Cited by 155Pancreatic function and diabetesDiabetes and associated disordersDiabetes Treatment and Management

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Beta cell mass in diabetes: a realistic therapeutic target?

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Meier, J. J.·2008·Diabetologia

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Abstract

Beta cell deficiency underlies both type 1 and type 2 diabetes, and restoration or replacement of beta cell function is therefore the logical long-term solution to therapy. This review sets out to describe the defects in beta cell mass and function in both forms of diabetes, summarises current understanding of the underlying causes of beta cell death, and the methodological limitations of determining beta cell mass in vivo. Finally, the potential effects of current and future treatment regimens on beta cell mass and turnover are considered.

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Self-citation
Late anastomotic leaks in pancreas transplant recipients – clinical characteristics and predisposing factors
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Research works printed but not linked: 1

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Sorted by citations

Autophagy in human type 2 diabetes pancreatic beta cells
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“In type 2 diabetes, increased apoptosis, a type of programmed cell death, contributes to beta cell loss [1].”
Background
Adaptive β-Cell Proliferation Is Severely Restricted With Advanced Age
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“Regeneration of -cell function in experimental animal models has been widely observed in rodents but remains elusive and controversial in humans (13,14).”
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Effects of High-Density Lipoproteins on Pancreatic β-Cell Insulin Secretion
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“Collectively, these studies lend strong support to the hypothesis that reductions in b-cell mass secondarily cause various abnormalities in b-cell function (especially pulsatile insulin secretion), a-cell function, and insulin action in patients with type 2 diabetes (38,39).”
ResultSelf-citation
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“Humans maintain normoglycemia until 50 % of the β-cells mass is lost (Meier, 2008).”
Background

See all 155

Authors: Meier, J. J.
Affiliations: St. Josef-Hospital (DE)
Corresponding author: Meier, J. J.
ORCID: Meier, J. J.
Venue: Diabetologia
Publisher: Springer Science and Business Media LLC
Published: 2008-03-04
Volume: 51
Issue: 5
Pages: 703-713
ISSN: 0012-186X (ISSN-L)
1432-0428
DOI: 10.1007/s00125-008-0936-9
OpenAlex: W2166312550
Cited by: 155
References: 104
Citations by year: 2025: 3 · 2024: 5 · 2023: 6 · 2022: 5 · 2021: 4 · 2020: 5 · 2019: 7 · 2018: 4 · 2017: 7 · 2016: 7 · 2015: 13 · 2014: 11 · 2013: 11 · 2012: 13
FWCI: 3.07
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Diabetologia (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: beta-cell mass, type 1 diabetes, type 2 diabetes, beta-cell death, diabetes treatment
MeSH terms: Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Humans, Hypoglycemic Agents, Insulin Resistance, Regeneration, Apoptosis, Insulin-Secreting Cells

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Beta cell mass in diabetes: a realistic therapeutic target?

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