The DOI matches its Crossref record; 104 of the 104 references it cites were found in a registry or an index.
Beta cell mass in diabetes: a realistic therapeutic target?
Open accessAbstract
Beta cell deficiency underlies both type 1 and type 2 diabetes, and restoration or replacement of beta cell function is therefore the logical long-term solution to therapy. This review sets out to describe the defects in beta cell mass and function in both forms of diabetes, summarises current understanding of the underlying causes of beta cell death, and the methodological limitations of determining beta cell mass in vivo. Finally, the potential effects of current and future treatment regimens on beta cell mass and turnover are considered.
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“Regeneration of β-cell function in experimental animal models has been widely observed in rodents but remains elusive and controversial in humans (13,14).”
From Adaptive β-Cell Proliferation Is Severely Restricted With Advanced Age (2009) · cites this paper as [14]
Experimental — accuracy not yet measuredIn the citing paper
“Sadly, expansion of bona fide human β-cells has not been convincingly demonstrated (13–15).”
From Adaptive β-Cell Proliferation Is Severely Restricted With Advanced Age (2009) · cites this paper as [14]
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Citations
Cites
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A., & Butler, P. C. (2003) · Diabetes · doi:10.2337/diabetes.52.1.102 · Cited by 4,011
Banting lecture 1988. Role of insulin resistance in human disease.
Reaven, G. (1988) · Diabetes · doi:10.2337/diabetes.37.12.1595 · Cited by 3,801
Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy
Kahn, S. E., Haffner, S. M., Heise, M. A., Herman, W. H., Holman, R. R., Jones, N. P., Kravitz, B. G., Lachin, J. M., O'Neill, M. C., Zinman, B., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa066224 · Cited by 2,962
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
Dor, Y., Brown, J., Martinez, O. I., & Melton, D. A. (2004) · Nature · doi:10.1038/nature02520 · Cited by 2,219
Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells
D’Amour, K. A., Bang, A. G., Eliazer, S., Kelly, O., Agulnick, A. D., Smart, N. G., Moorman, M. A., KROON, E. J., Carpenter, M. K., & Baetge, E. E. (2006) · Nature Biotechnology · doi:10.1038/nbt1259 · Cited by 1,913
Five-Year Follow-Up After Clinical Islet Transplantation
Ryan, E. A., Paty, B. W., Senior, P. A., Bigam, D., Alfadhli, E., Kneteman, N. M., Lakey, J. R. T., & Shapiro, A. M. J. (2005) · Diabetes · doi:10.2337/diabetes.54.7.2060 · Cited by 1,641
Pathologic anatomy of the pancreas in juvenile diabetes mellitus
Gepts, W. (1965) · Diabetes · doi:10.2337/diab.14.10.619 · Cited by 1,345
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus
Herold, K. C., Hagopian, W., Auger, J. A., Poumian-Ruiz, E., Taylor, L., Donaldson, D., Gitelman, S. E., Harlan, D. M., Xu, D., Zivin, R. A., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012864 · Cited by 1,222
Research works printed but not linked: 1
- Meier JJ, Butler PC (2005) Insulin secretion. In: DeGroot LJ, Jameson JL (eds) Endocrinology, 5th edn. Elsevier Saunders, Philadelphia, pp 961–973
Cited by
Sorted by citations
Autophagy in human type 2 diabetes pancreatic beta cells
Masini, M., Bugliani, M., Lupi, R., Guerra, S. D., Boggi, U., Filipponi, F., Marselli, L., Masiello, P., & Marchetti, P. (2009) · Diabetologia · doi:10.1007/s00125-009-1347-2 · Cited by 368
“In type 2 diabetes, increased apoptosis, a type of programmed cell death, contributes to beta cell loss [1].”
BackgroundAdaptive β-Cell Proliferation Is Severely Restricted With Advanced Age
Rankin, M. M., & Kushner, J. A. (2009) · Diabetes · doi:10.2337/db08-1198 · Cited by 327
“Regeneration of -cell function in experimental animal models has been widely observed in rodents but remains elusive and controversial in humans (13,14).”
BackgroundEffects of High-Density Lipoproteins on Pancreatic β-Cell Insulin Secretion
Fryirs, M. A., Barter, P. J., Appavoo, M., Tuch, B. E., Tabet, F., Heather, A. K., & Rye, K. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.207373 · Cited by 288
Role of Reduced β-Cell Mass Versus Impaired β-Cell Function in the Pathogenesis of Type 2 Diabetes
Meier, J. J., & Bonadonna, R. C. (2013) · Diabetes Care · doi:10.2337/dcs13-2008 · Cited by 246
“Collectively, these studies lend strong support to the hypothesis that reductions in b-cell mass secondarily cause various abnormalities in b-cell function (especially pulsatile insulin secretion), a-cell function, and insulin action in patients with type 2 diabetes (38,39).”
ResultSelf-citationStreptozotocin as a tool for induction of rat models of diabetes: a practical guide
Ghasemi, A., & Jeddi, S. (2022) · EXCLI journal · doi:10.17179/excli2022-5720 · Cited by 273
“Humans maintain normoglycemia until 50 % of the β-cells mass is lost (Meier, 2008).”
Background
Metadata
- Authors
- Meier, J. J.
- Affiliations
- St. Josef-Hospital (DE)
- Corresponding author
- Meier, J. J.
- ORCID
- Meier, J. J.
- Venue
- Diabetologia
- Published
- 2008-03-04
- Volume
- 51
- Issue
- 5
- Pages
- 703-713
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2166312550
- Cited by
- 155
- References
- 104
- Citations by year
- 2025: 3 · 2024: 5 · 2023: 6 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 7 · 2018: 4 · 2017: 7 · 2016: 7 · 2015: 13 · 2014: 11 · 2013: 11 · 2012: 13
- FWCI
- 3.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- beta-cell mass, type 1 diabetes, type 2 diabetes, beta-cell death, diabetes treatment
- MeSH terms
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Humans, Hypoglycemic Agents, Insulin Resistance, Regeneration, Apoptosis, Insulin-Secreting Cells
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