Impaired stroke volume and aerobic capacity in female adolescents with type 1 and type 2 diabetes mellitus
Open accessAbstract
Aim/hypothesis This study was designed to determine whether type 2 diabetic adolescents have reduced aerobic capacity and to investigate the role of cardiac output and arteriovenous oxygen difference (a-vO(2)) in their exercise response.Methods Female adolescents (age 12-18 years) with type 2 diabetes mellitus (n = 8) and type 1 diabetes mellitus (n = 12) and obese (n = 10) and non-obese (n = 10) non-diabetic controls were recruited for this study. Baseline data included maximal aerobic capacity (cycle ergometer) and body composition. Cardiac output and a-vO(2) were determined at rest and during submaximal exercise.Results Diabetic groups had lower aerobic capacity than non-diabetic groups (p < 0.05). Adolescents with type 2 diabetes had lower aerobic capacity than the type 1 diabetic group. Maximal heart rate was lower in the type 2 diabetic group (p < 0.05). Exercise stroke volume was 30-40% lower at 100 and 120 beats per min in the diabetic than in the non-diabetic groups (p < 0.05). The a-vO(2) value was not different in any condition.Conclusions and interpretation Type 2 diabetic adolescents have reduced aerobic capacity and reduced heart rate response to maximal exercise. Furthermore, type 2 and type 1 diabetic adolescent girls have a blunted exercise stroke volume response compared with non-diabetic controls. Central rather than peripheral mechanisms contribute to the reduced aerobic capacity in diabetic adolescents. Although of short duration, type 2 diabetes in adolescence is already affecting cardiovascular function in adolescents.
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The pattern of initial responsiveness followed by regression to baseline activity levels likely reflects diminishing adherence to digitally-promoted exercise protocols over extended periods.
“This pattern of initial responsiveness followed by regression to baseline activity levels likely reflects diminishing adherence to digitally-promoted exercise protocols over extended periods (46, 47).”
From The effectiveness of digital health intervention on glycemic control and physical activity in patients with type 2 diabetes: a systematic review and meta-analysis (2025) · cites this paper as [46]
The Methods and Results (page unavailable) describe exercise testing and cardiovascular responses in adolescents with diabetes, not a digital exercise intervention. Searches for declining adherence and regression to baseline activity found no passage addressing either point. (LLM, conf=0.76)
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Increased incidence of non-insulin-dependent diabetes mellitus among adolescents
Pinhas‐Hamiel, O., Dolan, L. M., Daniels, S. R., Standiford, D. A., Khoury, P. R., & Zeitler, P. S. (1996) · The Journal of Pediatrics · doi:10.1016/s0022-3476(96)80124-7 · Cited by 1,169 · see citing works
Poliner, L. R., DEHMER, G. J., Lewis, S. E., Parkey, R. W., Blomqvist, C. G., & Willerson, J. T. (1980) · Circulation · doi:10.1161/01.cir.62.3.528 · Cited by 408 · see citing works
Determinants of Exercise Capacity in Patients With Type 2 Diabetes
Fang, Z. Y., Sharman, J. E., Prins, J. B., & Marwick, T. H. (2005) · Diabetes Care · doi:10.2337/diacare.28.7.1643 · Cited by 197 · see citing works
COOPER, M. (2004) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2004.08.021 · Cited by 172 · see citing works
Reduced exercise arteriovenous O2difference in Type 2 diabetes
Baldi, J. C., Aoina, J. L., Oxenham, H., Bagg, W., & Doughty, R. N. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00879.2002 · Cited by 100 · see citing works
Self-citationPoirier, P., Bogaty, P. M., Philippon, F., Garneau, C., Fortin, C., & Dumesnil, J.-G. (2003) · Metabolism · doi:10.1016/s0026-0495(03)00091-x · Cited by 97 · see citing works
Cardiovascular Endurance and Heart Rate Variability in Adolescents With Type 1 or Type 2 Diabetes
Faulkner, M. S., Quinn, L., Rimmer, J. H., & Rich, B. H. (2005) · Biological Research For Nursing · doi:10.1177/1099800405275202 · Cited by 60 · see citing works
Pichler, G., Urlesberger, B., Jirak, P., et al. (2004) · Diabetes Care · doi:10.2337/diacare.27.8.1942 · Cited by 50 · see citing works
Impaired myocardial function in newly onset Type 2 diabetes associates with arterial stiffness☆
Loimaala, A., Groundstroem, K., Majahalme, S. K., Nenonen, A., & VUORI, I. M. (2005) · European Journal of Echocardiography · doi:10.1016/j.euje.2005.07.001 · Cited by 21 · see citing works
EXERCISE CAPACITY IS ABNORMAL IN YOUTH WITH TYPE 2 DIABETES.
Nadeau, K. J., Ehlers, L. B., Zeitler, P. S., et al. (2007) · Journal of Investigative Medicine · doi:10.1097/00042871-200701010-00012 · Cited by 1 · see citing works
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Body temperature regulation in diabetes
Kenny, G. P., Sigal, R. J., & McGinn, R. (2016) · Temperature · doi:10.1080/23328940.2015.1131506 · Cited by 297 · see citing works
Qiu, S., Cai, X., Schumann, U., Velders, M., Sun, Z., & Steinacker, J. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109767 · Cited by 128 · see citing works
Step counter use in type 2 diabetes: a meta-analysis of randomized controlled trials
Qiu, S., Cai, X., Chen, X., Yang, B., & Sun, Z. (2014) · BMC Medicine · doi:10.1186/1741-7015-12-36 · Cited by 106 · see citing works
Banks, A. Z., Mentz, R. J., Stebbins, A., Mikus, C. R., Schulte, P. J., Fleg, J. L., Cooper, L. S., Leifer, E. S., Badenhop, D. T., Keteyian, S. J., et al. (2016) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2015.12.007 · Cited by 56 · see citing works
Item, F., Heinzer-Schweizer, S., Wyss, M., Fontana, P., Lehmann, R., Henning, A., Weber, M., Boesiger, P., Boutellier, U., & Toigo, M. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00747.2010 · Cited by 22 · see citing works
Xue, H., Zhang, L., Shi, Y., Zhang, H., Zhang, C., Liu, Y., Tan, W., & Liu, Y. (2025) · Frontiers in Digital Health · doi:10.3389/fdgth.2025.1630588 · Cited by 15 · see citing works
- Authors
- Gusso, S., Hofman, P., Lalande, S., Cutfield, W., Robinson, E., & Baldi, J. C.
- Affiliations
- University of Auckland (NZ)
- Corresponding author
- Gusso, S.
- Venue
- Diabetologia
- Published
- 2008-04-30
- Volume
- 51
- Issue
- 7
- Pages
- 1317-1320
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2017500988
- Cited by
- 113
- References
- 10
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 7 · 2019: 5 · 2018: 8 · 2017: 13 · 2016: 6 · 2015: 4 · 2014: 10 · 2013: 6 · 2012: 13
- FWCI
- 22.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- ResearchSpace (University of Auckland) (submittedVersion)
- Funders
- Scheme for Promotion of Academic and Research Collaboration
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- type 1 diabetes, type 2 diabetes, adolescent girls, stroke volume, cardiorespiratory fitness, cardiac output, arteriovenous oxygen difference, maximal heart rate, exercise response, obesity, cardiovascular function
- MeSH terms
- Adolescent, Child, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Exercise Test, Female, Heart Rate, Humans, Oxygen Consumption, Stroke Volume, Exercise
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