardiovascular diseases and the unique anatomical relation to the hepatic portal circulation has led to an intense endeavour to unravel the specific endocrine functions of this visceral fat depot. The objective of this paper is to describe adipose tissue dysfunction, delineate the relation between adipose tissue dysfunction and obesity and to describe how adipose tissue dysfunction is involved in the development of diabetes mellitus type 2 and atherosclerotic vascular diseases. First, normal physiology of adipocytes and adipose tissue will be described.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1093/eurheartj/ehn387

Cites

137 of 137 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. [87]87. Bots ML, Visseren FL, Evans GW, Riley WA, Revkin JH, Tegeler CH, Shear CL, Duggan WT, Vicari RM, Grobbee DE, Kastelein JJ RADIANCE 2 Investigators. Torcetrapib and progression of carotid intima-media thickness in mixed dyslipidemia. The RADIANCE II study. Lancet 2007; 370 :153-160.

Cited by

Sorted by citations

Authors
Hajer, G. R., van Haeften, T. W., & Visseren, F. L. J.
Affiliations
University Medical Center Utrecht (NL)
Corresponding author
Visseren, F. L.J.
Venue
European Heart Journal
Published
2008-09-05
Volume
29
Issue
24
Pages
2959-2971
ISSN
  • 0195-668X (ISSN-L)
  • 1522-9645
OpenAlex
W2100784798
Cited by
1,410
References
136
Citations by year
2026: 23 · 2025: 54 · 2024: 45 · 2023: 55 · 2022: 58 · 2021: 68 · 2020: 83 · 2019: 69 · 2018: 85 · 2017: 88 · 2016: 98 · 2015: 100 · 2014: 134 · 2013: 130 · 2012: 103
FWCI
7.72
Type
journal article
Language
en
Open access
closed
Locations
  • European Heart Journal (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
adipose tissue dysfunction, visceral obesity, type 2 diabetes, metabolic syndrome, cardiovascular disease, atherosclerosis, adipokines, adiponectin, leptin, TNF-α, interleukin-6, plasminogen activator inhibitor-1, low-grade inflammation, portal circulation, cardiovascular risk factors
MeSH terms
Adipose Tissue, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Energy Metabolism, Female, Humans, Male, Obesity, Transcription Factors, Adipocytes, Leptin, Metabolic Syndrome, Risk Reduction Behavior, Intra-Abdominal Fat, Atherosclerosis, Subcutaneous Fat, Abdominal

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review